New insights on radiation-induced bystander signalling and its relationship to DNA repair

International Congress Series

Volumn 1299, Issue , 2007, Pages 121-127

  Prise, Kevin M ^a   Burdak Rothkamm, Susanne ^a   Folkard, Melvyn ^a   Kashino, Genro ^b   Shao, Chunlin ^c   Tartier, Laurence ^a  

^a Gray Cancer Institute   (United Kingdom)

^b KYOTO UNIVERSITY   (Japan)

^c FUDAN UNIVERSITY   (China)

Author keywords

Bystander effect; Cell signalling; Cytoplasmic target; DNA repair; Microbeam

Indexed keywords

EID: 33847637519     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2006.10.018     Document Type: Article

References (44)

1. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159 (2003) 567-580
2. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159 (2003) 581-596
3. Narayanan P.K., Goodwin E.H., and Lehnert B.E. α-Particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57 (1997) 3963-3971
4. Azzam E.I., De Toledo S.M., Spitz D.R., and Little J.B. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62 (2002) 5436-5442
5. Matsumoto H., Hayashi S., Hatashita M., et al. Induction of radioresistance to accelerated carbon-ion beams in recipient cells by nitric oxide excreted from irradiated donor cells of human glioblastoma. Int. J. Radiat. Biol. 76 (2000) 1649-1657
6. Shao C., Stewart V., Folkard M., Michael B.D., and Prise K.M. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res. 63 (2003) 8437-8442
7. Shao C., Furusawa Y., Aoki M., Matsumoto H., and Ando K. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int. J. Radiat. Biol. 78 (2002) 837-844
8. Mothersill C., and Seymour C.B. Bystander and delayed effects after fractionated radiation exposure. Radiat. Res. 158 (2002) 626-633
9. Ward J.F. The radiation induced lesions which trigger the bystander effect. Mutat. Res. 499 (2002) 151-154
10. Willson R.L. The reaction of oxygen with radiation-induced free radicals in DNA and related compounds. Int. J. Radiat. Biol. 17 (1970) 349-358
11. Boudaiffa B., Cloutier P., Hunting D., Huels M.A., and Sanche L. Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons. Science 287 (2000) 1658-1660
12. Ward J.F. Radiation mutagenesis: the initial DNA lesions responsible. Radiat. Res. 142 (1995) 362-368
13. Koyama S., Kodama S., Suzuki K., Matsumoto T., Miyazaki T., and Watanabe M. Radiation-induced long-lived radicals which cause mutation and transformation. Mutat. Res. 421 (1998) 45-54
14. Kumagai J., Masui K., Itagaki Y., et al. Long-lived mutagenic radicals induced in mammalian cells by ionizing radiation are mainly localized to proteins. Radiat. Res. 160 (2003) 95-102
15. Shao C., Folkard M., Michael B.D., and Prise K.M. Targeted cytoplasmic irradiation induces bystander responses. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13495-13500
16. Wu L.J., Randers-Pehrson G., Xu A., et al. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 4959-4964
17. Haimovitz-Friedman A., Kan C.-C., Ehleiter D., et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180 (1994) 525-535
18. Spitz D.R., Azzam E.I., Li J.J., and Gius D. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev. 23 (2004) 311-322
19. Taneja N., Tjalkens R., Philbert M.A., and Rehemtulla A. Irradiation of mitochondria initiates apoptosis in a cell free system. Oncogene 20 (2001) 167-177
20. Leach J.K., Van Tuyle G., Lin P.S., Schmidt-Ullrich R., and Mikkelsen R.B. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res. 61 (2001) 3894-3901
21. Shao C., Lyng F.M., Folkard M., and Prise K.M. Calcium fluxes modulate the radiation-induced bystander responses in targeted glioma and fibroblast cells. Radiat. Res. 166 (2006) 479-487
22. Prise K.M., Belyakov O.V., Folkard M., and Michael B.D. Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74 (1998) 793-798
23. Belyakov O.V., Malcolmson A.M., Folkard M., Prise K.M., and Michael B.D. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Br. J. Cancer 84 (2001) 674-679
24. Azzam E.I., de Toledo S.M., Gooding T., and Little J.B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150 (1998) 497-504
25. Nagasawa H., and Little J.B. Induction of sister chromatid exchanges by extremely low doses of α-particles. Cancer Res. 52 (1992) 6394-6396
26. Mothersill C., and Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of irradiated cells. Int. J. Radiat. Biol. 71 (1997) 421-427
27. Seymour C.B., and Mothersill C. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153 (2000) 508-511
28. Nagasawa H., and Little J.B. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiat. Res. 152 (1999) 552-557
29. Zhou H., Randers-Pehrson G., Waldren C.A., Vannais D., Hall E.J., and Hei T.K. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 2099-2104
30. Sawant S.G., Randers-Pehrson G., Geard C.R., Brenner D.J., and Hall E.J. The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155 (2001) 397-401
31. Yang H., Asaad N., and Held K.D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24 (2005) 2096-2103
32. Hu B., Wu L., Han W., et al. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 27 (2006) 245-251
33. Sokolov M.V., Smilenov L.B., Hall E.J., Panyutin I.G., Bonner W.M., and Sedelnikova O.A. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 24 (2005) 7257-7265
34. Huo L., Nagasawa H., and Little J.B. HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat. Res. 156 (2001) 521-525
35. Nagasawa H., Huo L., and Little J.B. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int. J. Radiat. Biol. 79 (2003) 35-41
36. Mothersill C., Seymour R.J., and Seymour C.B. Bystander effects in repair-deficient cell lines. Radiat. Res. 161 (2004) 256-263
37. Zheng L., Zhou M., Chai Q., et al. Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep. 6 (2005) 83-89
38. S. Burdak-Rothkamm, S.C. Short, M. Folkard, K. Rothkamm, K.M. Prise, ATR-dependent radiation-induced γH2AX foci in bystander primary human astrocytes and glioma cells, Oncogene (in press).
39. Little J.B., Nagasawa H., Li G.C., and Chen D.J. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat. Res. 159 (2003) 262-267
40. Lomax M.E., Cunniffe S., and O'Neill P. Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts. Biochemistry 43 (2004) 11017-11026
41. Gulston M., de Lara C., Jenner T., Davis E., and O'Neill P. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res. 32 (2004) 1602-1609
42. Balajee A.S., Ponnaiya B., Baskar R., and Geard C.R. Induction of replication protein A in bystander cells. Radiat. Res. 162 (2004) 677-686
43. Hill M.A., Ford J.R., Clapham P., et al. Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 alpha particles. Radiat. Res. 163 (2005) 36-44
44. Caldecott K.W. Mammalian DNA single-strand break repair: an X-ra(y)ted affair. Bioessays 23 (2001) 447-455