-
1
-
-
17544396164
-
Activators of peroxisome proliferators activated receptor gamma have depot specific effects on human preadipocyte differentiation
-
Adams M., Montague C.T., Prins J.B., Holder J.C., Smith S.A., Sanders L., Digby J.E., Sewter C.P., Lazar M.A., Chatterjee V.K., and O'Rahilly S. Activators of peroxisome proliferators activated receptor gamma have depot specific effects on human preadipocyte differentiation. J. Clin. Invest. 100 (1997) 3149-3153
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 3149-3153
-
-
Adams, M.1
Montague, C.T.2
Prins, J.B.3
Holder, J.C.4
Smith, S.A.5
Sanders, L.6
Digby, J.E.7
Sewter, C.P.8
Lazar, M.A.9
Chatterjee, V.K.10
O'Rahilly, S.11
-
2
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W., Leisten J.C., Motiwala A., Pierce S., Satoh Y., Bhagwat S.S., Manning A.M., and Anderson D.W. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 13681-13686
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
Bhagwat, S.S.11
Manning, A.M.12
Anderson, D.W.13
-
3
-
-
0033527569
-
PPARα negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
-
Delerive P., De Bosscher K., Besnard S., Vanden Berghe W., Peters J.M., Gonzalez F.J., Fruchart J.C., Tedgui A., Haegeman G., and Staels B. PPARα negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J. Biol. Chem. 274 (1999) 32048-32054
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32048-32054
-
-
Delerive, P.1
De Bosscher, K.2
Besnard, S.3
Vanden Berghe, W.4
Peters, J.M.5
Gonzalez, F.J.6
Fruchart, J.C.7
Tedgui, A.8
Haegeman, G.9
Staels, B.10
-
4
-
-
0034711185
-
Induction of IkBα expression as a mechanism contributing to the anti-inflammatory activities of PPARα activators
-
Delerive P., Gervois P., Fruchart J.C., and Staels B. Induction of IkBα expression as a mechanism contributing to the anti-inflammatory activities of PPARα activators. J. Biol. Chem. 275 (2000) 36703-36707
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36703-36707
-
-
Delerive, P.1
Gervois, P.2
Fruchart, J.C.3
Staels, B.4
-
5
-
-
0035897696
-
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
-
Expert panel on detection, evaluation and treatment of high blood cholesterol in adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285 (2001) 2486-2497
-
(2001)
JAMA
, vol.285
, pp. 2486-2497
-
-
Expert panel on detection, evaluation and treatment of high blood cholesterol,1
-
6
-
-
0035049305
-
Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women
-
Fernandez-Real J.M., Vayreda M., Richart C., Gutierrez C., Broch M., Vendrell J., and Ricart W. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J. Clin. Endocrinol. Metab. 86 (2001) 1154-1159
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 1154-1159
-
-
Fernandez-Real, J.M.1
Vayreda, M.2
Richart, C.3
Gutierrez, C.4
Broch, M.5
Vendrell, J.6
Ricart, W.7
-
7
-
-
0033860359
-
Insulin resistance and cardiovascular disease
-
Ginsberg H.N. Insulin resistance and cardiovascular disease. J. Clin. Invest. 106 (2000) 453-458
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 453-458
-
-
Ginsberg, H.N.1
-
8
-
-
0034931503
-
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
-
Han Z., Boyle D.L., Chang L., Bennett B., Karin M., Yang L., Manning A.M., and Firestein G.S. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108 (2001) 73-81
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 73-81
-
-
Han, Z.1
Boyle, D.L.2
Chang, L.3
Bennett, B.4
Karin, M.5
Yang, L.6
Manning, A.M.7
Firestein, G.S.8
-
9
-
-
0033779967
-
Cardiovascular disease in diabetes mellitus type 2: a potential role for novel cardiovascular risk factors
-
Hayden J.M., and Reaven P.D. Cardiovascular disease in diabetes mellitus type 2: a potential role for novel cardiovascular risk factors. Curr. Opin. Lipidol. 11 (2000) 519-528
-
(2000)
Curr. Opin. Lipidol.
, vol.11
, pp. 519-528
-
-
Hayden, J.M.1
Reaven, P.D.2
-
10
-
-
0036125944
-
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
-
Hirose H., Kawai T., Yamamoto Y., Taniyama M., Tomita M., Matsubara K., Okazaki Y., Ishii T., Oguma Y., Takei I., and Saruta T. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism 51 (2002) 314-317
-
(2002)
Metabolism
, vol.51
, pp. 314-317
-
-
Hirose, H.1
Kawai, T.2
Yamamoto, Y.3
Taniyama, M.4
Tomita, M.5
Matsubara, K.6
Okazaki, Y.7
Ishii, T.8
Oguma, Y.9
Takei, I.10
Saruta, T.11
-
11
-
-
19944422710
-
Impaired glucose tolerance is accompanied by decreased insulin sensitivity in tissues of mice implanted with cells that overexpress resistin
-
Kitagawa Y., Bujo H., Takahashi K., Shibasaki M., Ishikawa K., Yagui K., Hashimoto N., Noda K., Nakamura T., Yano S., and Saito Y. Impaired glucose tolerance is accompanied by decreased insulin sensitivity in tissues of mice implanted with cells that overexpress resistin. Diabetologia 47 (2004) 1847-1853
-
(2004)
Diabetologia
, vol.47
, pp. 1847-1853
-
-
Kitagawa, Y.1
Bujo, H.2
Takahashi, K.3
Shibasaki, M.4
Ishikawa, K.5
Yagui, K.6
Hashimoto, N.7
Noda, K.8
Nakamura, T.9
Yano, S.10
Saito, Y.11
-
12
-
-
0343415745
-
Species differences in induction of hepatic enzymes by BM 17.0744, an activator of peroxisome proliferator-activated receptor alpha (PPARα)
-
Meyer K., Volkl A., Endele R., Kuhnle H.F., and Pill J. Species differences in induction of hepatic enzymes by BM 17.0744, an activator of peroxisome proliferator-activated receptor alpha (PPARα). Arch. Toxicol. 73 (1999) 440-450
-
(1999)
Arch. Toxicol.
, vol.73
, pp. 440-450
-
-
Meyer, K.1
Volkl, A.2
Endele, R.3
Kuhnle, H.F.4
Pill, J.5
-
13
-
-
19444365254
-
Roles of degree of fat deposition and its localization on VEGF expression in adipocyte
-
Miyazawa-Hoshimoto S., Takahashi K., Bujo H., Hashimoto N., Yagui K., and Saito Y. Roles of degree of fat deposition and its localization on VEGF expression in adipocyte. Am. J. Physiol., Endocrinol Metabol. 288 (2005) E1128-E1136
-
(2005)
Am. J. Physiol., Endocrinol Metabol.
, vol.288
-
-
Miyazawa-Hoshimoto, S.1
Takahashi, K.2
Bujo, H.3
Hashimoto, N.4
Yagui, K.5
Saito, Y.6
-
14
-
-
0035671770
-
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients
-
Miyazaki Y., Glass L., Triplitt C., Matsuda M., Cusi K., Mahankali A., Mahankali S., Mandarino L.J., and DeFronzo R.A. Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients. Diabetologia 44 (2001) 2210-2219
-
(2001)
Diabetologia
, vol.44
, pp. 2210-2219
-
-
Miyazaki, Y.1
Glass, L.2
Triplitt, C.3
Matsuda, M.4
Cusi, K.5
Mahankali, A.6
Mahankali, S.7
Mandarino, L.J.8
DeFronzo, R.A.9
-
15
-
-
0030735542
-
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
-
Mohamed-Ali V., Goodrick S., Rawesh A., Katz D.R., Miles J.M., Yudkin J.S., Klein S., and Coppack S.W. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J. Clin. Endocrinol. Metab. 82 (1997) 4196-4200
-
(1997)
J. Clin. Endocrinol. Metab.
, vol.82
, pp. 4196-4200
-
-
Mohamed-Ali, V.1
Goodrick, S.2
Rawesh, A.3
Katz, D.R.4
Miles, J.M.5
Yudkin, J.S.6
Klein, S.7
Coppack, S.W.8
-
16
-
-
0031736064
-
Adipose tissue as an endocrine and paracrine organ
-
Mohamed-Ali V., Pinkney J.H., and Coppack S.W. Adipose tissue as an endocrine and paracrine organ. Int. J. Obes. 22 (1998) 1145-1158
-
(1998)
Int. J. Obes.
, vol.22
, pp. 1145-1158
-
-
Mohamed-Ali, V.1
Pinkney, J.H.2
Coppack, S.W.3
-
17
-
-
0032897935
-
BM 17.0744: a structurally new antidiabetic compound with insulin-sensitizing and lipid-lowering activity
-
Pill J., and Kuhnle H.F. BM 17.0744: a structurally new antidiabetic compound with insulin-sensitizing and lipid-lowering activity. Metabolism 48 (1999) 34-40
-
(1999)
Metabolism
, vol.48
, pp. 34-40
-
-
Pill, J.1
Kuhnle, H.F.2
-
18
-
-
0032484123
-
Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signalling, and reduces inflammatory cytokine production in aging
-
Poynter M.E., and Daynes R.A. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signalling, and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273 (1998) 32833-32841
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32833-32841
-
-
Poynter, M.E.1
Daynes, R.A.2
-
19
-
-
33947308257
-
-
Report of a WHO Consultation, Definition, diagnosis and classification of diabetes mellitus and its complications, 1999. Part 1 Diagnosis and classification of diabetes mellitus. World Health Organization, Department of Noncommunicable Disease Surveillance, Geneva.
-
-
-
-
20
-
-
0029037649
-
Pathophysiology of insulin resistance in human disease
-
Reaven G.M. Pathophysiology of insulin resistance in human disease. Physiol. Rev. 75 (1995) 473-486
-
(1995)
Physiol. Rev.
, vol.75
, pp. 473-486
-
-
Reaven, G.M.1
-
21
-
-
0035851187
-
PPAR: a nuclear regulator of metabolism, differentiation, and cell growth
-
Rosen E.D., and Spiegelman B.M. PPAR: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276 (2001) 37731-37734
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37731-37734
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
22
-
-
0017713248
-
Acquisition of increased hormone sensitivity during in vitro adipocyte development
-
Rubin C.S., Lai E., and Rosen O.M. Acquisition of increased hormone sensitivity during in vitro adipocyte development. J. Biol. Chem. 252 (1977) 3554-3557
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 3554-3557
-
-
Rubin, C.S.1
Lai, E.2
Rosen, O.M.3
-
23
-
-
0028865771
-
Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-α in monocytic cells involves cooperation between interferon regulatory factor-1, NFκB, and Sp1 transcription factors
-
Sancéau J., Kaisho T., Hirano T., Wietzerbin J.J., and Kaisho T. Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-α in monocytic cells involves cooperation between interferon regulatory factor-1, NFκB, and Sp1 transcription factors. J. Biol. Chem. 270 (1995) 27920-27931
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27920-27931
-
-
Sancéau, J.1
Kaisho, T.2
Hirano, T.3
Wietzerbin, J.J.4
Kaisho, T.5
-
24
-
-
2942573031
-
Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR)α activator, in non-human primates
-
Schafer S.A., Hansen B.C., Volkl A., Fahimi H.D., and Pill J. Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR)α activator, in non-human primates. Biochem. Pharmacol. 68 (2004) 239-251
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 239-251
-
-
Schafer, S.A.1
Hansen, B.C.2
Volkl, A.3
Fahimi, H.D.4
Pill, J.5
-
25
-
-
0036153739
-
Topical peroxisome proliferators activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
-
Sheu M.Y., Fowler A.J., Kao J., Schmuth M., Schoonjans K., Auwerx J., Fluhr J.W., Man M.Q., Elias P.M., and Feingold K.R. Topical peroxisome proliferators activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J. Invest. Dermatol. 118 (2002) 94-101
-
(2002)
J. Invest. Dermatol.
, vol.118
, pp. 94-101
-
-
Sheu, M.Y.1
Fowler, A.J.2
Kao, J.3
Schmuth, M.4
Schoonjans, K.5
Auwerx, J.6
Fluhr, J.W.7
Man, M.Q.8
Elias, P.M.9
Feingold, K.R.10
-
26
-
-
0035988185
-
Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-alpha?
-
Shibasaki M., Takahashi K., Itou T., Miyazawa S., Ito M., Kobayashi J., Bujo H., and Saito Y. Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-alpha?. Diabetologia 45 (2002) 518-526
-
(2002)
Diabetologia
, vol.45
, pp. 518-526
-
-
Shibasaki, M.1
Takahashi, K.2
Itou, T.3
Miyazawa, S.4
Ito, M.5
Kobayashi, J.6
Bujo, H.7
Saito, Y.8
-
27
-
-
0034454417
-
Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study
-
Straub R.H., Hense H.W., Andus T., Scholmerich J., Riegger G.A., and Schunkert H. Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study. J. Clin. Endocrinol. Metab. 85 (2000) 1340-1344
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 1340-1344
-
-
Straub, R.H.1
Hense, H.W.2
Andus, T.3
Scholmerich, J.4
Riegger, G.A.5
Schunkert, H.6
-
28
-
-
0034650330
-
Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo
-
Thieringer R., Fenyk-Melody J.E., Le Grand C.B., Shelton B.A.., Detmers P.A., Somers E.P., Carbin L., Moller D.E., Wright S.D., and Berger J. Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo. J. Immunol. 164 (2000) 1046-1054
-
(2000)
J. Immunol.
, vol.164
, pp. 1046-1054
-
-
Thieringer, R.1
Fenyk-Melody, J.E.2
Le Grand, C.B.3
Shelton, B.A..4
Detmers, P.A.5
Somers, E.P.6
Carbin, L.7
Moller, D.E.8
Wright, S.D.9
Berger, J.10
-
29
-
-
0033561678
-
Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes
-
Tuyt L.M., Dokter W.H., Birkenkamp K., Koopmans S.B., Lummen C., Kruijer W., and Vellenga E. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes. J. Immunol. 162 (1999) 4893-4902
-
(1999)
J. Immunol.
, vol.162
, pp. 4893-4902
-
-
Tuyt, L.M.1
Dokter, W.H.2
Birkenkamp, K.3
Koopmans, S.B.4
Lummen, C.5
Kruijer, W.6
Vellenga, E.7
-
30
-
-
0035403205
-
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
-
Vozarova B., Weyer C., Hanson K., Tataranni P.A., Bogardus C., and Pratley R.E. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes. Res. 9 (2001) 414-417
-
(2001)
Obes. Res.
, vol.9
, pp. 414-417
-
-
Vozarova, B.1
Weyer, C.2
Hanson, K.3
Tataranni, P.A.4
Bogardus, C.5
Pratley, R.E.6
-
31
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., and Ferrante Jr. A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112 (2003) 1796-1808
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
32
-
-
0347985272
-
Obesity-induced inflammatory changes in adipose tissue
-
Wellen K.E., and Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 112 (2003) 1785-1788
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1785-1788
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
33
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity related insulin resistance
-
Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., Sole J., Nichols A., Ross J.S., Tartaglia L.A., and Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity related insulin resistance. J. Clin. Invest. 112 (2003) 1821-1830
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
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