Activation of μ-opioid receptors improves insulin sensitivity in obese Zucker rats

Life Sciences

Volumn 80, Issue 16, 2007, Pages 1508-1516

  Tzeng, Thing Fong ^a   Lo, Chia Ying ^b   Cheng, Juei Tang ^b   Liu, I Min ^c  

^a Pao Chien Hospital   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TAJEN UNIVERSITY   (Taiwan)

Author keywords

Opioid receptors; Insulin resistance; Loperamide; Obese Zucker rats

Indexed keywords

FRUCTOSE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LOPERAMIDE; MU OPIATE RECEPTOR; NALOXONAZINE; NALOXONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; SERINE; TOLBUTAMIDE;

ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BLOCKING; WILD TYPE; ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; GENETICS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; ZUCKER RAT;

ANIMALIA; MUS; RATTUS;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN RESISTANCE; LOPERAMIDE; MICE; MICE, KNOCKOUT; NALOXONE; RATS; RATS, ZUCKER; RECEPTORS, OPIOID, MU;

EID: 33947206078     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.01.016     Document Type: Article

References (39)

1. Anai M., Funaki M., Ogihara T., Terasaki J., Inukai K., Katagiri H., Fukushima Y., Yazaki Y., Kikuchi M., Oka Y., and Asano T. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 47 1 (1998) 13-23
2. Bessesen D.H. The role of carbohydrates in insulin resistance. The Journal of Nutrition 131 10 (2001) 2782S-2786S
3. Bodnar R.J. Recent advances in the understanding of the effects of opioid agents on feeding and appetite. Expert Opinion on Investigational Drugs 7 4 (1998) 485-497
4. Carvalho E., Rondinone C., and Smith U. Insulin resistance in fat cells from obese Zucker rats-evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. Molecular and Cellular Biochemistry 206 1-2 (2000) 7-16
5. Chang S.L., Lin J.G., Chi T.C., Liu I.M., and Cheng J.T. An insulin-dependent hypoglycaemia induced by electroacupuncture at the Zhongwan (CV12) acupoint in diabetic rats. Diabetologia 42 2 (1999) 250-255
6. Cheng J.T., Liu I.M., Chi T.C., Tzeng T.F., Lu F.H., and Chang C.J. Plasma glucose lowering effect of tramadol in streptozotocin-induced diabetic rats. Diabetes 50 12 (2001) 2815-2821
7. Cheng J.T., Liu I.M., Tzeng T.F., Tsai C.C., and Lai T.Y. Plasma glucose lowering effect of β-endorphin in streptozotocin-induced diabetic rats. Hormone and Metabolic Research 34 10 (2002) 570-576
8. Cheng J.T., Liu I.M., and Hsu C.F. Rapid induction of insulin resistance in opioid mu-receptor knock-out mice. Neuroscience Letters 339 2 (2003) 139-142
9. Christ C.Y., Hunt D., Hancock J., Garcia-Macedo R., Mandarino L.J., and Ivy J.L. Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats. Journal of Applied Physiology 92 2 (2002) 736-744
10. Corsetti J.P., Sparks J.D., Peterson R.G., Smith R.L., and Sparks C.E. Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats. Atherosclerosis 148 2 (2000) 231-241
11. DeHaven-Hudkins D.L., Burgos L.C., Cassel J.A., Daubert J.D., DeHaven R.N., Mansson E., Nagasaka H., Yu G., and Yaksh T. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. The Journal of Pharmacology and Experimental Therapeutics 289 1 (1999) 494-502
12. Elliott S.S., Keim N.L., Stern J.S., Teff K., and Havel P.J. Fructose, weight gain, and the insulin resistance syndrome. The American Journal of Clinical Nutrition 76 5 (2002) 911-922
13. Essén B., Jansson E., Henriksson J., Taylor A.W., and Saltin B. Metabolic characteristics of fiber types in human skeletal muscle. Acta Physiologica Scandinavica 95 1 (1975) 153-165
14. Giorgino F., Laviola L., and Leonardini A. Pathophysiology of type 2 diabetes: rationale for different oral antidiabetic treatment strategies. Diabetes Research and Clinical Practice 68 (2005) S22-S29 (Suppl 1)
15. Godsland I.F., Luzio S., Wynn V., and Owens D.R. Methodological issues in the application of the minimal model: effects of glucose dose, basal glucose concentration, test duration and modelling constraint. Diabetes Research 26 4 (1994) 139-153
16. Heled Y., Shapiro Y., Shani Y., Moran D.S., Langzam L., Braiman L., Sampson S.R., and Meyerovitch J. Physical exercise enhances protein kinase C delta activity and insulin receptor tyrosine phosphorylation in diabetes-prone psammomys obesus. Metabolism, Clinical and Experimental 52 8 (2003) 1028-1033
17. Ivy J.L. Muscle insulin resistance amended with exercise training: role of GLUT4 expression. Medicine and Science in Sports and Exercise 36 7 (2004) 1207-1211
18. Kasiske B.L., O'Donnell M.P., and Keane W.F. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19 (1992) I110-I115 (1 Suppl)
19. Kendall D.M., Kim D., and Maggs D. Incretin mimetics and dipeptidyl peptidase-IV inhibitors: a review of emerging therapies for type 2 diabetes. Diabetes Technology and Therapeutics 8 3 (2006) 385-396
20. Kern M., Wells J.A., Stephens J.M., Elton C.W., Friedman J.E., Tapscott E.B., Pekala P.H., and Dohm G.L. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochemical Journal 270 2 (1990) 397-400
21. King P.A., Horton E.D., Hirshman M.F., and Horton E.S. Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. The Journal of Clinical Investigation 90 4 (1992) 1568-1575
22. Klippel A., Kavanaugh W.M., Pot D., and Williams L.T. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Molecular and Cellular Biology 17 1 (1997) 338-344
23. Ko W.C., Liu T.P., Cheng J.T., Tzeng T.F., and Liu I.M. Effect of opioid mu-receptors activation on insulin signals damaged by tumor necrosis factor alpha in myoblast C2C12 cells. Neuroscience Letters 397 3 (2006) 274-278
24. Kruger D.F., Gatcomb P.M., and Owen S.K. Clinical implications of amylin and amylin deficiency. The Diabetes Educator 25 3 (1999) 389-397
25. Liu I.M., Chi T.C., Chen Y.C., Lu F.H., and Cheng J.T. Activation of opioid mu-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats. Neuroscience Letters 265 3 (1999) 183-186
26. Liu I.M., Liou S.S., Chen W.C., Chen P.F., and Cheng J.T. Signals in the activation of opioid mu-receptors by loperamide to enhance glucose uptake into cultured C2C12 cells. Hormone and Metabolic Research 36 4 (2004) 210-214
27. Liu T.P., Liu I.M., Cheng J.T., Liu T.P., Liu I.M., and Cheng J.T. Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. Hormone and Metabolic Research 37 3 (2005) 146-151
28. Mhatre M., and Holloway F. Micro1-opioid antagonist naloxonazine alters ethanol discrimination and consumption. Alcohol 29 2 (2003) 109-116
29. Nozaki-Taguchi N., and Yaksh T.L. Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist-loperamide. Anesthesiology 90 1 (1999) 225-234
30. Petersen K.F., and Shulman G.I. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. The American Journal of Cardiology 90 5A (2002) G11-G18
31. Sesti G., Federici M., Hribal M.L., Lauro D., Sbraccia P., and Lauro R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. The FASEB Journal 15 12 (2001) 2099-2111
32. Shulman G.I. Cellular mechanisms of insulin resistance. The Journal of Clinical Investigation 106 2 (2000) 171-176
33. Smith E.M. Opioid peptides in immune cells. Advances in Experimental Medicine and Biology 521 (2003) 51-68
34. Song X.M., Ryder J.W., Kawano Y., Chibalin A.V., Krook A., and Zierath J.R. Muscle fiber type specificity in insulin signal transduction. The American Journal of Physiology 277 6 Pt 2 (1999) R1690-R1696
35. Su C.F., Chang Y.Y., Pai H.H., Liu I.M., Lo C.Y., and Cheng J.T. Infusion of β-endorphin improves insulin resistance in fructose-fed rats. Hormone and Metabolic Research 36 8 (2004) 571-577
36. Su C.F., Chang Y.Y., Pai H.H., Liu I.M., Lo C.Y., and Cheng J.T. Mediation of beta-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats. Diabetes/Metabolism Research and Reviews 21 2 (2005) 175-182
37. Tzeng T.F., Liu I.M., and Cheng J.T. Activation of opioid mu-receptors by loperamide to improve interleukin-6-induced inhibition of insulin signals in myoblast C2C12 cells. Diabetologia 48 7 (2005) 1386-1392
38. Wuster M., and Herz A. Opiate agonist action of antidiarrheal agents in vitro and in vivo-findings in support for selective action. Naunyn-Schmiedeberg's Archives of Pharmacology 301 3 (1978) 187-194
39. Yaksh T.L. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiologica Scandinavica 41 1 Pt 2 (1997) 94-111