-
1
-
-
0026555904
-
-
1143 Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on behavioral satiety sequence. McGuirk J, Muscat R, Willner P PHARMACOL BIOCHEM BEHAV 1992 41 4 801-805
-
1A/B agonist, eltoprazine, on behavioral satiety sequence. McGuirk J, Muscat R, Willner P PHARMACOL BIOCHEM BEHAV 1992 41 4 801-805
-
-
-
-
2
-
-
0025231342
-
-
92532 A role for the serotonin system in the mechanism of action of antidepressant treatments: Preclinical evidence. Blier P, de Montigny C, Chaput Y J CLIN PSYCHIAT 1990 51 4 14-21
-
92532 A role for the serotonin system in the mechanism of action of antidepressant treatments: Preclinical evidence. Blier P, de Montigny C, Chaput Y J CLIN PSYCHIAT 1990 51 4 14-21
-
-
-
-
3
-
-
0025917796
-
-
191261 Antipsychotic efficacy of the dopaminergic autoreceptor agonist EMD-49980 roxindole, Results of an open clinical study. Klimke A, Klieser E PHARMACOPSYCHIAT 1991 24 4 107-112
-
191261 Antipsychotic efficacy of the dopaminergic autoreceptor agonist EMD-49980 (roxindole). Results of an open clinical study. Klimke A, Klieser E PHARMACOPSYCHIAT 1991 24 4 107-112
-
-
-
-
4
-
-
0029923485
-
-
204907 Roxindole: Psychopharmacological profile of a dopamine D 2 autoreceptor agonist. Bartoszyk GD, Harting J, Minck K-O J PHARMACOL EXP THER 1996 276 1 41-48
-
2 autoreceptor agonist. Bartoszyk GD, Harting J, Minck K-O J PHARMACOL EXP THER 1996 276 1 41-48
-
-
-
-
5
-
-
0028218177
-
-
243757 Pindolol induces a rapid improvement in patients with depression treated with serotonin uptake inhibitors. Artigas F, Perez V, Alverez E ARCH GEN PSYCHIAT 1994 51 3 248-251
-
243757 Pindolol induces a rapid improvement in patients with depression treated with serotonin uptake inhibitors. Artigas F, Perez V, Alverez E ARCH GEN PSYCHIAT 1994 51 3 248-251
-
-
-
-
6
-
-
85143030050
-
-
243759 Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. Blier P, Bergeron R J CLIN PSYCHOPHARMACOL 1995 15 3 217-222
-
243759 Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. Blier P, Bergeron R J CLIN PSYCHOPHARMACOL 1995 15 3 217-222
-
-
-
-
7
-
-
33947321324
-
-
245884 EMD-68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties. Bartoszyk GD, Hegenbart R, Ziegler H EUR J PHARMACOL 1997 322 2-3 147-153 • Vilazodone demonstrates presynaptic 5-HT1A agonist activity in an animal behavioral model
-
1A agonist activity in an animal behavioral model.
-
-
-
-
8
-
-
33947307047
-
-
290882 The serotonin hypothesis of major depression. Maes M, Meltzer HY PSYCHOPHARMACOLOGY: THE FOURTH GENERATION OF PROGRESS Bloom FE, Kupfer DJ Eds, Raven Press, New York, NY, USA 933-944
-
290882 The serotonin hypothesis of major depression. Maes M, Meltzer HY PSYCHOPHARMACOLOGY: THE FOURTH GENERATION OF PROGRESS Bloom FE, Kupfer DJ (Eds). Raven Press, New York, NY, USA 933-944
-
-
-
-
9
-
-
0030051661
-
-
290997 Effect of pindolol on hormone secretion and body temperature: Partial agonist effects. Meltzer HY, Maes M J NEURAL TRANS 1996 103 1-2 77-88
-
290997 Effect of pindolol on hormone secretion and body temperature: Partial agonist effects. Meltzer HY, Maes M J NEURAL TRANS 1996 103 1-2 77-88
-
-
-
-
10
-
-
33947329680
-
-
303314 EMD-95750: 5-HT reuptake inhibiting and 5-HT1A antagonistic properties combined in a single NCE. Bottcher H, Andersson B, Bartoszyk GD, Devant R, Greiner HE, Hansson L, Seyfried CA, Sonesson C, Sternlof P ABSTR SOC NEUROSCI 1998 24 Pt 1 Abs 438.5
-
1A antagonistic properties combined in a single NCE. Bottcher H, Andersson B, Bartoszyk GD, Devant R, Greiner HE, Hansson L, Seyfried CA, Sonesson C, Sternlof P ABSTR SOC NEUROSCI 1998 24 Pt 1 Abs 438.5
-
-
-
-
11
-
-
33947313367
-
-
305090 Highlights from the 28th Annual Meeting of the Society for Neuroscience (Part II) Los Angeles, California. Gray D, Nicholls R IDDB MEETING REPORT 1998 November 7-12
-
305090 Highlights from the 28th Annual Meeting of the Society for Neuroscience (Part II) Los Angeles, California. Gray D, Nicholls R IDDB MEETING REPORT 1998 November 7-12
-
-
-
-
12
-
-
33947325182
-
-
350905 VN-2222, a potential antidepressant agent with affinity at the serotonin transporter and 5-HT1A receptors. Tordera R, Monge A, Del Rio J, Lasheras B METHOD FIND EXP CLIN PHARMACOL 1999 21 Suppl A 197
-
1A receptors. Tordera R, Monge A, Del Rio J, Lasheras B METHOD FIND EXP CLIN PHARMACOL 1999 21 Suppl A 197
-
-
-
-
13
-
-
0032849040
-
-
356600 Three- and four-dimensional-quantitative structure-activity relationship (3-D/4-D-QSAR) analyses of CYP2D6 inhibitors. Ekins S, Bravi G, Binkley S, Gillespie JS, Ring BJ, Wikel JH, Wrighton SA PHARMACOGENETICS 1999 9 4 477-489
-
356600 Three- and four-dimensional-quantitative structure-activity relationship (3-D/4-D-QSAR) analyses of CYP2D6 inhibitors. Ekins S, Bravi G, Binkley S, Gillespie JS, Ring BJ, Wikel JH, Wrighton SA PHARMACOGENETICS 1999 9 4 477-489
-
-
-
-
14
-
-
33947312691
-
-
399224 GlaxoSmithKline and Merck KGaA sign worldwide agreement on antidepressant. GlaxoSmithKline plc PRESS RELEASE 2001 February 15
-
399224 GlaxoSmithKline and Merck KGaA sign worldwide agreement on antidepressant. GlaxoSmithKline plc PRESS RELEASE 2001 February 15
-
-
-
-
15
-
-
0035254214
-
-
410033 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. Martinez-Esparza J, Oficialdegui AM, Pere-Silanesz S, Heras B, Orus L, Palop J-A, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC et al J MED CHEM 2001 44 3 418-428
-
1A serotonin receptors and serotonin transporter, as a new class of antidepressants. Martinez-Esparza J, Oficialdegui AM, Pere-Silanesz S, Heras B, Orus L, Palop J-A, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC et al J MED CHEM 2001 44 3 418-428
-
-
-
-
16
-
-
0035946825
-
-
416886 5-HT1A receptor activation and antidepressant-like effects: F-13714 has high efficacy and marked antidepressant potential. Koek W, Vacher B, Cosi, Assie M-B, Patoiesau J-F, Pauwels PJ, Colpaert FC EUR J PHARMACOL 2001 420 2-3 103-112
-
1A receptor activation and antidepressant-like effects: F-13714 has high efficacy and marked antidepressant potential. Koek W, Vacher B, Cosi, Assie M-B, Patoiesau J-F, Pauwels PJ, Colpaert FC EUR J PHARMACOL 2001 420 2-3 103-112
-
-
-
-
17
-
-
0035662833
-
-
438934 Antidepressant-like responses to the combined σ and 5-HT1A receptor agonist OPC-14523. Tottori K, Miwa T, Uwahodo Y, Yamada S, Nakai M, Oshiro Y, Kikuchi T, Altar CA NEUROPHARMACOL 2001 41 8 976-988
-
1A receptor agonist OPC-14523. Tottori K, Miwa T, Uwahodo Y, Yamada S, Nakai M, Oshiro Y, Kikuchi T, Altar CA NEUROPHARMACOL 2001 41 8 976-988
-
-
-
-
18
-
-
33947323937
-
-
486369 Merck KGaA and GlaxoSmithKline agree to end joint vilazodone development. Merck KGaA PRESS RELEASE 2003 April 17
-
486369 Merck KGaA and GlaxoSmithKline agree to end joint vilazodone development. Merck KGaA PRESS RELEASE 2003 April 17
-
-
-
-
19
-
-
33947302295
-
-
492104 Merck KGaA presentation 1st Quarter 2003. Merck KGaA 1ST QUARTER REPORT 2003 April 29
-
492104 Merck KGaA presentation 1st Quarter 2003. Merck KGaA 1ST QUARTER REPORT 2003 April 29
-
-
-
-
20
-
-
0038352213
-
-
502893 Modulation of serotonergic function in rat brain by VN-2222, a serotonin reuptake inhibitor and 5-HT1A receptor agonist. Romero L, Celada P, Martin-Ruiz R, Diaz-Mataix L, Mourelle M, Delgadillo J, Hervas I, Artigas F NEUROPSYCHOPHARMACOL 2003 28 3 445-456
-
1A receptor agonist. Romero L, Celada P, Martin-Ruiz R, Diaz-Mataix L, Mourelle M, Delgadillo J, Hervas I, Artigas F NEUROPSYCHOPHARMACOL 2003 28 3 445-456
-
-
-
-
21
-
-
0037012701
-
-
502894 Antidepressant-like activity of VN-2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. Tordera RM, Monge A, Del Rio J, Lasheras B EUR J PHARMACOL 2002 442 1-2 63-71
-
1A receptors. Tordera RM, Monge A, Del Rio J, Lasheras B EUR J PHARMACOL 2002 442 1-2 63-71
-
-
-
-
22
-
-
0034719438
-
-
542128 3,4-Dihydro-2(1H)-quinolinone as a novel antidepressant drug: Synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1- piperazinyl]-propyl]-3,4-dihydro-5-methoxy-21H, quinolinone. Oshiro Y, Sakurai Y, Sato S, Kurahashi N, Tanaka T, Kikuchi T, Tottori K, Uwahodo Y, Miwa T, Nishi T J MED CHEM 2000 43 2 177-189
-
542128 3,4-Dihydro-2(1H)-quinolinone as a novel antidepressant drug: Synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1- piperazinyl]-propyl]-3,4-dihydro-5-methoxy-2(1H) -quinolinone. Oshiro Y, Sakurai Y, Sato S, Kurahashi N, Tanaka T, Kikuchi T, Tottori K, Uwahodo Y, Miwa T, Nishi T J MED CHEM 2000 43 2 177-189
-
-
-
-
23
-
-
33947312017
-
-
560430 Genaissance Pharmaceuticals Licenses Compound from Merck KGaA. Genaissance Pharmaceuticals Inc PRESS RELEASE 2004 September 23
-
560430 Genaissance Pharmaceuticals Licenses Compound from Merck KGaA. Genaissance Pharmaceuticals Inc PRESS RELEASE 2004 September 23
-
-
-
-
24
-
-
1942476589
-
-
575913 A new synthesis of indole 5-carboxylic acids and 6-hydroxyindole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone. Heinrich T, Bottcher H BIOORG MED CHEM LETT 2004 14 10 2681-2684 • Synthesis of the active metabolite of vilazodone
-
575913 A new synthesis of indole 5-carboxylic acids and 6-hydroxyindole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone. Heinrich T, Bottcher H BIOORG MED CHEM LETT 2004 14 10 2681-2684 • Synthesis of the active metabolite of vilazodone.
-
-
-
-
25
-
-
33947324536
-
-
627525 Clinical Data acquires Genaissance for $56 million. Clinical Data Inc PRESS RELEASE 2005 October 07
-
627525 Clinical Data acquires Genaissance for $56 million. Clinical Data Inc PRESS RELEASE 2005 October 07
-
-
-
-
26
-
-
33947315149
-
-
647220 Clinical Data starts pivotal trial of antidepressant. Clinical Data Inc PRESS RELEASE 2006 January 26
-
647220 Clinical Data starts pivotal trial of antidepressant. Clinical Data Inc PRESS RELEASE 2006 January 26
-
-
-
-
27
-
-
33947315985
-
-
658933 Clinical Data initiates patient enrollment for vilazodone phase 3 clinical trial; top-line data anticipated in mid-2007. Clinical Data Inc PRESS RELEASE 2006 March 30
-
658933 Clinical Data initiates patient enrollment for vilazodone phase 3 clinical trial; top-line data anticipated in mid-2007. Clinical Data Inc PRESS RELEASE 2006 March 30
-
-
-
-
28
-
-
33947331574
-
-
660378 Pharmos sets strategic priorities for development of Vela compounds. Pharmos Corp PRESS RELEASE 2006 April 05
-
660378 Pharmos sets strategic priorities for development of Vela compounds. Pharmos Corp PRESS RELEASE 2006 April 05
-
-
-
-
29
-
-
33947316457
-
-
667315 Clinical Data to spin-out company for antidepressant drug. Clinical Data Inc PRESS RELEASE 2006 May 15
-
667315 Clinical Data to spin-out company for antidepressant drug. Clinical Data Inc PRESS RELEASE 2006 May 15
-
-
-
-
30
-
-
33947306453
-
-
676859 Depression & Anxiety, SMi's Second Conference, London, UK. Kneller S IDDB MEETING REPORT 2006 June 28-29
-
676859 Depression & Anxiety - SMi's Second Conference, London, UK. Kneller S IDDB MEETING REPORT 2006 June 28-29
-
-
-
-
31
-
-
33744832614
-
-
684671 An integrated in silico 3-D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. Becker OM, Dhanoa DS, Marantz Y, Chen D, Shacham S, Cheruku S, Heifetz A, Mohanty P, Fichman M, Sharadendu A, Nudelman RS J MED CHEM 2006 49 11 3116-3135
-
1A agonist (PRX-00023) for the treatment of anxiety and depression. Becker OM, Dhanoa DS, Marantz Y, Chen D, Shacham S, Cheruku S, Heifetz A, Mohanty P, Fichman M, Sharadendu A, Nudelman RS J MED CHEM 2006 49 11 3116-3135
-
-
-
-
32
-
-
33947301471
-
-
684982 Clinical Data's vilazodone patient enrollment over one-third complete. Clinical Data Inc PRESS RELEASE 2006 August 17
-
684982 Clinical Data's vilazodone patient enrollment over one-third complete. Clinical Data Inc PRESS RELEASE 2006 August 17
-
-
-
-
33
-
-
33947311541
-
-
688269 Effect of vilazodone on 5-HT efflux and reuptake in the guinea pig dorsal raphe nucleus. Roberts C, Hagan JJ, Bartoszyk GD, Kew JNC EUR J PHARMACOL 2005 517 1-2 59-63 • Vilazodone is an SSRI agent but not a 5-HT1A receptor agonist in a functional test in the rodent brain
-
1A receptor agonist in a functional test in the rodent brain.
-
-
-
-
34
-
-
33947314976
-
-
688270 Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor vilazodone. Hughes ZA, Starr KR, Langmead CJ, Hill M, Bartoszyk GD, Hagan JJ, Middlemiss DN, Dawson LA EUR J PHARMACOL 2005 510 1-2 49-57 • Vilazodone shows in vivo pharmacological profile of an SSRI agent plus a 5-HT1A receptor antagonist
-
1A receptor antagonist.
-
-
-
-
35
-
-
4444225028
-
-
688271 Dual 5-HT1A agonists and 5-HT reuptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity. Heinrich T, Bottcher H, Schiemann K, Holzemann G, Schwarz M, Bartoszyk GD, van Amsterdam C, Greiner HE, Seyfried CA BIOORG MED CHEM 2004 12 18 4843-4852
-
1A agonists and 5-HT reuptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity. Heinrich T, Bottcher H, Schiemann K, Holzemann G, Schwarz M, Bartoszyk GD, van Amsterdam C, Greiner HE, Seyfried CA BIOORG MED CHEM 2004 12 18 4843-4852
-
-
-
-
36
-
-
1842627852
-
-
688274 Phase I and II enzyme characterization of two sources of HepG2 cell lines. Hewitt NJ, Hewitt P XENOBIOTICA 2004 34 3 243-256
-
688274 Phase I and II enzyme characterization of two sources of HepG2 cell lines. Hewitt NJ, Hewitt P XENOBIOTICA 2004 34 3 243-256
-
-
-
-
37
-
-
6944238722
-
-
688275 Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. Adamec R, Bartoszyk GD, Burton P EUR J PHARMACOL 2004 504 1-2 65-77
-
688275 Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. Adamec R, Bartoszyk GD, Burton P EUR J PHARMACOL 2004 504 1-2 65-77
-
-
-
-
38
-
-
33947316620
-
-
688276 Behavioral and neurochemical effects of 5-(4-[4-(5-cyano-3- indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD-68843, A combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. Page ME, Cryan JF, Sullivan Arthur DA, Saucy B, Manning DR, Lucki I J PHARMACOL EXP THER 2002 302 3 1220-1227 • Vilazodone raises serotonin levels in rat frontal cortex to 3-fold those of fluoxetine
-
688276 Behavioral and neurochemical effects of 5-(4-[4-(5-cyano-3- indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD-68843): A combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. Page ME, Cryan JF, Sullivan Arthur DA, Saucy B, Manning DR, Lucki I J PHARMACOL EXP THER 2002 302 3 1220-1227 • Vilazodone raises serotonin levels in rat frontal cortex to 3-fold those of fluoxetine.
-
-
-
-
39
-
-
0034955153
-
-
688277 Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey and human using cryopreserved hepatocytes, microsomes and collagen gel-immobilized hepatocyte cultures. Hewitt NJ, Buhring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D DRUG METAB DISPOS 2001 29 7 1042-1050
-
688277 Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey and human using cryopreserved hepatocytes, microsomes and collagen gel-immobilized hepatocyte cultures. Hewitt NJ, Buhring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D DRUG METAB DISPOS 2001 29 7 1042-1050
-
-
-
-
40
-
-
0035793968
-
-
688279 Systemic EMD-68843 injections reduce anxiety in the shockprobe, but not the plus-maze test. Treit D, Degroot A, Kashluba S, Bartoszyk GD EUR J PHARMACOL 2001 414 2-3 245-248
-
688279 Systemic EMD-68843 injections reduce anxiety in the shockprobe, but not the plus-maze test. Treit D, Degroot A, Kashluba S, Bartoszyk GD EUR J PHARMACOL 2001 414 2-3 245-248
-
-
-
-
41
-
-
0035023887
-
-
688280 Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD-68843 on the sleep EEG in healthy men. Murck H, Frieboes RM, Antonijevic IA, Steiger A PSYCHOPHARMACOLOGY 2001 155 2 187-192 • Similar to SSRIs, vilazodone suppresses REM sleep but, unlike 5-HT1A agonists, vilazodone increases slow-wave sleep in this phase 1 clinical trial
-
1A agonists, vilazodone increases slow-wave sleep in this phase 1 clinical trial.
-
-
-
-
42
-
-
0033827059
-
-
688282 Drug action at the 5-HT1A receptor in vivo: Autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-11C]WAY-100635. Rabiner EA, Gunn RN, Wilkins MR, Sargent PA, Mocaer E, Sedman E, Cowen PJ, Grasby PM NUCL MED BIOL 2000 27 5 509-513 • Plasma levels of vilazodone correlate with 5-HT1A receptor occupancy in human brain
-
1A receptor occupancy in human brain.
-
-
-
-
43
-
-
33947324875
-
-
688285 Fast adaptive changes of the sleep regulatory system after a single dose of the putative antidepressive substance EMD-68843. Murck H, Frieboes RM, Antonijevic IA, Steiger A PHARMACOPSYCHIATRY 1999 32 Abs 146
-
688285 Fast adaptive changes of the sleep regulatory system after a single dose of the putative antidepressive substance EMD-68843. Murck H, Frieboes RM, Antonijevic IA, Steiger A PHARMACOPSYCHIATRY 1999 32 Abs 146
-
-
-
-
44
-
-
33947319009
-
-
692736 Mixed results for EPIX's PRX-00023 in phase III anxiety trial. EPIX Pharmaceuticals Inc PRESS RELEASE 2006 September 22
-
692736 Mixed results for EPIX's PRX-00023 in phase III anxiety trial. EPIX Pharmaceuticals Inc PRESS RELEASE 2006 September 22
-
-
-
-
45
-
-
33748493597
-
-
729897 Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist F-13714: A microdialysis study in the rat. Assie M-B, Lomenech H, Ravailhe V, Faucillon V, Newman-Tancredi A BR J PHARMACOL 2006 149 2 170-178
-
1A agonist F-13714: A microdialysis study in the rat. Assie M-B, Lomenech H, Ravailhe V, Faucillon V, Newman-Tancredi A BR J PHARMACOL 2006 149 2 170-178
-
-
-
-
46
-
-
33947325183
-
-
736653 Safety and efficacy study of vilazodone and discovering genetic markers associated with response in patients with major depressive disorder, 2006 October 30
-
736653 Safety and efficacy study of vilazodone and discovering genetic markers associated with response in patients with major depressive disorder. www.clinicaltrials.gov WEB SITE 2006 October 30
-
-
-
-
47
-
-
27744519023
-
-
741195 The future of selective serotonin reuptake inhibitors (SSRIs) in psychiatric treatment. Taylor S, Stein MB MED HYPOTHESES 2006 66 1 14-21
-
741195 The future of selective serotonin reuptake inhibitors (SSRIs) in psychiatric treatment. Taylor S, Stein MB MED HYPOTHESES 2006 66 1 14-21
-
-
-
-
48
-
-
0031671214
-
-
741551 Brain serotonin neurotransmission. Murphy DL, Andrews AM, Wichems CH, Tohda M, Greenberg B J CLIN PSYCHIAT 1998 59 15 4-12
-
741551 Brain serotonin neurotransmission. Murphy DL, Andrews AM, Wichems CH, Tohda M, Greenberg B J CLIN PSYCHIAT 1998 59 15 4-12
-
-
-
-
49
-
-
0034447177
-
-
741680 The augmention hypothesis for improvement of antidepressant therapy. Kinney GG, Taber MT, Gribkoff VK MOL NEUROBIOL 2000 21 3 137-152
-
741680 The augmention hypothesis for improvement of antidepressant therapy. Kinney GG, Taber MT, Gribkoff VK MOL NEUROBIOL 2000 21 3 137-152
-
-
-
-
50
-
-
33644854626
-
-
741686 Pindolol augmentation of antidepressant response. Artigas F, Adell A, Celada P CURR DRUG TARGETS 2006 7 2 139-147
-
741686 Pindolol augmentation of antidepressant response. Artigas F, Adell A, Celada P CURR DRUG TARGETS 2006 7 2 139-147
-
-
-
-
51
-
-
0034959682
-
-
741691 Pharmacology of rapid-onset antidepressant treatment strategies. Blier P J CLIN PSYCHIAT 2001 62 Suppl 15 12-17
-
741691 Pharmacology of rapid-onset antidepressant treatment strategies. Blier P J CLIN PSYCHIAT 2001 62 Suppl 15 12-17
-
-
-
-
52
-
-
4444353338
-
-
741693 Synthesis and structure-activity relationship in a class of indolebutylpiperazines as dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Heinrich T, Bottcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, van Amsterdam C J MED CHEM 2004 47 19 4684-4692 • Optimization of the benzofuran moiety and preclinical characterization of vilazodone
-
1A receptor agonists and serotonin reuptake inhibitors. Heinrich T, Bottcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, van Amsterdam C J MED CHEM 2004 47 19 4684-4692 • Optimization of the benzofuran moiety and preclinical characterization of vilazodone.
-
-
-
-
53
-
-
34547445666
-
-
742255 Mechanism of action of antidepressants. Artigas F, Nutt DJ, Shelton R PSYCHOPHARMACOL BULL 2002 36 2 123-132
-
742255 Mechanism of action of antidepressants. Artigas F, Nutt DJ, Shelton R PSYCHOPHARMACOL BULL 2002 36 2 123-132
-
-
-
-
54
-
-
0033621542
-
-
742260 Brain serotonin 1A receptor binding measured by positron emission tomography with [11C]WAY-100635. Effects of depression and antidepression treatment. Sargent PA, Husted-Kjaer K, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ ARCH GEN PSYCHIAT 2000 57 2 174-180
-
11C]WAY-100635. Effects of depression and antidepression treatment. Sargent PA, Husted-Kjaer K, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ ARCH GEN PSYCHIAT 2000 57 2 174-180
-
-
-
-
55
-
-
33645509721
-
-
742264 Behavioral depression and positron emission tomographydetermined serotonin 1A receptor binding potential in cynomolgus monkeys. Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JP, Henderson JA, Smith MA, Buchheimer N ARCH GEN PSYCHIAT 2006 63 4 396-403
-
742264 Behavioral depression and positron emission tomographydetermined serotonin 1A receptor binding potential in cynomolgus monkeys. Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JP, Henderson JA, Smith MA, Buchheimer N ARCH GEN PSYCHIAT 2006 63 4 396-403
-
-
-
-
56
-
-
0033804027
-
-
742319 Pindolol excites dopaminergic and adrenergic neurons, and inhibits serotonergic neurons, by activation of 5-HT1A receptors. Lejeune F, Millan MJ EUR J NEUROSCI 2000 12 9 3265-3275
-
1A receptors. Lejeune F, Millan MJ EUR J NEUROSCI 2000 12 9 3265-3275
-
-
-
-
57
-
-
0034130350
-
-
742323 Effects of chronic fluoxetine treatment in the presence and absence of, /-pindolol: A microdialysis study. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE BR J PHARMACOL 2000 130 4 797-804
-
742323 Effects of chronic fluoxetine treatment in the presence and absence of (+/-)pindolol: A microdialysis study. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE BR J PHARMACOL 2000 130 4 797-804
-
-
-
-
58
-
-
0035986335
-
-
742337 Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE J PSYCHOPHARMACOL 2002 16 2 145-152
-
742337 Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex. Dawson LA, Nguyen HQ, Smith DL, Schlechter LE J PSYCHOPHARMACOL 2002 16 2 145-152
-
-
-
-
59
-
-
0033214706
-
-
742347 Displacement of the binding of 5-HT1A receptor ligands to pre- and postsynaptic receptors by, pindolol. A comparative study in rodent, primate and human brain. Raurich A, Mengod G, Artigas F, Cortes R SYNAPSE 1999 34 1 68-76
-
1A receptor ligands to pre- and postsynaptic receptors by (-)pindolol. A comparative study in rodent, primate and human brain. Raurich A, Mengod G, Artigas F, Cortes R SYNAPSE 1999 34 1 68-76
-
-
-
-
60
-
-
0035111317
-
-
742350 New 3-[4-(aryl)piperazine-1-yl]-1-(benzo[b] thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants. Martinez J, Perez S, Oficialdegui AM, Heras B, Orus L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo J-C et al EUR J MED CHEM 2001 36 1 55-61
-
1A serotonin receptors and serotonin transporter as a new class of antidepressants. Martinez J, Perez S, Oficialdegui AM, Heras B, Orus L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo J-C et al EUR J MED CHEM 2001 36 1 55-61
-
-
-
-
61
-
-
22144438667
-
-
742368 In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. Jordan S, Chen R, Koprivica V, Hamilton R, Whitehead RE, Tottori K, Kikuchi T EUR J PHARMACOL 2005 517 3 165-173
-
1A receptors. Jordan S, Chen R, Koprivica V, Hamilton R, Whitehead RE, Tottori K, Kikuchi T EUR J PHARMACOL 2005 517 3 165-173
-
-
-
-
62
-
-
17544368021
-
-
742633 Strategies for producing faster-acting antidepressants. Adell A, Castro E, Celada P, Bortolozzi A, Pazos A, Artigas F DRUG DISCOV TODAY 2005 10 8 578-585
-
742633 Strategies for producing faster-acting antidepressants. Adell A, Castro E, Celada P, Bortolozzi A, Pazos A, Artigas F DRUG DISCOV TODAY 2005 10 8 578-585
-
-
-
-
63
-
-
33947302756
-
-
743137 Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol. Mos J, van Aken HH, van Oorschot R, Oliver B LIFE SCI 1997 61 1 11-19
-
743137 Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol. Mos J, van Aken HH, van Oorschot R, Oliver B LIFE SCI 1997 61 1 11-19
-
-
-
-
64
-
-
4444265294
-
-
747982 Indolebutylamines as selective 5-HT1A agonists. Heinrich T, Bottcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C J MED CHEM 2004 47 19 4677-4683
-
1A agonists. Heinrich T, Bottcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C J MED CHEM 2004 47 19 4677-4683
-
-
-
-
65
-
-
33947314187
-
-
753553 Clinical data completes vilazodone manufacturing technology transfer under license with Merck KGaA. Clinical Data Inc PRESS RELEASE 2006 December 22
-
753553 Clinical data completes vilazodone manufacturing technology transfer under license with Merck KGaA. Clinical Data Inc PRESS RELEASE 2006 December 22
-
-
-
-
66
-
-
0034704821
-
-
755283 5-HT reuptake inhibitors with 5-HT1A/1B antagonistic activity: A new approach toward efficient antidepressants. Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Bottcher H J MED CHEM 2000 43 6 1149-1157
-
1A/1B antagonistic activity: A new approach toward efficient antidepressants. Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Bottcher H J MED CHEM 2000 43 6 1149-1157
-
-
-
-
67
-
-
31644433603
-
-
763333 Two-week delay in onset of action of antidepressants: New evidence. Mitchell AJ BR J PSYCHIATRY 2006 188 2 105-106
-
763333 Two-week delay in onset of action of antidepressants: New evidence. Mitchell AJ BR J PSYCHIATRY 2006 188 2 105-106
-
-
-
-
68
-
-
33750694210
-
-
763345 Early onset of selective serotonin reuptake inhibitor antidepressant action: Systematic review and meta-analysis. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z ARCH GEN PSYCHIATRY 2006 63 11 1217-1223
-
763345 Early onset of selective serotonin reuptake inhibitor antidepressant action: Systematic review and meta-analysis. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z ARCH GEN PSYCHIATRY 2006 63 11 1217-1223
-
-
-
|