3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6354-6359

  Temiz Arpaci, Ozlem ^a   Tekiner Gulbas, Betul ^a   Yildiz, Ilkay ^a   Aki Sener, Esin ^a   Yalcin, Ismail ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

3D QSAR; Benzimidazoles; Benzothiazoles; Benzoxazoles; CoMFA; Oxazolo(4,5 b)pyridines; Topoisomerase II inhibitors

Indexed keywords

2 PHENYL 5 NITROBENZOXAZOLE; BENZENE DERIVATIVE; BENZOXAZOLE DERIVATIVE; GYRASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ATOM; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG ACTIVITY; EUKARYOTE; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BENZENE DERIVATIVES; COMPUTER SIMULATION; DNA TOPOISOMERASES, TYPE II; ELECTROSTATICS; ENZYME INHIBITORS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OXAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA;

EID: 27544484516     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.06.002     Document Type: Article

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