Potassium channel openers: The case of BK channel activators

Letters in Drug Design and Discovery

Volumn 3, Issue 4, 2006, Pages 210-218

  Nardi, A ^a,d   Calderone, V ^b   Olesen, S P ^a,c  

^a NEUROSEARCH A S   (Denmark)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d NeuroSearch ^*  (Denmark)

Author keywords

BK channel activator; BK channels; Drug design; Maxi K channels; Potassium channels; Synthesis

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; 2 AMINO 4 AZAINDOLE DERIVATIVE; 2 AMINP 3 CYANO 5 (2 FLUOROPHENYL) 4 METHYLPYRROLE; 3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; 3 AMINOQUINOLIN 2 ONE DERIVATIVE; 3 HYDROXYQUINOLIN 2 ONE; 3 MERCAPTOQUINOLIN 2 ONE; ANTIINFLAMMATORY AGENT; BENZANILIDE; BENZIMIDAZOLE DERIVATIVE; BMS 191011; BMS 223131; CGS 7181; CGS 7184; CHLORZOXAZONE; DIBENZYLTRIAZOLE; DITERPENE; EPOXYICOSATRIENOIC ACID; FLAVANOID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LY 1783; NIFLUMIC ACID; NS 1608; NS 8; OXADIAZOLONE DERIVATIVE; POTASSIUM CHANNEL STIMULATING AGENT; QUINOLONE DERIVATIVE; TAMOXIFEN; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASODILATOR AGENT;

BLOOD BRAIN BARRIER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DRUG ACTIVITY; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ERECTILE DYSFUNCTION; HEART PROTECTION; HUMAN; HYPERTENSION; NEUROLOGIC DISEASE; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; URINARY TRACT DISEASE;

EID: 33646804115     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018006776743242     Document Type: Review

References (121)

1. http://www.leaddiscovery.co.uk/reports/bs11report.html
2. Seebohm, G. Mol. Pharmacol., 2005, 67, 585-8.
3. Wickenden, A. Pharmacol. Ther., 2002, 94, 157-82.
4. Gopalakrishnan, M.; Shieh, C.C. Exp. Opin. Ther. Targets, 2004, 8, 437-58.
5. Moore, P. Nature, 2005, 438, 699-704.
6. Willumsen, N.J.; Bech, M.; Olesen, S.-P.; Jensen, B.S.; Korsgaard, M.P.; Christophersen, P. Receptors Channels, 2003, 9, 3-12.
7. Shieh, C.C.; Coghlan, M.; Sullivan, J.P.; Gopalakrishnan, M. Pharmacol. Rev., 2000, 52, 557-94.
8. Coghlan, M.J.; Carroll, W.A.; Gopalakrishnan, M. J. Med. Chem., 2001, 44, 1627-53.
9. Garcia, M.L.; Kaczorowski, G.J. Sci. STKE, 2005, 2005, pe46.
10. Heppner, T.J.; Herrera, G.M.; Bonev, A.D.; Hill-Eubanks, D.; Nelson, M.T. Adv. Exp. Med. Biol., 2003, 539, 347-57.
11. Meredith, A.L.; Thorneloe, K.S.; Werner, M.E.; Nelson, M.T.; Aldrich, R.W. J. Biol. Chem., 2004, 279, 36746-52.
12. Jaggar, J.H.; Wellman, G.C.; Heppner, T.J.; Porter, V.A.; Perez, G.J.; Gollasch, M.; Kleppisch, T.; Rubart, M.; Stevenson, A.S.; Lederer, W.J.; Knot, H.J.; Bonev, A.D.; Nelson, M.T. Acta Physiol. Scand., 1998, 164, 577-87.
13. Knaus, H.G.; Schwarzer, C.; Koch, R.O.; Eberhart, A.; Kaczorowski, G.J.; Glossmann, H.; Wunder, F.; Pongs, O.; Garcia, M.L.; Sperk, G. J. Neurosci., 1996, 16, 955-63.
14. Hu, H.; Shao, L.R.; Chavoshy, S.; Gu, N.; Trieb, M.; Behrens, R.; Laake, P.; Pongs, O.; Knaus, H.G.; Ottersen, O.P.; Storm, J.F. J. Neurosci., 2001, 21, 9585-97.
15. Brenner, R.; Chen, Q.H.; Vilaythong, A.; Toney, G.M.; Noebels, J.L.; Aldrich, R.W. Nat. Neurosci., 2005, 7, 1752-9.
16. Xu, W.; Liu, Y.; Wang, S.; McDonald, T.; Van Eyk, J.E.; Sidor, A.; O'Rourke, B. Science, 2002, 298, 1029-33.
17. Ohya, S.; Kuwata, Y.; Sakamoto, K.; Muraki, K.; Imaizumi, Y. Am. J. Physiol. Heart Circ. Physiol. , 2005, 289, H1635-42.
18. Beurg, M.; Hafidi, A.; Skinner, L.J.; Ruel, J.; Nouvian, R.; Henaff, M.; Puel, J.L.; Aran, J.M.; Dulon, D. Eur. J. Neurosci., 2005, 22, 1109-19.
19. Xu, J.W.; Slaughter, M.M. J. Neurosci., 2005, 25, 7660-8.
20. Werner, M.E.; Zvara, P.; Meredith, A.L.; Aldrich, R.W.; Nelson, M.T. J. Physiol., 2005, 567, 545-56.
21. Ningaraj, N.S.; Rao, M.; Black, K.L. Drug News Perspect., 2003, 16, 291-8.
22. Findlay, I.; Dunne, M.J.; Petersen, O.H. J. Memb. Biol., 1985, 83, 169-75.
23. Moczydlowski, E.; Alvarez, O.; Vergara, C.; Latorre, R. J. Membr. Biol., 1985, 83, 273-82.
24. Tricarico, D.; Mele, A.; Conte Camerino, D. Neurobiol. Dis., 2005, 20, 296-302.
25. Snetkov, V.A.; Ward, J.P. Exp. Physiol., 1999, 84, 835-846.
26. Sivarao, D.V.; Newberry, K.; Langdon, S.; Lee, A.V.; Hewawasam, P.; Plym, M.J.; Signor, L.; Myers, R.; Lodge, N.J. J. Pharmacol. Exp. Ther. , 2005, 313, 840-7.
27. Grunnet, M.; Hay-Schmidt, A.; Klaerke, D.A. Biochim. Biophys. Acta, 2005, 1714, 114-24.
28. Sato, T.; Saito, T.; Saegusa, N.; Nakaya, H. Circulation, 2005, 111, 198-203.
29. Shintani, Y.; Node, K.; Asanuma, H.; Sanada, S.; Takashima, S.; Asano, Y.; Liao, Y.; Fujita, M.; Hirata, A.; Shinozaki, Y.; Fukushima, T.; Nagamachi, Y.; Okuda, H.; Kim, J.; Tomoike, H.; Hori, M.; Kitakaze, M. J. Mol. Cell. Cardiol., 2004, 37, 1213-8.
30. Cao, C.M.; Chen, M.; Wong, T.M. Br. J. Pharmacol., 2005, 145, 984-91.
31. Mattson, M.P.; Kroemer, G. Trends Mol. Med., 2003, 9, 196-205.
32. Runden-Pran, E.; Haug, F.M.; Storm, J.F.; Ottersen, O.P. Neuroscience, 2002, 112, 277-88.
33. Gribkoff, V.K.; Starrett, J.E., Jr.; Dworetzky, S.I.; Hewawasam, P.; Boissard, C.G.; Cook, D. A.; Frantz, S.W.; Heman, K.; Hibbard, J.R.; Huston, K.; Johnson, G.; Krishnan, B.S.; Kinney, G.G.; Lombardo, L.A.; Meanwell, N.A.; Molinoff, P.B.; Myers, R.A.; Moon, S.L.; Ortiz, A.; Pajor, L.; Pieschl, R.L.; Post-Munson, D.J.; Signor, L.J.; Srinivas, N.; Taber, M.T.; Thalody, G.; Trojnacki, J.T.; Wiener, H.; Yeleswaram, K.; Yeola, S.W. Nat. Med., 2001, 7, 471-7.
34. Gribkoff, V.K.; Starrett, J.E., Jr.; Dworetzky, S.I. Adv. Pharmacol., 1997, 37, 319-48.
35. Rundfeldt, C. Epilepsy Res. , 1999, 35, 99-107.
36. Zhang, X. F.; Gopalakrishnan, M.; Shieh, C.C. Neuroscience, 2003, 122, 1003-11.
37. Xing, J.L.; Hu, S.J. Brain Res., 1999, 838, 218-21.
38. Olesen, S.-P.; Munch, E.; Watjen, F.; Drejer, J. Neuroreport, 1994, 5, 1001-4.
39. Olesen, S.-P.; Munch, E.; Moldt, P.; Drejer, J. Eur. J. Pharmacol., 1994, 251, 53-9.
40. Sheldon, J.H.; Norton, N.W.; Argentieri, T.M. J. Pharmacol. Exp. Ther., 1997, 283, 1193-200.
41. Alves, D.P.; Soares, A.C.; Francischi, J.N.; Castro, M.S.; Perez, A.C.; Duarte, I.D. Eur. J. Pharmacol. , 2004, 489, 59-65.
42. Khan, R.N.; Smith, S.K.; Ashford, M.L. Hum. Reprod., 1998, 13, 208-13.
43. Huang, Y.; Lau, C.W.; Ho, I.H. Eur. J. Pharmacol., 1997, 325, 21-7.
44. Malysz, J.; Buckner, S.A.; Daza, A.V.; Milicic, I.; Perez-Medrano, A.; Gopalakrishnan, M. Naunyn Schmiedebergs Arch. Pharmacol., 2004, 369, 481-9.
45. Hewawasam, P.; Fan, W.; Ding, M.; Flint, K.; Cook, D.; Goggins, G.D.; Myers, R.A.; Gribkoff, V.K.; Boissard, C.G.; Dworetzky, S.I.; Starrett, J.E., Jr.; Lodge, N.J. J. Med. Chem., 2003, 46, 2819-22.
46. Spektor, M.; Rodriguez, R.; Rosenbaum, R.S.; Wang, H.Z.; Melman, A.; Christ, G.J. J. Urol., 2002, 167, 2628-35.
47. Macmillan, S.; Sheridan, R.D.; Chilvers, E.R.; Patmore, L. Br. J. Pharmacol., 1995, 116, 1656-60.
48. Calderone, V. Curr. Med. Chem., 2002, 9, 1385-95.
49. Meanwell, N.A., Sit, S.-Y., Gao, J., Boissard, C.G., Lum-Ragan, J., Dworetzky, S.I., Gribkoff, V.K. Bioorg. Med. Chem. Lett., 1996, 6, 1641-1646.
50. Gribkoff, V.K.; Lum-Ragan, J.T.; Boissard, C.G.; Post-Munson, D.J.; Meanwell, N.A.; Starrett, J.E., Jr.; Kozlowski, E.S.; Romine, J.L.; Trojnacki, J.T.; McKay, M.C.; Zhong, J.; Dworetzky, S.I. Mol. Pharmacol., 1996, 50, 206-17.
51. Hewawasam, P., Meanwell, N.A., Gribkoff, V.K., Dworetzky, S.I., Boissard, C.G. Bioorg. Med. Chem. Lett., 1997, 7, 1255-1260.
52. Hewawasam, P.; Erway, M.; Moon, S.L.; Knipe, J.; Weiner, H.; Boissard, C.G.; Post-Munson, D.J.; Gao, Q.; Huang, S.; Gribkoff, V.K.; Meanwell, N.A. J. Med. Chem., 2002, 45, 1487-99.
53. Hewawasam, P.; Gribkoff, V.K.; Pendri, Y.; Dworetzky, S.I.; Meanwell, N.A.; Martinez, E.; Boissard, C.G.; Post-Munson, D.J.; Trojnacki, J.T.; Yeleswaram, K.; Pajor, L.M.; Knipe, J.; Gao, Q.; Perrone, R.; Starrett, J.E., Jr. Bioorg. Med. Chem. Lett., 2002, 12, 1023-6.
54. Hewawasam, P.; Meanwell, N.A.; Gribkoff, V.K. 1996, US5565483.
55. Hewawasam, P.; Meanwell, N.A.; Gribkoff, V.K. 1997, US5602169.
56. Kiesewetter, D.O.; Jagoda, E.M.; Starrett, J.E., Jr.; Gribkoff, V.K.; Hewawasam, P.; Srinivas, N.; Salazar, D.; Eckelman, W.C. Nucl. Med. Biol., 2002, 29, 55-9.
57. Cheney, J.A.; Weisser, J.D.; Bareyre, F.M.; Laurer, H.L.; Saatman, K.E.; Raghupathi, R.; Gribkoff, V.K.; Starrett, J.E., Jr.; McIntosh, T.K. J. Cereb. Blood Flow Metab. , 2001, 21, 396-403.
58. Starrett, J.E., Jr. et al. Abstracts of Papers, 227th ACS National meeting, Anaheim, CA, United States, 2004.
59. Schroder, R.L.; Strobaek, D.; Olesen, S.-P.; Christophersen, P. Pflugers Arch., 2003, 446, 607-16.
60. Schroder, R. L.; Jespersen, T.; Christophersen, P.; Strobaek, D.; Jensen, B.S.; Olesen, S.-P. Neuropharmacology, 2001, 40, 888-98.
61. Dupuis, D.S.; Schroder, R.L.; Jespersen, T.; Christensen, J.K.; Christophersen, P.; Jensen, B. S.; Olesen, S.-P. Eur. J. Pharmacol., 2002, 437, 129-37.
62. Korsgaard, M.P.; Hartz, B.P.; Brown, W.D.; Ahring, P.K.; Strobaek, D.; Mirza, N.R. J. Pharmacol. Exp. Ther., 2005, 314, 282-92.
63. Hewawasam, P.; Fan, W.; Knipe, J.; Moon, S.L.; Boissard, C.G.; Gribkoff, V.K.; Starrett, J.E. Bioorg. Med. Chem. Lett., 2002, 12, 1779-83.
64. Sit, S.-Y.; Meanwell, N.A. 1998, WO9823273.
65. Hewawasam, P.; Fan, W.; Cook, D.A.; Newberry, K.S.; Boissard, C.G.; Gribkoff, V.K.; Starrett, J.; Lodge, N.J. Bioorg. Med. Chem. Lett., 2004, 14, 4479-82.
66. Boy, K.M.; Guernon, J.M.; Sit, S.Y.; Xie, K.; Hewawasam, P.; Boissard, C.G.; Dworetzky, S. I.; Natale, J.; Gribkoff, V.K.; Lodge, N.; Starrett, J.E., Jr. Bioorg. Med. Chem. Lett., 2004, 14, 5089-93.
67. Boy, K.M. 2005, US2005096329.
68. Boy, K.; Hewawasam, P.; Sit, S.-Y.; Xie, K. 2005, US 2005176763
69. Vrudhula, V.M.; Dasgupta, B.; Boissard, C.G.; Gribkoff, V.K.; Santone, K.S.; Dalterio, R.A.; Lodge, N.J.; Starrett, J.E., Jr. Bioorg. Med. Chem. Lett., 2005, 15, 4286-90.
70. Romine, J.L.; Martin, S.W.; Gribkoff, V.K.; Boissard, C.G.; Dworetzky, S.I.; Natale, J.; Li, Y.; Gao, Q.; Meanwell, N.A.; Starrett, J.E., Jr. J. Med. Chem., 2002, 45, 2942-52.
71. Romine, J.L.; Martin, S.W.; Hewawasam, P.; Meanwell, N.A.; Gribkoff, V.K.; Starrett, J.E. Jr. 1998, WO9804135.
72. Hewawasam, P.; Ding, M.; Starrett, J.E. Jr, 1999, WO9938510.
73. Hewawasam, P.; Erway, M.; Thalody, G.; Weiner, H.; Boissard, C.G.; Gribkoff, V.K.; Meanwell, N.A.; Lodge, N.; Starrett, J.E., Jr. Bioorg. Med. Chem. Lett., 2002, 12, 1117-20.
74. Hewawasam, P.; Ding, M.; Chen, N.; King, D.; Knipe, J.; Pajor, L.; Ortiz, A.; Gribkoff, V.K.; Starrett, J. Bioorg. Med. Chem. Lett. , 2003, 13, 1695-8.
75. Calderone, V.; Giorgi, I.; Livi, O.; Martinotti, E.; Mantuano, E.; Martelli, A.; Nardi, A. Eur. J. Med. Chem., 2005, 40, 521-8.
76. Calderone, V.; Giorgi, I.; Livi, O.; Martinotti, E.; Martelli, A.; Nardi, A. Farmaco, 2005, 60, 367-75.
77. Biagi, G.; Calderone, V.; Giorgi, I.; Livi, O.; Martinotti, E.; Martelli, A.; Nardi, A. Farmaco, 2004, 59, 397-404.
78. Silverman, R.B. The Organic Chemistry of Drug Design and Drug Action, 2nd ed.; Elsevier Academic Press: London, 2004.
79. Biagi, G.; Giorgi, I.; Livi, O.; Nardi, A.; Calderone, V.; Martelli, A.; Martinotti, E.; LeRoy Salerni, O. Eur. J. Med. Chem., 2004, 39, 491-8.
80. Hosaka, T.; Kusama, M.; Ohba, K.; Kono, R.; Kohnomi, S., 2004, WO2004035570.
81. Kono, R.; Kohnomi, S.; Aihara, H.; Hosaka, T.; Kashiwagi, T., 2004, EP1400243.
82. Hongu, M.; Hosaka, T.; Kashiwagi, T.; Kono, R.; Kobayashi, H., 2002, WO2002083111.
83. Olesen, S.-P.; Moldt, P.; Pedersen, O., 1994, WO9422807.
84. Hu, S.; Kim, H.S. Eur. J. Pharmacol. , 1996, 318, 461-8.
85. Siemer, C.; Bushfield, M.; Newgreen, D.; Grissmer, S. J. Membr. Biol., 2000, 173, 57-66.
86. Mora, T.C.; Suarez-Kurtz, G. Br. J. Pharmacol., 2005, 144, 636-41.
87. Li, Y.; Johnson, G.; Romine, J.L.; Meanwell, N.A.; Martin, S.W.; Dworetzky, S.I.; Boissard, C.G.; Gribkoff, V.K.; Starrett, J.E., Jr. Bioorg. Med. Chem. Lett., 2003, 13, 1437-9.
88. Wu, S.N.; Chen, C.C.; Li, H.F.; Lo, Y.K.; Chen, S.A.; Chiang, H.T. Thorax, 2002, 57, 67-74.
89. Hu, S.; Fink, C.A.; Kim, H.S.; Lappe, R.W. Drug Dev. Res., 1997, 41, 10-21.
90. Butera, J.A.; Jenkins, D.J.; Lennox, J.R.; Sheldon, J.H.; Norton, N.W.; Warga, D.; Argentieri, T. M. Bioorg. Med. Chem .Lett., 2005, 15, 2495-501.
91. Butera, J.A.; Antane, S.A.; Hirth, B.; Lennox, J.R.; Sheldon, J.H.; Norton, N.W.; Warga, D.; Argentieri, T.M. Bioorg. Med. Chem. Lett., 2001, 11, 2093-7.
92. Gormemis, A.E.; Ha, T.S.; Im, I.; Jung, K.Y.; Lee, J.Y.; Park, C.S.; Kim, Y.C. Chembiochem., 2005, 6, 1745-1748.
93. Tanaka, M.; Sasaki, Y.; Hukui, T.; Kyotani, J.; Hayashi, S.; Hamada, K.; Kimura, Y.; Ukai, Y.; Kitano, M.; Kimura, K. J. Urol., 1998, 159, 21.
94. Tanaka, M.; Sasaki, Y.; Kimura, Y.; Fukui, T.; Hamada, K.; Ukai, Y. BJU Int. , 2003, 92, 1031-6.
95. http://www.nipponshinyaku.co.jp/english/business_act/reserch/develop.html
96. Turner, S.C.; Carroll, W.A.; White, T.K.; Gopalakrishnan, M.; Coghlan, M.J.; Shieh, C.C.; Zhang, X.F.; Parihar, A.S.; Buckner, S.A.; Milicic, I.; Sullivan, J.P. Bioorg. Med. Chem. Lett., 2003, 13, 2003-7.
97. Turner, S.C.; White, T.K.; Carroll, W.A. 2004, US2004192697.
98. Nardi, A.; Calderone, V.; Chericoni, S.; Morelli, I. Planta Med., 2003, 69, 885-92.
99. Calderone, V.; Chericoni, S.; Martinelli, C.; Testai, L.; Nardi, A.; Morelli, I.; Breschi, M.C.; Martinotti, E. Naunyn Schmiedebergs Arch. Pharmacol. , 2004, 370, 290-8.
100. Yi, L.; Starrett, J.E.; Meanwell, N.A.; Johnson, G.; Harte, W.E.; Dworetzky, S.I.; Boissard, C.G.; Gribkoff V.K. Bioorg. Med. Chem. Lett., 1997, 4, 759-762.
101. Imaizumi, Y.; Sakamoto, K.; Yamada, A.; Hotta, A.; Ohya, S.; Muraki, K.; Uchiyama, M.; Ohwada, T. Mol. Pharmacol., 2002, 62, 836-46.
102. Sakamoto, K.; Nonomura, T.; Ohya, S.; Muraki, K.; Ohwada, T.; Imaizumi, Y. J. Pharmacol. Exp. The., 2005, [Epub ahead of print].
103. Ohwada, T.; Nonomura, T.; Maki, K.; Sakamoto, K.; Ohya, S.; Muraki, K.; Imaizumi, Y. Bioorg. Med. Chem. Lett., 2003, 13, 3971-4.
104. Dick, G.M.; Rossow, C.F.; Smirnov, S.; Horowitz, B.; Sanders, K.M. J. Biol. Chem., 2001, 276, 34594-9.
105. Sha, Y.; Tashima, T.; Mochizuki, Y.; Toriumi, Y.; Adachi-Akahane, S.; Nonomura, T.; Cheng, M.; Ohwada, T. Chem. Pharm. Bull. (Tokyo), 2005, 53, 1372-3.
106. Wu, S.N. Curr. Med. Chem., 2003, 10, 649-61.
107. Liu, Y.C.; Lo, Y.K.; Wu, S.N. Brain Res., 2003, 959, 86-97.
108. Li, P.C.; Liang, J.T.; Huang, H.T.; Lin, P.H.; Wu, S.N. J. Cell. Physiol., 2002, 192, 188-99.
109. Giangiacomo, K.M.; Kamassah, A.; Harris, G.; McManus, O.B. J. Gen. Physiol., 1998, 112, 485-501.
110. Valverde, M.A.; Rojas, P.; Amigo, J.; Cosmelli, D.; Orio, P.; Bahamonde, M.I.; Mann, G.E.; Vergara, C.; Latorre, R. Science, 1999, 285, 1929-31.
111. Ahring, P.K.; Strobaek, D.; Christophersen, P.; Olesen, S.-P.; Johansen, T.E. FEBS Lett., 1997, 415, 67-70.
112. Strobaek, D.; Christophersen, P.; Holm, N.R.; Moldt, P.; Ahring, P.K.; Johansen, T.E.; Olesen, S.-P. Neuropharmacology, 1996, 35, 903-14.
113. Yamada, A.; Gaja, N.; Ohya, S.; Muraki, K.; Narita, H.; Ohwada, T.; Imaizumi, Y. Jpn. J. Pharmacol., 2001, 86, 342-50.
114. Fukao, M.; Mason, H.S.; Kenyon, J.L.; Horowitz, B.; Keef, K.D. Mol. Pharmacol., 2001, 59, 16-23.
115. Singh, S.B.; Goetz, M.A.; Zink, D.L.; Dombrowski, A.W.; Polishook, J.D.; Garcia, M.L.; Schmalhofer, W.; McManus, O.B.; Kaczorowski, G.J. J. Chem. Soc. Perkin. Trans., 1994, 1, 3349-3352.
116. Clarke, A.L.; Petrou, S.; Walsh, J.V., Jr.; Singer, J.J. Am. J. Physiol. Cell. Physiol., 2003, 284, C607-19.
117. Dumoulin, M.; Salvail, D.; Gaudreault, S.B.; Cadieux, A.; Rousseau, E. Am. J. Physiol., 1998, 275, L423-31.
118. Lee, S.H.; Hensens, O.D.; Helms, G.L.; Liesch, J.M.; Zink, D.L.; Giacobbe, R.A.; Bills, G.F.; Stevens-Miles, S.; Garcia, M.L.; Schmalhofer, W.A.; et al. J. Nat. Prod., 1995, 58, 1822-8.
119. McKay, M.C.; Dworetzky, S.I.; Meanwell, N.A.; Olesen, S.P.; Reinhart, P.H.; Levitan, I.B.; Adelman, J.P.; Gribkoff, V.K. J Neurophysiol., 1994, 71, 1873-82.
120. Holland, M.; Langton, P.D.; Standen, N.B.; Boyle, J.P. Br. J. Pharmacol., 1996, 117, 119-29.
121. Edwards, G.; Niederste-Hollenberg, A.; Schneider, J.; Noack, T.; Weston, A.H. Br. J. Pharmacol. , 1994, 113, 1538-47.