Renal expression of the sodium/phosphate cotransporter gene, Npt2, is not required for regulation of renal 1α-hydroxylase by phosphate

Endocrinology

Volumn 142, Issue 3, 2001, Pages 1124-1129

  Tenenhouse, H S ^a,c   Martel, J ^a   Gauthier, C ^a   Zhang, M Y H ^b   Portale, A A ^b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; OXYGENASE; PHOSPHATE; SODIUM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION REGULATION; HORMONAL REGULATION; KIDNEY TUBULE EPITHELIUM; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; URINE LEVEL; VITAMIN METABOLISM;

EID: 0035089848     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.3.8029     Document Type: Article

References (61)

1. Regulation of the metabolism of vitamin D
2. The role of the vitamin D endocrine system in health and disease
3. Vitamin D
4. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase
5. Cloning of the human 25-hydroxyvitamin D-1α-hydroxylase and mutations causing vitamin D-dependent rickets type 1
6. Complete structure of the human gene for the vitamin D 1α-hydroxylase, P450c1α
7. 3 1α-hydroxylase and vitamin D synthesis
8. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus
9. 3 1α-hydroxylase
10. 3-1alpha;-hydroxylase cDNA
11. Two novel 1α-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type 1
12. 3 1α-hydroxylase gene in patients with pseudovitamin D-deficiency rickets
13. Genetics of vitamin D 1α-hydroxylase deficiency in 17 families
14. Novel mutations in the 1α-hydroxylase (P450c1) gene in three families with pseudovitamin D-deficiency rickets resulting in loss of functional enzyme activity in blood-derived macrophages
15. 3-1alpha;-hydroxylase gene in normocalcemic rats
16. 3 in intact animals
17. 3-1α-hydroxylase gene
18. 3-1α-hydroxylase gene promoter
19. The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus
20. Influence of phosphate depletion on the biosynthesis and circulating level of 1α-25-dihydroxyvitamin D
21. 3 synthesis in rat kidney in vitro
22. Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans
23. Phosphate transport along the nephron
24. Renal regulation of phosphate excretion
25. Mendelian hypophosphatemias
26. Mendelian hypophosphatemias
27. X-Linked hypophosphatemia: A homologous disorder in humans and mice
28. Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse
29. Abnormal regulation of renal vitamin D catabolism by dietary phosphate in murine X-linked hypophosphatemic rickets
30. Renal phosphate transport and vitamin D metabolism in X-linked hypophosphatemic Gy mice: Responses to phosphate deprivation
31. Impaired phosphorus conservation and 1,25-dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets
32. Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: Evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity
33. Abnormal relationship between serum phosphate concentration and renal 25-hydroxycholecalciferol-1α-hydroxylase activity in X-linked hypophosphatemic mice
34. Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin D-1α-hydroxylase activity in the hypophosphatemic mouse: Evidence for a generalized defect of vitamin D metabolism
35. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria and skeletal abnormalities
36. Expression of Na-Pi cotransport in rat kidney: Localization by RT-PCR and immunohistochemistry
37. + -phosphate cotransporter genes in routine kidney
38. Molecular regulation of renal phosphate transport
39. Effects of Npt2 gene ablation and low-phosphate diet on renal Na/phosphate cotransport and cotransporter gene expression
40. Npt2 gene disruption confers resistance to the inhibitory action of PTH on renal Na-phosphate cotransport
41. 3
42. Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice
43. + -phosphate cotransporter (Npt2) mRNA in phosphate-deprived Hyp mice
44. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia
45. The defect in transcellular transport of phosphate in the nephron is located in brush-border membranes in X-linked hypophosphatemia (Hyp mouse model)
46. Renal handling of phosphate in vivo and in vitro by the X-linked hypophosphatemic male mouse: Evidence for a defect in the brush border membrane
47. The Gy mutation: Another cause of X-linked hypophosphatemia in mouse
48. Hypophosphatemia: Mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets
49. 3-1-hydroxylase activity in the vitamin D and calcium deficient X-linked Hyp mouse
50. 3-1-hydroxylase activity in the X-linked Hyp mouse
51. 3, in renal slices from the X-linked hypophosphatemic (Hyp) mouse: Abnormal response to fall in serum calcium
52. Abnormal adenosine 3′,5′-monophosphate stimulation of renal 1,25-dihydroxyvitamin D production in Hyp mice: Evidence that 25-hydroxyvitamin D-1α-hydroxylase dysfunction results from aberrant intracellular function
53. Abnormal parathyroid hormone-related peptide stimulation of renal 25-hydroxyvitamin D-1-hydroxylase in Hyp mice: Evidence for a generalized defect of enzyme activity in the proximal convoluted tubule
54. 3 synthesis in the kidney
55. 3 1α-hydroxylase and 24-hydroxylase along the rat nephron
56. PHEX gene and hypophosphatemia
57. Hereditary hypophosphatemic rickets with hypercalciuria
58. Hereditary hypophosphatemic rickets with hypercalciuria is not caused by mutations in the Na/Pi cotransporter NPT2 gene
59. Posttranscriptional regulation of the proximal tubule NaPi-II transporter in response to PTH and dietary P(i)
60. Identification of regulatory sequences and binding proteins in the type II sodium/phosphate cotransporter NPT2 gene responsive to dietary phosphate
61. RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate