Biological effects of field emission-type X-rays generated by nanotechnology

Journal of Radiation Research

Volumn 48, Issue 2, 2007, Pages 153-161

  Nakazato, Tomoharu ^a   Nakanishi, Makoto ^a   Kita, Shigetomo ^b   Okuyama, Fumio ^b   Shibamoto, Yuta ^a   Otsuka, Takanobu ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Carbon nanotube; Field emission; Nanotechnology; X ray

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; DAMAGE DETECTION; DNA; ELECTRON SOURCES; FIELD EMISSION; RADIOTHERAPY; THERMIONIC EMISSION; X RAY APPARATUS; YARN;

BIOLOGICAL EFFECTS; CELL CYCLE; CELL-BE; CELL/B.E; COMPACT SYSTEM; DNA DAMAGES; INTRACAVITARY RADIOTHERAPY; INTRAOPERATIVE RADIOTHERAPY; X RAY GENERATORS; X-RAY SOURCES;

CARBON NANOTUBES;

EID: 34047232383     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.06071     Document Type: Article

References (34)

1. Sugie, H., Tanemura, M., Filip, K., Iwata, K., Takahashi, K. and Okuyama, F. (2001) Carbon nanotubes as electron source in an X-ray tube. Appl. Phys. Lett. 78: 2578-2580.
2. Fowler, R. H. and Nordheim, L. W. (1928) Electron emission in intense electric fields. Proc. Roy. Soc. London Ser. A 119: 173-181.
3. Iijima, S. (1991) Helical microtubles of graphic carbon. Nature 354: 56-58.
4. Collins, P. G. and Zettl, A. (1997) Unique characteristics of cold cathode carbon-nanotubematrix field emitters. Phys. Rev. 55: 9391-9399.
5. Yue, G. Z., Qiu, Q., Gao, B., Cheng, Y., Zhang, Z., Shimada, H., Chang, S., Lu, J. P. and Zhou, O. (2002) Generation of continuous and pulsed diagnostic imaging of X-radiation using a carbon-nanotube-based field emission cathode. Appl. Phys. Lett. 81: 355-357.
6. Matsumoto, T. and Mimura, H. (2003) Point X-ray source using graphite nanofibers and its application to X-ray radiography. Appl. Phys. Lett. 82: 1637-1639.
7. Yamaguchi, A., Kobayashi, N., Aoki, N., Motoi, Y. and Mitsuoka, Y. (2004) Compact soft X-ray source for biological applications. Nucl. Sci. Symp. N36: 124-127.
8. Kita, S., Sakai, Y., Fukushima, T., Mizuta, Y., Ogawa, A., Senda, S. and Okuyama, F. (2004) Characterization of field-electron emission from carbon nanofibers grown on Pd wire. Appl. Phys. Lett. 85: 4478-4480.
9. Haga, A., Senda, S., Sakai, Y., Mizuta, Y., Kita, S. and Okuyama, F. (2004) A miniature Xray tube. Appl. Phys. Lett. 84: 5679-5681.
10. Endo, S., Hoshi, M., Takada, J., Takatsuji, T., Ejima, Y., Saigusa, S., Tachibana, A., Sasaki, M. S. (2006) Development, beam characterization and chromosomal effectiveness of X-rays of RTBC characteristic X-ray generator. J. Radiat. Res. 47: 103-112.
11. Khanna, K. K. and Jackson, S. P. (2001) DNA double-strand breaks: signaling, repair and cancer connection. Nat. Genet. 27: 247-254.
12. Geiman, T. M. and Robertson, K. D. (2002) Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together? J. Cell. Biochem. 87: 117-125.
13. Vaziri, H., Squire, J. A., Pandita, T. K., Bradley, G., Kuba, R. M., Zhang, H., Gulyas, S., Hill, R. P., Nolan, G. P. and Benchimol, S. (1999) Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol. Cell. Biol. 19: 2373-2379.
14. Ohyama, H., Muto, M. and Yamada, T. (1992) Apoptosis in newly established radiosensitive mouse lymphoma cell lines. Elsevier. Science. Publishers. 361-364.
15. Kawai, H., Yamada, Y., Tatsuka, M., Niwa, O., Yamamoto, K. I. and Suzuki, F. (1999) Down-regulation of nuclear factor κB is required for p53-dependent apoptosis in X-rayirradiated mouse lymphoma cells and thymocytes. Cancer Res. 59: 6038-6041.
16. Senda, S., Tanemura, M., Sakai, Y., Ichikawa, Y., Kita, S., Otsuka, T., Haga, A. and Okuyama, F. (2004) New field-emission x-ray radiography system. Rev. Sci. Instrum. 75: 1366-1368.
17. Ogino, H., Shibamoto, Y., Sugie, C and Ito, M. (2005) Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction. J. Radiat. Res. 46: 401-406.
18. Sugie, C., Shibamoto, Y., Ito, M., Ogino, H., Suzuki, H., Uto, Y., Nagasawa, H and Hori, H. (2005) Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo. J. Radiat. Res. 46: 453-459.
19. th Edition, Eds. C. A. Perez, L. W. Brady, E. C. Halperin and R. K. Schmidt-Ullrich, pp. 180-218, Lippincott Williams & Wilkins, Philadelphia.
20. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. and Bonner, W. M. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273: 5858-5868.
21. Yoshida, K., Yoshida, S. H., Shimoda, C. and Morita, T. (2003) Expression and radiationinduced phosphorylation of histone H2AX in mammalian cells. J. Radiat. Res. 44: 47-51.
22. Rogakou, E. P., Boon, C., Redon, C. and Bonner, W. M. (1999) Megabase chromatin domains involved in DNA double strand breaks in vivo. Cell. Biol. 146: 905-915.
23. Gatei, M., Sloper, K., Sörensen, C., Syljuäsen, R., Falck, J., Hobson, K., Savage, K., Lukas, J., Zhou, B. B., Bartek, J. and Khanna, K. K. (2003) Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278: 14806-14811.
24. Zhao, H. and Worms, H. P. (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21: 4129-4139.
25. Peng, C. Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S. and W. H. (1997) Piwnica, Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine216. Science 277: 1501-1505.
26. Matsuoka, S., Huang, M. and Elledge, S. J. (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1897.
27. Bartek, J., Falck, J. and Lukas, J. (2001) CHK2 kinase - a busy messenger. Nat. Rev. Mol. Cell. Biol. 2: 877-886.
28. Abraham, R. T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes. & Dev. 15: 2177-2196.
29. Jack, M. T., Woo, R. A., Hirao, A., Cheung, A., Mak, T. W. and Lee, P. W. K. (2002) Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. PNAS. 99: 9825-9829.
30. Levine, A. J. (1977) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
31. Gire, V., Roux, P., Thomas, D. W., Brondello, J. M. and Dulic, V. (2004) DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO. J. 23: 2554-2563.
32. Gavrieli, Y., Sherman, Y. and Sasson, S. A. B. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Cell. Biol. 119: 493-501.
33. Bernhard, E. J., Maity, A., Muschel, R. J. and Mckenna, W. G. (1995) Effects of ionizing radiation on cell cycle progression. A review. Radiat. Environ. Biophys. 34: 79-83.
34. Senda, S., Sakai, Y., Mizuta, Y., Kita, S. and Okuyama, F. (2004) Super-miniature X-ray tube. Appl. Phys. Lett. 85: 5679-5681.