Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 α particles

Radiation Research

Volumn 163, Issue 1, 2005, Pages 36-44

  Hill, M A ^a   Ford, J R ^b   Clapham, P ^a   Marsden, S J ^a   Stevens, D L ^a   Townsend, K M S ^a   Goodhead, D T ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b Texas AandM University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; PLUTONIUM 238;

ALPHA RADIATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CELL CYCLE; CELL NUCLEUS; COCULTURE; CONTROLLED STUDY; CYTOPLASM; DNA REPAIR; EPITHELIUM CELL; HYPOTHESIS; IRRADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RAT; TRACHEA MUCOSA;

ALPHA PARTICLES; ANIMALS; BYSTANDER EFFECT; CELL NUCLEUS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; MALE; PLUTONIUM; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; RADIATION DOSAGE; RATS; RATS, INBRED F344; RESPIRATORY MUCOSA; TRACHEA;

EID: 11144303464     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3282     Document Type: Article

References (37)

1. United Nations Scientific Committee on the Effects of Atomic Radiation, Report to the General Assembly. United Nations, New York, 1993.
2. R. Iyer and B. E. Lehnert, Effects of ionising radiation in targeted and non targeted cells. Arch. Biochem. Biophys. 376, 14-25 (2000).
3. C. Mothersill and C. B. Seymour, Radiation induced bystander effects: Past history and future directions. Radiat. Res. 155, 759-767 (2001).
4. M. H. Barcellos-Hoff and A. L. Brooks, Extracellular signaling through the microenvironment: A hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiat Res. 156, 618-627 (2001).
5. W. F. Morgan, Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567-580 (2003).
6. W. F. Morgan, Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159, 581-596 (2003).
7. F. Ballarini, M. Biaggi, A. Ottolenghi and O. Sapora, Cellular communication and bystander effects: A critical review for modeling low dose radiation action. Mutat. Res. 501, 1-12 (2002).
8. H. Nagasawa, J. B. Little, W. C. Inkret, S. Carpenter, K. Thompson, M. R. Raju, D. J. Chen and G. F. Strniste, Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. Mutat. Res. 244, 233-238 (1990).
9. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha particles. Cancer Res. 52, 6394-6396 (1992).
10. G. E. Deshpande, S. Bailey, B. Marrone and B. Lehnert, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target. Radiat. Res. 145, 260-267 (1996).
11. J. R. Hickman, J. Lechner and N. Johnson, Alpha particle induced p53 protein expression in a rat lung epithelial cell strain. Cancer Res. 54, 5797-5800 (1994).
12. E. Azzam, S. M. Toledo, T. Gooding and J. B. Little, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150, 497-504 (1998).
13. S. A. Lorimore, M. A. Kadhim, D. Pocock, D. L. Papworth, D. L. Papworth, D. L. Stevens, D. T. Goodhead and E. G. Wright, Chromosomal instability in descendants of unirradiated surviving cells after α-particle irradiation. Proc. Natl. Acad. Sci. USA 95, 5730-5733 (1998).
14. M. Kadhim, S. J. Marsden, A. Malcolmson, M. Folkard, D. T. Goodhead, K. M. Prise and B. D. Michael, Long-term genomic instability in human lymphocytes induced by single-particle irradiation. Radiat. Res. 155, 122-126 (2001).
15. K. M. Prise, O. V. Belyakov, M. Folkard and B. D. Michael, Studies of bystander effects in human fibroblast using a charged particle microbeam. Int. J. Radiat. Biol. 74, 793-798 (1998).
16. O. V. Belyakov, A. M. Malcolmson, M. Folkard, K. M. Prise and B. D. Michael, Direct evidence for a bystander effect of ionising radiation in primary human fibroblasts. Br. J. Cancer. 84, 674-679 (2001).
17. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall and T. K. Hei, Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97, 2099-2104 (2000).
18. S. G. Sawant, G. Randers-Pehrson, C. R. Geard, D. J. Brenner and E. J. Hall, The bystander effect in radiation oncogenesis. I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155, 397-401 (2001).
19. C. Mothersill and C. B. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
20. C. Mothersill and C. B. Seymour, Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiat. Res. 149, 256-262 (1998).
21. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000).
22. H. Zhou, M. Suzuki, C. R. Geard and T. K. Hei, Effects of irradiated medium with or without cells on bystander cell responses. Mutat. Res. 499, 135-141 (2002).
23. C. R. Geard, G. Jenkins-Baker, S. A. Marino and B. Ponnaiya, Novel approaches with track segment alpha particles and cell co-cultures in studies of bystander effects. Radiat. Prot. Dosim. 99, 233-236 (2002).
24. A. S. Balajee and C. R. Geard, Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res. 29, 1341-1351 (2001).
25. D. T. Goodhead, D. A. Bance, A. Stretch and R. E. Wilkinson, A versatile plutonium-238 irradiator for radiobiological studies with α-particles. Int. J. Radiat. Biol. 59, 195-210 (1991).
26. P. J. Walsh, Stopping power and range of alpha particles. Health Phys. 19, 587-597 (1970).
27. J. F. Ziegler, Helium Stopping Powers and Ranges in all Elemental Matter. Pergamon, New York, 1977.
28. 210Po alpha particles on survival and preneoplastic transformation of primary rat tracheal epithelial cells irradiated while in suspension or in the intact tissue. Radiat. Res. 136, 89-96 (1993).
29. K. M. S. Townsend and S. J. Marsden, Nuclear area measurements on viable cells, using confocal microscopy. Int. J. Radiat. Biol. 61, 549-551 (1992).
30. P. McCullagh and J. A. Nelder, Generalized Linear Models. Chapman and Hall, London, 1989.
31. A. Bishayee, H. Z. Hill, D. Stein, D. V. Rao and R. W. Howell, Free-radical-initiated and gap-junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155, 335-344 (2001).
32. C. Mothersill, K. O'Malley and C. B. Seymour, Characterization of a bystander effect induced in human tissue explant cultures by low LET radiation. Radiat. Prot. Dosim. 99, 163-167 (2002).
33. F. M. Lyng, C. B. Seymour and C. Mothersill, Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: A possible mechanism for bystander-induced genomic instability. Radiat. Res. 157, 365-370 (2002).
34. G. R. Watson, S. A. Lorimore, D. A. Macdonald and E. G. Wright, Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation. Cancer Res. 60, 5608-5611 (2000).
35. O. V. Belyakov, M. Folkard, C. Mothersill, K. M. Prise and B. D. Michael, Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiat. Prot. Dosim. 99, 249-251 (2002).
36. 2 particle number and size on the frequency and distribution of chromosome aberrations in the liver of the Chinese hamster. Radiat. Res. 59, 693-709 (1974).
37. 2 particles in the Chinese hamster. Radiat. Res. 157, 365-370 (1983).