GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway

Biochemical and Biophysical Research Communications

Volumn 356, Issue 3, 2007, Pages 648-654

  Tezuka, Norio ^a   Brown, Anthony M C ^b,c   Yanagawa, Shin ichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b ROCKEFELLER UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Catenin; Axin; GRB10; LRP6; Wnt

Indexed keywords

ADAPTOR PROTEIN; AXIN; BETA CATENIN; FRIZZLED PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; WNT PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BINDING SITES; GRB10 ADAPTOR PROTEIN; HUMANS; MICE; RATS; RECEPTORS, LDL; REPRESSOR PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; WNT PROTEINS;

EID: 33947683304     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.03.019     Document Type: Article

References (22)

1. Logan C.Y., and Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20 (2004) 781-810
2. Polakis P. Wnt signaling and cancer. Genes Dev. 14 (2000) 1837-1851
3. Liu C., Li Y., Semenov M., Han C., Bang G.-H., Tan Y., Zhang Z., Lin X., and He X. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108 (2002) 837-847
4. He X., Semenov M., Tamai K., and Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development 131 (2004) 1663-1677
5. Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J., and He X. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438 (2005) 873-877
6. Holt L.J., and Siddle K. Grb10 and Grb14: enigmatic regulators of insulin action and more?. Biochem. J. 388 (2005) 393-406
7. Morrione A. Grb10 adaptor protein as regulator of insulin-like growth factor receptor. J. Cell. Physiol. 197 (2003) 307-311
8. Ooi J., Yajnik V., Immanuel D., Gordon M., Moskow J.J., Buchberg A.M., and Margolis B. The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene 10 (1995) 1621-1630
9. Wick K.R., Werner E.D., Langlais P., Ramos F.J., Dong L.Q., Shoelson S.E., and Liu F. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J. Biol. Chem. 278 (2003) 8460-8467
10. Charalambou M., Smith F.M., Bennett W.R., Crew T.E., Mackenzie F., and Ward A. Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc. Natl. Acad. Sci. USA 100 (2003) 8292-8297
11. Shiura H., Miyoshi K., Konishi A., Wakisaka-Saito N., Suzuki R., Muguruma K., Kohda T., Wakana S., Yokoyama M., Ishino F., and Kaneko-Ishino T. Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1 R and IR cascades. Biochem. Biophys. Res. Commun. 329 (2005) 909-916
12. Veeman M.T., Slusarski D.C., Kaykas A., Hallagan-Louie S., and Moon R.T. Zebrafish Prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13 (2003) 680-685
13. DasGupta R., Kaykas A., Moon R.T., and Perrimon N. Functional genomic analysis of the Wnt-wingless signaling pathway. Science 308 (2005) 826-833
14. Yanagawa S., Matsuda Y., Lee J.-S., Matsubayashi H., Sese S., Kadowaki T., and Ishimoto A. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 21 (2002) 1733-1742
15. Brennan K., Gonzalez-Sancho J.M., Castelo-Soccio L.A., Howe L.R., and Brown A.M.C. Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins. Oncogene 23 (2004) 4873-4884
16. Takahashi N., Ishihara S., Takada S., Tsukita S., and Nagafuchi A. Posttranscriptional regulation of α-catenin expression is required for Wnt signaling in L cells. Biochem. Biophys. Res. Commun. 277 (2000) 691-698
17. Shibamoto S., Higano K., Takada R., Ito F., Takeichi M., and Takada S. Cytoskeltal reorganization by soluble Wnt-3a protein signaling. Gene Cell 3 (1998) 659-670
18. Clements J.C., Worby C.A., Simonson-Leff N., Muda M., Maehara T., Hemmings B.A., and Dixon J.E. Use of double-stranded RNA interference in Drosophila. Proc. Natl. Acad. Sci. USA 97 (2000) 6499-6503
19. Mikels A., and Nusse R. Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. Plos Biol. 4 (2006) 570-582
20. Ramos F.J., Langlais P.R., Hu D., Dong L.O., and Liu F. Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism negative regulation. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E1262-E1266
21. Vecchione A., Marchese A., Henry P., Rotin D., and Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol. Cell. Biol. 23 (2003) 3363-3372
22. Morrione A., Plant P., Valentinis B., Staub O., Kumar S., Rotin D., and Baserga R. mGrb10 interacts with Nedd4. J. Biol. Chem. 274 (1999) 24094-24099