Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells

Journal of Allergy and Clinical Immunology

Volumn 119, Issue 4, 2007, Pages 982-990

  Ebner, Susanne ^a,c   Nguyen, Van Anh ^a   Forstner, Markus ^a,c   Wang, Yui Hsi ^d   Wolfram, Dolores ^b   Liu, Yong Jun ^d   Romani, Nikolaus ^a,c  

^a Departments of Dermatology and Venereology   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c Kompetenzzentrum Medizin Tirol   (Austria)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Atopic dermatitis; dendritic cells; Langerhans cells; thymic stromal lymphopoietin

Indexed keywords

CD86 ANTIGEN; CHEMOKINE; CYTOKINE; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T6 ANTIGEN; THYMIC STROMAL LYMPHOPOIETIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL ISOLATION; CELL MATURATION; CELL MIGRATION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LANGERHANS CELL; MAGNETISM; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN-PRESENTING CELLS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SEPARATION; CELL SURVIVAL; CYTOKINES; DERMATITIS, ATOPIC; EPIDERMIS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INFLAMMATION MEDIATORS; INTERLEUKIN-7; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; STROMAL CELLS; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TISSUE CULTURE TECHNIQUES; UP-REGULATION;

EID: 34047130119     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.01.003     Document Type: Article

References (48)

1. Romani N., Holzmann S., Tripp C.H., Koch F., and Stoitzner P. Langerhans cells-dendritic cells of the epidermis. APMIS 111 (2003) 725-740
2. Romani N., Tripp C.H., Ratzinger G., Heufler C., Koch F., Saeland S., et al. Epidermal langerhans cells. In: Lutz M.B., Romani N., and Steinkasserer A. (Eds). Handbook of dendritic cells, biology, diseases and therapies (2006), Wiley-VCH Verlag, Weinheim, Germany 73-100
3. Schuler G., and Steinman R.M. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161 (1985) 526-546
4. Kissenpfennig A., and Malissen B. Langerhans cells-revisiting the paradigm using genetically engineered mice. Trends Immunol 27 (2006) 132-139
5. Romani N., Ebner S., Tripp C.H., Flacher V., Koch F., and Stoitzner P. Epidermal Langerhans cells-changing views on their function in vivo. Immunol Lett 106 (2006) 119-125
6. Silberberg I.R., Baer L., and Rosenthal S.A. The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. J Invest Dermatol 66 (1976) 210-217
7. Toews G.B., Bergstresser P.R., and Streilein J.W. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124 (1980) 445-453
8. Stary G., Bangert C., Stingl G., and Kopp T. Dendritic cells in atopic dermatitis: expression of FcεRI on two distinct inflammation-associated subsets. Int Arch Allergy Immunol 138 (2005) 278-290
9. Novak N., and Bieber T. The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis. J Am Acad Dermatol 53 pt 2 (2005) S171-S176
10. Stingl G., and Maurer D. IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells. Int Arch Allergy Immunol 113 (1997) 24-29
11. Liu Y.-J., Soumelis V., Watanabe N., Ito T., Wang Y.H., De Waal Malefijt R., et al. TSLP: an epithelial cell cytokine that regulates t cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol (2006) Nov 27 [epub ahead of print]
12. Liu Y.J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med 203 (2006) 269-273
13. Soumelis V., Reche P.A., Kanzler H., Yuan W., Edward G., Homey B., et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3 (2002) 673-680
14. Gilliet M., Soumelis V., Watanabe N., Hanabuchi S., Antonenko S., Waal-Malefyt R., et al. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J Exp Med 197 (2003) 1059-1063
15. Yoo J., Omori M., Gyarmati D., Zhou B.H., Aye T., Brewer A., et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 202 (2005) 541-549
16. Li M., Messaddeq N., Teletin M., Pasquali J.-L., Metzger D., and Chambon P. Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A 102 (2005) 14795-14800
17. Wang Y.H., Ito T., Wang Y.H., Homey B., Watanabe N., Martin R., et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 24 (2006) 827-838
18. Guo M., Gong S.C., Maric S., Misulovin Z., Pack M., Mahnke K., et al. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Human Immunol 61 (2000) 729-738
19. Romani N., Bhardwaj N., Pope M., Koch F., Swiggard W.J., O'Doherty U., et al. Dendritic cells. In: Herzenberg L.A., Weir D.M., Herzenberg L., and Blackwell C. (Eds). Weir's handbook of experimental immunology (1997), Blackwell Science, Oxford p. 156.1-14
20. Lenz A., Heine M., Schuler G., and Romani N. Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization. J Clin Invest 92 (1993) 2587-2596
21. Koch F., Kämpgen E., Schuler G., and Romani N. Effective enrichment of murine epidermal Langerhans cells by a modified-"mismatched"-panning technique. J Invest Dermatol 99 (1992) 803-807
22. Graf D., Korthäuer U., Mages H.W., Senger G., and Kroczek R.A. Cloning of TRAP, a ligand for CD40 on human T cells. Eur J Immunol 22 (1992) 3191-3194
23. Ito T., Wang Y.H., Duramad O., Hori T., Delespesse G.J., Watanabe N., et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 202 (2005) 1213-1223
24. Heufler C., Koch F., and Schuler G. Granulocyte-macrophage colony-stimulating factor and interleukin-1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J Exp Med 167 (1988) 700-705
25. Ebner S., Lenz A., Reider D., Fritsch P., Schuler G., and Romani N. Expression of maturation-/migration-related molecules on human dendritic cells from blood and skin. Immunobiology 198 (1998) 568-587
26. Novak N., Valenta R., Bohle B., Laffer S., Haberstok J., Kraft S., et al. FcεRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro. J Allergy Clin Immunol 113 (2004) 949-957
27. Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M., Travis M., et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 167 (2001) 336-343
28. Hauser C., Snapper C.M., Ohara J., Paul W.E., and Katz S.I. T helper cells grown with hapten-modified cultured Langerhans' cells produce interleukin 4 and stimulate IgE production by B cells. Eur J Immunol 19 (1989) 245-251
29. Kissenpfennig A., Henri S., Dubois B., Laplace-Builhé C., Perrin P., Romani N., et al. Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22 (2005) 643-654
30. Bennett C.L., van Rijn E., Jung S., Inaba K., Steinman R.M., Kapsenberg M.L., et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169 (2005) 569-576
31. Kaplan D.H., Jenison M.C., Saeland S., Shlomchik W.D., and Shlomchik M.J. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23 (2005) 611-620
32. Zhou B., Comeau M.R., De Smedt T., Liggitt H.D., Dahl M.E., Lewis D.B., et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 6 (2005) 1047-1053
33. Ying S., O'Connor B., Ratoff J., Meng Q., Mallett K., Cousins D., et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 174 (2005) 8183-8190
34. Stumbles P.A., Upham J.W., and Holt P.G. Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract. APMIS 111 (2003) 741-755
35. Van Rijt L.S., and Lambrecht B.N. Dendritic cells in asthma: a function beyond sensitization. Clin Exp Allergy 35 (2005) 1125-1134
36. Valladeau J., Duvert-Frances V., Pin J.J., Dezutter-Dambuyant C., Vincent C., Massacrier C., et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol 29 (1999) 2695-2704
37. Artis D., Humphreys N.E., Bancroft A.J., Rothwell N.J., Potten C.S., and Grencis R.K. Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 190 (1999) 953-962
38. Iwasaki M., Saito K., Takemura M., Sekikawa K., Fujii H., Yamada Y., et al. TNF-alpha contributes to the development of allergic rhinitis in mice. J Allergy Clin Immunol 112 (2003) 134-140
39. Chen L., Martinez O., Overbergh L., Mathieu C., Prabhakar B.S., and Chan L.S. Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin Exp Immunol 138 (2004) 375-387
40. Imai T., Baba M., Nishimura M., Kakizaki M., Takagi S., and Yoshie O. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J Biol Chem 272 (1997) 15036-15042
41. Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol 28 (1998) 582-588
42. Bonecchi R., Bianchi G., Bordignon P.P., D'Ambrosio D., Lang R., Borsatti A., et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187 (1998) 129-134
43. Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., Sinigaglia F., et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol 161 (1998) 547-551
44. h2 cells toward antigen- presenting cells by the CC chemokines thymus and activation- regulated chemokine and macrophage-derived chemokine. Int Immunol 11 (1999) 81-88
45. Kakinuma T., Nakamura K., Wakugawa M., Mitsui H., Tada Y., Saeki H., et al. Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 107 (2001) 535-541
46. Jahnz-Rozyk K., Targowski T., Paluchowska E., Owczarek W., and Kucharczyk A. Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis. Allergy 60 (2005) 685-688
47. Gombert M., Dieu-Nosjean M.C., Winterberg F., Bünemann E., Kubitza R.C., Da Cunha L., et al. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J Immunol 174 (2005) 5082-5091
48. Homey B., Steinhoff M., Ruzicka T., and Leung D.Y. Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol 118 (2006) 178-189