Exhaustive exercise induces differential changes in serum granulysin and circulating number of natural killer cells

Tohoku Journal of Experimental Medicine

Volumn 210, Issue 2, 2006, Pages 117-124

  Zhang, Xiumin ^a   Matsuo, Kaori ^a   Farmawati, Arta ^a   Higashi, Yohei ^a   Ogawa, Kazuyuki ^b   Nagata, Kinya ^b   Nagatomi, Ryoichi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b BML   (Japan)

Author keywords

Exhaustive exercise; Natural killer cells; Serum granulysin

Indexed keywords

ADRENALIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DOPAMINE; GRANULYSIN; NORADRENALIN;

ADULT; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL POPULATION; CELL SIZE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; EXHAUSTION; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPOTHESIS; LYMPHOCYTE; NATURAL KILLER CELL; NORMAL HUMAN; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RADIOIMMUNOASSAY; REST; RUNNING; TIME; TREADMILL EXERCISE; VOLUNTEER;

ADULT; ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CERCOPITHECUS AETHIOPS; COS CELLS; EXERCISE; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; MALE;

EID: 33750039161     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.210.117     Document Type: Article

References (24)

1. Benschop, R.J., Nijkamp, F.P., Ballieux, R.E. & Heijnen, C.J. (1994) The effects of beta-adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium. Br. J. Pharmacol., 113, 1311-1316.
2. Deuster, P.A., Curiale, A.M., Cowan, M.L. & Finkelman, F.D. (1988) Exercise-induced changes in populations of peripheral blood mononuclear cells. Med. Sci. Sports Exerc., 20, 276-280.
3. Dill, D.B. & Costill, D.L. (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J. Appl. Physiol., 37, 247-248.
4. Field, C.J., Gougeon, R. & Marliss, E.B. (1991) Circulating mononuclear cell numbers and function during intense exercise and recovery. J. Appl. Physiol., 71, 1089-1097.
5. Gansert, J.L., Kiessler, V., Engele, M., Wittke, F., Rollinghoff, M., Krensky, A.M., Porcelli, S.A., Modlin, R.L. & Stenger, S. (2003) Human NKT cells express granulysin and exhibit antimycobacterial activity. J. Immunol., 170, 3154-3161.
6. Holmqvist, N., Secher, N.H., Sander-Jensen, K., Knigge, U., Warberg, J. & Schwartz, T.W. (1986) Sympathoadrenal and parasympathetic responses to exercise. J. Sports Sci., 4, 123-128.
7. Krensky, A.M. (2000) Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. Biochem. Pharmacol., 59, 317-320.
8. Landmann, R. (1992) Beta-adrenergic receptors in human leukocyte subpopulations. Eur. J. Clin. Invest., 22, 30-36.
9. Maisel, A.S., Harris, T., Rearden, C.A. & Michel, M.C. (1990) Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure. Circulation, 82, 2003-2010.
10. Miles, M.P., Mackinnon, L.T., Grove, D.S., Williams, N.I., Bush, J.A., Marx, J.O., Kraemer, W.J. & Mastro, A.M. (2002) The relationship of natural killer cell counts, perforin mRNA and CD2 expression to post-exercise natural killer cell activity in humans. Acta Physiol. Scand., 174, 317-325.
11. Nielsen, H.B., Secher, N.H., Kappel, M., Hanel, B. & Pedersen, B.K. (1996) Lymphocyte, NK and LAK cell responses to maximal exercise. Int. J. Sports Med., 17, 60-65.
12. Nielsen, H.B.. Secher. N.H., Kappel, M. & Pedersen. B.K. (1998) N-acetylcysteine does not affect the lymphocyte proliferation and natural killer cell activity responses to exercise. Am. J. Physiol., 275, R1227-1231.
13. Nieman, D.C., Miller, A.R., Henson, D.A., Warren, B.J., Gusewitch, G., Johnson, R.L., Davis, J.M., Butterworth, D.E. & Nehlsen-Cannarella, S.L. (1993) Effects of high-vs moderate-intensity exercise on natural killer cell activity. Med. Sci. Sports Exerc., 25, 1126-1134.
14. Obata-Onai, A., Hashimoto, S., Onai, N., Kurachi, M., Nagai, S., Shizuno, K., Nagahata, T., Matsushima, K. & Mathushima, K. (2002) Comprehensive gene expression analysis of human NK cells and CD8(+) T lymphocytes. Int. Immunol., 14, 1085-1098.
15. Ogawa, K., Takamori, Y, Suzuki, K., Nagasawa, M., Takano, S., Kasahara, Y., Nakamura, Y., Kondo, S., Sugamura, K., Nakamura, M. & Nagata, K. (2003) Granulysin in human serum as a marker of cell-mediated immunity. Eur. J. Immunol., 33, 1925-1933.
16. Pena, S.V. & Krensky, A.M. (1997) Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity. Semin Immunol., 9, 117-125.
17. Pena, S.V., Hanson, D.A., Carr, B.A., Goralski, T.J. & Krensky, A.M. (1997) Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. J. Immunol., 158, 2680-2688.
18. Sakai, M., Ogawa, K., Shiozaki, A., Yoneda, S., Sasaki, Y., Nagata, K. & Saito, S. (2004) Serum granulysin is a marker for Th1 type immunity in pre-eclampsia. Clin. Exp. Immunol., 136, 114-119.
19. Schedlowski, M., Hosch, W., Oberbeck, R., Benschop, R.J., Jacobs, R., Raab, H.R. & Schmidt, R.E. (1996) Catecholamines modulate human NK cell circulation and function via spleen-independent beta 2-adrenergic mechanisms. J. Immunol., 156, 93-99.
20. Shinkai, S., Shore, S., Shek, P.N. & Shephard, R.J. (1992) Acute exercise and immune function. Relationship between lymphocyte activity and changes in subset counts. Int. J. Sports Med., 13, 452-461.
21. Stenger, S., Hanson, D.A., Teitelbaum, R., Dewan, P., Niazi, K.R., Froelich, C.J., Ganz, T., Thoma-Uszynski, S., Melian, A., Bogdan, C., Porcelli, S.A., Bloom, B.R., Krensky, A.M. & Modlin, R.L. (1998) An antimicrobial activity of cytolytic T cells mediated by granulysin. Science, 282, 121-125.
22. Van Der Pompe, G., Bernards, N., Kavelaars, A. & Heijnen, C. (2001) An exploratory study into the effect of exhausting bicycle exercise on endocrine and immune responses in post-menopausal women: relationships between vigour and plasma cortisol concentrations and lymphocyte proliferation following exercise. Int. J. Sports Med., 22, 447-453.
23. Woods, J.A., Evans, J.K., Wolters, B.W., Ceddia, M.A. & Mcauley, E. (1998) Effects of maximal exercise on natural killer (NK) cell cytotoxicity and responsiveness to interferon-alpha in the young and old. J. Gerontol. A Biol. Sci. Med. Sci., 53, B430-437.
24. Yoshimura, M., Komori, T., Nakanishi, T. & Takahashi, H. (1993) Estimation of sulphoconjugated catecholamine concentrations in plasma by high-performance liquid chromatography. Ann. Clin. Biochem., 30, 135-141.