The balance shift in Th1/Th2 related IL-12/IL-5 cytokines in Graves' disease during methimazole therapy

Autoimmunity

Volumn 40, Issue 1, 2007, Pages 31-37

  Molnár, Ildikó ^a  

^a Kenezy Teaching Hospital   (Hungary)

Author keywords

Cytokines; Graves' disease; IL 12; IL 5; Methimazole therapy; Ophthalmopathy

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 5; THIAMAZOLE; THYROID HORMONE; THYROTROPIN RECEPTOR ANTIBODY;

ADULT; AGE; AGED; ANTIBODY BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE DISEASE; FEMALE; GRAVES DISEASE; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; THYROID HORMONE BLOOD LEVEL; TREATMENT DURATION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; FEMALE; GRAVES DISEASE; GRAVES OPHTHALMOPATHY; HUMANS; INTERLEUKIN-12; INTERLEUKIN-5; MALE; METHIMAZOLE; MIDDLE AGED; TH1 CELLS; TH2 CELLS; THYROID HORMONES;

EID: 33847418425     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930601165388     Document Type: Article

References (28)

1. Förster, G.,.Otto, E.,.Hansen, C.,.Ochs, K. and Kahaly, G. (1998) Analysis of orbital T cells in thyroid-associated ophthalmopathy. Clin Exp Immunol, 112, pp. 427-434.
2. Grubeck-Loebenstein, B.,.Trieb, K.,.Sztankay, A.,.Holter, W.,.Anderl, H. and Wick, G. (1994) Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ an specifically recognize autologous fibroblasts. J Clin Invest, 93, pp. 2738-2743.
3. Weetman, AP,.Ajjan, RA and Watson, PF (1997) Cytokines and Graves' disease. Bailliére's Clin Endocrinol Met, 11, pp. 481-497.
4. Romagnani, R. (2006) Regulatory T cells: Which role in the pathogenesis and treatment of allergic disorders?. Allergy, 61, pp. 3-14.
5. Yang, D.,.Hiromatsu, Y.,.Hoshino, T.,.Inoue, Y.,.Itoh, K. and Nonaka, K. (1999) Dominant infiltration of TH1-type CD4+ T cells at the retrobulbar space of patients with thyroid-associated ophthalmopathy. Thyroid, 9, pp. 305-310.
6. Ward, LS and Fernandes, GA (2000) Serum cytokine levels in autoimmune and non-autoimmune hyperthyroid states. Braz J Med Biol Res, 33, pp. 65-69.
7. Bahn, RS (2003) Pathophysiology of Graves' ophthalmopathy: The cycle of disease. J Clin Endocrinol Metab, 88, pp. 1939-1946.
8. Braley-Mullen, H.,.Sharp, GC,.Tang, H.,.Chen, K.,.Kyriakos, M. and Bickel, JT (1998) Interleukin-12 promotes activation of effector cells that induce a severe destructive granulomatous form of murine experimental autoimmune thyroiditis. Am J Pathol, 152, pp. 1347-1358.
9. Trinchieri, G. and Scott, P. (1994) The role of interleukin 12 in the immune response, disease and therapy. Immunol Today, 15, pp. 460-463.
10. Sanderson, CJ,.Campbell, HD and Young, IG (1988) Molecular and cellular biology of eosinophil differentiation factor (interleukin-5) and its effects on human and mouse B cells. Immunol Rev, 102, pp. 29-50.
11. Sanderson, CJ (1992) Interleukin-5, eosiniphils, and disease. Blood, 79, pp. 3101-3109.
12. Bagley, CJ,.Lopez, AF and Vadas, MA (1997) New frontiers for IL-5. J Allergy Clin Immunol, 99, pp. 725-728.
13. Balazs, C.,.Kiss, E.,.Leovey, A. and Farid, NR (1986) The immunosuppressive effect of methimazole on cell-mediated immunity is mediated by its capacity to inhibit peroxidase and to scavenge free oxygen radicals. Clin Endocrinol (Oxf), 25, pp. 7-16.
14. Werner, SC (1977) Modification of classification of eye changes of Graves' disease: Recommendations of the ad hoc Committee of American Thyroid Association. J Clin Endocrinol Metab, 44, pp. 203-204.
15. Pinkse, GGM,.Tysma, OHM,.Bergen, CAM,.Kester, MGD,.Ossendorp, F.,.van Veelen, PA,.Keymeulen, B.,.Pipeleers, D.,.Drijfhout, JW and Roep, BO (2005) Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes. Proc Natl Acad Sci USA, 102, pp. 18425-18430.
16. Hidaka, Y.,.Okumura, M.,.Shimaoka, Y.,.Takeoka, K.,.Tada, H. and Amino, N. (1998) Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis. Thyroid, 8, pp. 235-239.
17. Heuer, M.,.Aust, G.,.Ode-Hakim, S. and Scherbaum, WA (1996) Different cytokine mRNA profiles in Graves' disease, Hashimoto's thyroiditis, and nonautoimmune thyroid disorders determined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Thyroid, 6, pp. 97-106.
18. Takeoka, K.,.Hidaka, Y.,.Hanada, H.,.Nomura, T.,.Tanaka, S.,.Takano, T. and Amino, N. (2003) Increase in serum levels of autoantibodies after attack of seasonal allergic rhinitis in patients with Graves' disease. Int Arch Allergy Immunol, 132, pp. 268-276.
19. Molnar, I.,.Horvath, S. and Balazs, C. (1996) Detectable serum IgE levels in Graves' ophthalmopathy. Eur J Med Res, 1, pp. 543-546.
20. Raikow, RB,.Dalbow, MH,.Kennerdell, JS,.Compher, K.,.Machen, L.,.Hiller, W. and Blendermann, D. (1990) Immunohistochemical evidence for IgE involvement in Graves' orbitopathy. Ophthalmology, 97, pp. 629-635.
21. Dayan, CM and Daniels, GH (1996) Chronic autoimmune thyroiditis. N Engl J Med, 335, pp. 99-107.
22. Hidaka, Y.,.Okumura, M.,.Fukata, S.,.Shimaoka, Y.,.Takeoka, K.,.Tada, H.,.Kuma, K. and Amino, N. (1999) Increased serum concentration of interleukin-12 in patients with silent thyroiditis and Graves' disease. Thyroid, 9, pp. 149-153.
23. Tamaru, M.,.Matsuura, B. and Onji, M. (1999) Increased levels of serum interleukin-12 in Graves' disease. Eur J Endocrinol, 141, pp. 111-116.
24. Tamaru, M.,.Matsuura, B.,.Miyauchi, S. and Onji, M. (1999) Dendritic cells produce interleukin-12 in hyperthyroid mice. Eur J Endocrinol, 141, pp. 625-629.
25. Kocjan, T.,.Wraber, B.,.Kocijančič, A. and Hojker, S. (2004) Methimazole upregulates T-cell-derived cytokines without improving the existing Th1/Th2 imbalance in Graves' disease. J Endocrinol Invest, 27, pp. 302-307.
26. Roubenhoff, R.,.Harris, TB,.Abad, LW,.Wilson, PW,.Dallal, GE and Dinarello, CA (1998) Monocyte cytokine production in an elderly population: Effect of age and inflammation. J Gerontol A Biol Sci Med Sci, 53, pp. M20-M26.
27. Nikolich-Zugich, J. (2005) T cell aging: Naive but not young. J Exp Med, 201, pp. 837-840.
28. Eaton, SM,.Burns, EM,.Kusser, K.,.Randall, TD and Haynes, L. (2004) Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med, 200, pp. 1613-1622.