Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures

Journal of Biomolecular Screening

Volumn 12, Issue 3, 2007, Pages 396-405

  Kool, Jeroen ^a   Eggink, Mark ^a   Van Rossum, Huub ^a   Van Liempd, Sebastiaan M ^a   Van Elswijk, Danny A ^b   Irth, Hubertus ^b   Commandeur, Jan N M ^a   Meerman, John H N ^a   Vermeulen, Nico P E ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b Kiadis BV   (Netherlands)

Author keywords

Enzyme affinity detection (EAD); Glutathione S tranferase PI (GST P1); Glutathione S tranferases (GSTs); High resolution screening (HRS); Online

Indexed keywords

2 AMINO 4 [1 (CARBOXYMETHYLCARBAMOYL) 2 HEXYLSULFANYLETHYLCARBAMOYL]BUTYRIC ACID; 2 AMINO 4 [2 [2 (4 CARBOXYMETHOXY 2,3 DICHLOROBENZOYL)BUTYLSULFANYL] 1 (CARBOXYPHENYLMETHYLCARBAMOYL)ETHYLCARBAMOYL]BUTYRIC ACID; 2 AMINO 4 [2 BENZYLSULFANYL 1 [(CARBOXYPHENYLMETHYL)CARBAMOYL]ETHYLCARBAMOYL]BUTYRIC ACID; 2 CHLORO 5 NITROBENZALDEHYDE; 2 CHLORO 5 NITROBENZONITRILE; 2 CHLORO 5 NITROPYRIDINE; 4 CHLORO 3 DINITROBENZALDEHYDE; 4 CHLORO 3 NITROBENZALDEHYDE; 4 CHLORO 3 NITROBENZOIC ACID BUTYL ESTER; 5 (4 AMINO 4 CARBOXYBUTYRYLAMINO) 5 (1 METHYLHEXYLCARBAMOYL)PENTANOIC ACID; ACROLEIN; BENZALDEHYDE DERIVATIVE; BENZONITRILE; CINNAMALDEHYDE; CROTONALDEHYDE; ENZYME INHIBITOR; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE P1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CHEMICAL REACTION; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ELECTROPHILIC STRESS; FLOW INJECTION ANALYSIS; IC 50; ONLINE SYSTEM; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANIMALS; AUTOMATIC DATA PROCESSING; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ETHACRYNIC ACID; FLOW INJECTION ANALYSIS; GLUTATHIONE S-TRANSFERASE PI; HUMANS; INHIBITORY CONCENTRATION 50; ONLINE SYSTEMS; RATS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

RATTUS;

EID: 34047121556     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057107299527     Document Type: Article

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