Modifications of the GSK3β substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 2068-2073

  Kayser, Katherine J ^a   Glenn, Matthew P ^a   Sebti, Said M ^b,c   Cheng, Jin Q ^b,c,d   Hamilton, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c Department of Interdisciplinary Oncology ^*  (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Akt; Cancer; Peptidomimetics; Protein kinase B; Substrate mimetic

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCYLARGINYLPROLYLARGINYLTHREONYLTHREONYLSERYLPHENYLALANINE; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PEPTIDE; PROTEIN KINASE B;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MODIFICATION; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR MIMICRY; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; DRUG SCREENING; ENZYME SPECIFICITY; HUMAN; METHODOLOGY; NEOPLASM; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MODELS, CHEMICAL; NEOPLASMS; PEPTIDES; PROTO-ONCOGENE PROTEINS C-AKT; SUBSTRATE SPECIFICITY;

EID: 33847673698     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.004     Document Type: Article

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