-
4
-
-
0021985413
-
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
-
Ulrich A (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756-761
-
(1985)
Nature
, vol.313
, pp. 756-761
-
-
Ulrich, A.1
-
5
-
-
0027143218
-
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells
-
Lee CH, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG Jr, White MF, Schlessinger J, Skolnik EY (1993): Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci USA 90:11713-11717
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11713-11717
-
-
Lee, C.H.1
Li, W.2
Nishimura, R.3
Zhou, M.4
Batzer, A.G.5
Myers Jr., M.G.6
White, M.F.7
Schlessinger, J.8
Skolnik, E.Y.9
-
7
-
-
0033913213
-
Signaling pathways in insulin action: Molecular targets of insulin resistance
-
Pessin JE, Saltiel AR (2000) Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 106:165-169
-
(2000)
J Clin Invest
, vol.106
, pp. 165-169
-
-
Pessin, J.E.1
Saltiel, A.R.2
-
8
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
-
(2000)
J Clin Invest
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
9
-
-
0034455290
-
Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes
-
Egawa K, Nakashima N, Sharma PM, Maegawa H, Nagai Y, Kashiwagi A, Kikkawa R, Olefsky JM (2000) Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. Endocrinology 141:1930-1935
-
(2000)
Endocrinology
, vol.141
, pp. 1930-1935
-
-
Egawa, K.1
Nakashima, N.2
Sharma, P.M.3
Maegawa, H.4
Nagai, Y.5
Kashiwagi, A.6
Kikkawa, R.7
Olefsky, J.M.8
-
10
-
-
0031022434
-
Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
-
Stephens JM, Lee J, Pilch PF (1997) Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem 272: 971-976
-
(1997)
J Biol Chem
, vol.272
, pp. 971-976
-
-
Stephens, J.M.1
Lee, J.2
Pilch, P.F.3
-
11
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly M, Payett P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283:1544-1548
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payett, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
Normandin, D.7
Cheng, A.8
Himms-Hagen, J.9
Chan, C.C.10
Ramachandran, C.11
Gresser, M.J.12
Tremblay, M.L.13
Kennedy, B.P.14
-
12
-
-
0031943479
-
Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases
-
Goldstein BJ, Ahmad F, Ding W, Li PM, Zhang WR (1998) Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 182:91-99
-
(1998)
Mol Cell Biochem
, vol.182
, pp. 91-99
-
-
Goldstein, B.J.1
Ahmad, F.2
Ding, W.3
Li, P.M.4
Zhang, W.R.5
-
13
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
-
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271:665-668
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
14
-
-
0020579309
-
Insulin resistance in Cushing's syndrome
-
Nosadini R, Del Prato S, Tiengo A, Valerio A, Muggeo M, Opocher G, Mantero F, Duner E, Marescotti C, Mollo F, Belloni F (1983) Insulin resistance in Cushing's syndrome. J Clin Endocrin Metab 57:529-536
-
(1983)
J Clin Endocrin Metab
, vol.57
, pp. 529-536
-
-
Nosadini, R.1
Del Prato, S.2
Tiengo, A.3
Valerio, A.4
Muggeo, M.5
Opocher, G.6
Mantero, F.7
Duner, E.8
Marescotti, C.9
Mollo, F.10
Belloni, F.11
-
15
-
-
0021072412
-
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects
-
Pagano G, Cavallo-Perin P, Cassader M, Bruno A, Ozzello A, Masciola P, Dall'omo AM, Imbimbo B (1983) An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. J Clin Invest 72:1814-1820
-
(1983)
J Clin Invest
, vol.72
, pp. 1814-1820
-
-
Pagano, G.1
Cavallo-Perin, P.2
Cassader, M.3
Bruno, A.4
Ozzello, A.5
Masciola, P.6
Dall'omo, A.M.7
Imbimbo, B.8
-
16
-
-
0031839468
-
Increased glucocorticoid sensitivity in islet beta-cells: Effects on glucose 6-phosphatase, glucose cycling and insulin release
-
Ling ZC, Khan A, Delauny F, Davani B, Ostenson CG, Gustafsson JA, Okret S, Landau BR, Efendic S (1998) Increased glucocorticoid sensitivity in islet beta-cells: Effects on glucose 6-phosphatase, glucose cycling and insulin release. Diabetologia 41:634-639
-
(1998)
Diabetologia
, vol.41
, pp. 634-639
-
-
Ling, Z.C.1
Khan, A.2
Delauny, F.3
Davani, B.4
Ostenson, C.G.5
Gustafsson, J.A.6
Okret, S.7
Landau, B.R.8
Efendic, S.9
-
17
-
-
0025017302
-
Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes
-
Mueckler M (1990): Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes. Diabetes 39:6-11
-
(1990)
Diabetes
, vol.39
, pp. 6-11
-
-
Mueckler, M.1
-
18
-
-
0024512585
-
Identification of a novel gene encoding an insulin-responsive glucose transporter protein
-
Birnbaum MJ (1989) Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57: 305-315
-
(1989)
Cell
, vol.57
, pp. 305-315
-
-
Birnbaum, M.J.1
-
20
-
-
18044393626
-
Insulin signal transduction in human skeletal muscle: Identifying the defects in Type II diabetes
-
Björnholm M, Zierath JR (2005) Insulin signal transduction in human skeletal muscle: Identifying the defects in Type II diabetes. Biochem Soc Trans 33:354-357
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 354-357
-
-
Björnholm, M.1
Zierath, J.R.2
-
21
-
-
0026595349
-
Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle
-
Marette A, Burdett E, Douen A, Vranic M, Klip A (1992) Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle. Diabetes 41:1562-1569
-
(1992)
Diabetes
, vol.41
, pp. 1562-1569
-
-
Marette, A.1
Burdett, E.2
Douen, A.3
Vranic, M.4
Klip, A.5
-
23
-
-
0041659271
-
Push/pull mechanisms of GLUT4 traffic in muscle cells
-
Rudich A, Klip A (2003) Push/pull mechanisms of GLUT4 traffic in muscle cells. Acta Physiol Scand 178: 297-308
-
(2003)
Acta Physiol Scand
, vol.178
, pp. 297-308
-
-
Rudich, A.1
Klip, A.2
-
24
-
-
33745622820
-
Exogenous nitric oxide inhibits IRS-1 expression in rat hepatocytes and skeletal myocytes
-
Badal S, Brown PD, Ragoobirsingh D (2003) Exogenous nitric oxide inhibits IRS-1 expression in rat hepatocytes and skeletal myocytes. J Biomed Sci 13: 561-568
-
(2003)
J Biomed Sci
, vol.13
, pp. 561-568
-
-
Badal, S.1
Brown, P.D.2
Ragoobirsingh, D.3
-
25
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein, utilizing the principle of protein-dye binding
-
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein, utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
27
-
-
0026669756
-
Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes
-
Ogawa A, Johnson JH, Ohneda M, McAllister CT, Inman L, Alam T, Unger RH (1992) Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. J Clin Invest 90: 497-504
-
(1992)
J Clin Invest
, vol.90
, pp. 497-504
-
-
Ogawa, A.1
Johnson, J.H.2
Ohneda, M.3
McAllister, C.T.4
Inman, L.5
Alam, T.6
Unger, R.H.7
-
28
-
-
0028933938
-
Glucocorticoid-induced insulin resistance: Dexamethasone inhibits the activation of glucose transport in rat skeletal muscle by both insulin- and non-insulin-related stimuli
-
Weinstein SP, Paquin T, Pritsker A, Haber RS (1995) Glucocorticoid-induced insulin resistance: Dexamethasone inhibits the activation of glucose transport in rat skeletal muscle by both insulin- and non-insulin-related stimuli. Diabetes 44: 441-445
-
(1995)
Diabetes
, vol.44
, pp. 441-445
-
-
Weinstein, S.P.1
Paquin, T.2
Pritsker, A.3
Haber, R.S.4
-
29
-
-
0033820515
-
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction
-
Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, Fukushima Y, Onishi Y, Ono H, Fujishiro M, Kikuchi M, Oka Y, Asano T (2000) Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes 49:1700-1708
-
(2000)
Diabetes
, vol.49
, pp. 1700-1708
-
-
Sakoda, H.1
Ogihara, T.2
Anai, M.3
Funaki, M.4
Inukai, K.5
Katagiri, H.6
Fukushima, Y.7
Onishi, Y.8
Ono, H.9
Fujishiro, M.10
Kikuchi, M.11
Oka, Y.12
Asano, T.13
-
30
-
-
0028085078
-
The insulin signaling system
-
White MF, Kahn CR (1994) The insulin signaling system. J Biol Chem 269:1-4
-
(1994)
J Biol Chem
, vol.269
, pp. 1-4
-
-
White, M.F.1
Kahn, C.R.2
-
31
-
-
0032939904
-
Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats
-
Anai M, Funaki M, Ogihara T, Kanda A, Onishi Y, Sakoda H, Inukai K, Nawano M, Fukushima Y, Yazaki Y, Kikuchi M, Oka Y, Asano T (1999) Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats. Diabetes 48:158-169
-
(1999)
Diabetes
, vol.48
, pp. 158-169
-
-
Anai, M.1
Funaki, M.2
Ogihara, T.3
Kanda, A.4
Onishi, Y.5
Sakoda, H.6
Inukai, K.7
Nawano, M.8
Fukushima, Y.9
Yazaki, Y.10
Kikuchi, M.11
Oka, Y.12
Asano, T.13
-
32
-
-
2642683510
-
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
-
Kerouz NJ, Horsch D, Pons S, Kahn CR (1997) Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest 100: 3164-72
-
(1997)
J Clin Invest
, vol.100
, pp. 3164-3172
-
-
Kerouz, N.J.1
Horsch, D.2
Pons, S.3
Kahn, C.R.4
-
33
-
-
0032698470
-
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
-
Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB (1999) Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104:733-741
-
(1999)
J Clin Invest
, vol.104
, pp. 733-741
-
-
Kim, Y.B.1
Nikoulina, S.E.2
Ciaraldi, T.P.3
Henry, R.R.4
Kahn, B.B.5
-
34
-
-
0028024916
-
Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes
-
Turnbow MA, Keller SR, Rice KM, Garner CW (1994) Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes. J Biol Chem 269:2516-2520
-
(1994)
J Biol Chem
, vol.269
, pp. 2516-2520
-
-
Turnbow, M.A.1
Keller, S.R.2
Rice, K.M.3
Garner, C.W.4
-
35
-
-
0027489828
-
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats
-
Saad MJA, Folli F, Kahn JA, Kahn CR (1993) Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest 92:2065-2072
-
(1993)
J Clin Invest
, vol.92
, pp. 2065-2072
-
-
Saad, M.J.A.1
Folli, F.2
Kahn, J.A.3
Kahn, C.R.4
-
36
-
-
0027163954
-
Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo
-
Giorgino F, Almahfouz A, Goodyear LJ, Smith RJ (1993) Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. J Clin Invest 91:2020-2030
-
(1993)
J Clin Invest
, vol.91
, pp. 2020-2030
-
-
Giorgino, F.1
Almahfouz, A.2
Goodyear, L.J.3
Smith, R.J.4
-
37
-
-
27144504547
-
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 3007 phosphorylation in insulin resistance of type 2 diabetes
-
Danielsson A, Öst A, Nystrom F, Strålfors P (2005) Attenuation of insulin-stimulated insulin receptor substrate-1 serine 3007 phosphorylation in insulin resistance of type 2 diabetes. J Biol Chem 280:34389-343925
-
(2005)
J Biol Chem
, vol.280
, pp. 34389-343925
-
-
Danielsson, A.1
Öst, A.2
Nystrom, F.3
Strålfors, P.4
-
38
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
-
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J (2002) Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277: 48115-48121
-
(2002)
J Biol Chem
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
39
-
-
6344258131
-
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance
-
Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y (2004) Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Mol Cell Biol 24:9668-9681
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9668-9681
-
-
Liu, Y.F.1
Herschkovitz, A.2
Boura-Halfon, S.3
Ronen, D.4
Paz, K.5
Leroith, D.6
Zick, Y.7
-
40
-
-
0035155272
-
Serine/threonine phosphorylation of IRS-1 triggers its degradation: Possible regulation by tyrosine phosphorylation
-
Pederson TM, Kramer DL, Rondinone CM (2001) Serine/threonine phosphorylation of IRS-1 triggers its degradation: Possible regulation by tyrosine phosphorylation. Diabetes 50:24-31
-
(2001)
Diabetes
, vol.50
, pp. 24-31
-
-
Pederson, T.M.1
Kramer, D.L.2
Rondinone, C.M.3
-
41
-
-
0036149984
-
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
-
Zhande R, Mitchell JJ, Wu J, Sun XJ (2002) Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1. Mol Cell Biol 22:1016-1026
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1016-1026
-
-
Zhande, R.1
Mitchell, J.J.2
Wu, J.3
Sun, X.J.4
-
42
-
-
0026762722
-
Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone
-
Haber RS, Weinstein SP (1992) Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone. Diabetes 41:728-735
-
(1992)
Diabetes
, vol.41
, pp. 728-735
-
-
Haber, R.S.1
Weinstein, S.P.2
-
43
-
-
0029911347
-
In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution
-
Coderre L, Vallega GA, Pilch PF, Chipkin SR (1996) In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution. Am J Physiol 271: E643-648
-
(1996)
Am J Physiol
, vol.271
-
-
Coderre, L.1
Vallega, G.A.2
Pilch, P.F.3
Chipkin, S.R.4
-
44
-
-
0032549222
-
Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells
-
Ewart HS, Somwar R, Klip A (1998) Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells. FEBS Lett 425: 179-183
-
(1998)
FEBS Lett
, vol.425
, pp. 179-183
-
-
Ewart, H.S.1
Somwar, R.2
Klip, A.3
-
45
-
-
0027484069
-
Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle
-
Weinstein SP, Holand A, O'Boyle E, Haber RS (1993) Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle. Metabolism 42: 1365-1369
-
(1993)
Metabolism
, vol.42
, pp. 1365-1369
-
-
Weinstein, S.P.1
Holand, A.2
O'Boyle, E.3
Haber, R.S.4
-
46
-
-
0025667903
-
Differential regulation of GLUT-1 and GLUT-4 glucose transporter mRNA levels in 3T3-L1 adipocytes
-
Chu DT, Isaacson CM, Bell PA, (1990) Differential regulation of GLUT-1 and GLUT-4 glucose transporter mRNA levels in 3T3-L1 adipocytes. Biochem Soc Trans 18: 1247-1248
-
(1990)
Biochem Soc Trans
, vol.18
, pp. 1247-1248
-
-
Chu, D.T.1
Isaacson, C.M.2
Bell, P.A.3
-
47
-
-
0028876441
-
Regulation of glucose transporters in cultured rat adipocytes: Synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation
-
Hajduch E, Hainault I, Meunier C, Jardel C, Hainque B, Guerre-Millo M, Lavau M (1995) Regulation of glucose transporters in cultured rat adipocytes: Synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation. Endocrinology 136:4782-4789
-
(1995)
Endocrinology
, vol.136
, pp. 4782-4789
-
-
Hajduch, E.1
Hainault, I.2
Meunier, C.3
Jardel, C.4
Hainque, B.5
Guerre-Millo, M.6
Lavau, M.7
-
48
-
-
0036204548
-
Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
-
Buren J, Liu HX, Jensen J, Eriksson JW (2002) Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol 146: 419-429
-
(2002)
Eur J Endocrinol
, vol.146
, pp. 419-429
-
-
Buren, J.1
Liu, H.X.2
Jensen, J.3
Eriksson, J.W.4
|