Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir

Antiviral Chemistry and Chemotherapy

Volumn 12, Issue 5, 2001, Pages 301-306

  Balzarini, Jan ^a   Haller Meier, Friederike ^a   De Clercq, Erik ^a   Meier, Chris ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

CycloSal prodrugs; Guanosine analogues; Herpes simplex virus; HIV

Indexed keywords

ABACAVIR DERIVATIVE; ACICLOVIR DERIVATIVE; ANTIVIRUS AGENT; CARBOVIR DERIVATIVE; CYCLOSALIGENIN DERIVATIVE; FUNCTIONAL GROUP; GUANOSINE DERIVATIVE; PRODRUG; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MINIMUM INHIBITORY CONCENTRATION; MOLONEY MURINE SARCOMA ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; STRUCTURE ACTIVITY RELATION; VIRUS RESISTANCE;

EID: 0035715817     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020101200505     Document Type: Article

References (26)

1. Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives
2. Anti-HIV and anti-HBV activity and resistance profile of 2′,3′-dideoxy- 3′-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109
3. Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives
4. Antiretrovirus specificity and intracellular metabolism of 2′,3′-dideoxythymidinc (stavudine) and its 5′-monophosphate triester prodrug So324
5. Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection
6. Intracellular metabolism of cyclosaligenyl 3′-azido-2′,3′-dideoxythymidine monophosphate, a prodrug of 3′-azido-2′,3′-dideoxythymidine (zidovudine)
7. Cyclosaligenyl-2′,3′-didehydro-2′,3′-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP
8. DNA polymerases versus HIV reverse transcriptase in AIDS therapy
9. Moloney sarcoma virus-induced tumors in mice: Inhibition or stimulation by (polyrI:polyrC)
10. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus
11. A strategy to introduce therapeutic nucleoside 5′-phosphates into cells
12. Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2′-deoxy-5-fluorouridine 5′-monophosphate (FdUMP): A strategy to introduce nucletoides into cells
13. Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: Intracellular delivery of 3′-azido-2′,3′-dideoxythymidine 5′-monophosphate
14. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
15. Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite
16. Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine (d4A) have markedly improved anti-HIV potency and selectivity
17. Pro nucleotides recent advances in the design of efficient tools for the delivery of biologically active nucleoside monophosphates
18. Chemistry and anti-herpes simplex virus type 1 evaluation of cycloSal-nucleotides of acyclic nucleoside analogues
19. cycloSal-2′,3′-dideoxy-2′,3′-didehydrothymidine monophosphate (cycloSal-d4TMP) - synthesis and antiviral evaluation of a new d4TMP delivery system
20. CycloSal pronucleotides of 2′,3′-dideoxyadenosine and 2′,3′-dideoxy-2′,3′-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system
21. cycloSal-pronucleotides of 2′-fluoro-ara- and 2′-fluoro-ribo-2′,3′-dideoxyadenosine as a strategy to bypass a metabolic blockade
22. cycloSaligenyl-5-[(E)-2-bromovinyl]-2′-deoxyuridine monophosphate (cycloSal-BVDUMP) pronucleotides active against Epstein-Barr-virus
23. Rational design for cytosolic delivery of nucleoside monophosphates: "SATE" and "DTE" as enzyme-labile transient phosphate protecting groups
24. The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship
25. Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: Toward a rational approach for intracellular delivery of nucleoside 5′-monophosphates
26. Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides