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Volumn 10, Issue 3, 2007, Pages 193-201

Drug evaluation: Vilazodone - A combined SSRI and 5-HT1A partial agonist for the treatment of depression

(1)  De Paulis, Tomas a  

a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ANTIDEPRESSANT AGENT; BUSPIRONE; CITALOPRAM; DIAZEPAM; EMD 86006; EMD 95750; EPTAPIRONE; FLESINOXAN; GEPIRONE; IPSAPIRONE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [3 [4 [4 (CYCLOHEXYLMETHYLSULFONAMIDO)BUTYL] 1 PIPERAZINYL]PHENYL]ACETAMIDE; OPC 14523; PAROXETINE; PINDOLOL; PIPERAZINE DERIVATIVE; ROXINDOLE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; VILAZODONE; VN 2222;

EID: 33947326248     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (43)

References (68)
  • 1
    • 0026555904 scopus 로고    scopus 로고
    • 1143 Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on behavioral satiety sequence. McGuirk J, Muscat R, Willner P PHARMACOL BIOCHEM BEHAV 1992 41 4 801-805
    • 1A/B agonist, eltoprazine, on behavioral satiety sequence. McGuirk J, Muscat R, Willner P PHARMACOL BIOCHEM BEHAV 1992 41 4 801-805
  • 2
    • 0025231342 scopus 로고    scopus 로고
    • 92532 A role for the serotonin system in the mechanism of action of antidepressant treatments: Preclinical evidence. Blier P, de Montigny C, Chaput Y J CLIN PSYCHIAT 1990 51 4 14-21
    • 92532 A role for the serotonin system in the mechanism of action of antidepressant treatments: Preclinical evidence. Blier P, de Montigny C, Chaput Y J CLIN PSYCHIAT 1990 51 4 14-21
  • 3
    • 0025917796 scopus 로고    scopus 로고
    • 191261 Antipsychotic efficacy of the dopaminergic autoreceptor agonist EMD-49980 roxindole, Results of an open clinical study. Klimke A, Klieser E PHARMACOPSYCHIAT 1991 24 4 107-112
    • 191261 Antipsychotic efficacy of the dopaminergic autoreceptor agonist EMD-49980 (roxindole). Results of an open clinical study. Klimke A, Klieser E PHARMACOPSYCHIAT 1991 24 4 107-112
  • 4
    • 0029923485 scopus 로고    scopus 로고
    • 204907 Roxindole: Psychopharmacological profile of a dopamine D 2 autoreceptor agonist. Bartoszyk GD, Harting J, Minck K-O J PHARMACOL EXP THER 1996 276 1 41-48
    • 2 autoreceptor agonist. Bartoszyk GD, Harting J, Minck K-O J PHARMACOL EXP THER 1996 276 1 41-48
  • 5
    • 0028218177 scopus 로고    scopus 로고
    • 243757 Pindolol induces a rapid improvement in patients with depression treated with serotonin uptake inhibitors. Artigas F, Perez V, Alverez E ARCH GEN PSYCHIAT 1994 51 3 248-251
    • 243757 Pindolol induces a rapid improvement in patients with depression treated with serotonin uptake inhibitors. Artigas F, Perez V, Alverez E ARCH GEN PSYCHIAT 1994 51 3 248-251
  • 6
    • 85143030050 scopus 로고    scopus 로고
    • 243759 Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. Blier P, Bergeron R J CLIN PSYCHOPHARMACOL 1995 15 3 217-222
    • 243759 Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. Blier P, Bergeron R J CLIN PSYCHOPHARMACOL 1995 15 3 217-222
  • 7
    • 33947321324 scopus 로고    scopus 로고
    • 245884 EMD-68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties. Bartoszyk GD, Hegenbart R, Ziegler H EUR J PHARMACOL 1997 322 2-3 147-153 • Vilazodone demonstrates presynaptic 5-HT1A agonist activity in an animal behavioral model
    • 1A agonist activity in an animal behavioral model.
  • 8
    • 33947307047 scopus 로고    scopus 로고
    • 290882 The serotonin hypothesis of major depression. Maes M, Meltzer HY PSYCHOPHARMACOLOGY: THE FOURTH GENERATION OF PROGRESS Bloom FE, Kupfer DJ Eds, Raven Press, New York, NY, USA 933-944
    • 290882 The serotonin hypothesis of major depression. Maes M, Meltzer HY PSYCHOPHARMACOLOGY: THE FOURTH GENERATION OF PROGRESS Bloom FE, Kupfer DJ (Eds). Raven Press, New York, NY, USA 933-944
  • 9
    • 0030051661 scopus 로고    scopus 로고
    • 290997 Effect of pindolol on hormone secretion and body temperature: Partial agonist effects. Meltzer HY, Maes M J NEURAL TRANS 1996 103 1-2 77-88
    • 290997 Effect of pindolol on hormone secretion and body temperature: Partial agonist effects. Meltzer HY, Maes M J NEURAL TRANS 1996 103 1-2 77-88
  • 10
    • 33947329680 scopus 로고    scopus 로고
    • 303314 EMD-95750: 5-HT reuptake inhibiting and 5-HT1A antagonistic properties combined in a single NCE. Bottcher H, Andersson B, Bartoszyk GD, Devant R, Greiner HE, Hansson L, Seyfried CA, Sonesson C, Sternlof P ABSTR SOC NEUROSCI 1998 24 Pt 1 Abs 438.5
    • 1A antagonistic properties combined in a single NCE. Bottcher H, Andersson B, Bartoszyk GD, Devant R, Greiner HE, Hansson L, Seyfried CA, Sonesson C, Sternlof P ABSTR SOC NEUROSCI 1998 24 Pt 1 Abs 438.5
  • 11
    • 33947313367 scopus 로고    scopus 로고
    • 305090 Highlights from the 28th Annual Meeting of the Society for Neuroscience (Part II) Los Angeles, California. Gray D, Nicholls R IDDB MEETING REPORT 1998 November 7-12
    • 305090 Highlights from the 28th Annual Meeting of the Society for Neuroscience (Part II) Los Angeles, California. Gray D, Nicholls R IDDB MEETING REPORT 1998 November 7-12
  • 12
    • 33947325182 scopus 로고    scopus 로고
    • 350905 VN-2222, a potential antidepressant agent with affinity at the serotonin transporter and 5-HT1A receptors. Tordera R, Monge A, Del Rio J, Lasheras B METHOD FIND EXP CLIN PHARMACOL 1999 21 Suppl A 197
    • 1A receptors. Tordera R, Monge A, Del Rio J, Lasheras B METHOD FIND EXP CLIN PHARMACOL 1999 21 Suppl A 197
  • 13
    • 0032849040 scopus 로고    scopus 로고
    • 356600 Three- and four-dimensional-quantitative structure-activity relationship (3-D/4-D-QSAR) analyses of CYP2D6 inhibitors. Ekins S, Bravi G, Binkley S, Gillespie JS, Ring BJ, Wikel JH, Wrighton SA PHARMACOGENETICS 1999 9 4 477-489
    • 356600 Three- and four-dimensional-quantitative structure-activity relationship (3-D/4-D-QSAR) analyses of CYP2D6 inhibitors. Ekins S, Bravi G, Binkley S, Gillespie JS, Ring BJ, Wikel JH, Wrighton SA PHARMACOGENETICS 1999 9 4 477-489
  • 14
    • 33947312691 scopus 로고    scopus 로고
    • 399224 GlaxoSmithKline and Merck KGaA sign worldwide agreement on antidepressant. GlaxoSmithKline plc PRESS RELEASE 2001 February 15
    • 399224 GlaxoSmithKline and Merck KGaA sign worldwide agreement on antidepressant. GlaxoSmithKline plc PRESS RELEASE 2001 February 15
  • 15
    • 0035254214 scopus 로고    scopus 로고
    • 410033 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. Martinez-Esparza J, Oficialdegui AM, Pere-Silanesz S, Heras B, Orus L, Palop J-A, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC et al J MED CHEM 2001 44 3 418-428
    • 1A serotonin receptors and serotonin transporter, as a new class of antidepressants. Martinez-Esparza J, Oficialdegui AM, Pere-Silanesz S, Heras B, Orus L, Palop J-A, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC et al J MED CHEM 2001 44 3 418-428
  • 16
    • 0035946825 scopus 로고    scopus 로고
    • 416886 5-HT1A receptor activation and antidepressant-like effects: F-13714 has high efficacy and marked antidepressant potential. Koek W, Vacher B, Cosi, Assie M-B, Patoiesau J-F, Pauwels PJ, Colpaert FC EUR J PHARMACOL 2001 420 2-3 103-112
    • 1A receptor activation and antidepressant-like effects: F-13714 has high efficacy and marked antidepressant potential. Koek W, Vacher B, Cosi, Assie M-B, Patoiesau J-F, Pauwels PJ, Colpaert FC EUR J PHARMACOL 2001 420 2-3 103-112
  • 17
    • 0035662833 scopus 로고    scopus 로고
    • 438934 Antidepressant-like responses to the combined σ and 5-HT1A receptor agonist OPC-14523. Tottori K, Miwa T, Uwahodo Y, Yamada S, Nakai M, Oshiro Y, Kikuchi T, Altar CA NEUROPHARMACOL 2001 41 8 976-988
    • 1A receptor agonist OPC-14523. Tottori K, Miwa T, Uwahodo Y, Yamada S, Nakai M, Oshiro Y, Kikuchi T, Altar CA NEUROPHARMACOL 2001 41 8 976-988
  • 18
    • 33947323937 scopus 로고    scopus 로고
    • 486369 Merck KGaA and GlaxoSmithKline agree to end joint vilazodone development. Merck KGaA PRESS RELEASE 2003 April 17
    • 486369 Merck KGaA and GlaxoSmithKline agree to end joint vilazodone development. Merck KGaA PRESS RELEASE 2003 April 17
  • 19
    • 33947302295 scopus 로고    scopus 로고
    • 492104 Merck KGaA presentation 1st Quarter 2003. Merck KGaA 1ST QUARTER REPORT 2003 April 29
    • 492104 Merck KGaA presentation 1st Quarter 2003. Merck KGaA 1ST QUARTER REPORT 2003 April 29
  • 20
    • 0038352213 scopus 로고    scopus 로고
    • 502893 Modulation of serotonergic function in rat brain by VN-2222, a serotonin reuptake inhibitor and 5-HT1A receptor agonist. Romero L, Celada P, Martin-Ruiz R, Diaz-Mataix L, Mourelle M, Delgadillo J, Hervas I, Artigas F NEUROPSYCHOPHARMACOL 2003 28 3 445-456
    • 1A receptor agonist. Romero L, Celada P, Martin-Ruiz R, Diaz-Mataix L, Mourelle M, Delgadillo J, Hervas I, Artigas F NEUROPSYCHOPHARMACOL 2003 28 3 445-456
  • 21
    • 0037012701 scopus 로고    scopus 로고
    • 502894 Antidepressant-like activity of VN-2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. Tordera RM, Monge A, Del Rio J, Lasheras B EUR J PHARMACOL 2002 442 1-2 63-71
    • 1A receptors. Tordera RM, Monge A, Del Rio J, Lasheras B EUR J PHARMACOL 2002 442 1-2 63-71
  • 22
    • 0034719438 scopus 로고    scopus 로고
    • 542128 3,4-Dihydro-2(1H)-quinolinone as a novel antidepressant drug: Synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1- piperazinyl]-propyl]-3,4-dihydro-5-methoxy-21H, quinolinone. Oshiro Y, Sakurai Y, Sato S, Kurahashi N, Tanaka T, Kikuchi T, Tottori K, Uwahodo Y, Miwa T, Nishi T J MED CHEM 2000 43 2 177-189
    • 542128 3,4-Dihydro-2(1H)-quinolinone as a novel antidepressant drug: Synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1- piperazinyl]-propyl]-3,4-dihydro-5-methoxy-2(1H) -quinolinone. Oshiro Y, Sakurai Y, Sato S, Kurahashi N, Tanaka T, Kikuchi T, Tottori K, Uwahodo Y, Miwa T, Nishi T J MED CHEM 2000 43 2 177-189
  • 23
    • 33947312017 scopus 로고    scopus 로고
    • 560430 Genaissance Pharmaceuticals Licenses Compound from Merck KGaA. Genaissance Pharmaceuticals Inc PRESS RELEASE 2004 September 23
    • 560430 Genaissance Pharmaceuticals Licenses Compound from Merck KGaA. Genaissance Pharmaceuticals Inc PRESS RELEASE 2004 September 23
  • 24
    • 1942476589 scopus 로고    scopus 로고
    • 575913 A new synthesis of indole 5-carboxylic acids and 6-hydroxyindole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone. Heinrich T, Bottcher H BIOORG MED CHEM LETT 2004 14 10 2681-2684 • Synthesis of the active metabolite of vilazodone
    • 575913 A new synthesis of indole 5-carboxylic acids and 6-hydroxyindole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone. Heinrich T, Bottcher H BIOORG MED CHEM LETT 2004 14 10 2681-2684 • Synthesis of the active metabolite of vilazodone.
  • 25
    • 33947324536 scopus 로고    scopus 로고
    • 627525 Clinical Data acquires Genaissance for $56 million. Clinical Data Inc PRESS RELEASE 2005 October 07
    • 627525 Clinical Data acquires Genaissance for $56 million. Clinical Data Inc PRESS RELEASE 2005 October 07
  • 26
    • 33947315149 scopus 로고    scopus 로고
    • 647220 Clinical Data starts pivotal trial of antidepressant. Clinical Data Inc PRESS RELEASE 2006 January 26
    • 647220 Clinical Data starts pivotal trial of antidepressant. Clinical Data Inc PRESS RELEASE 2006 January 26
  • 27
    • 33947315985 scopus 로고    scopus 로고
    • 658933 Clinical Data initiates patient enrollment for vilazodone phase 3 clinical trial; top-line data anticipated in mid-2007. Clinical Data Inc PRESS RELEASE 2006 March 30
    • 658933 Clinical Data initiates patient enrollment for vilazodone phase 3 clinical trial; top-line data anticipated in mid-2007. Clinical Data Inc PRESS RELEASE 2006 March 30
  • 28
    • 33947331574 scopus 로고    scopus 로고
    • 660378 Pharmos sets strategic priorities for development of Vela compounds. Pharmos Corp PRESS RELEASE 2006 April 05
    • 660378 Pharmos sets strategic priorities for development of Vela compounds. Pharmos Corp PRESS RELEASE 2006 April 05
  • 29
    • 33947316457 scopus 로고    scopus 로고
    • 667315 Clinical Data to spin-out company for antidepressant drug. Clinical Data Inc PRESS RELEASE 2006 May 15
    • 667315 Clinical Data to spin-out company for antidepressant drug. Clinical Data Inc PRESS RELEASE 2006 May 15
  • 30
    • 33947306453 scopus 로고    scopus 로고
    • 676859 Depression & Anxiety, SMi's Second Conference, London, UK. Kneller S IDDB MEETING REPORT 2006 June 28-29
    • 676859 Depression & Anxiety - SMi's Second Conference, London, UK. Kneller S IDDB MEETING REPORT 2006 June 28-29
  • 31
    • 33744832614 scopus 로고    scopus 로고
    • 684671 An integrated in silico 3-D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. Becker OM, Dhanoa DS, Marantz Y, Chen D, Shacham S, Cheruku S, Heifetz A, Mohanty P, Fichman M, Sharadendu A, Nudelman RS J MED CHEM 2006 49 11 3116-3135
    • 1A agonist (PRX-00023) for the treatment of anxiety and depression. Becker OM, Dhanoa DS, Marantz Y, Chen D, Shacham S, Cheruku S, Heifetz A, Mohanty P, Fichman M, Sharadendu A, Nudelman RS J MED CHEM 2006 49 11 3116-3135
  • 32
    • 33947301471 scopus 로고    scopus 로고
    • 684982 Clinical Data's vilazodone patient enrollment over one-third complete. Clinical Data Inc PRESS RELEASE 2006 August 17
    • 684982 Clinical Data's vilazodone patient enrollment over one-third complete. Clinical Data Inc PRESS RELEASE 2006 August 17
  • 33
    • 33947311541 scopus 로고    scopus 로고
    • 688269 Effect of vilazodone on 5-HT efflux and reuptake in the guinea pig dorsal raphe nucleus. Roberts C, Hagan JJ, Bartoszyk GD, Kew JNC EUR J PHARMACOL 2005 517 1-2 59-63 • Vilazodone is an SSRI agent but not a 5-HT1A receptor agonist in a functional test in the rodent brain
    • 1A receptor agonist in a functional test in the rodent brain.
  • 34
    • 33947314976 scopus 로고    scopus 로고
    • 688270 Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor vilazodone. Hughes ZA, Starr KR, Langmead CJ, Hill M, Bartoszyk GD, Hagan JJ, Middlemiss DN, Dawson LA EUR J PHARMACOL 2005 510 1-2 49-57 • Vilazodone shows in vivo pharmacological profile of an SSRI agent plus a 5-HT1A receptor antagonist
    • 1A receptor antagonist.
  • 35
    • 4444225028 scopus 로고    scopus 로고
    • 688271 Dual 5-HT1A agonists and 5-HT reuptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity. Heinrich T, Bottcher H, Schiemann K, Holzemann G, Schwarz M, Bartoszyk GD, van Amsterdam C, Greiner HE, Seyfried CA BIOORG MED CHEM 2004 12 18 4843-4852
    • 1A agonists and 5-HT reuptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity. Heinrich T, Bottcher H, Schiemann K, Holzemann G, Schwarz M, Bartoszyk GD, van Amsterdam C, Greiner HE, Seyfried CA BIOORG MED CHEM 2004 12 18 4843-4852
  • 36
    • 1842627852 scopus 로고    scopus 로고
    • 688274 Phase I and II enzyme characterization of two sources of HepG2 cell lines. Hewitt NJ, Hewitt P XENOBIOTICA 2004 34 3 243-256
    • 688274 Phase I and II enzyme characterization of two sources of HepG2 cell lines. Hewitt NJ, Hewitt P XENOBIOTICA 2004 34 3 243-256
  • 37
    • 6944238722 scopus 로고    scopus 로고
    • 688275 Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. Adamec R, Bartoszyk GD, Burton P EUR J PHARMACOL 2004 504 1-2 65-77
    • 688275 Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. Adamec R, Bartoszyk GD, Burton P EUR J PHARMACOL 2004 504 1-2 65-77
  • 38
    • 33947316620 scopus 로고    scopus 로고
    • 688276 Behavioral and neurochemical effects of 5-(4-[4-(5-cyano-3- indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD-68843, A combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. Page ME, Cryan JF, Sullivan Arthur DA, Saucy B, Manning DR, Lucki I J PHARMACOL EXP THER 2002 302 3 1220-1227 • Vilazodone raises serotonin levels in rat frontal cortex to 3-fold those of fluoxetine
    • 688276 Behavioral and neurochemical effects of 5-(4-[4-(5-cyano-3- indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD-68843): A combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. Page ME, Cryan JF, Sullivan Arthur DA, Saucy B, Manning DR, Lucki I J PHARMACOL EXP THER 2002 302 3 1220-1227 • Vilazodone raises serotonin levels in rat frontal cortex to 3-fold those of fluoxetine.
  • 39
    • 0034955153 scopus 로고    scopus 로고
    • 688277 Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey and human using cryopreserved hepatocytes, microsomes and collagen gel-immobilized hepatocyte cultures. Hewitt NJ, Buhring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D DRUG METAB DISPOS 2001 29 7 1042-1050
    • 688277 Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey and human using cryopreserved hepatocytes, microsomes and collagen gel-immobilized hepatocyte cultures. Hewitt NJ, Buhring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D DRUG METAB DISPOS 2001 29 7 1042-1050
  • 40
    • 0035793968 scopus 로고    scopus 로고
    • 688279 Systemic EMD-68843 injections reduce anxiety in the shockprobe, but not the plus-maze test. Treit D, Degroot A, Kashluba S, Bartoszyk GD EUR J PHARMACOL 2001 414 2-3 245-248
    • 688279 Systemic EMD-68843 injections reduce anxiety in the shockprobe, but not the plus-maze test. Treit D, Degroot A, Kashluba S, Bartoszyk GD EUR J PHARMACOL 2001 414 2-3 245-248
  • 41
    • 0035023887 scopus 로고    scopus 로고
    • 688280 Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD-68843 on the sleep EEG in healthy men. Murck H, Frieboes RM, Antonijevic IA, Steiger A PSYCHOPHARMACOLOGY 2001 155 2 187-192 • Similar to SSRIs, vilazodone suppresses REM sleep but, unlike 5-HT1A agonists, vilazodone increases slow-wave sleep in this phase 1 clinical trial
    • 1A agonists, vilazodone increases slow-wave sleep in this phase 1 clinical trial.
  • 42
    • 0033827059 scopus 로고    scopus 로고
    • 688282 Drug action at the 5-HT1A receptor in vivo: Autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-11C]WAY-100635. Rabiner EA, Gunn RN, Wilkins MR, Sargent PA, Mocaer E, Sedman E, Cowen PJ, Grasby PM NUCL MED BIOL 2000 27 5 509-513 • Plasma levels of vilazodone correlate with 5-HT1A receptor occupancy in human brain
    • 1A receptor occupancy in human brain.
  • 43
    • 33947324875 scopus 로고    scopus 로고
    • 688285 Fast adaptive changes of the sleep regulatory system after a single dose of the putative antidepressive substance EMD-68843. Murck H, Frieboes RM, Antonijevic IA, Steiger A PHARMACOPSYCHIATRY 1999 32 Abs 146
    • 688285 Fast adaptive changes of the sleep regulatory system after a single dose of the putative antidepressive substance EMD-68843. Murck H, Frieboes RM, Antonijevic IA, Steiger A PHARMACOPSYCHIATRY 1999 32 Abs 146
  • 44
    • 33947319009 scopus 로고    scopus 로고
    • 692736 Mixed results for EPIX's PRX-00023 in phase III anxiety trial. EPIX Pharmaceuticals Inc PRESS RELEASE 2006 September 22
    • 692736 Mixed results for EPIX's PRX-00023 in phase III anxiety trial. EPIX Pharmaceuticals Inc PRESS RELEASE 2006 September 22
  • 45
    • 33748493597 scopus 로고    scopus 로고
    • 729897 Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist F-13714: A microdialysis study in the rat. Assie M-B, Lomenech H, Ravailhe V, Faucillon V, Newman-Tancredi A BR J PHARMACOL 2006 149 2 170-178
    • 1A agonist F-13714: A microdialysis study in the rat. Assie M-B, Lomenech H, Ravailhe V, Faucillon V, Newman-Tancredi A BR J PHARMACOL 2006 149 2 170-178
  • 46
    • 33947325183 scopus 로고    scopus 로고
    • 736653 Safety and efficacy study of vilazodone and discovering genetic markers associated with response in patients with major depressive disorder, 2006 October 30
    • 736653 Safety and efficacy study of vilazodone and discovering genetic markers associated with response in patients with major depressive disorder. www.clinicaltrials.gov WEB SITE 2006 October 30
  • 47
    • 27744519023 scopus 로고    scopus 로고
    • 741195 The future of selective serotonin reuptake inhibitors (SSRIs) in psychiatric treatment. Taylor S, Stein MB MED HYPOTHESES 2006 66 1 14-21
    • 741195 The future of selective serotonin reuptake inhibitors (SSRIs) in psychiatric treatment. Taylor S, Stein MB MED HYPOTHESES 2006 66 1 14-21
  • 48
    • 0031671214 scopus 로고    scopus 로고
    • 741551 Brain serotonin neurotransmission. Murphy DL, Andrews AM, Wichems CH, Tohda M, Greenberg B J CLIN PSYCHIAT 1998 59 15 4-12
    • 741551 Brain serotonin neurotransmission. Murphy DL, Andrews AM, Wichems CH, Tohda M, Greenberg B J CLIN PSYCHIAT 1998 59 15 4-12
  • 49
    • 0034447177 scopus 로고    scopus 로고
    • 741680 The augmention hypothesis for improvement of antidepressant therapy. Kinney GG, Taber MT, Gribkoff VK MOL NEUROBIOL 2000 21 3 137-152
    • 741680 The augmention hypothesis for improvement of antidepressant therapy. Kinney GG, Taber MT, Gribkoff VK MOL NEUROBIOL 2000 21 3 137-152
  • 50
    • 33644854626 scopus 로고    scopus 로고
    • 741686 Pindolol augmentation of antidepressant response. Artigas F, Adell A, Celada P CURR DRUG TARGETS 2006 7 2 139-147
    • 741686 Pindolol augmentation of antidepressant response. Artigas F, Adell A, Celada P CURR DRUG TARGETS 2006 7 2 139-147
  • 51
    • 0034959682 scopus 로고    scopus 로고
    • 741691 Pharmacology of rapid-onset antidepressant treatment strategies. Blier P J CLIN PSYCHIAT 2001 62 Suppl 15 12-17
    • 741691 Pharmacology of rapid-onset antidepressant treatment strategies. Blier P J CLIN PSYCHIAT 2001 62 Suppl 15 12-17
  • 52
    • 4444353338 scopus 로고    scopus 로고
    • 741693 Synthesis and structure-activity relationship in a class of indolebutylpiperazines as dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Heinrich T, Bottcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, van Amsterdam C J MED CHEM 2004 47 19 4684-4692 • Optimization of the benzofuran moiety and preclinical characterization of vilazodone
    • 1A receptor agonists and serotonin reuptake inhibitors. Heinrich T, Bottcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, van Amsterdam C J MED CHEM 2004 47 19 4684-4692 • Optimization of the benzofuran moiety and preclinical characterization of vilazodone.
  • 53
    • 34547445666 scopus 로고    scopus 로고
    • 742255 Mechanism of action of antidepressants. Artigas F, Nutt DJ, Shelton R PSYCHOPHARMACOL BULL 2002 36 2 123-132
    • 742255 Mechanism of action of antidepressants. Artigas F, Nutt DJ, Shelton R PSYCHOPHARMACOL BULL 2002 36 2 123-132
  • 54
    • 0033621542 scopus 로고    scopus 로고
    • 742260 Brain serotonin 1A receptor binding measured by positron emission tomography with [11C]WAY-100635. Effects of depression and antidepression treatment. Sargent PA, Husted-Kjaer K, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ ARCH GEN PSYCHIAT 2000 57 2 174-180
    • 11C]WAY-100635. Effects of depression and antidepression treatment. Sargent PA, Husted-Kjaer K, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ ARCH GEN PSYCHIAT 2000 57 2 174-180
  • 55
    • 33645509721 scopus 로고    scopus 로고
    • 742264 Behavioral depression and positron emission tomographydetermined serotonin 1A receptor binding potential in cynomolgus monkeys. Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JP, Henderson JA, Smith MA, Buchheimer N ARCH GEN PSYCHIAT 2006 63 4 396-403
    • 742264 Behavioral depression and positron emission tomographydetermined serotonin 1A receptor binding potential in cynomolgus monkeys. Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JP, Henderson JA, Smith MA, Buchheimer N ARCH GEN PSYCHIAT 2006 63 4 396-403
  • 56
    • 0033804027 scopus 로고    scopus 로고
    • 742319 Pindolol excites dopaminergic and adrenergic neurons, and inhibits serotonergic neurons, by activation of 5-HT1A receptors. Lejeune F, Millan MJ EUR J NEUROSCI 2000 12 9 3265-3275
    • 1A receptors. Lejeune F, Millan MJ EUR J NEUROSCI 2000 12 9 3265-3275
  • 57
    • 0034130350 scopus 로고    scopus 로고
    • 742323 Effects of chronic fluoxetine treatment in the presence and absence of, /-pindolol: A microdialysis study. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE BR J PHARMACOL 2000 130 4 797-804
    • 742323 Effects of chronic fluoxetine treatment in the presence and absence of (+/-)pindolol: A microdialysis study. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE BR J PHARMACOL 2000 130 4 797-804
  • 58
    • 0035986335 scopus 로고    scopus 로고
    • 742337 Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE J PSYCHOPHARMACOL 2002 16 2 145-152
    • 742337 Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE J PSYCHOPHARMACOL 2002 16 2 145-152
  • 59
    • 0033214706 scopus 로고    scopus 로고
    • 742347 Displacement of the binding of 5-HT1A receptor ligands to pre- and postsynaptic receptors by, pindolol. A comparative study in rodent, primate and human brain. Raurich A, Mengod G, Artigas F, Cortes R SYNAPSE 1999 34 1 68-76
    • 1A receptor ligands to pre- and postsynaptic receptors by (-)pindolol. A comparative study in rodent, primate and human brain. Raurich A, Mengod G, Artigas F, Cortes R SYNAPSE 1999 34 1 68-76
  • 60
    • 0035111317 scopus 로고    scopus 로고
    • 742350 New 3-[4-(aryl)piperazine-1-yl]-1-(benzo[b] thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Martinez J, Perez S, Oficialdegui AM, Heras B, Orus L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo J-C et al EUR J MED CHEM 2001 36 1 55-61
    • 1A serotonin receptors and serotonin transporter as a new class of antidepressants. Martinez J, Perez S, Oficialdegui AM, Heras B, Orus L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo J-C et al EUR J MED CHEM 2001 36 1 55-61
  • 61
    • 22144438667 scopus 로고    scopus 로고
    • 742368 In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. Jordan S, Chen R, Koprivica V, Hamilton R, Whitehead RE, Tottori K, Kikuchi T EUR J PHARMACOL 2005 517 3 165-173
    • 1A receptors. Jordan S, Chen R, Koprivica V, Hamilton R, Whitehead RE, Tottori K, Kikuchi T EUR J PHARMACOL 2005 517 3 165-173
  • 62
    • 17544368021 scopus 로고    scopus 로고
    • 742633 Strategies for producing faster-acting antidepressants. Adell A, Castro E, Celada P, Bortolozzi A, Pazos A, Artigas F DRUG DISCOV TODAY 2005 10 8 578-585
    • 742633 Strategies for producing faster-acting antidepressants. Adell A, Castro E, Celada P, Bortolozzi A, Pazos A, Artigas F DRUG DISCOV TODAY 2005 10 8 578-585
  • 63
    • 33947302756 scopus 로고    scopus 로고
    • 743137 Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol. Mos J, van Aken HH, van Oorschot R, Oliver B LIFE SCI 1997 61 1 11-19
    • 743137 Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol. Mos J, van Aken HH, van Oorschot R, Oliver B LIFE SCI 1997 61 1 11-19
  • 64
    • 4444265294 scopus 로고    scopus 로고
    • 747982 Indolebutylamines as selective 5-HT1A agonists. Heinrich T, Bottcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C J MED CHEM 2004 47 19 4677-4683
    • 1A agonists. Heinrich T, Bottcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C J MED CHEM 2004 47 19 4677-4683
  • 65
    • 33947314187 scopus 로고    scopus 로고
    • 753553 Clinical data completes vilazodone manufacturing technology transfer under license with Merck KGaA. Clinical Data Inc PRESS RELEASE 2006 December 22
    • 753553 Clinical data completes vilazodone manufacturing technology transfer under license with Merck KGaA. Clinical Data Inc PRESS RELEASE 2006 December 22
  • 66
    • 0034704821 scopus 로고    scopus 로고
    • 755283 5-HT reuptake inhibitors with 5-HT1A/1B antagonistic activity: A new approach toward efficient antidepressants. Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Bottcher H J MED CHEM 2000 43 6 1149-1157
    • 1A/1B antagonistic activity: A new approach toward efficient antidepressants. Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Bottcher H J MED CHEM 2000 43 6 1149-1157
  • 67
    • 31644433603 scopus 로고    scopus 로고
    • 763333 Two-week delay in onset of action of antidepressants: New evidence. Mitchell AJ BR J PSYCHIATRY 2006 188 2 105-106
    • 763333 Two-week delay in onset of action of antidepressants: New evidence. Mitchell AJ BR J PSYCHIATRY 2006 188 2 105-106
  • 68
    • 33750694210 scopus 로고    scopus 로고
    • 763345 Early onset of selective serotonin reuptake inhibitor antidepressant action: Systematic review and meta-analysis. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z ARCH GEN PSYCHIATRY 2006 63 11 1217-1223
    • 763345 Early onset of selective serotonin reuptake inhibitor antidepressant action: Systematic review and meta-analysis. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z ARCH GEN PSYCHIATRY 2006 63 11 1217-1223


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