Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2

Journal of Bone and Mineral Research

Volumn 18, Issue 4, 2003, Pages 644-657

  Chau, Hien ^a   El Maadawy, Sherif ^a   McKee, Marc D ^a   Tenenhouse, Harriet S ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

1,25 dihydroxyvitamin D; Hypercalciuria; Phosphate wasting

Indexed keywords

CALCITRIOL; COTRANSPORTER; PHOSPHATE; SODIUM; SODIUM PHOSPHATE COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; ELECTRON DIFFRACTION; GENE DISRUPTION; HOMOZYGOSITY; HYPERCALCEMIA; HYPERCALCIURIA; HYPOPHOSPHATEMIA; KIDNEY CALCIFICATION; MOUSE; NEPHROLITHIASIS; NONHUMAN; RISK FACTOR; SPECTROSCOPY;

EID: 0012311140     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.4.644     Document Type: Article

References (55)

1. Knox FG and Haramati A 1985 Renal regulation of phosphate excretion. In: Seldin DW, Giebisch G (eds.) The Kidney: Physiology and Pathophysiology. Raven Press, New York, NY, USA, pp. 1381-1396.
2. Gmaj P, Murer H 1986 Cellular mechanisms of inorganic phosphate transport in kidney. Physiol Rev 66:36-70.
3. Tenenhouse HS 1997 Cellular and molecular mechanisms of renal phosphate transport. J Bone Miner Res 12:159-164.
4. Murer H, Hernando N, Forster I, Biber J 2000 Proximal tubular phosphate reabsorption: Molecular mechanisms. Physiol Rev 80: 1373-1409.
5. +-phosphate cotransporter genes in murine kidney. Am J Physiol 44:F527-F534.
6. Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Broer S, Biber J, Murer H, Lang F 1996 Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc Natl Acad Sci USA 93:5347-5351.
7. Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J, Murer H 1993 Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sci USA 90:5979-5983.
8. Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD 1994 Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-phosphate symporters. Proc Natl Acad Sci USA 91:7071-7075.
9. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS 1998 Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria and skeletal abnormalities. Proc Natl Acad Sci USA 95:5372-5377.
10. Hoag HM, Martel J, Gauthier C, Tenenhouse HS 1999 Effects of Npt2 gene ablation and low-phosphate diet on renal Na/phosphate cotransport and cotransporter gene expression. J Clin Invest 104: 679-686.
11. Zhao N, Tenenhouse HS 2000 Npt2 gene disruption confers resistance to the inhibitory action of PTH on renal Na-phosphate cotransport. Endocrinology 141:2159-2165.
12. Tenenhouse HS, Martel J, Gauthier C, Zhang MYH, Portate AA 2001 Renal expression of the sodium/phosphate cotransporter gene, Npt2, is not required for regulation of renal 1α-hydroxylase by phosphate. Endocrinology 142:1124-1129.
13. Jones G, Tenenhouse HS 2002 1,25(OH)2D, the preferred substrate for CYP24. J Bone Miner Res 17:179-180.
14. Tenenhouse HS, Gauthier C, Martel J, Hoendergp JGJ, Hartog A, Meyer MH, Meyer RA Jr, Bindels RJM 2002 Na/Pi cotransporter (Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channel I and 2. Pflügers Arch 444:670-676.
15. Scheinman SJ 2000 New insights into causes and treatments of kidney stones. Hosp Pract 35:49-68.
16. Prie D, Ravery V, Boccon-Gibod L, Friedlander G 2001 Frequency of renal phosphate leak among patients with calcium nephrolithiasis. Kidney Int 60:272-276.
17. Bushinsky DA 1999 Genetic hypercalciuric stone-forming rats. Curr Opin Nephrol Hypertens 8:479-488.
18. Hsu SM, Raine L, Fanger H 1981 Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580.
19. McKee MD, Nanci A, Khan SR 1995 Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of renal calculi. J Bone Miner Res 10:1913-1929.
20. 3-24-hydroxylase. J Bone Miner Res 10:1951-1959.
21. Tenenhouse HS, Scriver CR 1979 Renal brush border membrane adaptation to phosphorus deprivation in the Hyp/Y mouse. Nature 281:225-227.
22. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
23. Custer M, Lötscher M, Biber J, Murer H, Kaissling B 1994 Expression of Na-Pi cotransport in rat kidney: Localization by RT-PCR and immunohistochemistry. Am J Physiol 266:F767-F774.
24. Curto KA, Sweeney WE, Avner ED, Piesco NP, Curthoys NP 1988 Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. J Histochem Cytochem 36:159-166.
25. Taufiq S, Collins JF, Ghishan FK 1997 Posttranscriptional mechanisms regulate ontogenic changes in rat renal sodium-phosphate transporter. Am J Physiol 272:R134-R141.
26. Traebert M, Lotscher M, Aschwanden R, Ritthaler T, Biber, Murer H, Kaissling B 1999 Distribution of the sodium/phosphate transporter during postnatal ontogeny of the rat kidney. J Am Soc Nephrol 10:1407-1415.
27. Hock JM, Gunness-Hey M, Poser J, Olson H, Bell NH, Raisz LG 1986 Stimulation of undermineralized matrix formation by 1,25 dihydroxyvitamin D3 in long bones of rats. Calcif Tissue Int 38:79-86.
28. St-Arnaud R, Arabian A, Travers R, Barletta F, Raval-Pandya M, Chapin K, Depovere J, Mathieu C, Christakos S, Demay MB, Glorieux FH 2000 Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1, 25-dihydroxyvitamin D and not to the absence of 24, 25-dihydroxyvitamin D. Endocrinology 141:2658-2666.
29. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D 2001 Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98:7498-7503.
30. Yamagata M, Kimoto A, Michigami T, Nakayama M, Ozono K 2001 Hydroxylases involved in vitamin D metabolism are differentially expressed in murine embryonic kidney: Application of whole mount in situ hybridization. Endocrinology 142:3223-3230.
31. Kohri K, Nomura S, Kitamura Y, Nagata T, Yoshioka K, Iguchi M, Yamate T, Umekawa T, Suzuki Y, Sinohara H 1993 Structure and expression of the mRNA encoding urinary stone protein (osteopontin). J Biol Chem 268:15180-15184.
32. Umekawa T, Kohri K, Kurita T, Hirota S, Nomura S, Kitamura Y 1995 Expression of osteopontin messenger RNA in the rat kidney on experimental model of renal stone. Biochem Mol Biol Int 35:223-230.
33. Jiang XJ, Feng T, Chang LS, Kong XT, Wang G, Zhang ZW, Guo YL 1998 Expression of osteopontin mRNA in normal and stone-forming rat kidney. Urol Res 26:389-394.
34. Yagisawa T, Chandhoke PS, Fan J, Lucia S 1998 Renal osteopontin expression in experimental urolithiasis. J Endourol 12:171-176.
35. Hughes J, Steitz S, Alpers CE, Couzer WG, Giachelli CM, Johnson RJ 1999 Osteopontin (OPN) inhibits the renal deposition of calcium oxalate. J Am Soc Nephrol 10:A3091.
36. Shiraga H, Min W, VanDusen WJ, Clayman MD, Miner D, Terrell CH, Sherbotie JR, Foreman JW, Przysiecki C, Neilson EG 1992 Inhibition of calcium oxalate crystal growth in vitro by uropontin: Another member of the aspartic acid-rich protein superfamily. Proc Natl Acad Sci USA 89:426-430.
37. Worcester EM, Beshensky AM 1995 Osteopontin inhibits nucleation of calcium oxalate crystals. Ann NY Acad Sci 760:375-377.
38. Boskey AL, Maresca M, Ullrich W, Doty SB, Butler WT, Prince CW 1993 Osteopontin-hydroxyapatite interactions in vitro: Inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner 22:147-159.
39. Hunter GK, Kyle CA, Goldberg HA 1994 Modulation of crystal formation by bone phosphoproteins: Structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem J 300:723-728.
40. Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, Gejyo F 2001 Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney Int 60:1645-1657.
41. 3 24-hydroxylase): Implications for differing mechanisms of regulation and involvement of multiple factors. Endocrinology 136:3971-3982.
42. Noda M, Vogel RL, Craig AM, Prahl J, DeLuca HF, Denhardt DT 1990 Identification of a DNA sequence responsible for binding of the 1, 25-dihydroxyvitamin D3 receptor and 1, 25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc Natl Acad Sci USA 87:9995-9999.
43. Yasui T, Fujita K, Sasaki S, Iguchi M, Hirota S, Nomura S, Azuma Y, Ohta T, Kohri K 1998 Alendronate inhibits osteopontin expression enhanced by parathyroid hormone-related peptide (PTHrP) in the rat kidney. Urol Res 26:355-360.
44. Beck GRJ, Zerler B, Moran E 2000 Phosphate is a specific signal for induction of osteopontin gene expression. Proc Natl Acad Sci USA 97:8352-8357.
45. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM 2000 Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 87:E10-E17.
46. Tenenhouse HS, Scriver CR, McInnes RR, Glorieux FH 1978 Renal handling of phosphate in vivo and in vitro by the X-linked hypophosphatemic male mouse: Evidence for a defect in the brush border membrane. Kidney Int 14:236-244.
47. Tenenhouse HS, Jones G 1990 Abnormal regulation of renal vitamin D catabolism by dietary phosphate in murine X-linked hypophosphatemic rickets. J Clin Invest 85:1450-1455.
48. Wada T, McKee MD, Steitz S, Giachelli CM 1999 Calcification of vascular smooth muscle cell cultures: Inhibition by osteopontin. Circ Res 84:166-178.
49. Tenenhouse HS 1999 Recent advances in epithelial sodium-coupled phosphate transport. Curr Opin Nephrol Hypertens 8:407-414.
50. Brodehl J, Gellissen K, Weber HP 1982 Postnatal development of tubular phosphate reabsorption. Clin Nephrol 17:163-171.
51. Johnson V, Spitzer A 1986 Renal reabsorption of phosphate during development: Whole kidney events. Am J Physiol 251:F251-F256.
52. Tieder M, Modai D, Samuel R, Arie R, Halabe A, Bab I, Gabizon D, Lieberman UA 1985 Hereditary hypophosphatemic rickets with hypercalciuria. N Engl J Med 312:611-617.
53. Tieder M, Modai D, Shaked U, Samuel R, Arie R, Halabe A, Maor J, Weissgarten J, Averbukh Z, Cohen N, Edelstein S, Lieberman UA 1987 "Idiopathic" hypercalciuria and hereditary hypophosphatemic rickets. N Engl J Med 316:125-129.
54. -/- mice. Bone 29:467-476.
55. Jones AO, Tzenova J, Frappier D, Crumley M, Roslin NM, Kos CH, Tieder M, Langman CB, Proesmans W, Carpenter TO, Rice A, Anderson D, Morgan K, Fujiwara TM, Tenenhouse HS 2001 Hereditary hypophosphatemic rickets with hypercalciuria is not caused by mutations in the Na/Pi cotransporter NPT2 gene. J Am Soc Nephrol 12:507-514.