메뉴 건너뛰기




Volumn 10, Issue 5, 2005, Pages 1031-1041

Role of phosphoinositide 3-kinase in the autophagic death of serum-deprived PC12 cells

Author keywords

Apoptosis; Autophagic cell death; LY294002; PI3 kinases

Indexed keywords

CASPASE INHIBITOR; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

EID: 24644461555     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-005-0741-6     Document Type: Article
Times cited : (24)

References (49)
  • 2
    • 8044257699 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
    • Blommaart EFC, Krause U, Schellens JPM, Vreeling- Sindelárová H, Meijer AJ. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997; 243: 240-246.
    • (1997) Eur J Biochem , vol.243 , pp. 240-246
    • Blommaart, E.F.C.1    Krause, U.2    Schellens, J.P.M.3    Vreeling- Sindelárová, H.4    Meijer, A.J.5
  • 3
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cell
    • Petiot A, Ogier-Denis E, Blommaart EFC, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cell. J Biol Chem 2000; 275: 992-998.
    • (2000) J Biol Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.C.3    Meijer, A.J.4    Codogno, P.5
  • 4
    • 0442323561 scopus 로고    scopus 로고
    • Autophagy: In sickness and in health
    • Cuervo AM. Autophagy: In sickness and in health. Trends Cell Biol 2004; 14: 70-77.
    • (2004) Trends Cell Biol , vol.14 , pp. 70-77
    • Cuervo, A.M.1
  • 5
    • 0025283961 scopus 로고
    • Developmental cell death: Morphological diversity and multiple mechanisms
    • Clarke PGH. Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol 1990; 181: 195-213.
    • (1990) Anat Embryol , vol.181 , pp. 195-213
    • Clarke, P.G.H.1
  • 7
    • 0042380209 scopus 로고    scopus 로고
    • N-methyl-D-aspartate-triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway
    • Borsello T, Croquelois K, Hornung JP, Clarke PGH. N-methyl-D-aspartate- triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway. Eur J Neurosci 2003; 18: 473-485.
    • (2003) Eur J Neurosci , vol.18 , pp. 473-485
    • Borsello, T.1    Croquelois, K.2    Hornung, J.P.3    Clarke, P.G.H.4
  • 8
    • 0034304390 scopus 로고    scopus 로고
    • The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review
    • Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review. Neurochem Res 2000; 25: 1161-1172.
    • (2000) Neurochem Res , vol.25 , pp. 1161-1172
    • Nixon, R.A.1    Cataldo, A.M.2    Mathews, P.M.3
  • 9
    • 0032971161 scopus 로고    scopus 로고
    • Caspase-independent programmed cell death with necrotic morphology
    • Kitanaka C, Kuchino Y. Caspase-independent programmed cell death with necrotic morphology. Cell Death Differ 1999; 6: 508-515.
    • (1999) Cell Death Differ , vol.6 , pp. 508-515
    • Kitanaka, C.1    Kuchino, Y.2
  • 10
    • 0034012322 scopus 로고    scopus 로고
    • Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
    • Bursch W, Hochegger K, Török L, Marian B, Ellinger A, Hermann RS. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 2000; 113: 1189-1198.
    • (2000) J Cell Sci , vol.113 , pp. 1189-1198
    • Bursch, W.1    Hochegger, K.2    Török, L.3    Marian, B.4    Ellinger, A.5    Hermann, R.S.6
  • 12
    • 0029741890 scopus 로고    scopus 로고
    • Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
    • Bursch W, Ellinger A, Kienzl H, et al. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy. Carcinogenesis 1996; 17: 1595-1607.
    • (1996) Carcinogenesis , vol.17 , pp. 1595-1607
    • Bursch, W.1    Ellinger, A.2    Kienzl, H.3
  • 13
    • 0032959390 scopus 로고    scopus 로고
    • Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
    • Isahara K, Ohsawa Y, Kanamori S, et al. Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases. Neuroscience 1999; 91: 233-249.
    • (1999) Neuroscience , vol.91 , pp. 233-249
    • Isahara, K.1    Ohsawa, Y.2    Kanamori, S.3
  • 14
    • 0032455357 scopus 로고    scopus 로고
    • An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins
    • Ohsawa Y, Isahara K, Kanamori S, et al. An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins. Arch Histol Cytol 1998; 61: 395-403.
    • (1998) Arch Histol Cytol , vol.61 , pp. 395-403
    • Ohsawa, Y.1    Isahara, K.2    Kanamori, S.3
  • 15
    • 0032870475 scopus 로고    scopus 로고
    • Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
    • Xue LZ, Fletcher GC, Tolkovsky AM. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution. Molec Cell Neurosci 1999; 14: 180-198.
    • (1999) Molec Cell Neurosci , vol.14 , pp. 180-198
    • Xue, L.Z.1    Fletcher, G.C.2    Tolkovsky, A.M.3
  • 16
    • 0842279780 scopus 로고    scopus 로고
    • Caspases function in autophagic programmed cell death in Drosophila
    • Martin DN, Baehrecke EH. Caspases function in autophagic programmed cell death in Drosophila. Development 2004; 131: 275-284.
    • (2004) Development , vol.131 , pp. 275-284
    • Martin, D.N.1    Baehrecke, E.H.2
  • 17
    • 0034849783 scopus 로고    scopus 로고
    • Autophagic cell death and its execution by lysosomal cathepsins
    • Uchiyama Y. Autophagic cell death and its execution by lysosomal cathepsins. Arch Histol Cytol 2001; 64: 233-246.
    • (2001) Arch Histol Cytol , vol.64 , pp. 233-246
    • Uchiyama, Y.1
  • 18
    • 0021133597 scopus 로고
    • Identical populations of phagocytes and dying neurons revealed by intravascularly injected horseradish peroxidase, and by endogenous glutaraldehyde-resistant acid phosphatase, in the brains of chick embryos
    • Clarke PGH. Identical populations of phagocytes and dying neurons revealed by intravascularly injected horseradish peroxidase, and by endogenous glutaraldehyde-resistant acid phosphatase, in the brains of chick embryos. Histochem J 1984; 16: 955-969.
    • (1984) Histochem J , vol.16 , pp. 955-969
    • Clarke, P.G.H.1
  • 20
    • 0032510559 scopus 로고    scopus 로고
    • A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
    • Kobayashi T, Stang E, Fang KS, de M, Parton RG, Gruenberg J. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature. 1998; 392: 193-197.
    • (1998) Nature , vol.392 , pp. 193-197
    • Kobayashi, T.1    Stang, E.2    Fang, K.S.3    De, M.4    Parton, R.G.5    Gruenberg, J.6
  • 21
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylmositol 3-kinase complex functions at the trans-Golgi networkBeclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylmositol 3-kinase complex functions at the trans-Golgi networkBeclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Reports 2001; 2: 330-335.
    • (2001) EMBO Reports , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 22
    • 0024370374 scopus 로고
    • Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos
    • Hornung JP, Koppel H, Clarke PGH. Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos. J Comp Neurol 1989; 283: 425-437.
    • (1989) J Comp Neurol , vol.283 , pp. 425-437
    • Hornung, J.P.1    Koppel, H.2    Clarke, P.G.H.3
  • 23
    • 0029185514 scopus 로고
    • Neuron death in vertebrate development: In vivo methods
    • Clarke PGH, Oppenheim RW. Neuron death in vertebrate development: In vivo methods. Methods Cell Biol 1995; 46: 277-321.
    • (1995) Methods Cell Biol , vol.46 , pp. 277-321
    • Clarke, P.G.H.1    Oppenheim, R.W.2
  • 26
    • 0005677775 scopus 로고
    • 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen PO, Gordon PB. 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Nat Acad Sci USA 1982; 79: 1889-1892.
    • (1982) Proc Nat Acad Sci USA , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 28
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351: 95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 29
    • 0033856462 scopus 로고    scopus 로고
    • PI3-kinase inhibition: A target for drug development?
    • Stein RC, Waterfield MD. PI3-kinase inhibition: A target for drug development? Mol Med Today 2000; 6: 347-357.
    • (2000) Mol Med Today , vol.6 , pp. 347-357
    • Stein, R.C.1    Waterfield, M.D.2
  • 30
    • 0029582765 scopus 로고
    • Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology
    • Takegawa K, DeWald DB, Emr SD. Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. J Cell Sci 1995; 108: 3745-3756.
    • (1995) J Cell Sci , vol.108 , pp. 3745-3756
    • Takegawa, K.1    DeWald, D.B.2    Emr, S.D.3
  • 31
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
    • Marte BM, Downward J. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 1997; 22: 355-358.
    • (1997) Trends Biochem Sci , vol.22 , pp. 355-358
    • Marte, B.M.1    Downward, J.2
  • 33
    • 1842370285 scopus 로고    scopus 로고
    • Nerve growth factor protects PC12 cells against peroxymtrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase
    • Spear N, Estevez AG, Barbeito L, Beckman JS, Johnson GV. Nerve growth factor protects PC12 cells against peroxymtrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase. J Neurochem 1997; 69: 53-59.
    • (1997) J Neurochem , vol.69 , pp. 53-59
    • Spear, N.1    Estevez, A.G.2    Barbeito, L.3    Beckman, J.S.4    Johnson, G.V.5
  • 34
    • 0035446966 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia
    • Aki T, Mizukami Y, Oka Y, et al. Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia. Biochemical J 2001; 358: 481-487.
    • (2001) Biochemical J , vol.358 , pp. 481-487
    • Aki, T.1    Mizukami, Y.2    Oka, Y.3
  • 35
    • 0346753579 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-denved cell line H9c2
    • Aki T, Yamaguchi K, Fujimiya T, Mizukami Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-denved cell line H9c2. Oncogene 2003; 22: 8529-8535.
    • (2003) Oncogene , vol.22 , pp. 8529-8535
    • Aki, T.1    Yamaguchi, K.2    Fujimiya, T.3    Mizukami, Y.4
  • 36
    • 0026683322 scopus 로고
    • Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide
    • Sandvig K, van Deurs B. Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide. Exp Cell Res. 1992; 200: 253-262.
    • (1992) Exp Cell Res , vol.200 , pp. 253-262
    • Sandvig, K.1    Van Deurs, B.2
  • 37
    • 0030883558 scopus 로고    scopus 로고
    • Inhibition of autophagy abrogates tumour necrosis factor a induced apoptosis in human T-lymphoblastic leukaemic cells
    • Jia L, Dourmashkin RR, Allen PD, Gray AB, Newland AC, Kelsey SM. Inhibition of autophagy abrogates tumour necrosis factor a induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol 1997; 98: 673-685.
    • (1997) Br J Haematol , vol.98 , pp. 673-685
    • Jia, L.1    Dourmashkin, R.R.2    Allen, P.D.3    Gray, A.B.4    Newland, A.C.5    Kelsey, S.M.6
  • 38
    • 0030608832 scopus 로고    scopus 로고
    • Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells
    • Jia L, Dourmashkin RR, Newland AC, Kelsey SM. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia Res 1997; 21: 973-983.
    • (1997) Leukemia Res , vol.21 , pp. 973-983
    • Jia, L.1    Dourmashkin, R.R.2    Newland, A.C.3    Kelsey, S.M.4
  • 39
    • 0029148577 scopus 로고
    • Role for Phosphatidylinositol 3-Kinase in the Sorting and Transport of Newly Synthesized Lysosomal-Enzymes in Mammalian-Cells
    • Brown WJ, DeWald DB, Emr SD, Plutner H, Balch WE. Role for Phosphatidylinositol 3-Kinase in the Sorting and Transport of Newly Synthesized Lysosomal-Enzymes in Mammalian-Cells. J Cell Biol 1995; 130: 781-796.
    • (1995) J Cell Biol , vol.130 , pp. 781-796
    • Brown, W.J.1    DeWald, D.B.2    Emr, S.D.3    Plutner, H.4    Balch, W.E.5
  • 40
    • 0032500842 scopus 로고    scopus 로고
    • Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation
    • Shibata M, Kanamori S, Isahara K, et al. Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation. Biochem Biophys Res Comm 1998; 251: 199-203.
    • (1998) Biochem Biophys Res Comm , vol.251 , pp. 199-203
    • Shibata, M.1    Kanamori, S.2    Isahara, K.3
  • 41
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu L, Alva A, Su H, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304: 1500-1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3
  • 42
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • Shimizu S, Kanaseki T, Mizushima N, et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol 2004; 6: 1221-1228.
    • (2004) Nature Cell Biol , vol.6 , pp. 1221-1228
    • Shimizu, S.1    Kanaseki, T.2    Mizushima, N.3
  • 43
    • 0035040496 scopus 로고    scopus 로고
    • Steroid regulation of autophagic programmed cell death during development
    • Lee CY, Baehrecke EH. Steroid regulation of autophagic programmed cell death during development. Development 2001; 128: 1443-1455.
    • (2001) Development , vol.128 , pp. 1443-1455
    • Lee, C.Y.1    Baehrecke, E.H.2
  • 45
    • 0033118229 scopus 로고    scopus 로고
    • Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
    • Chi SJ, Kitanaka C, Noguchi K, et al. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Oncogene. 1999; 18: 2281-2290.
    • (1999) Oncogene , vol.18 , pp. 2281-2290
    • Chi, S.J.1    Kitanaka, C.2    Noguchi, K.3
  • 46
    • 0035144813 scopus 로고    scopus 로고
    • L-Caspase-9 interactions in the developing nervous system: Evidence for multiple death pathways
    • L-Caspase-9 interactions in the developing nervous system: Evidence for multiple death pathways. J Neurosci 2001; 21: 169-175.
    • (2001) J Neurosci , vol.21 , pp. 169-175
    • Zaidi, A.U.1    D'Sa-Eipper, C.2    Brenner, J.3
  • 48
    • 0035283083 scopus 로고    scopus 로고
    • Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: Relevance to therapeutical application for Parkinson's disease
    • Shimoke K, Chiba H. Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: Relevance to therapeutical application for Parkinson's disease. J Neurosci Res 2001; 63: 402-409.
    • (2001) J Neurosci Res , vol.63 , pp. 402-409
    • Shimoke, K.1    Chiba, H.2
  • 49
    • 0035887215 scopus 로고    scopus 로고
    • Sphingosine-induced apoptosis is dependent on lysosomal proteases
    • Kagedal K, Zhao M, Svensson I, Brunk UT. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 2001; 359: 335-343.
    • (2001) Biochem J , vol.359 , pp. 335-343
    • Kagedal, K.1    Zhao, M.2    Svensson, I.3    Brunk, U.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.