Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest

American Journal of Physiology - Cell Physiology

Volumn 292, Issue 3, 2007, Pages

  Zahedi, Kamyar ^a   Bissler, John J ^a   Wang, Zhaohui ^a   Josyula, Anuradha ^a   Lu, Lu ^a   Diegelman, Paula ^b   Kisiel, Nick ^b   Porter, Carl W ^b   Soleimani, Manoocher ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cell cycle arrest; Cell proliferation; DNA repair; Ischemia reperfusion injury; Polyamine depletion

Indexed keywords

ATM PROTEIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ORNITHINE DECARBOXYLASE; POLYAMINE; SPERMINE SYNTHASE; ACYLTRANSFERASE; DIAMINE ACETYLTRANSFERASE; DIAMINE N-ACETYLTRANSFERASE; SPERMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; EPITHELIUM CELL; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; ISCHEMIA; KIDNEY; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; REPERFUSION INJURY; CELL LINE; CYTOLOGY; METABOLISM; PHYSIOLOGY; UPREGULATION;

ACETYLTRANSFERASES; CELL LINE; DNA DAMAGE; EPITHELIAL CELLS; G2 PHASE; HOMEOSTASIS; HUMANS; KIDNEY; POLYAMINES; SPERMIDINE; UP-REGULATION;

EID: 33947324832     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00451.2006     Document Type: Article

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