Blood-brain barrier transport of pramipexole, a dopamine D2 agonist

Life Sciences

Volumn 80, Issue 17, 2007, Pages 1564-1571

  Okura, Takashi ^a   Ito, Rie ^a   Ishiguro, Naoki ^b   Tamai, Ikumi ^b   Deguchi, Yoshiharu ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Blood brain barrier; Dopamine agonist; Immortalized brain capillary endothelial cell; Organic cation; Transporter

Indexed keywords

4 AMINOHIPPURIC ACID; AMANTADINE; ARGININE; CARBON 14; CARNITINE; CHOLINE; CORTICOSTERONE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; GUANIDINE; INULIN; LYSINE; MEPYRAMINE; MESSENGER RNA; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PENICILLIN G; POTASSIUM ION; PRAMIPEXOLE; PROCAINAMIDE; QUINIDINE; SEROTONIN; SODIUM ION; TETRYLAMMONIUM; THIONEINE; TRITIUM; VALINOMYCIN; VERAPAMIL;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN PERFUSION; CELL MEMBRANE POTENTIAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; IONIC STRENGTH; ISOTOPE LABELING; NONHUMAN; PARKINSON DISEASE; PH; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; TEMPERATURE DEPENDENCE;

ANIMALS; BENZOTHIAZOLES; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; CATIONS; CELL LINE, TRANSFORMED; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; ION CHANNELS; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PERFUSION; PYRILAMINE; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RNA, MESSENGER;

RATTUS;

EID: 33947122622     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.01.035     Document Type: Article

References (27)

1. Boström E., Simonsson U., and Hammarlund-Udenaes M. In vivo blood-brain barrier transport of oxycodone in the rat- indications for active influxand implications for PK/PD. Drug Metabolism and Disposition 34 (2006) 1624-1631
2. 1-specific opioid peptide, H-Tyr-d-Arg-Phe-beta-Ala-OH (TAPA). Journal of Neurochemistry 84 (2003) 1154-1161
3. Domino E.F., Ni L., Zhang H., Kohno Y., and Sasa M. Talipexole or pramipexole combinations with chloro-APB (SKF 82958) in MPTP-induced hemiparkinsonian monkeys. European Journal of Pharmacology 325 (1997) 137-144
4. Friedrich A., George R.L., Bridges C.C., Prasad P.D., and Ganapathy V. Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4). Biochimica et Biophysica Acta 1512 (2001) 299-307
5. Gründemann D., Harlfinger S., Golz S., Geerts A., Lazar A., Berkels R., Jung N., Rubbert A., and Schomig E. Discovery of the Ergothioneine Transporter. Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 5256-5261
6. Ishiguro N., Nozawa T., Tsujihata A., Saito A., Kishimoto W., Yokoyama K., Yotsumoto T., Sakai K., Igarashi T., and Tamai I. Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. Drug Metabolism and Disposition 32 (2004) 519-524
7. 2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metabolism and Disposition 33 (2005) 495-499
8. Jonker J.W., and Schinkel A.H. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). The Journal of Pharmacology and Experimental Therapeutics 308 (2004) 2-9
9. Kido Y., Tamai I., Okamoto M., Suzuki F., and Tsuji A. Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. Pharmaceutical Research 17 (2000) 55-62
10. Kido Y., Tamai I., Ohnari A., Sai Y., Kagami T., Nezu J., Nikaido H., Hashimoto N., Asano M., and Tsuji A. Functional relevance of carnitine transporter OCTN2 to brain distribution of l-carnitine and acetyl-l-carnitine across the blood-brain barrier. Journal of Neurochemistry 79 (2001) 959-969
11. Kido Y., Tamai I., Uchino H., Suzuki F., Sai Y., and Tsuji A. Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier. The Journal of Pharmacy and Pharmacology 53 (2001) 497-503
12. Koepsell H., Schmitt B.M., and Gorboulev V. Organic cation transporters. Reviews of Physiology, Biochemistry and Pharmacology 150 (2003) 36-90
13. Kristufek D., Rudorfer W., Pifl C., and Huck S. Organic cation transporter mRNA and function in the rat superior cervical ganglion. The Journal of Physiology 543 (2002) 117-134
14. Marek K., Seibyl J., Shoulson I., Holloway R., Kieburtz K., McDermott M., Kamp C., Shinaman A., Fahn S., Lang A., Weiner W., and Welsh M. Dopamine transporter brain imaging to assess the effects of pramipexole vs. levodopa on Parkinson disease progression. JAMA: the Journal of the American Medical Association 287 (2002) 1653-1661
15. Mierau J., and Schingnitz G. Biochemical and pharmacological studies on pramipexole, a potent and selective dopamine D2 receptor agonist. European Journal of Pharmacology 215 (1992) 161-170
16. Mierau J., Schneider F.J., Ensinger H.A., Chio C.L., Lajiness M.E., and Huff R.M. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. European Journal of Pharmacology 290 (1995) 29-36
17. Monte J.C., Nagle M.A., Eraly S.A., and Nigam S.K. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochemical and Biophysical Research Communications 323 (2004) 429-436
18. Ohashi R., Tamai I., Nezu J., Nikaido H., Hashimoto N., Oku A., Sai Y., Shimane M., and Tsuji A. Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Molecular Pharmacology 59 (2001) 358-366
19. Sung J.H., Yu K.H., Park J.S., Tsuruo T., Kim D.D., Shim C.K., and Chung S.J. Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport. Drug Metabolism and Disposition 33 (2005) 440-448
20. Sweet D.H., Miller D.S., and Pritchard J.B. Ventricular choline transport a role for organic cation transporter 2 expressed in choroid plexus. The Journal of Biological Chemistry 276 (2001) 41611-41619
21. Takasato Y., Rapoport S.I., and Smith Q.R. An in situ brain perfusion technique to study cerebrovascular transport in the rat. The American Journal of Physiology 247 (1984) H484-H493
22. Tsuji A. Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx: the Journal of the American Society for Experimental NeuroTherapeutics 2 (2005) 54-62
23. Urakami Y., Okuda M., Masuda S., Saito H., and Inui K. Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. The Journal of Pharmacology and Experimental Therapeutics 287 (1998) 800-805
24. Yabuuchi H., Tamai I., Nezu J., Sakamoto K., Oku A., Shimane M., Sai Y., and Tsuji A. Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. The Journal of Pharmacology and Experimental Therapeutics 289 (1999) 768-773
25. Yamazaki M., Terasaki T., Yoshioka K., Nagata O., Kato H., Ito Y., and Tsuji A. Carrier-mediated transport of H1-antagonist at the blood-brain barrier: mepyramine uptake into bovine brain capillary endothelial cells in primary monolayer cultures. Pharmaceutical Research 11 (1994) 975-978
26. Yamazaki M., Terasaki T., Yoshioka K., Nagata O., Kato H., Ito Y., and Tsuji A. Carrier-mediated transport of H1-antagonist at the blood-brain barrier: a common transport system of H1-antagonists and lipophilic basic drugs. Pharmaceutical Research 11 (1994) 1516-1518
27. Yamazaki M., Fukuoka H., Nagata O., Kato H., Ito Y., Terasaki T., and Tsuji A. Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique. Biological & Pharmaceutical Bulletin 17 (1994) 676-679