Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices

Rapid Communications in Mass Spectrometry

Volumn 21, Issue 6, 2007, Pages 961-970

  Kiffe, Michael ^a   Graf, Daniel ^a   Trunzer, Markus ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; BIOMOLECULES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; MASS SPECTROMETRY; RADIOACTIVITY;

ABSORPTION DISTRIBUTION METABOLISM AND EXCRETIONS; BIOLOGICAL MATRIXES; DRUG CANDIDATES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIES; IN-VIVO; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; SAMPLE PRETREATMENT; STRUCTURAL ELUCIDATION; TWO-DIMENSIONAL; TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY;

METABOLITES;

EID: 33947234593     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.2923     Document Type: Article

References (26)

1. Korfmacher WA. Using Mass Spectrometry for Drug Metabolism Studies. CRC Press: Boca Raton, London, New York, Washington, DC, 2005.
2. Willoughby R, Sheehan E, Mitrovich S. A Global View of LC/ MS - How To Solve Your Most Challenging Analytical Problems (2nd edn). Global View publishing: Pittsburgh, Pennsylvania, 2002.
3. Erickson BE. Anal. Chem. 2000; 72: 711A.
4. Gérard H, Bourgogne E. Mass Spectrom. Rev. 2003; 22: 195.
5. Bell DS, Jones AD. Solute attributes and molecular interactions contributing to 'U-Shape' retention on fluorinated HPLC stationary phase, Supelco Aldrich.
6. Bonfiglio R, King RC, Olah TV, Merkle K. Rapid Commun. Mass Spectrom. 1999; 13: 1175.
7. Legido-Quigley C, Smith NW, Mallet D. J. Chromatogr. A 2002; 976: 11.
8. Rozing G. Trends in HPLC Column Formats - Microbore, Nanobore and Smaller, Recent developments, LC-Column Technology, 2003.
9. Shou WZ, Magis L, Li AC, Naidong W, Bryant MS. J. Mass. Spectrom. 2005; 40: 1347.
10. Dear GJ, Ayrton J, Plumb R, Fraser IJ. Rapid Commun. Mass Spectrom. 1999; 13: 456.
11. Staack RF, Varesio E, Hopfgartner G. Rapid Commun. Mass Spectrom. 2005; 19: 618.
12. Boernsen KO, Gatzek S, Imbert G. Anal. Chem. 2005; 77: 7255.
13. Ynddal L, Hansen SH. J. Chromatogr. A 2003; 1020: 59.
14. Li M, Alnouti Y, Leverence R, Bi H, Gusev AI. J. Chromatogr. B 2005; 825: 152.
15. Foltz DJ, Castro-Perez J, Riley P, Entwisle JR, Baker TR. J. Chromatogr. B 2005; 825: 144.
16. Gao S, Zhang ZP, Karnes HT. J. Chromatogr. B 2005; 825: 98.
17. Nassar AEF, Talaat RE. Drug Discovery Today 2004; 9: 317.
18. Lee MS, Kerns EH, Hali ME, Liu J, Volk KJ. LC-GC 1997; 15: 542.
19. Niessen WMA. J. Chromatogr. A 1999; 856: 179.
20. Oliveira EJ, Watson DG. Biomed. Chromatogr. 2000; 14: 351.
21. Kostiainen R, Kotiaho T, Kuuranne T, Auriola S. J. Mass Spectrom. 2003; 38: 357.
22. Hopfgartner G, Bourgogne E. Mass Spectrom. Rev. 2003; 22: 195.
23. Lee MS, Kerns EH. Mass Spectrom. Rev. 1999; 18: 187.
24. Levsen K, Schiebel HM, Behnke B, Dötzer R, Dreher W, Elend M, Thiele H. J. Chromatogr. A 2005; 1067: 55.
25. McLuckey SA, Wells JM. Chem. Rev. 2001; 101: 571.
26. Vollmer M, Hörth P, Nägele E. Anal. Chem. 2004; 76: 5180.