메뉴 건너뛰기




Volumn 287, Issue 5458, 2000, Pages 1658-1660

Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; PLASMID DNA;

EID: 0038188968     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5458.1658     Document Type: Article
Times cited : (2063)

References (31)
  • 1
    • 0000245704 scopus 로고
    • J. T. Lett and H. Adler, Eds. Academic Press, New York
    • J. F. Ward, in Advances in Radiation Biology 5, J. T. Lett and H. Adler, Eds. (Academic Press, New York, 1977), pp. 181-239.
    • (1977) Advances in Radiation Biology 5 , vol.5 , pp. 181-239
    • Ward, J.F.1
  • 5
    • 0003691937 scopus 로고
    • ICRU, Washington, DC
    • International Commission on Radiation Units and Measurements, ICRU Report 31 (ICRU, Washington, DC, 1979).
    • (1979) ICRU Report 31
  • 6
    • 0343203301 scopus 로고    scopus 로고
    • S. M. Pimblott and J. A. LaVerne, in (3), pp. 3-12
    • S. M. Pimblott and J. A. LaVerne, in (3), pp. 3-12.
  • 9
    • 0027139888 scopus 로고
    • -6 torr) and contained salt (EDTA, ratio of DNA to EDTA = 1:1 by weight) during electron irradiation; the latter was reported to shield the DNA toward low-energy electrons
    • -6 torr) and contained salt (EDTA, ratio of DNA to EDTA = 1:1 by weight) during electron irradiation; the latter was reported to shield the DNA toward low-energy electrons.
    • (1993) Int. J. Radiat. Biol. , vol.64 , pp. 651
    • Folkard, M.1
  • 11
    • 0031567761 scopus 로고    scopus 로고
    • _, Chem. Phys. Lett. 279, 223 (1997).
    • (1997) Chem. Phys. Lett. , vol.279 , pp. 223
  • 13
    • 0343203298 scopus 로고    scopus 로고
    • L. Sanche, unpublished data
    • L. Sanche, unpublished data.
  • 16
    • 0343203297 scopus 로고    scopus 로고
    • note
    • -3, assuming minimal clustering of the plasmids in the solid.
  • 17
    • 0026600950 scopus 로고
    • with the plasmid solids containing a mixture of A and C conformations. Removal of this intrinsic hydration water is believed to lead to substantial conformational changes and DSBs, which are not observed in our unirradiated control samples held under UHV
    • Desiccation leaves plasmid DNA with its structural water of about 2.5 water molecules per base pair [S. G. Swarts, M. D. Sevilla, D. Becker, C. J. Tokar, K. T. Wheeler, Radiat. Res. 129, 333 (1992)], with the plasmid solids containing a mixture of A and C conformations. Removal of this intrinsic hydration water is believed to lead to substantial conformational changes and DSBs, which are not observed in our unirradiated control samples held under UHV.
    • (1992) Radiat. Res. , vol.129 , pp. 333
    • Swarts, S.G.1    Sevilla, M.D.2    Becker, D.3    Tokar, C.J.4    Wheeler, K.T.5
  • 20
    • 0343203296 scopus 로고    scopus 로고
    • B. D. Michael et al., in (3), pp. 251-258
    • B. D. Michael et al., in (3), pp. 251-258.
  • 23
    • 0005070375 scopus 로고
    • _, J. Phys. Chem. 95, 4902 (1991).
    • (1991) J. Phys. Chem. , vol.95 , pp. 4902
  • 26
    • 0000896264 scopus 로고    scopus 로고
    • For vertical electron attachment energies in gas-phase nucleobases below 5 eV, see K. Aflatooni, G. A. Gallup, P. D. Burrow, J. Phys. Chem. A 102, 6205 (1998); for detachment energies in solvated uracil cluster anions, see J. H. Hendricks, S. A. Lyapustina, H. L. de Clercq, K. H. Bowen, J. Chem. Phys. 108, 8 (1998).
    • (1998) J. Phys. Chem. A , vol.102 , pp. 6205
    • Aflatooni, K.1    Gallup, G.A.2    Burrow, P.D.3
  • 27
    • 11344270521 scopus 로고    scopus 로고
    • For vertical electron attachment energies in gas- phase nucleobases below 5 eV, see K. Aflatooni, G. A. Gallup, P. D. Burrow, J. Phys. Chem. A 102, 6205 (1998); for detachment energies in solvated uracil cluster anions, see J. H. Hendricks, S. A. Lyapustina, H. L. de Clercq, K. H. Bowen, J. Chem. Phys. 108, 8 (1998).
    • (1998) J. Chem. Phys. , vol.108 , pp. 8
    • Hendricks, J.H.1    Lyapustina, S.A.2    De Clercq, H.L.3    Bowen, K.H.4
  • 30
    • 0342768677 scopus 로고    scopus 로고
    • Sample exposure-response curves can be seen at Science Online
    • Sample exposure-response curves can be seen at Science Online (www.sciencemag.org/feature/data/1044957.shl).
  • 31
    • 0342768676 scopus 로고    scopus 로고
    • note
    • We thank A. J. Waker for helpful comments and suggestions. Supported by the Medical Research Council of Canada.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.