Species differences in induction of hepatic enzymes by BM 17.0744, an activator of peroxisome proliferator-activated receptor alpha (PPARα)

Archives of Toxicology

Volumn 73, Issue 8-9, 1999, Pages 440-450

  Meyer, Kirstin ^a   Völkl, Alfred ^b   Endele, Richard ^a   Kühnle, Hans Frieder ^a   Pill, Johannes ^a  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Oxidation pathway; BM 17.0744; Peroxisome proliferators; Peroxisomes; Species differences

Indexed keywords

2,2 DICHLORO 12 (4 CHLOROPHENYL)DODECANOIC ACID; 5,8,11,14 ICOSATETRAYNOIC ACID; ACYL COENZYME A OXIDASE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CARNITINE ACETYLTRANSFERASE; CHOLESTEROL; CYTOCHROME C OXIDASE; ESTERASE; LIVER ENZYME; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; RECEPTOR SUBTYPE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG SPECIFICITY; ENZYME INDUCTION; FATTY ACID OXIDATION; FEMALE; GUINEA PIG; KIDNEY MASS; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BLOTTING, NORTHERN; BODY WEIGHT; CELL NUCLEUS; DOGS; ENZYME INDUCTION; GUINEA PIGS; LAURIC ACIDS; LIPID METABOLISM; LIVER; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SPECIES SPECIFICITY; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0343415745     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050633     Document Type: Article

References (54)

1. Baudhuin P, Beaufay H, Rahman-Li Y, Sellinger OZ, Wattiaux R, Jacques P, De Duve C (1964) Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat-liver tissue. Biochem J 92: 179-184
2. Beaufay H, Amar-Costesec A, Feytmans E, Thinés-Sempoux D, Wibo M, Robbi M, Berthet J (1974) Analytical study of microsomes and isolated subcellular membranes from rat liver. J Cell Biol 61: 188-200
3. Beier K, Völkl A, Hashimoto T, Fahimi HD (1988) Selective induction of peroxisomal enzymes by the hypolipidemic drug bezafibrate. Detection of modulations by automatic image analysis in conjunction with immunoelectron microscopy and immunoblotting. Eur J Cell Biol 46: 383-393
4. Bentley P, Calder I, Elcombe C, Grasso P, Stringer D, Wiegand H-J (1993) Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem Toxicol 31: 857-907
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
6. Braissant O, Foufelle F, Scotto C, Dauça M, Wahli W (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology 137: 354-366
7. Burnette WN (1981) "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112: 195-203
8. Chen CA, Okayama H (1988) Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. BioTechniques 6: 632-638
9. Cherkaoui Malki M, Assaka L, Pacot C, Bardot O, Latruffe N (1991) Effect of different hypolipemic agents on rat liver peroxisomal and mitochondrial functions and biogenesis. Cell Mol Biol 37: 723-733
10. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
11. Cooperstein SJ, Lazarow A (1951) A microspectrophotometric method for the determination of cytochrome oxidase. J Biol Chem 189: 665-670
12. De Duve C (1965) Functions of microbodies (peroxisomes). J Cell Biol 27: 25A-26A
13. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W (1992) Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68: 879-887
14. Elango N, Vivekananda J, Strong R, Katz MS (1997) Nuclei isolation from bone cells for nuclear run-on assays. BioTechniques 23: 422-424
15. Esbenshade TA, Kamanna VS, Newman HAI, Tortorella V, Witiak DT, Feller DR (1990) In vivo and in vitro peroxisome proliferation properties of selected clofibrate analogues in the rat: structure-activity-relationships. Biochem Pharmacol 40: 1263-1274
16. Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889-895
17. Fahimi HD, Sies H (1987) Peroxisomes in biology and medicine. Springer-Verlag, Heidelberg
18. Fahimi HD, Reinicke A, Sujatta M, Yokota S, Özel M, Hartig F, Stegmeier K (1982) The short- and long-term effects of bezafibrate in the rat. Ann NY Acad Sci 386: 111-135
19. Folch J, Lees M, Stanley GHS (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509
20. Gibson GG, Orton TC, Tamburini PP (1982) Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). Biochem J 203: 161-168
21. Hess R, Stäubli W, Riess W (1965) Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 208: 856-858
22. Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645-650
23. Johnson EF, Palmer CNA, Griffin KJ, Hsu M-H (1996) Role of the peroxisome proliferator-activated receptor in cytochrome P450 4 A gene regulation. FASEB J 10: 1241-1248
24. Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA 90: 2160-2164
25. Kletzien RF, Clarke SD, Ulrich RG (1992) Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol Pharmacol 41: 393-398
26. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 91: 7355-7359
27. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
28. Lake BG (1995) Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals. Annu Rev Pharmacol Toxicol 35: 483-507
29. Lake BG, Gray TJB (1985) Species differences in hepatic peroxi-some proliferation. Biochem Soc Trans 13: 859-861
30. Lazarow PB, Shio H, Leroy-Houyet MA (1982) Specificity in the action of hypolipidemic drugs: increase of peroxisomal β-oxidation largely dissociated from hepatomegaly and peroxisome proliferation in the rat. J Lipid Res 23: 317-326
31. Lee SS-T, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ (1995) Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15: 3012-3022
32. Lock EA, Mitchell AM, Elcombe CR (1989) Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu Rev Pharmacol Toxicol 29: 145-163
33. Markwell MAK, Bieber LL, Tolbert NE (1977) Differential increase of hepatic peroxisomal, mitochondrial and microsomal carnitine acyltransferases in clofibrate-fed rats. Biochem Pharmacol 26: 1697-1702
34. Marquis NR, Fritz IB (1965) The distribution of carnitine, acetylcarnitine and carnitine acetyltransferase in rat tissue. J Biol Chem 240: 2193-2196
35. Meyer K, Voss E, Neidlein R, Kühnle H-F, Pill J (1998) ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents. Eur J Med Chem 33: 775-787
36. Moody DE, Reddy JK (1978) Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol 45: 497-504
37. Nemali MR, Reddy MK, Usuda N, Reddy PG, Comeau LD, Rao MS, Reddy JK (1989) Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens. Toxicol Appl Pharmacol 97: 72-87
38. Orton TC, Adam HK, Bentley M, Holloway B, Tucker MJ (1984) Clobuzarit: species differences in the morphological and biochemical response of the liver following chronic administration. Toxicol Appl Pharmacol 73: 138-151
39. Peters JM, Hennuyer N, Staels B, Fruchart J-C, Fievet C, Gonzalez FJ, Auwerx J (1997) Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor α-deficient mice. J Biol Chem 272: 27307-27312
40. Pill J, Kühnle H-F (1999) BM 17.0744: a structurally new antidiabetic compound with insulin-sensitizing and lipid-lowering activity. Metabolism 48: 34-40
41. Pill J, Völkl A, Hartig F, Fahimi HD (1992) Differences in the response of Sprague-Dawley and Lewis rats to bezafibrate: the hypolipidemic effect and the induction of peroxisomal enzymes. Arch Toxicol 66: 327-333
42. Priest DG, Pitts OM (1972) Reaction intermediate effects on the spectrophotometric uricase assay. Anal Biochem 50: 195-205
43. Reaven GM (1988) Banting lecture: role of insulin resistance in human disease. Diabetes 37: 1595-1607
44. Reddy JK, Goel SK, Nemali MR, Carrino JJ, Laffler TG, Reddy MK, Sperbeck SJ, Osumi T, Hashimoto T, Lalwani ND, Rao MS (1986) Transcriptional regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc Natl Acad Sci USA 83: 1747-1751
45. Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37: 907-925
46. Siedel J, Schlumberger H, Klose S, Ziegenhorn J, Wahlefeld AW (1981) Improved reagent for the enzymatic determination of serum cholesterol. J Clin Chem Clin Biochem 19: 838-839
47. Small GM, Burdett K, Connock MJ (1985) A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem J 227: 205-210
48. Takayama M, Itoh S, Nagasaki T, Tanimizu I (1977) A new enzymatic method for determination of serum choline-containing phospholipids. Clin Chim Acta 79: 93-98
49. Wahlefeld AW (1974) Triglyceride: Bestimmung nach enzymatischer Verseifung. In Bergmeyer HU (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim, pp 1878-1882
50. Wahli W, Braissant O, Desvergne B (1995) Peroxisome proliferator activated receptors: transcriptional regulators of adipogenensis, lipid metabolism and more... Chem Biol 2: 261-266
51. Watanabe T, Horie S, Yamada J, Isaji M, Nishigaki T, Naito J, Suga T (1989) Species differences in the effects of bezafibrate, a hypolipidemic agent, on hepatic peroxisome-associated enzymes. Biochem Pharmacol 38: 367-371
52. Wharton DC, Tzagoloff A (1967) Cytochrome oxidase from beef heart mitochondria. Methods Enzymol 10: 245-250
53. Widnell CC, Tata JR (1964) A procedure for the isolation of enzymically active rat-liver nuclei. Biochem J 92: 313-317
54. Zhan J, Fahimi HD, Völkl A (1997) Sensitive nonradioactive dot blot/ribonuclease protection assay for quantitative determination of mRNA. BioTechniques 22: 500-505