Transgenic mice over-expressing GABABR1a receptors acquire an atypical absence epilepsy-like phenotype

Neurobiology of Disease

Volumn 26, Issue 2, 2007, Pages 439-451

  Wu, Ying ^a   Chan, Katherine F Y ^a,d   Eubanks, James H ^b   Guin Ting Wong, C ^a   Cortez, Miguel A ^a,d   Shen, Liqing ^a   Che Liu, Chun ^a   Perez Velazquez, Jose ^a,d   Tian Wang, Yu ^c   Jia, Zhengping ^a   Carter Snead III, O ^a,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Absence seizures; Behavior; Epileptogenesis; GABAB receptor; Neurophysiology; Transgenic Mouse

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; ETHOSUXIMIDE; GAMMA BUTYROLACTONE; PROTEIN GABA B R1A; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; EPILEPTIC DISCHARGE; EPILEPTOGENESIS; GENE OVEREXPRESSION; GENOTYPE PHENOTYPE CORRELATION; HIPPOCAMPUS; HUMAN; LEARNING DISORDER; LIMBIC SYSTEM; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPIKE WAVE; THALAMOCORTICAL TRACT; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN CHEMISTRY; DISEASE MODELS, ANIMAL; EPILEPSY, ABSENCE; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; MICE; MICE, TRANSGENIC; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONAL PLASTICITY; PHENOTYPE; RECEPTORS, GABA-B; SYNAPTIC TRANSMISSION;

EID: 34147118613     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.01.013     Document Type: Article

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