메뉴 건너뛰기




Volumn 35, Issue 4, 2007, Pages 523-533

The pathophysiology of paroxysmal nocturnal hemoglobinuria

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW; BONE MARROW CELL; GENE MUTATION; HEMATOPOIESIS; HUMAN; MOLECULAR CLONING; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROGENY; REVIEW; SOMATIC CELL; SPINAL CORD DISEASE; STEM CELL; X CHROMOSOME LINKAGE;

EID: 33947227491     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.01.046     Document Type: Review
Times cited : (88)

References (93)
  • 1
    • 0027412627 scopus 로고
    • The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis
    • Miyata T., Takeda J., Iida Y., et al. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science 259 (1993) 1318-1320
    • (1993) Science , vol.259 , pp. 1318-1320
    • Miyata, T.1    Takeda, J.2    Iida, Y.3
  • 2
    • 0027310539 scopus 로고
    • Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria
    • Takeda J., Miyata T., Kawagoe K., et al. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell 73 (1993) 703-711
    • (1993) Cell , vol.73 , pp. 703-711
    • Takeda, J.1    Miyata, T.2    Kawagoe, K.3
  • 3
    • 0028057618 scopus 로고
    • Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria
    • Miyata T., Yamada N., Iida Y., et al. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 330 (1994) 249-255
    • (1994) N Engl J Med , vol.330 , pp. 249-255
    • Miyata, T.1    Yamada, N.2    Iida, Y.3
  • 4
    • 0037800971 scopus 로고
    • Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor
    • Nicholson-Weller A., March J.P., Rosenfeld S.I., and Austen K.F. Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor. Proc Natl Acad Sci U S A 80 (1983) 5066-5070
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 5066-5070
    • Nicholson-Weller, A.1    March, J.P.2    Rosenfeld, S.I.3    Austen, K.F.4
  • 5
    • 0006386057 scopus 로고
    • Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria
    • Pangburn M.K., Schreiber R.D., and Muller-Eberhard H.J. Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A 80 (1983) 5430-5434
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 5430-5434
    • Pangburn, M.K.1    Schreiber, R.D.2    Muller-Eberhard, H.J.3
  • 6
    • 0022465626 scopus 로고
    • Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein
    • Davitz M.A., Low M.G., and Nussenzweig V. Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein. J Exp Med 163 (1986) 1150-1161
    • (1986) J Exp Med , vol.163 , pp. 1150-1161
    • Davitz, M.A.1    Low, M.G.2    Nussenzweig, V.3
  • 7
    • 0024411828 scopus 로고
    • Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria
    • Holguin M.H., Fredrick L.R., Bernshaw N.J., Wilcox L.A., and Parker C.J. Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria. J Clin Invest 84 (1989) 7-17
    • (1989) J Clin Invest , vol.84 , pp. 7-17
    • Holguin, M.H.1    Fredrick, L.R.2    Bernshaw, N.J.3    Wilcox, L.A.4    Parker, C.J.5
  • 8
    • 0025176664 scopus 로고
    • Erythrocyte membrane inhibitor of reactive lysis: effects of phosphatidylinositol-specific phospholipase C on the isolated and cell-associated protein
    • Holguin M.H., Wilcox L.A., Bernshaw N.J., Rosse W.F., and Parker C.J. Erythrocyte membrane inhibitor of reactive lysis: effects of phosphatidylinositol-specific phospholipase C on the isolated and cell-associated protein. Blood 75 (1990) 284-289
    • (1990) Blood , vol.75 , pp. 284-289
    • Holguin, M.H.1    Wilcox, L.A.2    Bernshaw, N.J.3    Rosse, W.F.4    Parker, C.J.5
  • 11
    • 0033808293 scopus 로고    scopus 로고
    • Paroxysmal nocturnal hemoglobinuria and the risk of venous thrombosis: review and recommendations for management of the pregnant and nonpregnant patient
    • Ray J.G., Burows R.F., Ginsberg J.S., and Burrows E.A. Paroxysmal nocturnal hemoglobinuria and the risk of venous thrombosis: review and recommendations for management of the pregnant and nonpregnant patient. Haemostasis 30 (2000) 103-117
    • (2000) Haemostasis , vol.30 , pp. 103-117
    • Ray, J.G.1    Burows, R.F.2    Ginsberg, J.S.3    Burrows, E.A.4
  • 12
    • 2442532784 scopus 로고    scopus 로고
    • Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan
    • Nishimura J.I., Kanakura Y., Ware R.E., et al. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) 83 (2004) 193-207
    • (2004) Medicine (Baltimore) , vol.83 , pp. 193-207
    • Nishimura, J.I.1    Kanakura, Y.2    Ware, R.E.3
  • 14
    • 16044365965 scopus 로고    scopus 로고
    • Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology
    • Socie G., Mary J.Y., de Gramont A., et al. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology. Lancet 348 (1996) 573-577
    • (1996) Lancet , vol.348 , pp. 573-577
    • Socie, G.1    Mary, J.Y.2    de Gramont, A.3
  • 15
    • 0024804936 scopus 로고
    • Prognostic features of paroxysmal nocturnal hemoglobinuria in Japan
    • Fujioka S., and Takayoshi T. Prognostic features of paroxysmal nocturnal hemoglobinuria in Japan. Acta Haematol Japan 52 (1989) 1386-1394
    • (1989) Acta Haematol Japan , vol.52 , pp. 1386-1394
    • Fujioka, S.1    Takayoshi, T.2
  • 16
    • 0025517475 scopus 로고
    • Characteristics of paroxysmal nocturnal hemoglobinuria in China. Clinical analysis of 476 cases
    • Le X.F., Yang T.Y., Yang X.Y., and Wang X.M. Characteristics of paroxysmal nocturnal hemoglobinuria in China. Clinical analysis of 476 cases. Chin Med J (Engl) 103 (1990) 885-889
    • (1990) Chin Med J (Engl) , vol.103 , pp. 885-889
    • Le, X.F.1    Yang, T.Y.2    Yang, X.Y.3    Wang, X.M.4
  • 17
    • 0141704468 scopus 로고    scopus 로고
    • Paroxysmal nocturnal hemoglobinuria: the Mexican experience
    • Gongora Bianchi R.A. Paroxysmal nocturnal hemoglobinuria: the Mexican experience. Rev Invest Clin 49 (1997) 85S-88S
    • (1997) Rev Invest Clin , vol.49
    • Gongora Bianchi, R.A.1
  • 18
    • 78651129366 scopus 로고
    • Paroxysmal nocturnal haemoglobinuria: variation in clinical severity and association with bone-marrow hypoplasia
    • Dacie J.V., and Lewis S.M. Paroxysmal nocturnal haemoglobinuria: variation in clinical severity and association with bone-marrow hypoplasia. Br J Haematol 7 (1961) 442-457
    • (1961) Br J Haematol , vol.7 , pp. 442-457
    • Dacie, J.V.1    Lewis, S.M.2
  • 19
    • 0000035046 scopus 로고
    • Paroxsymal nocturnal haemoglobinuria
    • Dacie J.V. Paroxsymal nocturnal haemoglobinuria. Proc R Soc Med 56 (1963) 587-596
    • (1963) Proc R Soc Med , vol.56 , pp. 587-596
    • Dacie, J.V.1
  • 20
    • 0014060844 scopus 로고
    • The aplastic anaemia-paroxysmal nocturnal haemoglobinuria syndrome
    • Lewis S.M., and Dacie J.V. The aplastic anaemia-paroxysmal nocturnal haemoglobinuria syndrome. Br J Haematol 13 (1967) 236-251
    • (1967) Br J Haematol , vol.13 , pp. 236-251
    • Lewis, S.M.1    Dacie, J.V.2
  • 21
    • 0036223611 scopus 로고    scopus 로고
    • Historical aspects of paroxysmal nocturnal haemoglobinuria: "defining the disease."
    • Parker C.J. Historical aspects of paroxysmal nocturnal haemoglobinuria: "defining the disease.". Br J Haematol 117 (2002) 3-22
    • (2002) Br J Haematol , vol.117 , pp. 3-22
    • Parker, C.J.1
  • 22
    • 0013911413 scopus 로고
    • Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody
    • Rosse W.F., and Dacie J.V. Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody. J Clin Invest 45 (1966) 736-748
    • (1966) J Clin Invest , vol.45 , pp. 736-748
    • Rosse, W.F.1    Dacie, J.V.2
  • 23
    • 0013910557 scopus 로고
    • Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. II. The role of complement components in the increased sensitivity of PNH red cells to immune lysis
    • Rosse W.F., and Dacie J.V. Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. II. The role of complement components in the increased sensitivity of PNH red cells to immune lysis. J Clin Invest 45 (1966) 749-757
    • (1966) J Clin Invest , vol.45 , pp. 749-757
    • Rosse, W.F.1    Dacie, J.V.2
  • 24
    • 0015593110 scopus 로고
    • Variations in the red cells in paroxysmal nocturnal haemoglobinuria
    • Rosse W.F. Variations in the red cells in paroxysmal nocturnal haemoglobinuria. Br J Haematol 24 (1973) 327-342
    • (1973) Br J Haematol , vol.24 , pp. 327-342
    • Rosse, W.F.1
  • 25
    • 0024447639 scopus 로고
    • Relationship between the membrane inhibitor of reactive lysis and the erythrocyte phenotypes of paroxysmal nocturnal hemoglobinuria
    • Holguin M.H., Wilcox L.A., Bernshaw N.J., Rosse W.F., and Parker C.J. Relationship between the membrane inhibitor of reactive lysis and the erythrocyte phenotypes of paroxysmal nocturnal hemoglobinuria. J Clin Invest 84 (1989) 1387-1394
    • (1989) J Clin Invest , vol.84 , pp. 1387-1394
    • Holguin, M.H.1    Wilcox, L.A.2    Bernshaw, N.J.3    Rosse, W.F.4    Parker, C.J.5
  • 26
    • 0014832992 scopus 로고
    • Paroxysmal nocturnal hemoglobinuria: evidence for monoclonal origin of abnormal red cells
    • Oni S.B., Osunkoya B.O., and Luzzatto L. Paroxysmal nocturnal hemoglobinuria: evidence for monoclonal origin of abnormal red cells. Blood 36 (1970) 145-152
    • (1970) Blood , vol.36 , pp. 145-152
    • Oni, S.B.1    Osunkoya, B.O.2    Luzzatto, L.3
  • 27
    • 0029871217 scopus 로고    scopus 로고
    • Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria
    • Endo M., Ware R.E., Vreeke T.M., et al. Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria. Blood 87 (1996) 2546-2557
    • (1996) Blood , vol.87 , pp. 2546-2557
    • Endo, M.1    Ware, R.E.2    Vreeke, T.M.3
  • 28
    • 0037769826 scopus 로고    scopus 로고
    • The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): a high incidence of multiple mutations and evidence of a mutational hot spot
    • Mortazavi Y., Merk B., McIntosh J., Marsh J.C., Schrezenmeier H., and Rutherford T.R. The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): a high incidence of multiple mutations and evidence of a mutational hot spot. Blood 101 (2003) 2833-2841
    • (2003) Blood , vol.101 , pp. 2833-2841
    • Mortazavi, Y.1    Merk, B.2    McIntosh, J.3    Marsh, J.C.4    Schrezenmeier, H.5    Rutherford, T.R.6
  • 29
    • 0028299834 scopus 로고
    • Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria
    • Bessler M., Mason P., Hillmen P., and Luzzatto L. Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria. Lancet 343 (1994) 951-953
    • (1994) Lancet , vol.343 , pp. 951-953
    • Bessler, M.1    Mason, P.2    Hillmen, P.3    Luzzatto, L.4
  • 30
    • 0030942613 scopus 로고    scopus 로고
    • A patient with paroxysmal nocturnal hemoglobinuria bearing four independent PIG-A mutant clones
    • Nishimura J., Inoue N., Wada H., et al. A patient with paroxysmal nocturnal hemoglobinuria bearing four independent PIG-A mutant clones. Blood 89 (1997) 3470-3476
    • (1997) Blood , vol.89 , pp. 3470-3476
    • Nishimura, J.1    Inoue, N.2    Wada, H.3
  • 31
    • 28444483571 scopus 로고    scopus 로고
    • Diagnosis and management of paroxysmal nocturnal hemoglobinuria
    • Parker C., Omine M., Richards S., et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 106 (2005) 3699-3709
    • (2005) Blood , vol.106 , pp. 3699-3709
    • Parker, C.1    Omine, M.2    Richards, S.3
  • 32
    • 33947264416 scopus 로고    scopus 로고
    • Evolution of GPI-deficient clones predicts clinical course in paroxysmal nocturnal hemoglobinuria
    • Richards S.J., Cullen M.J., Dickinson A.J., Hall C., Hill A., and Hillmen P. Evolution of GPI-deficient clones predicts clinical course in paroxysmal nocturnal hemoglobinuria. Blood 104 (2004) 53a
    • (2004) Blood , vol.104
    • Richards, S.J.1    Cullen, M.J.2    Dickinson, A.J.3    Hall, C.4    Hill, A.5    Hillmen, P.6
  • 33
    • 0037089219 scopus 로고    scopus 로고
    • Long-term support of hematopoiesis by a single stem cell clone in patients with paroxysmal nocturnal hemoglobinuria
    • Nishimura Ji J., Hirota T., Kanakura Y., et al. Long-term support of hematopoiesis by a single stem cell clone in patients with paroxysmal nocturnal hemoglobinuria. Blood 99 (2002) 2748-2751
    • (2002) Blood , vol.99 , pp. 2748-2751
    • Nishimura Ji, J.1    Hirota, T.2    Kanakura, Y.3
  • 34
    • 28444446885 scopus 로고    scopus 로고
    • Clinical significance of increased PNH-type cells in the peripheral blood of patients with aplastic anemia and refractory anemia
    • Omine M., and Kinoshita T. (Eds), Springer, Tokyo
    • Nakao S., Wang H., and Chuhjo T. Clinical significance of increased PNH-type cells in the peripheral blood of patients with aplastic anemia and refractory anemia. In: Omine M., and Kinoshita T. (Eds). Paroxysmal nocturnal hemoglobinuria and related disorders: molecular aspects of pathogenesis (2003), Springer, Tokyo 129-138
    • (2003) Paroxysmal nocturnal hemoglobinuria and related disorders: molecular aspects of pathogenesis , pp. 129-138
    • Nakao, S.1    Wang, H.2    Chuhjo, T.3
  • 35
    • 0041737643 scopus 로고    scopus 로고
    • Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells
    • Ishiyama K., Chuhjo T., Wang H., Yachie A., Omine M., and Nakao S. Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. Blood 102 (2003) 1211-1216
    • (2003) Blood , vol.102 , pp. 1211-1216
    • Ishiyama, K.1    Chuhjo, T.2    Wang, H.3    Yachie, A.4    Omine, M.5    Nakao, S.6
  • 36
    • 0035058599 scopus 로고    scopus 로고
    • Relative increase of granulocytes with a paroxysmal nocturnal haemoglobinuria phenotype in aplastic anaemia patients: the high prevalence at diagnosis
    • Wang H., Chuhjo T., Yamazaki H., et al. Relative increase of granulocytes with a paroxysmal nocturnal haemoglobinuria phenotype in aplastic anaemia patients: the high prevalence at diagnosis. Eur J Haematol 66 (2001) 200-205
    • (2001) Eur J Haematol , vol.66 , pp. 200-205
    • Wang, H.1    Chuhjo, T.2    Yamazaki, H.3
  • 37
    • 0036893544 scopus 로고    scopus 로고
    • Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome
    • Wang H., Chuhjo T., Yasue S., Omine M., and Nakao S. Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome. Blood 100 (2002) 3897-3902
    • (2002) Blood , vol.100 , pp. 3897-3902
    • Wang, H.1    Chuhjo, T.2    Yasue, S.3    Omine, M.4    Nakao, S.5
  • 39
    • 0029899213 scopus 로고    scopus 로고
    • Syngeneic bone marrow transplantation without conditioning in a patient with paroxysmal nocturnal hemoglobinuria: in vivo evidence that the mutant stem cells have a survival advantage
    • Endo M., Beatty P.G., Vreeke T.M., Wittwer C.T., Singh S.P., and Parker C.J. Syngeneic bone marrow transplantation without conditioning in a patient with paroxysmal nocturnal hemoglobinuria: in vivo evidence that the mutant stem cells have a survival advantage. Blood 88 (1996) 742-750
    • (1996) Blood , vol.88 , pp. 742-750
    • Endo, M.1    Beatty, P.G.2    Vreeke, T.M.3    Wittwer, C.T.4    Singh, S.P.5    Parker, C.J.6
  • 40
    • 0025952076 scopus 로고
    • The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis
    • Rosse W.F., Hoffman S., Campbell M., Borowitz M., Moore J.O., and Parker C.J. The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis. Br J Haematol 79 (1991) 99-107
    • (1991) Br J Haematol , vol.79 , pp. 99-107
    • Rosse, W.F.1    Hoffman, S.2    Campbell, M.3    Borowitz, M.4    Moore, J.O.5    Parker, C.J.6
  • 41
    • 0030912049 scopus 로고    scopus 로고
    • The pathophysiology of acquired aplastic anemia
    • Young N.S., and Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med 336 (1997) 1365-1372
    • (1997) N Engl J Med , vol.336 , pp. 1365-1372
    • Young, N.S.1    Maciejewski, J.2
  • 42
    • 0030757260 scopus 로고    scopus 로고
    • T-cell receptor β chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia
    • Manz C.Y., Dietrich P.Y., Schnuriger V., Nissen C., and Wodnar-Filipowicz A. T-cell receptor β chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia. Blood Cells Mol Dis 23 (1997) 110-122
    • (1997) Blood Cells Mol Dis , vol.23 , pp. 110-122
    • Manz, C.Y.1    Dietrich, P.Y.2    Schnuriger, V.3    Nissen, C.4    Wodnar-Filipowicz, A.5
  • 43
    • 0036660175 scopus 로고    scopus 로고
    • Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V β CDR3 spectratyping and flow cytometry
    • Risitano A.M., Kook H., Zeng W., Chen G., Young N.S., and Maciejewski J.P. Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V β CDR3 spectratyping and flow cytometry. Blood 100 (2002) 178-183
    • (2002) Blood , vol.100 , pp. 178-183
    • Risitano, A.M.1    Kook, H.2    Zeng, W.3    Chen, G.4    Young, N.S.5    Maciejewski, J.P.6
  • 44
    • 0033135936 scopus 로고    scopus 로고
    • Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia
    • Zeng W., Nakao S., Takamatsu H., et al. Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia. Blood 93 (1999) 3008-3016
    • (1999) Blood , vol.93 , pp. 3008-3016
    • Zeng, W.1    Nakao, S.2    Takamatsu, H.3
  • 45
    • 0037092948 scopus 로고    scopus 로고
    • Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens
    • Kook H., Risitano A.M., Zeng W., et al. Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens. Blood 99 (2002) 3668-3675
    • (2002) Blood , vol.99 , pp. 3668-3675
    • Kook, H.1    Risitano, A.M.2    Zeng, W.3
  • 46
    • 0034307521 scopus 로고    scopus 로고
    • Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria
    • Karadimitris A., Manavalan J.S., Thaler H.T., et al. Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood 96 (2000) 2613-2620
    • (2000) Blood , vol.96 , pp. 2613-2620
    • Karadimitris, A.1    Manavalan, J.S.2    Thaler, H.T.3
  • 47
    • 0033609114 scopus 로고    scopus 로고
    • Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals
    • Araten D.J., Nafa K., Pakdeesuwan K., and Luzzatto L. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proc Natl Acad Sci U S A 96 (1999) 5209-5214
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5209-5214
    • Araten, D.J.1    Nafa, K.2    Pakdeesuwan, K.3    Luzzatto, L.4
  • 48
    • 0035655579 scopus 로고    scopus 로고
    • Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes
    • Ware R.E., Pickens C.V., DeCastro C.M., and Howard T.A. Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes. Exp Hematol 29 (2001) 1403-1409
    • (2001) Exp Hematol , vol.29 , pp. 1403-1409
    • Ware, R.E.1    Pickens, C.V.2    DeCastro, C.M.3    Howard, T.A.4
  • 50
    • 0029873584 scopus 로고    scopus 로고
    • Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria
    • Kawagoe K., Kitamura D., Okabe M., et al. Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood 87 (1996) 3600-3606
    • (1996) Blood , vol.87 , pp. 3600-3606
    • Kawagoe, K.1    Kitamura, D.2    Okabe, M.3
  • 51
    • 0030955185 scopus 로고    scopus 로고
    • Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion
    • Rosti V., Tremml G., Soares V., Pandolfi P.P., Luzzatto L., and Bessler M. Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion. J Clin Invest 100 (1997) 1028-1036
    • (1997) J Clin Invest , vol.100 , pp. 1028-1036
    • Rosti, V.1    Tremml, G.2    Soares, V.3    Pandolfi, P.P.4    Luzzatto, L.5    Bessler, M.6
  • 52
    • 0033230376 scopus 로고    scopus 로고
    • Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by a mouse model of paroxysmal nocturnal hemoglobinuria
    • Murakami Y., Kinoshita T., Maeda Y., Nakano T., Kosaka H., and Takeda J. Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by a mouse model of paroxysmal nocturnal hemoglobinuria. Blood 94 (1999) 2963-2970
    • (1999) Blood , vol.94 , pp. 2963-2970
    • Murakami, Y.1    Kinoshita, T.2    Maeda, Y.3    Nakano, T.4    Kosaka, H.5    Takeda, J.6
  • 53
    • 0033231095 scopus 로고    scopus 로고
    • Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene
    • Tremml G., Dominguez C., Rosti V., et al. Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene. Blood 94 (1999) 2945-2954
    • (1999) Blood , vol.94 , pp. 2945-2954
    • Tremml, G.1    Dominguez, C.2    Rosti, V.3
  • 54
    • 0033608998 scopus 로고    scopus 로고
    • Hypermutation in derepressed operons of Escherichia coli K12
    • Wright B.E., Longacre A., and Reimers J.M. Hypermutation in derepressed operons of Escherichia coli K12. Proc Natl Acad Sci U S A 96 (1999) 5089-5094
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5089-5094
    • Wright, B.E.1    Longacre, A.2    Reimers, J.M.3
  • 56
    • 0035865618 scopus 로고    scopus 로고
    • Telomere length in leukocyte subpopulations of patients with aplastic anemia
    • Brummendorf T.H., Maciejewski J.P., Mak J., Young N.S., and Lansdorp P.M. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 97 (2001) 895-900
    • (2001) Blood , vol.97 , pp. 895-900
    • Brummendorf, T.H.1    Maciejewski, J.P.2    Mak, J.3    Young, N.S.4    Lansdorp, P.M.5
  • 57
    • 0036095964 scopus 로고    scopus 로고
    • Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria
    • Horikawa K., Kawaguchi T., Ishihara S., et al. Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria. Blood 99 (2002) 24-29
    • (2002) Blood , vol.99 , pp. 24-29
    • Horikawa, K.1    Kawaguchi, T.2    Ishihara, S.3
  • 59
    • 0028802581 scopus 로고
    • Defective glycosyl phosphatidylinositol anchor synthesis and paroxysmal nocturnal hemoglobinuria
    • Kinoshita T., Inoue N., and Takeda J. Defective glycosyl phosphatidylinositol anchor synthesis and paroxysmal nocturnal hemoglobinuria. Adv Immunol 60 (1995) 57-103
    • (1995) Adv Immunol , vol.60 , pp. 57-103
    • Kinoshita, T.1    Inoue, N.2    Takeda, J.3
  • 60
    • 0028228227 scopus 로고
    • Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria
    • Ware R.E., Howard T.A., Kamitani T., Change H.M., Yeh E.T., and Seldin M.F. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood 83 (1994) 3753-3757
    • (1994) Blood , vol.83 , pp. 3753-3757
    • Ware, R.E.1    Howard, T.A.2    Kamitani, T.3    Change, H.M.4    Yeh, E.T.5    Seldin, M.F.6
  • 61
    • 0028884057 scopus 로고
    • The molecular basis of paroxysmal nocturnal hemoglobinuria
    • Rosse W.F., and Ware R.E. The molecular basis of paroxysmal nocturnal hemoglobinuria. Blood 86 (1995) 3277-3286
    • (1995) Blood , vol.86 , pp. 3277-3286
    • Rosse, W.F.1    Ware, R.E.2
  • 62
    • 0036892682 scopus 로고    scopus 로고
    • Inefficient response of T lymphocytes to glycosylphosphatidylinositol anchor-negative cells: implications for paroxysmal nocturnal hemoglobinuria
    • Murakami Y., Kosaka H., Maeda Y., et al. Inefficient response of T lymphocytes to glycosylphosphatidylinositol anchor-negative cells: implications for paroxysmal nocturnal hemoglobinuria. Blood 100 (2002) 4116-4122
    • (2002) Blood , vol.100 , pp. 4116-4122
    • Murakami, Y.1    Kosaka, H.2    Maeda, Y.3
  • 63
    • 0028978684 scopus 로고
    • Emergence of CD52-, phosphatidylinositolglycan-anchor-deficient T lymphocytes after in vivo application of Campath-1H for refractory B-cell non-Hodgkin lymphoma
    • Hertenstein B., Wagner B., Bunjes D., et al. Emergence of CD52-, phosphatidylinositolglycan-anchor-deficient T lymphocytes after in vivo application of Campath-1H for refractory B-cell non-Hodgkin lymphoma. Blood 86 (1995) 1487-1492
    • (1995) Blood , vol.86 , pp. 1487-1492
    • Hertenstein, B.1    Wagner, B.2    Bunjes, D.3
  • 64
    • 84952306043 scopus 로고    scopus 로고
    • Decrease in sensitivity of PIG-A mutant cells to natural killer cells conferred by missing of stress-inducible membrane proteins ULBPs
    • Hanaoka N., Kawaguchi T., Horikawa K., et al. Decrease in sensitivity of PIG-A mutant cells to natural killer cells conferred by missing of stress-inducible membrane proteins ULBPs. Blood 104 (2004) 774a
    • (2004) Blood , vol.104
    • Hanaoka, N.1    Kawaguchi, T.2    Horikawa, K.3
  • 65
    • 0032535591 scopus 로고    scopus 로고
    • Structurally specific heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche
    • Gupta P., Oegema Jr. T.R., Brazil J.J., Dudek A.Z., Slungaard A., and Verfaillie C.M. Structurally specific heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche. Blood 92 (1998) 4641-4651
    • (1998) Blood , vol.92 , pp. 4641-4651
    • Gupta, P.1    Oegema Jr., T.R.2    Brazil, J.J.3    Dudek, A.Z.4    Slungaard, A.5    Verfaillie, C.M.6
  • 66
    • 1642618181 scopus 로고    scopus 로고
    • Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells
    • Siebertz B., Stocker G., Drzeniek Z., Handt S., Just U., and Haubeck H.D. Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. Biochem J 344 Pt 3 (1999 December 15) 937-943
    • (1999) Biochem J , vol.344 , Issue.PART 3 , pp. 937-943
    • Siebertz, B.1    Stocker, G.2    Drzeniek, Z.3    Handt, S.4    Just, U.5    Haubeck, H.D.6
  • 67
    • 0029878968 scopus 로고    scopus 로고
    • Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican
    • Steinfeld R., Van Den Berghe H., and David G. Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican. J Cell Biol 133 (1996) 405-416
    • (1996) J Cell Biol , vol.133 , pp. 405-416
    • Steinfeld, R.1    Van Den Berghe, H.2    David, G.3
  • 68
    • 0030831119 scopus 로고    scopus 로고
    • Dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen
    • Jackson S.M., Nakato H., Sugiura M., et al. Dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen. Dpp. Development 124 (1997) 4113-4120
    • (1997) Dpp. Development , vol.124 , pp. 4113-4120
    • Jackson, S.M.1    Nakato, H.2    Sugiura, M.3
  • 69
    • 0030663121 scopus 로고    scopus 로고
    • Glypican-3 is a binding protein on the HepG2 cell surface for tissue factor pathway inhibitor
    • Mast A.E., Higuchi D.A., Huang Z.F., Warshawsky I., Schwartz A.L., and Broze Jr. G.J. Glypican-3 is a binding protein on the HepG2 cell surface for tissue factor pathway inhibitor. Biochem J 327 Pt 2 (1997) 577-583
    • (1997) Biochem J , vol.327 , Issue.PART 2 , pp. 577-583
    • Mast, A.E.1    Higuchi, D.A.2    Huang, Z.F.3    Warshawsky, I.4    Schwartz, A.L.5    Broze Jr., G.J.6
  • 70
    • 0141613833 scopus 로고    scopus 로고
    • Transforming growth factor-β signaling in normal and malignant hematopoiesis
    • Kim S.J., and Letterio J. Transforming growth factor-β signaling in normal and malignant hematopoiesis. Leukemia 17 (2003) 1731-1737
    • (2003) Leukemia , vol.17 , pp. 1731-1737
    • Kim, S.J.1    Letterio, J.2
  • 71
    • 3142693322 scopus 로고    scopus 로고
    • Glypican-1 antisense transfection modulates TGF-β-dependent signaling in Colo-357 pancreatic cancer cells
    • Li J., Kleeff J., Kayed H., et al. Glypican-1 antisense transfection modulates TGF-β-dependent signaling in Colo-357 pancreatic cancer cells. Biochem Biophys Res Commun 320 (2004) 1148-1155
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 1148-1155
    • Li, J.1    Kleeff, J.2    Kayed, H.3
  • 72
    • 0034284766 scopus 로고    scopus 로고
    • Glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development
    • Paine-Saunders S., Viviano B.L., Zupicich J., Skarnes W.C., and Saunders S. Glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol 225 (2000) 179-187
    • (2000) Dev Biol , vol.225 , pp. 179-187
    • Paine-Saunders, S.1    Viviano, B.L.2    Zupicich, J.3    Skarnes, W.C.4    Saunders, S.5
  • 73
    • 1542572120 scopus 로고    scopus 로고
    • Glycosylphosphatidylinositol-anchored proteins regulate transforming growth factor-β signaling in human keratinocytes
    • Tam B.Y., Finnson K.W., and Philip A. Glycosylphosphatidylinositol-anchored proteins regulate transforming growth factor-β signaling in human keratinocytes. J Biol Chem 278 (2003) 49610-49617
    • (2003) J Biol Chem , vol.278 , pp. 49610-49617
    • Tam, B.Y.1    Finnson, K.W.2    Philip, A.3
  • 74
    • 0033233211 scopus 로고    scopus 로고
    • Reduced TGF-β1 in patients with aplastic anaemia in vivo and in vitro
    • Rizzo S., Killick S.B., Patel S., et al. Reduced TGF-β1 in patients with aplastic anaemia in vivo and in vitro. Br J Haematol 107 (1999) 797-803
    • (1999) Br J Haematol , vol.107 , pp. 797-803
    • Rizzo, S.1    Killick, S.B.2    Patel, S.3
  • 75
    • 0042235817 scopus 로고    scopus 로고
    • Effect of proinflammatory cytokines on PIGA-hematopoiesis
    • Kulkarni S., and Bessler M. Effect of proinflammatory cytokines on PIGA-hematopoiesis. Exp Hematol 31 (2003) 770-778
    • (2003) Exp Hematol , vol.31 , pp. 770-778
    • Kulkarni, S.1    Bessler, M.2
  • 76
    • 3042671662 scopus 로고    scopus 로고
    • Increased resistance of PIG-A-bone marrow progenitors to tumor necrosis factor α and interferon γ: possible implications for the in vivo dominance of paroxysmal nocturnal hemoglobinuria clones
    • Barcellini W., Fermo E., Guia Imperiali F., et al. Increased resistance of PIG-A-bone marrow progenitors to tumor necrosis factor α and interferon γ: possible implications for the in vivo dominance of paroxysmal nocturnal hemoglobinuria clones. Haematologica 89 (2004) 651-656
    • (2004) Haematologica , vol.89 , pp. 651-656
    • Barcellini, W.1    Fermo, E.2    Guia Imperiali, F.3
  • 77
    • 0035726553 scopus 로고    scopus 로고
    • Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria
    • Araten D.J., Swirsky D., Karadimitris A., et al. Cytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria. Br J Haematol 115 (2001) 360-368
    • (2001) Br J Haematol , vol.115 , pp. 360-368
    • Araten, D.J.1    Swirsky, D.2    Karadimitris, A.3
  • 78
    • 9044253714 scopus 로고    scopus 로고
    • Analysis of PIG-A gene in a patient who developed reciprocal translocation of chromosome 12 and paroxysmal nocturnal hemoglobinuria during follow-up of aplastic anemia
    • Nishimura J.I., Inoue N., Azenishi Y., et al. Analysis of PIG-A gene in a patient who developed reciprocal translocation of chromosome 12 and paroxysmal nocturnal hemoglobinuria during follow-up of aplastic anemia. Am J Hematol 51 (1996) 229-233
    • (1996) Am J Hematol , vol.51 , pp. 229-233
    • Nishimura, J.I.1    Inoue, N.2    Azenishi, Y.3
  • 79
    • 33845494914 scopus 로고    scopus 로고
    • Molecular basis of clonal expansion of hematopoiesis in two patients with paroxysmal nocturnal hemoglobinuria (PNH)
    • Inoue N., Izui-Sarumaru T., Murakami Y., et al. Molecular basis of clonal expansion of hematopoiesis in two patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood 108 (2006) 4232-4236
    • (2006) Blood , vol.108 , pp. 4232-4236
    • Inoue, N.1    Izui-Sarumaru, T.2    Murakami, Y.3
  • 80
    • 33947254164 scopus 로고    scopus 로고
    • Identification of a novel hematopoietic cell translocation in a patient with paroxysmal nocturnal hemoglobinuria
    • Meyers G., Babcock W.H., Best R.G., and Parker C.J. Identification of a novel hematopoietic cell translocation in a patient with paroxysmal nocturnal hemoglobinuria. Blood 104 (2004) 15b
    • (2004) Blood , vol.104
    • Meyers, G.1    Babcock, W.H.2    Best, R.G.3    Parker, C.J.4
  • 81
    • 0035958594 scopus 로고    scopus 로고
    • The expression of HMGA genes is regulated by their 3′ UTR
    • Borrmann L., Wilkening S., and Bullerdiek J. The expression of HMGA genes is regulated by their 3′ UTR. Oncogene 20 (2001) 4537-4541
    • (2001) Oncogene , vol.20 , pp. 4537-4541
    • Borrmann, L.1    Wilkening, S.2    Bullerdiek, J.3
  • 82
    • 0036246736 scopus 로고    scopus 로고
    • Molecular genetics of benign tumors
    • Hess J.L., and Kossev P. Molecular genetics of benign tumors. Cancer Invest 20 (2002) 362-372
    • (2002) Cancer Invest , vol.20 , pp. 362-372
    • Hess, J.L.1    Kossev, P.2
  • 83
    • 0028197368 scopus 로고
    • HMG domain proteins: architectural elements in the assembly of nucleoprotein structures
    • Grosschedl R., Giese K., and Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet 10 (1994) 94-100
    • (1994) Trends Genet , vol.10 , pp. 94-100
    • Grosschedl, R.1    Giese, K.2    Pagel, J.3
  • 84
    • 0035904395 scopus 로고    scopus 로고
    • Molecular biology of HMGA proteins: hubs of nuclear function
    • Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277 (2001) 63-81
    • (2001) Gene , vol.277 , pp. 63-81
    • Reeves, R.1
  • 85
    • 10744227944 scopus 로고    scopus 로고
    • Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2
    • Tessari M.A., Gostissa M., Altamura S., et al. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol 23 (2003) 9104-9116
    • (2003) Mol Cell Biol , vol.23 , pp. 9104-9116
    • Tessari, M.A.1    Gostissa, M.2    Altamura, S.3
  • 86
    • 0034058123 scopus 로고    scopus 로고
    • A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia
    • Santulli B., Kazmierczak B., Napolitano R., et al. A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia. Cancer Genet Cytogenet 119 (2000) 70-73
    • (2000) Cancer Genet Cytogenet , vol.119 , pp. 70-73
    • Santulli, B.1    Kazmierczak, B.2    Napolitano, R.3
  • 87
    • 0345374898 scopus 로고    scopus 로고
    • HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia
    • Pierantoni G.M., Santulli B., Caliendo I., et al. HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. Int J Oncol 23 (2003) 363-367
    • (2003) Int J Oncol , vol.23 , pp. 363-367
    • Pierantoni, G.M.1    Santulli, B.2    Caliendo, I.3
  • 88
    • 0344420249 scopus 로고    scopus 로고
    • Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia
    • Andrieux J., Demory J.L., Dupriez B., et al. Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia. Genes Chromosomes Cancer 39 (2004) 82-87
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 82-87
    • Andrieux, J.1    Demory, J.L.2    Dupriez, B.3
  • 89
    • 33751220843 scopus 로고    scopus 로고
    • t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene
    • Storlazzi C.T., Albano F., Locunsolo C., et al. t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene. Leukemia 20 (2006) 2190-2192
    • (2006) Leukemia , vol.20 , pp. 2190-2192
    • Storlazzi, C.T.1    Albano, F.2    Locunsolo, C.3
  • 90
    • 13544270235 scopus 로고    scopus 로고
    • Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies
    • Odero M.D., Grand F.H., Iqbal S., et al. Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies. Leukemia 19 (2005) 245-252
    • (2005) Leukemia , vol.19 , pp. 245-252
    • Odero, M.D.1    Grand, F.H.2    Iqbal, S.3
  • 91
    • 33748904355 scopus 로고    scopus 로고
    • The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
    • Hillmen P., Young N.S., Schubert J., et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 355 (2006) 1233-1243
    • (2006) N Engl J Med , vol.355 , pp. 1233-1243
    • Hillmen, P.1    Young, N.S.2    Schubert, J.3
  • 92
    • 0030932540 scopus 로고    scopus 로고
    • Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?
    • Luzzatto L., Bessler M., and Rotoli B. Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise?. Cell 88 (1997) 1-4
    • (1997) Cell , vol.88 , pp. 1-4
    • Luzzatto, L.1    Bessler, M.2    Rotoli, B.3
  • 93
    • 0037441586 scopus 로고    scopus 로고
    • Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia
    • Frickhofen N., Heimpel H., Kaltwasser J.P., and Schrezenmeier H. Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. Blood 101 (2003) 1236-1242
    • (2003) Blood , vol.101 , pp. 1236-1242
    • Frickhofen, N.1    Heimpel, H.2    Kaltwasser, J.P.3    Schrezenmeier, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.