Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)

Blood

Volumn 108, Issue 13, 2006, Pages 4232-4236

  Inoue, Norimitsu ^b   Izui Sarumaru, Tomohisa ^b   Murakami, Yoshiko ^b   Endo, Yuichi ^b   Nishimura, Jun Ichi ^b   Kurokawa, Ken ^b   Kuwayama, Maki ^b   Shime, Hiroaki ^b   Machii, Takashi ^b   Kanakura, Yuzuru ^b   Meyers, Gabrielle ^b   Wittwer, Carl ^b   Chen, Zhong ^b   Babcock, William ^b   Frei Lahr, Debra ^b   Parker, Charles J ^b   Kinoshita, Taroh ^a  

^a OSAKA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLATED PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN; PHOSPHATIDYLINOSITOL;

ADULT; ARTICLE; BONE MARROW; BONE MARROW CELL; CASE REPORT; CHROMOSOME 12; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PRIORITY JOURNAL; UNTRANSLATED REGION;

EID: 33845494914     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-05-025148     Document Type: Article

References (25)

1. Takeda J, Miyata T, Kawagoe K, et al. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell. 1993;73:703-711.
2. Miyata T, Takeda J, Iida Y, et al. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science. 1993;259:1318-1320.
3. Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709.
4. Hu R, Mukhina GL, Piantadosi S, Barber JP, Jones RJ, Brodsky RA. PIG-A mutations in normal hematopoiesis. Blood. 2005;105:3848-3854.
5. Kawagoe K, Kitamura D, Okabe M, et al. Glycosylphosphatidylinositol- anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood. 1996;87:3600-3606.
6. Rotoli B, Luzzatto L. Paroxysmal nocturnal haemoglobinuria. Baillieres Clin Haematol. 1989;2:113-138.
7. Young NS, Maciejewski JP. Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?" J Clin Invest. 2000;106:637-641.
8. - blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. Blood. 2006;107:1308-1314.
9. Frickhofen N, Heimpel H, Kaltwasser JP, Schrezenmeier H. Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. Blood. 2003;101:1236-1242.
10. Inoue N, Murakami Y, Kinoshita T. Molecular genetics of paroxysmal nocturnal hemoglobinuria. Int J Hematol. 2003;77:107-112.
11. Inoue N, Izui T, Kuwayama M, et al. A possible intrinsic mechanism for clonal expansion of PNH abnormal cells. In: Omine T, Kinoshita T, eds. Paroxysmal Nocturnal Hemoglobinuria and Related Disorders. Tokyo, Japan: Springer-Verlag; 2003:117-126.
12. Hollander N, Selvaraj P, Springer TA. Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins. J Immunol. 1988;141:4283-4290.
13. Beillard E, Pallisgaard N, van der Velden VH, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQPCR): a Europe against cancer program. Leukemia. 2003;17:2474-2486.
14. Ashar HR, Tkachenko A, Shah P, Chada K. HMGA2 is expressed in an allele-specific manner in human lipomas. Cancer Genet Cytogenet. 2003;143:160-168.
15. Nishimura JI, Inoue N, Azenishi Y, et al. Analysis of PIG-A gene in a patient who developed reciprocal translocation of chromosome 12 and paroxysmal nocturnal hemoglobinuria during follow-up of aplastic anemia. Am J Hematol. 1996;51:229-233.
16. Grosschedl R, Giese K, Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet. 1994;10:94-100.
17. Hess JL, Kossev P. Molecular genetics of benign tumors. Cancer Invest. 2002;20:362-372.
18. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene. 2001;277:63-81.
19. Tessari MA, Gostissa M, Altamura S, et al. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol. 2003;23:9104-9116.
20. Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001;22:1583-1591.
21. Arlotta P, Tai AK, Manfioletti G, Clifford C, Jay G, Ono SJ. Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas. J Biol Chem. 2000;275:14394-14400.
22. Baldassarre G, Fedele M, Battista S, et al. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sci U S A. 2001;98:7970-7975.
23. Battista S, Fidanza V, Fedele M, et al. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res. 1999;59:4793-4797.
24. Borrmann L, Wilkening S, Bullerdiek J. The expression of HMGA genes is regulated by their 3′UTR. Oncogene. 2001;20:4537-4541.
25. Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995;333:1253-1258.