Hypoxia-like transcriptional activation in TMT-induced degeneration: Microarray expression analysis on PC12 cells

Journal of Neurochemistry

Volumn 100, Issue 6, 2007, Pages 1688-1702

  Lattanzi, Wanda ^a   Bernardini, Camilla ^a   Gangitano, Carlo ^a   Michetti, Fabrizio ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Apoptosis; Hypoxia; Microarray; Pheochromocytoma 12; Trimethyltin

Indexed keywords

TRIMETHYLTIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL DEGENERATION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GLYCOLYSIS; HYPOXIA; LIPOGENESIS; MICROARRAY ANALYSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION INITIATION;

ANIMALS; ANOXIA; CELL DEATH; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PC12 CELLS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; TRIMETHYLTIN COMPOUNDS;

EID: 33847698244     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04331.x     Document Type: Article

References (74)

1. Bando H., Toi M., Kitada K. and Koike M. (2003) Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231. Biomed. Pharmacother. 57, 333-340.
2. Bedo G., Vargas M., Ferreiro M. J., Chalar C. and Agrati D. (2005) Characterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression. Int. J. Dev. Biol. 49, 431-436.
3. Berg J. M., Tymoczko J. L. and Stryer L. (2002) Biochemistry, 5th Edn. W. H. Freeman and Co., New York.
4. Bossenmeyer-Pourie C., Lievre V., Grojean S., Koziel V., Pillot T. and Daval J. L. (2002) Sequential expression patterns of apoptosis- and cell cycle-related proteins in neuronal response to severe or mild transient hypoxia. Neuroscience 114, 869-882.
5. Bouldin T. W., Goines N. D., Bagnell R. C. and Krigman M. R. (1981) Pathogenesis of trimethyltin neuronal toxicity. Ultra-structural and cytochemical observations. Am. J. Pathol. 104, 237-249.
6. Boyer I. J. (1989) Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals. Toxicology 55, 253-258.
7. Brazma A., Hingamp P., Quackenbush J. et al. (2001) Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 29, 365-371.
8. Brown A. W., Aldridge W. N., Street B. W. and Verschoyle R. D. (1979) The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat. Am. J. Pathol. 97, 59-82.
9. Brown A. W., Cavanagh J. B., Verschoyle R. D., Gysbers M. F., Jones H. B. and Aldridge W. N. (1984) Evolution of the intracellular changes in neurons caused by trimethyltin. Neuropathol. Appl. Neurobiol. 10, 267-283.
10. Buck-Koehntop B. A., Mascioni A., Buffy J. J. and Veglia G. (2005) Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. J. Mol. Biol. 354, 652-665.
11. Burton T. R., Henson E. S., Baijal P., Eisenstat D. D. and Gibson S. B. (2006) The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia. Int. J. Cancer 118, 1660-1669.
12. Cannon R. L., Hoover D. B., Baisden R. H. and Woodruff M. L. (1994) Effects of trimethyltin (TMT) on choline acetyltransferase activity in the rat hippocampus. Influence of dose and time following exposure. Mol. Chem. Neuropathol. 23, 27-45.
13. Chang L. W., Tiemeyer T. M., Wenger G. R. and McMillan D. E. (1982) Neuropathology of mouse hippocampus in acute trimethyltin intoxication. Neurobehav. Toxicol. Teratol. 4, 149-156.
14. Chang L. W., Wenger G. R. and McMillan D. E. (1984) Neuropathology of trimethyltin intoxication. IV. Changes in the spinal cord. Environ. Res. 34, 123-134.
15. Chow S. C. and Orrenius S. (1994) Rapid cytoskeleton modification in thymocytes induced by the immunotoxicant tributyltin. Toxicol. Appl. Pharmacol. 127, 19-26.
16. Dyer R. S., Walsh T. J., Wonderlin W. F. and Bercegeay M. (1982) The trimethyltin syndrome in rats. Neurobehav. Toxicol. Teratol. 4, 127-133.
17. Erler J. T., Bennewith K. L., Nicolau M., Dornhofer N., Kong C., Le Q. T., Chi J. T., Jeffrey S. S. and Giaccia A. J. (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222-1226.
18. Faden A. I., Movsesyan V. A., Knoblach S. M., Ahmed F. and Cernak I. (2005) Neuroprotective effects of novel small peptides in vitro and after brain injury. Neuropharmacology 49, 410-424.
19. Fei P., Wang W., Kim S. H. et al. (2004) Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell 6, 597-609.
20. Feldman R. G., White R. F. and Eriator I. I. (1993) Trimethyltin encephalopathy. Arch. Neurol. 50, 1320-1324.
21. Florea A. M., Splettstoesser F., Dopp E., Rettenmeier A. W. and Busselberg D. (2005a) Modulation of intracellular calcium homeostasis by trimethyltin chloride in human tumour cells: neuroblastoma SY5Yand cervix adenocarcinoma HeLa S3. Toxicology 216, 1-8.
22. Florea A. M., Dopp E. and Busselberg D. (2005b) Elevated Ca2+(i) transients induced by trimethyltin chloride in HeLa cells: types and levels of response. Cell Calcium 37, 251-258.
23. Fortemps E., Amand G., Bomboir A., Lauwerys R. and Laterre E. C. (1978) Trimethyltin poisoning. Report of two cases. Int. Arch. Occup. Environ. Health 41, 1-6.
24. Gasso S., Sanfeliu C., Sunol C., Rodriguez-Farre E. and Cristofol R. M. (2000) Trimethyltin and triethyltin differentially induce spontaneous noradrenaline release from rat hippocampal slices. Toxicol. Appl. Pharmacol. 162, 189-196.
25. Geloso M. C., Vercelli A., Corvino V., Repici M., Boca M., Haglid K., Zelano G. and Michetti F. (2002) Cyclooxygenase-2 and caspase 3 expression in trimethyltin-induced apoptosis in the mouse hippocampus. Exp. Neurol. 175, 152-160.
26. Geloso M. C., Vinesi P. and Michetti F. (1997) Calretinin-containing neurons in trimethyltin-induced neurodegeneration in the rat hippocampus. An immunocytochemical study. Exp. Neurol. 146, 67-73.
27. Gennari A., Viviani B., Galli C. L., Marinovich M., Pieters R. and Corsini E. (2000) Organotins induce apoptosis by disturbance of [Ca(2+)](i) and mitochondrial activity, causing oxidative stress and activation of caspases in rat thymocytes. Toxicol. Appl. Pharmacol. 169, 185-190.
28. Goda N., Ryan H. E., Khadivi B., McNulty W., Rickert R. C. and Johnson R. S. (2003) Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol. Cell. Biol. 23, 359-369.
29. Greijer A. E., van der Groep P., Kemming D. et al. (2005) Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J. Pathol. 206, 291-304.
30. Gui-bin J., Qun-fang Z. and Bin H. (2000) Tin compounds and major trace metal elements in organotin-poisoned patient's urine and blood measured by gas chromatography-flame photometric detector and inductively coupled plasma-mass spectrometry. Bull. Environ. Contam. Toxicol. 65, 277-284.
31. Guillon-Munos A., van Bemmelen M. X. and Clarke P. G. (2005) Role of phosphoinositide 3-kinase in the autophagic death of serumdeprived PC12 cells. Apoptosis 10, 1031-1041.
32. Gunasekar P., Li L., Prabhakaran K., Eybl V., Borowitz J. L. and Isom G. E. (2001) Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells. Toxicol. Sci. 64, 83-89.
33. Han X. J., Chae J. K., Lee M. J., You K. R., Lee B. H. and Kim D. G. (2005) Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells. J. Biol. Chem. 280, 23 122-23 129.
34. Hansen M. B., Nielsen S. E. and Berg K. (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210.
35. Harkins A. B. and Armstrong D. L. (1992) Trimethyltin alters membrane properties of CA1 hippocampal neurons. Neurotoxicology 13, 569-581.
36. Harry G. J. and Lefebvre d'Hellencourt C. (2003) Dentate gyrus: alterations that occur with hippocampal injury. Neurotoxicology 24, 343-356.
37. Hatzivassiliou G., Zhao F., Bauer D. E., Andreadis C., Shaw A. N., Dhanak D., Hingorani S. R., Tuveson D. A. and Thompson C. B. (2005) ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8, 311-321.
38. Jahnke G. D., Brunssen S., Maier W. E. and Harry G. J. (2001) Neurotoxicant-induced elevation of adrenomedullin expression in hippocampus and glia cultures. J. Neurosci. Res. 66, 464-474.
39. Jenkins S. M. and Barone S. (2004) The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxidative stress in PC12 cells. Toxicol. Lett. 147, 63-72.
40. Kafer A. and Krug H. F. (1994) Effects of organometals on cellular signaling. I. Influence of metabolic inhibitors on metal-induced arachidonic acid liberation. Environ. Health Perspect. 102(Suppl. 3), 325-330.
41. Kane M. D., Yang C. W., Gunasekar P. G. and Isom G. E. (1998) Trimethyltin stimulates protein kinase C translocation through receptor-mediated phospholipase C activation in PC12 cells. J. Neurochem. 70, 509-514.
42. Kanzawa T., Zhang L., Xiao L., Germano I. M., Kondo Y. and Kondo S. (2005) Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 24, 980-991.
43. Karpiak V. C., Bridges R. J. and Eyer C. L. (2001) Organotins disrupt components of glutamate homeostasis in rat astrocyte cultures. J. Toxicol. Environ. Health A 63, 273-287.
44. Kim J. W., Tchernyshyov I., Semenza G. L. and Dang C. V. (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3, 177-185.
45. Kreyberg S., Torvik A., Bjorneboe A., Wiik-Larsen W. and Jacobsen D. (1992) Trimethyltin poisoning: report of a case with postmortem examination. Clin. Neuropathol. 11, 256-259.
46. Kruger K., Diepgrond V., Ahnefeld M., Wackerbeck C., Madeja M., Binding N. and Musshoff U. (2005) Blockade of glutamatergic and GABAergic receptor channels by trimethyltin chloride. Br. J. Pharmacol. 144, 283-292.
47. Leeman M. F., Curran S. and Murray G. I. (2002) The structure, regulation, and function of human matrix metalloproteinase-13. Crit. Rev. Biochem. Mol. Biol. 37, 149-166.
48. Lefebvre d'Hellencourt C. and Harry G. J. (2005) Molecular profiles of mRNA levels in laser capture microdissected murine hippocampal regions differentially responsive to TMT-induced cell death. J. Neurochem. 93, 206-220.
49. Li Y., Jenkins C. W., Nichols M. A. and Xiong Y. (1994) Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9, 2261-2268.
50. Livak K. J. and Schmittgen T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408.
51. Lock A. E. (1976) The action of triethyltin in the respiration of rat brain cortex slices. J. Neurochem. 26, 887-892.
52. Lopez-Lazaro M. (2006) HIF-1: hypoxia-inducible factor or dysoxia-inducible factor? FASEB J. 20, 828-832.
53. Luhe A., Hildebrand H., Bach U., Dingermann T. and Ahr H. J. (2003) A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: expression profiling in vivo and in vitro employing cDNA microarrays. Toxicol. Sci. 73, 315-328.
54. Naalsund L. U. and Fonnum F. (1986) The effect of trimethyltin on three glutamergic and gabaergic transmitter parameters in vitro: high affinity uptake, release and receptor binding. Neurotoxicology 7, 53-62.
55. Nishimura T., Schwarzer C., Furtinger S., Imai H., Kato N. and Sperk G. (2001) Changes in the GABA-ergic system induced by trimethyltin application in the rat. Brain Res. Mol. Brain Res. 97, 1-6.
56. Noland E. A., Taylor D. H. and Bull R. J. (1982) Monomethyl-and trimethyltin compounds induce learning deficiencies in young rats. Neurobehav. Toxicol. Teratol. 4, 539-544.
57. Noraberg J., Gramsbergen J. B., Fonnum F. and Zimmer J. (1998) Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures. Brain Res. 783, 305-315.
58. Ogita K., Nitta Y., Watanabe M., Nakatani Y., Nishiyama N., Sugiyama C. and Yoneda Y. (2004) In vivo activation of c-Jun N-terminal kinase signaling cascade prior to granule cell death induced by trimethyltin in the dentate gyrus of mice. Neuropharmacology 47, 619-630.
59. Ortiz A., Teruel J. A. and Aranda F. J. (2005) Effect of triorganotin compounds on membrane permeability. Biochim. Biophys. Acta 1720, 137-142.
60. Papandreou I., Cairns R. A., Fontana L., Lim A. L. and Denko N. C. (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3, 187-197.
61. Pavlakovic G., Kane M. D., Eyer C. L., Kanthasamy A. and Isom G. E. (1995) Activation of protein kinase C by trimethyltin: relevance to neurotoxicity. J. Neurochem. 65, 2338-2343.
62. Richter-Landsberg C. and Besser A. (1994) Effects of organotins on rat brain astrocytes in culture. J. Neurochem. 63, 2202-2209.
63. Salnikow K., Davidson T. and Costa M. (2002) The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environ. Health Perspect. 110(Suppl. 5), 831-834.
64. Semenza G. L., Roth P. H., Fang H. M. and Wang G. L. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23 757-23 763.
65. Sharp F. R. and Bernaudin M. (2004) HIF1 and oxygen sensing in the brain. Nat. Rev. Neurosci. 5, 437-448.
66. Shimokawa N., Miyazaki W., Iwasaki T. and Koibuchi N. (2006) Low dose hydroxylated PCB induces c-Jun expression in PC12 cells. Neurotoxicology 27, 176-183.
67. Stanton M. E., Jensen K. F. and Pickens C. V. (1991) Neonatal exposure to trimethyltin disrupts spatial delayed alternation learning in preweanling rats. Neurotoxicol. Teratol. 13, 525-530.
68. Subramaniam S. and Unsicker K. (2006) Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death. Neuroscience 138, 1055-1065.
69. Tabakman R., Jiang H., Shahat I., Arien-Zakay H., Levine R. and Lazarovici P. (2005) Neuroprotection by NGF in the PC12 in vitro OGD model. Involvement of mitogen-activated protein kinases and gene expression. Ann. N. Y. Acad. Sci. 1053, 84-96.
70. Tajiri S., Oyadomari S., Yano S., Morioka M., Gotoh T., Hamada J. I., Ushio Y. and Mori M. (2004) Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death Differ. 11, 403-415.
71. Thompson T. A., Lewis J. M., Dejneka N. S., Severs W. B., Polavarapu R. and Billingsley M. L. (1996) Induction of apoptosis by organotin compounds in vitro: neuronal protection with antisense oligonucleotides directed against stannin. J. Pharmacol. Exp. Ther. 276, 1201-1216.
72. Viviani B., Rossi A. D., Chow S. C. and Nicotera P. (1995) Organotin compounds induce calcium overload and apoptosis in PC12 cells. Neurotoxicology 16, 19-25.
73. Vrana K. E., Freeman W. M. and Aschner M. (2003) Use of microarray technologies in toxicology research. Neurotoxicology 24, 321-332.
74. Xu Z., Patterson T. A., Wren J. D., Han T., Shi L., Duhart H., Ali S. F. and Slikker W. Jr (2005) A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bio-informatics tools. BMC Bioinformatics 6(Suppl. 2), S8.