Does glutathione S-transferase Pi (GST-Pi) a marker protein for cancer?

Molecular and Cellular Biochemistry

Volumn 253, Issue 1-2, 2003, Pages 319-327

  Aliya, S ^a   Reddanna, P ^b   Thyagaraju, K ^a  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

Chemical toxicity; Expression of GSTs; Glutathione S transferases; Phenobarbitol

Indexed keywords

CYTOSINE; GENE PRODUCT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GUANINE; PROTEIN C FOS; PROTEIN C JUN; SULFUR; TRANSCRIPTION FACTOR AP 1; TUMOR MARKER; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL TISSUE; CARCINOGENESIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE MARKER; ENZYME PURIFICATION; EXON; GENE STRUCTURE; GENETIC CODE; GENETIC REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVIEW; TUMOR CELL;

ANIMALS; ANTICARCINOGENIC AGENTS; ENZYME ACTIVATION; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; NEOPLASMS; RATS; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

ANIMALIA;

EID: 0142150156     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026036521852     Document Type: Review

References (90)

1. Talalay P, De Long MJ, Prochaska HJ: Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc Natl Acad Sci USA 85: 8261-8265, 1988
2. Fabey RC, SundquistAR: In: Evolution of Glutathione Metabolism and Biological Significance. Academic Press, New York, 1991
3. Kaplowitz N, Clifton G, Kuhlen Kamp J, Wallin JD: Comparison of renal and hepatic glutathione S-transferases in male and female rats. Biochem J 158: 243, 1976
4. Dixit R, Mukthar H, Seth PK, Krishna Murthi CR: Binding of acryl amine with glutathione S-transferases. Chem Biol Interact 32: 353-359, 1980
5. Li N, Reddanna P, Thyagaraju K, Reddy CC, Tu CPD: Expression of glutathione S-transferases in rat brain. J Biol Chem 261: 7596-7599, 1986
6. Wahllander A, Soboll S, Sies H, Linke I, Muller M: Hepatic mitochondrial and cytosolic glutathione content and the sub cellular distribution of glutathione S-transferases. FEBS Lett 97: 138-140, 1979
7. Kraus P: Resolution, purification and some properties of three-glutathione transferases from rat liver mitochondria. Hoppe Seyler's Z Physiol Chem 361: 9-15, 1980
8. Stasiecki P, Oesch T, Bruder G, Jarasch ED, Franke WW: Distribution of enzymes involved in the metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes. Eur J Cell Biol 21: 79-92, 1980
9. Mukhtar H, Baars AJ, Bremier DD: Differences in inducibility of particulate and cytosolic rat liver glutathione S-transferases activities. Xenobiotica. 11: 367-371, 1981
10. Mannervik B: The isoenzymes of glutathione S-transferase. Adv Enzymol Relat Areas Mol Biol 57: 357, 1985
11. Mantle TJ, Pickett CB, Hayes JD (eds): In: Glutathione S-Transferases and Carcinogenesis. Taylor and Francis, London, 1987
12. Pickett CB, Donohue AM, Lu YH, Hales BF: Rat liver glutathione S-transferase B the functional mRNAs specific for the YaYc subunits are induced differentially by phenobarbital. Arch Biochem Biophys 215: 539, 1982
13. Spencer SR, Xue L, Klenz EM, Talalay P: The potency of inducers of NAD(P)H: (quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations. Biochem J 273: 711-717, 1991
14. Hayes JD, Judah DJ, Neal GE: Resistance to affatoxin B1 Is associated with the expression of a novel aldoketo reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin. Cancer Res 53: 3887-3894, 1993
15. Bock KW: Roles of UDP-glucuronosyltransferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol 26: 129-150, 1991
16. Mandel HG, Manson MM, Judah DJ, Simpson JL, Greem JA, Forrester LM, Wolf CR, Neal GE: Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat. Cancer Res 47: 5218-5223, 1987
17. Borroz KI, Buetler TM, Eaton DL: Modulation of γ-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole. Toxicol Appl Pharmacol 126: 150-155, 1994
18. Warholm M, Guthenberg C, Mannervik B, von Bahr C, Glaumann H: Identification of a new glutathione S-transferase in human liver. Acta Chem Scand B34: 607-610, 1980
19. Dolan C: Regulation of mouse hepatic glutathione S-transferases. PhD Thesis, University of Edinburgh, 1990
20. Hayes JD, Wolf CR: Molecular mechanisms of drug resistance. Biochem J 272: 281-295, 1990
21. Pemble SE, Taylor JB: An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences, Biochem J 287: 957-963, 1992
22. Buetler TM, Eaton DL: Glutathione S-transferases, amino acid sequence comparison, classification and phylogenetic relationship. Environ Carcinogen Exotoxical Rev C10: 181-203
23. Mannervik B, Alin P, Guthenberg C, Jensson H, Tahir MK, Warholm M, Jornvall H: Identification of three classes of cytosolic glutathione S-transferases common to several mammalian species: Correlation between structural data and enzymatic properties. Proc Natl Acad Sci USA 82: 7202-7206, 1985
24. Meyer DJ, Thomas M: Characterization of rat spleen prostaglandin - H D- isomerase as a sigma class glutathione S-transferase. Biochem J 311: 739-742, 1995
25. Thyagaraju K, Reddanna P, Devi KN, Hildenbrandt GR, Reddy CC: Structural multiplicity of GSTs. J Parasitol Appl Animal Biol 3: 23-29, 1994
26. Morgenstern R, Depierre JW: Microsomal glutathione S-transferase, purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition. Eur J Biochem 134: 591-597, 1983
27. Nicholson DW, Ali A, Villiancourt JP, Calay cay JR, Mumford RA, Zamboni RJ, Ford Hutchinson AW: Purification to homogenesity and the N-terminal sequence of human LTC4 synthase: A homodimeric glutathione S-transferases composed of 18-kDa subunits. Proc Natl Acad Sci USA 90: 2015-2019, 1993
28. Armstrong RN: Glutathione S-transferases: Structure and mechanism of an archetypical detoxification enzyme. Adv Enzymol Relat Areas Mol Biol 69: 1-44, 1994
29. Liu S, Zhang P, Ji X, Johnson WW, Gilliland GL, Amstrong RN: Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 3-3 of glutathione S-transferase. J Biol Chem 267: 4296-4299, 1992
30. Ji XH, Von Rosenvinge EC, Johnson WW, Tomarev SI, Piatigorsky J, Amstrong RN, Gilliland GL: Three dimensional structure, catalytic properties and evolution of a sigma class glutathione S-transferase from squid, a progenitor of the lens, S-crystallins of cephalopods. Biochemistry 34: 5317-5328, 1995
31. Wilce MCJ, Board PG, Feil SC, Parker MW: Crystal structure of a theta class glutathione S-transferase. EMBO J 14: 2133-2143, 1995
32. Hiratsula A, Yokoi A, Sesbata N, Watabe T, Satosh K, Hatayama I, Sato K: Glutathione conjugation of the fluorophotometric epoxide substrate, 7-glycidoxycoumarin (GOC), by rat liver glutathione S-transferase isozymes. Biochem Pharmacol 38: 2609-2613, 1989
33. Satoh K, Hatayama , Tsuchida S, Sato K: Biochemical characteristics of a preneoplastic marker enzyme glutathione S-transferase P-form (7-7). Arch Biochem Biophys 285: 312-316, 1991
34. Mannervik B, Danielson UH: Glutathione S-transferases, structure and catalytic activity. CRC Crit Rev Biochem Mol Biol 23: 283-337, 1988
35. Clark AG, Smith JN, Speir TW: Cross specificity in some vertebrate and insect glutathione S-transferases with methyl parathion (dimethyl p-nitrophenyl phosphorothionate), 1-chloro-2,4-dinitrobenzene and Scrotonyl-N-cysteamine as substrates. Biochem J 135: 385-392, 1973
36. Hayes JD, Pufford DJ: The glutathione S-transferase super gene family: Regulation of GST and the contribution of the isoenzyme to cancer chemoprotection and drug resistance Crit Rev Biochem Mol Biol 30: 445-600, 1995
37. Chasseaud LF: The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electorphilic agents. Adv Cancer Res 29: 175-274, 1979
38. van Bladeren PJ, vander Gen A, Breimer DD, Mohan GR: Stereoselecstive activation of vicinal dihalogen compounds by glutathione conjugation. Biochem Pharmacol 28: 2521-2524, 1979
39. Anders MW, Vamvakas S, Dekant W: In: J.D. Hayes, C.B. Pickett, Mantle (eds). Bioactivation of Haloalkenes Through Glutathione Conjugation in GSTs and Drug Resistance. Taylor and Francis, London, 1990, pp 121-130
40. Andersson C, Mosialou E, Weinander R, Morgenstern R: Enzymology of microsomal glutathione S-transferase. Adv Pharmacol: 19-35, 1994
41. Keen JH, Jakoby WB: Glutathione S-transferases catalysis of nucleophilic reaction of glutathione. J Biol Chem 253: 5654-5657, 1978
42. Mannervik B: Glutathione and the evolution of enzymes for detoxification of products of oxygen metobolism. Chemica Scripta 26B: 281-284, 1986
43. Mosialou E, Ekstrom G, Adang AEP, Morgenstern R: Evidence that rat liver microsomal glutathione S-transferases is responsible for glutathione dependent protection against lipid peroxidation. Biochem Pharmacol 45: 1645-1651, 1993
44. Prochaska HJ, Talalay P: Regulatory mechanisms of monofunctional and bifunctional anti carcinogenic enzyme inducers in murine liver. Cancer Res 48: 4776-4782, 1988
45. Satoh K, Kitahara A, Soma Y. Inaba Y, Hatayama I, Sato K: Purification, induction and distribution of placental glutathione S-transferases: A new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc Natl Acad Sci USA 82: 3964, 1985
46. Kitahara A, Satoh K, Nishimura K, Ishikawa T, Ruike K, Sato K, Tsuda H, Ito N: Changes in molecular forms of rat hepatic glutathione S-transferases during chemical hepatocarcinogenesis. Cancer Res 44: 2698-2703, 1984
47. Tsuchida S, Sato K: Glutathione S-transferases and cancer. CRC Crit Rev Biochem Mol Biol 27: 337-384, 1992
48. Sato K: Glutathione S-transferases and hepatocarcinogenesis. Jpn J Cancer Res 79: 556, 1988
49. Dwivedi PP, Kumar A, Prasad AK, Pandya KP, Ray PK: Induction of glutathione S-transferases isoenzyme by protein A in rat liver. Biochem Biophys Res Commun 169: 476, 1990
50. 2α formation. J Biol Chem 265: 5418, 1990
51. Anders MW, Lash LH, Dekant W, Elfarra AA, Dohn DR: Biosynthesis of biotransformation of glutathione conjugants to toxic metabolites. CRC Crit Rev Toxicol, 18: 311, 1988
52. Pickett CB, Lu AYH: Glutathione S-transferases: Gene structure, regulation and biological function. Annu Rev Biochem 58: 743-764, 1989
53. Okuda A, Sakai M, Muramatsu M: The structure of rat glutathione S-transferase P gene and related pseudogenes. J Biol Chem 262: 3858, 1987
54. Cowell LC, Dixon KH, Pemble SF, Ketterer B, Taylor JB: The structure of the human glutathione S-transferases π gene. Biochem J 255: 79, 1988
55. Power C, Sinha S, Webber C, Manson MM, Neal GE: Transformation related to expression of glutathione S-transferase P in rat liver cells. Carcinogenesis 8: 797, 1987
56. Vadenberghe Y, Morel F, Foriers A, Ketterer B, Vercruysee A, Guillonzo A, Rogiers V: Effect of phenobarbital on the expression of glutathione S-transferase isozyme in cultured rat hepatocytes. FEBS Lett 251: 59, 1989
57. Hatayama L, Yamada Y, Tanaka K, Sato K: Induction of glutathione S-transferase P form in primary cultured rat hepatocytes by epidermal growth factor and insulin. Jpn J Cancer Res 82: 807, 1991
58. Muramatsu M, Okuda A, Imagawa M, Sakai M: In: J.D. Hayes, C.B. Pickett (eds). Regulation of Glutathione S-Transferase P Gene During Hepatocarcinogenesis of the Rat, in Glutathione S-Transferases and Drug Resistance. Mantle, Taylor and Francis, London, 1989, p 165
59. Okuda A, Imagawa M, Maedam Y, Sakai M, Muramatsu M: Structural and functional analysis of enhancer GPE1 having a phorbol-12-0-tetra decanote 13-acetate responsive element like sequence found in the rat glutathione S-transferase P gene. J Biol Chem 264: 16919, 1989
60. Imagawa M, Osada S, Okuda A, Muramatsu M: Silencer binding proteins function on multiple cis-elements in the glutathione S-transferase P gene. Nucleic Acids Res 19: 5, 1991
61. Violet D: Glutathione S-transferases: Gene structure and regulation of expression. CRC Crit Rev Biochem Mol Biol 28: 173-207, 1993
62. Matsumoto M, Imagewa M, Aoki Y: Identification of an enhancer element of class Pi GST gene required for expression by a coplanar polychlorinated biphenyl, Biochem J 338: 599-605, 1999
63. Campbell JAH, Corrigall AV, Guy A, Kirsch RE: Immunohistologic localization of alpha, mu and pi class glutathione S-transferases in human tissues. Cancer 67: 1608-1613, 1991
64. Harvey JW, Beulter E: Binding of heme by GST: A possible role of the erythrocyte. Blood 60: 1227-1230, 1982
65. Harries LW, Stubbins MJ, Forman D, Howard GCW, Wolf CR: Identification of genetic polymorphisms at the GST pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 18: 641-644, 1997
66. Ali Osman F, Akande O, Antoun G, Mao JX, Buolamwini J: Molecular cloning characterization and expression in E. coli of full length cDNAs of three pi gene human variants. Evidence for differential catalytic activity of the encoded proteins. J Biol Chem 272: 10004-10012, 1997
67. Sundberg K: Carcinogenic polycyclic aromatic hydrocarbons: Role of human glutathione S-transferases in conjugate formation and DNA protection. Thesis submitted from Karolinska Institute, 2001
68. Guthenberg C, Mannervik B: Purification of glutathione S-transferases from rat lung by affinity chromatography, evidence for an enzyme form absent in rat liver. Biochem Biophys Res Commun 86: 1304-1310, 1979
69. Jakoby WB: Glutathione S-transferases: A group of multifunctional detoxification proteins. Adv Enzymol 46: 383-414, 1978
70. Hayes JD, Gilligan D, Chapman BJ, Beckett GJ: Purification of human hepatic glutathione S-transferases and the development of a radioimmunoassay for their measurement in plasma. Clin Chem Acta 134: 107-121, 1983
71. Tew KD, Monks A, Borne L, Rosser D, Akerman G, Montali JA, Wheatly JB, Schmidt JE Jr: Glutathione associated enzyme in the human cell lines of the National Cancer Institute Drug screening program. Mol Pharmacol 50: 149-159, 1996
72. McCaughan FM, Brown AL, Harrison DJ: The effect of inhibition of glutathione S-transferase P on the growth of Jurkhat human T cell line. J Pathol 172: 357-362, 1994
73. Albin N, Massaad L, Toussaint C, Mathieu MC, Morizet J, Parise O, Gouyette A, Chabot GG: Main drug-metabolizing enzyme systems in human breast tumors and peritumoral tissues. Cancer Res 53: 3541-3546, 1993
74. Maugart-Loubootin C, Charrier J, Sagin C, Cuilliere P, Martin S, Menegalli D, Lajat Y, Resche F, Ali-Osman F: Correlation between glutathione S-transferases (GST) Pi expression in human astrocytomas determined by RT-PCR and histological grade. Proc Annu Meet Am Assoc Cancer Res 37: A2305, 1996
75. Sato K, Satoh K, Tsuchida S, Hatayama I, Shen H Yokoyama Y, Yamada Y, Tamai K: Specific expression of glutathione S-transferase Pi forms in (Pre)neoplastic tissues - their properties and functions. Tohoku J Exp Med 168: 97-103, 1992
76. Schiffer D: Expression of the placental form of glutathione S-transferase in pediatric gliomas. Childs Nervous System 9: 3, 1993
77. Sasano H, Miuazaki S, Shiga K, Goukon Y, Nishihira T, Nagura H: Glutathione S-transferase in human esophageal carcinoma. Anticancer Res 13: 363-368, 1993
78. Miyara H, Hida T, Nishida K, Takahashi T, Sugiura T, Ariyoshi Y, Morishita M, Takahashi T, Ueda R: Modification of chemo-radiosensitivity of a human lung cancer cell line by introduction of the glutathione S-Transferase pi gene. Jpn J Clin Oncol 26: 1-5, 1996
79. Mousseau M, Chauvin C, Nissou MF, Chaffanet M, Plantaz D, Pasquier B, Schaerer R, Benabid A: A study of the expression of 4 chemoresistance related genes in human primary and metastatic brain tumors. Eur J Cancer 29: 753-759, 1993
80. Kitteringham NR, Powell H, Clement YN, Dodd CC, Tettey JN, Pirmohamed M, Smith DA, Mclellan LI, Park BK: Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and gamma-glutamylcysteine synthetase. Hepatology 32: 321-333, 2000
81. Henderson CJ, Wolf CR, Kitteringham NR, Powell H, Otto D, Park BK: Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. Proc Natl Acad Sci USA 97: 12741-12745, 2000
82. Granzen B, Efferth T, Keller U, Beniers AJ, Mertens R, Jakse G, Fuzesi L: Differential expression of the drug resistance markers DNA topoisomerase II alpha and glutathione S-transferase-pi in the histological compartments of Wilms'tumors. Anticancer Res 21: 771-776, 2001
83. Aoyama T, Kojima F, Yamazaki T, Tatee T, Abe F, Muraoka Y, Naganawa H, Aoyagi T, Takeuchi T: Benastatin-C and benastatin-D, new inhibitors of glutathione S-transferase, produced by streptomyces sp. M1384-DF12 - production, isolation, structure determination and biological activities. J Antibiotics 46: 712-718, 1993
84. Jakoby WB, Ketterer B, Mannervik B: Glutathione S-transferases: Nomenclature. Biochem Pharmacol 33: 2539-2540, 1984
85. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferase AA from rat liver. Arch Biochem Biophys 175: 710-716, 1976
86. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferase the first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139, 1974
87. Chang M, Hong Y, Burgess JR, Tu CPD, Reddy CC: Isozyme specificity of rat liver glutathione S-transferases in the formation of PGF2α and PGE2 from PGH2. Arch Biochem Biophys 259: 548-557, 1987
88. Thyagaraju K, Devi KN, Hildenbrandt GR, Reddy CC: Purification and characterization of 12 forms of rat brain GSTs. J Parasitol Appl Animal Biol 5: 33-48, 1996
89. Meyer DJ, Coles B, Pemble SE, Gilmore KS, Fraser GM, Ketterer B: Theta, a new class of glutathione S-transferases purified from rat and man. Biochem J 274: 409-414, 1991
90. Board PG, Blackburn AC, Baker R, Chelvanayagam G, Woollatt E, Jermin L: Identification and characterization of the Zeta class of glutathione S-transferases in a range of species from plants to humans. International Workshop on Glutathione S-Transferases, Italy, 1997