Analysis of orbital T cells in thyroid-associated ophthalmopathy

Clinical and Experimental Immunology

Volumn 112, Issue 3, 1998, Pages 427-434

  Forster G ^a   Otto, E ^a   Hansen, C ^a   Ochs, K ^a   Kahaly, G ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cytokine profiles; Orbital T cell lines; Thyroid antigens; Thyroid associated ophthalmopathy

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOTOXIN; MONOCLONAL ANTIBODY CD3; PROTEIN; STEROID; THYROGLOBULIN; THYROID PEROXIDASE; THYROTROPIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; EYE DISEASE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; LYMPHOCYTIC INFILTRATION; MALE; MONONUCLEAR CELL; ORBIT; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYROID GLAND;

ADULT; ANTIGENS, CD; CELL MOVEMENT; CYTOKINES; EYE; FEMALE; GRAVES DISEASE; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0031861644     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00613.x     Document Type: Article

References (39)

1. Burch HB, Wartofsky L. Graves' ophthalmopathy. Current concepts regarding pathogenesis and management. Endocr Rev 1993; 14:747-93.
2. Weetman AP. Thyroid-associated eye disease: pathophysiology. Lancet 1991; 338:25-28.
3. Weetman AP, Cohen S, Gatter KC, Fells P, Shine B. Immunohistochemical analysis of retrobulbar tissues in Graves' ophthalmopathy. Clin Exp Immunol 1989; 75:222-1.
4. Smith TJ, Bahn RS, Gorman CA, Cheavens M. Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts. J Clin Endocrinol Metab 1991; 72:1169-71.
5. Kahaly G, Stover C, Otto E, Beyer J, Schuler M. Glycosaminoglycans in thyroid-associated ophthalmopathy. Autoimmunity 1992; 13:81-88.
6. Hansen C, Otto E, Kuhlemann K, Förster G, Kahaly G. Glycosaminoglycans in autoimmunity. Clin Exp Rheumatol 1996; 14:59-67.
7. Tan GH, Dutton CM, Bahn RS. Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1 induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab 1996; 81:449-52.
8. Bahn RS, Heufelder AE. Pathogenesis of Graves' ophthalmopathy N Engl J Med 1993; 329:1468-75.
9. Hiromatsu Y, Tanaka K, Ishisaka N et al. Human histocompatibility leucocyte antigen-DR and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 1995; 80:685-91.
10. Kahaly G, Hansen C, Felke B, Dienes HP. Immunohistochemical staining of retrobulbar adipose tissue in Graves' ophthalmopathy. Clin Immunol Immunopathol 1994; 73:53-62.
11. + and specifically recognize autologous fibroblasts. J Clin Invest 1994; 93:2738-43.
12. Weetman AP. The role of T lymphocytes in thyroid-associated ophthalmopathy. Autoimmunity 1992; 13:69-73.
13. De Carli M, D'Elios MM, Mariotti S et al. Cytolytic T cells with Th1-like cytokine profile predominate in retroorbital lymphocytic infiltrates of Graves' ophthalmopathy. J Clin Endocrinol Metab 1993; 77:1120-4.
14. McLachlan SM, Prummel MF, Rapoport B. Cell-mediated or humoral immunity in Graves' ophthalmopathy? Profiles of T-cell cytokines amplified by polymerase chain reaction from orbital tissue. J Clin Endocrinol Metab 1994; 78:1070-4.
15. Pappa A, Calder V, Ajjan R, Fells P, Ludgate M. Weetman AP, Lightman S. Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy (TAO). Clin Exp Immunol 1997; 109:362-9.
16. Otto E, Ochs K, Leyendecker E et al. Autoimmune endocrine ophthalmopathy and retrobulbar antigens. Horm Metab Res 1995; 27:533-8.
17. Otto E, Ochs K, Hansen C, Wall J, Kahaly G. Orbital tissue-derived T lymphocytes from patients with Graves' ophthalmopathy recognize autologous orbital antigens. J Clin Endocrinol Metab 1996; 81:3045-50.
18. Arnold K, Tandon N, McIntosh RS, Elisei R, Ludgate M, Weetman AP. T cell responses to orbital antigens in thyroid-associated ophthalmopathy. Clin Exp Immunol 1994; 96:329-34.
19. Perros P, Kendall-Taylor P. Demonstration of thyrotropin binding sites in orbital connective tissue: possible role in the pathogenesis of thyroid-associated ophthalmopathy. J Endocrinol Invest 1994; 17:163-70.
20. Laemmli EK. Cleavage structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
21. Guile H, Schoel B, Kaufmann SHE. Direct blotting with viable cells of protein mixtures separated by two-dimensional gel electrophoresis. J Immunol Methods 1990; 133:253-61.
22. Londei M, Grubeck-Loebenstein B, de Berardinis P, Greenall C, Feldmann M. Efficient propagation and cloning of human T cells in the absence of antigen by means of OKT3, interleukin-2, and antigen-presenting cells. Scand J Immunol 1988; 27:35-46.
23. Yamamura M, Uyemura K, Deans RJ et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1991; 254:277-9.
24. Sorg R, Enczmann J, Sorg U, Heermeier K, Schneider EM, Wernet P. Rapid and sensitive mRNA phenotyping for interleukins (IL-1 to IL-6) and colony-stimulating factors (G-CSF, M-CSF, and GM-CSF) by reverse transcription and subsequent polymerase chain reaction. Exp Hematol 1991; 19:882-7.
25. Brenner CA, Tam AW, Nelson PA et al. Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cells. BioTechniques 1989; 7:1096-103.
26. + blood dendritic cells. Blood 1995; 86:3295-301.
27. Cony DB, Ampel NM, Christian L, Locksley RM, Galgiani JN. Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis. J Infect Dis 1996; 174:440-3.
28. Haubruck H, Mauch L, Cook NJ et al. Expression of recombinant human thyroid peroxidase by the baculovirus system and its use in ELISA screening for diagnosis of autoimmune thyroid disease. Autoimmunity 1993; 15:275-84.
29. Stover C, Otto E, Beyer J, Kahaly G. Cellular immunity and retrobulbar fibroblasts in Graves' ophthalmopathy. Thyroid 1994; 4:161-5.
30. Heufelder AE, Bahn RS. Detection and localization of cytokine immunoreactivity in retro-ocular connective tissue in Graves' ophthalmopathy. Eur J Clin Invest 1993; 23:10-17.
31. Hirano T. The biology of IL-6. Chem Immunol 1992; 51:153-80.
32. Moore KW, O'Garra A, de Waal Malefyt R, Viera P, Mosmann TR. Interleukin-10. Ann Rev Immunol 1993; 11:165-90.
33. Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S. Human IL-10 is produced by both type 1 helper (Th1), type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150:353-60.
34. Aust G, Heuer M, Laue S et al. Expression of tumor necrosis factor-alpha (TNF-α) mRNA and protein in pathological thyroid tissue and carcinoma cell lines. Clin Exp Immunol 1996; 105:148-54.
35. Schwarz EM, Salgame P, Bloom BR. Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. Proc Natl Acad Sci USA 1993; 90:7734-8.
36. Ridge JP, Fuchs EJ, Matzinger P. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996; 271:1723-6.
37. Sarzotti DS, Robbins PM, Hoffman I. Induction of protective CTL responses in newborn mice by murine retrovirus. Science 1996; 271:1726-8.
38. Forsthuber HC, Yip PV, Lehmann H. Induction of Th1 and Th2 immunity in neonatal mice. Science 1996; 271:1728-30.
39. Arnold K, Weetman AP. Cell-mediated immunity in thyroid-associated ophthalmopathy. Orbit 1996; 15:159-64.