5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential

European Journal of Pharmacology

Volumn 420, Issue 2-3, 2001, Pages 103-112

  Koek, Wouter ^a   Vacher, Bernard ^a   Cosi, Cristina ^a   Assié, Marie Bernadette ^a   Patoiseau, Jean François ^a   Pauwels, Petrus J ^a   Colpaert, Francis C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

(Rat); 5 HT1A receptor; 35S GTP S binding; Antidepressant; cAMP; Forced swimming test; Intrinsic activity

Indexed keywords

2 [4 [4 (7 BENZOFURANYL)PIPERAZINO]BUTYL] 4 METHYL 2H,4H 1,2,4 TRIAZIN 3,5 DIONE; 2 [4 [4 (7 METHOXY 1 NAPHTHYL)PIPERAZINO]BUTYL] 4 METHYL 2H,4H 1,2,4 TRIAZIN 3,5 DIONE MALEIC ACID; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 CHLORO 4 FLUOROPHENYL [4 FLUORO 4 [[(5 METHYL 6 METHYLAMINOPYRIDIN 2 YLMETHYL)AMINO]METHYL]PIPERIDIN 1 YL METHANONE; BUSPIRONE; EPTAPIRONE; F 11461; F 12826; F 13714; MALEIC ACID DERIVATIVE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; 3 CHLORO 4 FLUOROPHENYL (4 FLUORO 4 (((5 METHYL 6 METHYLAMINOPYRIDIN 2 YLMETHYL)AMINO)METHYL)PIPERIDIN 1 YL)METHANONE; 3-CHLORO-4-FLUOROPHENYL-(4-FLUORO-4-(((5-METHYL-6-METHYLAMINOPYRIDIN-2-YLMETHYL)AMINO)METHYL)PIPERIDIN-1-YL)METHANONE; AMINOPYRIDINE DERIVATIVE; ANTIDEPRESSANT AGENT; CYCLIC AMP; FORSKOLIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FORCED SWIMMING TEST; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; BINDING COMPETITION; DOSE RESPONSE; GENETICS; HELA CELL; HUMAN; METABOLISM; MOTOR ACTIVITY; RADIOASSAY; RAT STRAIN; SWIMMING;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMINOPYRIDINES; ANIMAL; ANTIDEPRESSIVE AGENTS; BINDING, COMPETITIVE; BUSPIRONE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HELA CELLS; HUMAN; MALE; MOTOR ACTIVITY; PIPERAZINES; PIPERIDINES; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SWIMMING;

EID: 0035946825     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01011-1     Document Type: Article

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