p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells

Cancer Research

Volumn 67, Issue 4, 2007, Pages 1660-1669

  Thoms, Hazel C ^a   Dunlop, Malcolm G ^a   Stark, Lesley A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 12,13 DIHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H)DIONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLSALICYLIC ACID; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TARGETING;

APOPTOSIS; ASPIRIN; CELL CYCLE; CELL NUCLEOLUS; COLORECTAL NEOPLASMS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; ENZYME ACTIVATION; HT29 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TRANSCRIPTION FACTOR RELA;

EID: 33847710203     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1038     Document Type: Article

References (45)

1. Baeuerle PA. Pro-inflammatory signaling: last pieces in the NF-κB puzzle? Curr Biol 1998;8:R19-22.
2. Karin M. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 1999;18:6867-74.
3. Aggarwal BB. Nuclear factor-κB: the enemy within. Cancer Cell 2004;6:203-8.
4. Greten FR, Karin M. The IKK/NF-κB activation pathway - a target for prevention and treatment of cancer. Cancer Lett 2004;206:193-9.
5. Ni J, Takayama K, Inoshima N, et al. Gene transfer of inhibitor κB in human lung cancer cell line NCI-H460 inhibits tumorigenesis and angiogenesis in vivo. Anticancer Res 2005;25:69-77.
6. Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001;107:241-6.
7. Greten FR, Eckmann L, Greten TF, et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-96.
8. Luo JL, Maeda S, Hsu LC, et al. Inhibition of NF-κB in cancer cells converts inflammation-induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression. Cancer Cell 2004;6:297-305.
9. Stark LA, Dunlop MG. Nucleolar sequestration of RelA (p65) regulates NF-κB-driven transcription and apoptosis. Mol Cell Biol 2005;25:5985-6004.
10. Chen LF, Greene WC. Shaping the nuclear action of NF-κB. Nat Rev Mol Cell Biol 2004;5:392-401.
11. Campbell KJ, Rocha S, Perkins ND. Active repression of antiapoptotic gene expression by RelA(p65) NF-κ B. Mol Cell 2004;13:853-65.
12. Dejardin E. The alternative NF-κB pathway from biochemistry to biology: pitfalls and promises for future drug development Biochem Pharmacol 2006;72:1161-79.
13. Sumbayev W, Yasinska IM. Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species. Arch Biochem Biophys 2005;436:406-12.
14. Schwenger P, Bellosta P, Vietor I, et al. Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation. Proc Natl Acad Sci U S A 1997;94:2869-73.
15. Iordanov M, Bender K, Ade T, et al. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase. EMBO J 1997;16:1009-22.
16. Miki H, Yamada H, Mitamura K. Involvement of p38 MAP kinase in apoptotic and proliferative alteration in human colorectal cancers. Anticancer Res 1999;19:5283-91.
17. Kato T, Jr., Delhase M, Hoffmann A, Karin M. CK2 is a C-terminal IκB kinase responsible for NF-κB activation during the UV response. Mol Cell 2003;12:829-39.
18. Din FV, Stark LA, Dunlop MG. Aspirin-induced nuclear translocation of NF-κB and apoptosis in colorectal cancer is independent of p53 status and mismatch repair proficiency. Br J Cancer 2005;92:1137-43.
19. Zhu G, Conner SE, Zhou X, et al. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-4 inhibitors. J Med Chem 2003;46:2027-30.
20. Stark LA, Din FV, Zwacka RM, Dunlop MG. Aspirin-induced activation of the NF-κB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells. FASEB J 2001;15:1273-5.
21. Ge B, Gram H, Di Padova F, et al. MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α. Science 2002;295:1291-4.
22. Casanovas O, Miro F, Estanyol JM, et al. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J Biol Chem 2000;275:35091-7.
23. Law BK, Waltner-Law ME, Entingh AJ, et al. Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. J Biol Chem 2000;275:38261-7.
24. Guo Y, Harwalkar J, Stacey DW, Hitomi M. Destabilization of cyclin D1 message plays a critical role in cell cycle exit upon mitogen withdrawal. Oncogene 2005;24:1032-42.
25. Lutzen A, Bisgaard HC, Rasmussen LJ. Cyclin D1 expression and cell cycle response in DNA mismatch repair-deficient cells upon methylation and UV-C damage. Exp Cell Res 2004;292:123-34.
26. Mistry P, Deacon K, Mistry S, et al. NF-κB promotes survival during mitotic cell cycle arrest. J Biol Chem 2004;279:1482-90.
27. Cuenda A, Rouse J, Doza YN, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995;364:229-33.
28. Kummer JL, Rao PK, Heidenreich KA. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem 1997; 272:20490-4.
29. Bodero AJ, Ye R, Lees-Miller SP. UV-light induces p38 MAPK-dependent phosphorylation of Bcl10. Biochem Biophys Res Commun 2003;301:923-6.
30. de Alvaro C, Teruel T, Hernandez R, Lorenzo M. Tumor necrosis factor α produces insulin resistance in skeletal muscle by activation of inhibitor κB kinase in a p38 MAPK-dependent manner. J Biol Chem 2004;279:17070-8.
31. Ortiz MA, Lopez-Hernandez FJ, Bayon Y, et al. Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH(2)-terminal kinase/p38 mitogen-activated protein kinases. Cancer Res 2001;61:8504-12.
32. Duval D, Malaise M, Reinhardt B, et al. A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells. Cell Death Differ 2004;11:331-41.
33. Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J Cell Biochem 2005;96:906-13.
34. Schwenger P, Alpert D, Skolnik EY, Vilcek J. Cell-type-specific activation of c-Jun N-terminal kinase by salicylates. J Cell Physiol 1999;179:109-14.
35. Ordan O, Rotem R, Jaspers I, Flescher E. Stress-responsive JNK mitogen-activated protein kinase mediates aspirin-induced suppression of B16 melanoma cellular proliferation. Br J Pharmacol 2003;138:1156-62.
36. Mifflin RC, Saada JI, Di Mari JF, et al. Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol 2004;65:470-8.
37. Zarabin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res 2005;15:11-8.
38. 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat Med 2001;7:1041-7.
39. Montalto M, Maggiano N, Ricci R, et al. Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells. Digestion 2004;69:225-8.
40. Walsh MF, Thamilselvan V, Grotelueschen R, et al. Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death. Cell Physiol Biochem 2003;13:135-46.
41. Stacey DW. Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol 2003;15:158-63.
42. Subbegowda R, Frommel TO. Aspirin toxicity for human colonic tumor cells results from necrosis and is accompanied by cell cycle arrest Cancer Res 1998;58:2772-6.
43. Khafif A, Hurst R, Kyker K, et al. Curcumin: a new radio-sensitizer of squamous cell carcinoma cells. Otolaryngol Head Neck Surg 2005;132:317-21.
44. Chen M, Capps C, Willerson JT, Zoldhelyi P. E2F-1 regulates nuclear factor-κB activity and cell adhesion: potential antiinflammatory activity of the transcription factor E2F-1. Circulation 2002;106:2707-13.
45. Li J, Joo SH, Tsai MD. An NF-κB-specific inhibitor, IκBα, binds to and inhibits cyclin-dependent kinase 4. Biochemistry 2003;42:13476-83.