Gene expression changes in long-term culture of T-cell clones: Genomic effects of chronic antigenic stress in aging and immunosenescence

Aging Cell

Volumn 6, Issue 2, 2007, Pages 155-163

  Mazzatti, Dawn J ^a   White, Andrew ^a   Forsey, Rosalyn J ^b   Powell, Jonathan R ^a   Pawelec, Graham ^c  

^a UNILEVER RESEARCH   (United Kingdom)

^b LCG Bioscience   (United Kingdom)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Aging; Immunosenescence; Microarray; T cell clone

Indexed keywords

ADENOSINE A2A RECEPTOR; BETA CATENIN; BIOLOGICAL MARKER; CD40 ANTIGEN; CD7 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CCR7; COMPLEMENTARY DNA; EARLY GROWTH RESPONSE FACTOR 2; EPIDERMAL GROWTH FACTOR; FRUCTOSE BISPHOSPHATE ALDOLASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GAP JUNCTION PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRANULYSIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERLEUKIN 8; L SELECTIN; PROTEIN C FOS; RELAXIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSFORMING GROWTH FACTOR BETA;

ADAPTIVE IMMUNITY; AGING; APOPTOSIS; ARTICLE; CELL AGING; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNITY; IN VITRO STUDY; LYMPHOCYTE CLONE; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; SIGNAL TRANSDUCTION; STRESS; SURVIVAL RATE; T LYMPHOCYTE;

AGED, 80 AND OVER; ANTIGENS; CELL AGING; CELLS, CULTURED; CLONAL ANERGY; CLONE CELLS; GENE EXPRESSION; GENE REGULATORY NETWORKS; GENOME, HUMAN; HUMANS; T-LYMPHOCYTES;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 4;

EID: 33947395245     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2007.00269.x     Document Type: Article

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