Transcriptional activation of the oxytocin promoter by oestrogens uses a novel non-classical mechanism of oestrogen receptor action

Journal of Neuroendocrinology

Volumn 17, Issue 4, 2005, Pages 197-207

  Koohi, M K ^a   Ivell, R ^a,b   Walther, Norbert ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; OXYTOCIN; RALOXIFENE; TAMOXIFEN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; ESTROGEN RESPONSIVE ELEMENT; GEL MOBILITY SHIFT ASSAY; GENETIC CODE; GENETIC TRANSFECTION; GERM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ADENOCARCINOMA; ANIMALS; BREAST NEOPLASMS; CATTLE; CELL LINE, TUMOR; EPITHELIAL CELLS; ESTROGEN ANTAGONISTS; ESTROGENS; GENE EXPRESSION REGULATION; HUMANS; OXYTOCIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); UP-REGULATION;

EID: 17844386840     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01298.x     Document Type: Article

References (51)

1. Miller FD, Ozimek G, Milner RJ, Bloom FE. Regulation of neuronal oxytocin mRNA by ovarian steroids in the mature and developing hypothalamus. Proc Natl Acad Sci USA 1989; 86: 2468-2472.
2. Chibbar R, Toma JG, Mitchell BF, Miller FD. Regulation of neural oxytocin gene expression by gonadal steroids in pubertal rats. Mol Endocrinol 1990; 4: 2030-2038.
3. Lefebvre DL, Farookhi R, Larcher A, Neculeca J, Zingg HH. Uterine oxytocin gene expression: I. Induction during pseudopregnancy and the estrous cycle. Endocrinology 1994; 134: 2556-2561.
4. Burbach JPH, Adan RAH, van Tol HHM, Verbeeck MAE, Axelson JF, van Leeuwen FW, Beekman JM, Ab G. Regulation of the rat oxytocin gene by estradiol: examination of promoter activity in transfected cells and of messenger ribonucleic acid and peptide levels in the hypothalamo-neurohypophyseal system. J Neuroendocrinol 1990; 2: 633-639.
5. Richard S, Zingg HH, The human oxytocin gene promoter is regulated by estrogens. J Biol Chem 1990; 265: 6098-6103.
6. Stedronsky K, Telgmann R, Tillmann G, Walther N, Ivell R. The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene. J Neuroendocrinol 2002; 14: 472-485.
7. Wehrenberg U, von Goedecke S, Ivell R, Walther N. The orphan receptor SF-1 binds to the COUP-like element in the promoter of the actively transcribed oxytocin gene. J Neuroendocrinol 1994; 6: 1-4.
8. Wehrenberg U, Ivell R, Jansen M, von Goedecke S, Walther N. Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary. Proc Natl Acad Sci USA 1994; 91: 1440-1444.
9. Jensen EV, Jacobsen HI. Basic guides to the mechanism of estrogen action. Rec Progr Horm Res 1962; 18: 387-418.
10. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P. Human oestrogen receptor cDNA. sequence, expression and homology to v-erb-A. Nature 1986; 320: 134-139.
11. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996; 93: 5925-5930.
12. Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucl Acids Res 2001; 29: 2905-2919.
13. Webb P, Lopez GN, Uht RM, Kushner PJ. Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 1995; 9: 443-456.
14. Webb P, Nguyen P, Valentine C, Lopez GN, Kwok Gr McInerney E, Katzenellenbogen BS, Enmark E, Gustafsson JA, Nilsson S, Kushner PJ. The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol Endocrinol 1999; 13: 1672-1685.
15. Porter W, Saville B, Hoivik D, Safe S. Functional synergy between the transcription factor Sp1 and the estrogen receptor. Mol Endocrinol 1997; 11: 1569-1580.
16. Zou A, Marschke KB, Arnold KE, Berger EM, Fitzgerald P, Mais DE, Allegretto EA. Estrogen receptor beta activates the human retinoic acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen. Mol Endocrinol 1999; 13: 418-430.
17. Saville B, Wormke M, Wang F, Nguyen T, Emnark E, Kuiper G, Gustafsson JA, Safe S. Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J Biol Chem 2000; 275: 5379-5387.
18. Collins P, Webb C. Estrogen hits the surface. Nature Med 1999; 5: 1130-1131.
19. Kato S, Masuhiro Y, Watanabe M, Kobayashi Y, Takeyama KI, Endoh H, Yanagisawa J. Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways. Genes Cells 2000; 5: 593-601.
20. Wong CW, McNally C, Nickbarg E, Komma BS, Cheskis BJ. Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc Natl Acad Sci USA 2002; 99: 14783-14788.
21. Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 2003; 144: 4562-4574.
22. Frasor J, Stossi F, Danes JM, Komm B, Lyttle CR, Katzenellenbogen BS. Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res 2004; 64: 1522-1533.
23. Frasor J, Katzenellenbogen BS. Identification of genes selectively regulated by the SERM tamoxifen in breast cancer cells. Proc AACR 2004; 45: 1474.
24. Ruppert S, Scherer G, Schutz G. Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature 1984; 308: 554-557.
25. Jakacka M, Ito M, Weiss J, Chien PY, Gehm BD, Jameson JL. Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway. J Biol Chem 2001; 276: 13615-13621.
26. Walther N, Jansen M, Ergun S, Kascheike B, Ivell R. Sertoli cell lines established from H-2Kb-tsA58 transgenic mice differentially regulate the expression of cell-specific genes. Exp Cell Res 1996; 225: 411-421.
27. Clyne CD, Speed CJ, Zhou J, Simpson ER. Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 2002; 277: 20591-20597.
28. 28 Bonnelye E, Vanacker JM, Dittmar T, Begue A, Desbiens X, Denhardt DT, Aubin JE, Laudet V, Fournier B. The ERR-1 orphan receptor is a transcriptional activator expressed during bone development. Mol Endocrinol 1997; 11: 905-916.
29. Wilson TE, Fahrner TJ, Milbrandt J. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 1993; 13: 5794-5804.
30. Vanacker JM, Pettersson K, Gustafsson JA, Laudet V. Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta. EMBO J 1999; 18: 4270-4279.
31. Shughrue PJ, Dellovade TL, Merchenthaler I. Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-beta. Progr Brain Res 2002; 139: 15-29.
32. Walther N, Wehrenberg U, Brackmann B, Ivell R. Mapping of the bovine oxytocin gene control region: identification of binding sites for luteal nuclear proteins in the 5′ non-coding region of the gene. J Neuroendocrinol 1991; 3: 539-549.
33. Inoue S, Kondo S, Hashimoto M, Kondo T, Muramatsu M. Isolation of estrogen receptor-binding sites in human genomic DNA. Nucl Acids Res 1991; 19: 4091-4096.
34. Giguere V, Yang N, Segui P, Evans RM. Identification of a new class of steroid hormone receptors. Nature 1988; 331: 91-94.
35. Giguere V. To ERR in the estrogen pathway. Trends Endocrinol Metab 2002; 13: 220-225.
36. Pettersson K, Svensson K, Mattsson R, Carlsson B, Ohlsson R, Berkenstam R. Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev 1996; 54: 211-223.
37. Lu D, Kiriyama Y, Lee KY, Giguere V. Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors. Cancer Res 2001; 61: 6755-6761.
38. Johnston SD, Liu X, Zuo F, Eisenbraun TL, Wiley SR, Kraus RJ, Mertz JE. Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol 1997; 11: 342-351
39. Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lakins J, Lupu R. Expression and regulation of estrogen receptor beta in human breast tumors and cell lines. Oncol Rep 2000; 7: 157-167.
40. Sladek R, Bader JA, Giguere V. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol 1997; 17: 5400-5409.
41. Yang N, Shigeta H, Shi H, Teng CT. Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J Biol Chem 1996; 271: 5795-5804.
42. Yan ZH, Medvedev A, Hirose T, Gotoh H, Jetten AM. Characterization of the response element and DNA binding properties of the nuclear orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor. J Biol Chem 1997; 272: 10565-10572.
43. Greschik H, Wurtz JM, Hublitz P, Kohler F, Moras D, Schule R. Characterization of the DNA-binding and dimerization properties of the nuclear orphan receptor germ cell nuclear factor. Mol Cell Biol 1999; 19: 690-703.
44. Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 1999; 3: 521-526.
45. Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol 2002; 22: 7193-7203.
46. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H, Metzger D, Chambon P. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995; 270: 1491-1494.
47. Ikeda K, Ogawa S, Tsukui T, Horie-Inoue K, Ouchi Y, Kato S, Muramatsu M, Inoue S. Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription. Mol Endocrinol 2004; 18: 1131-1143.
48. Hentschke M, Susens U, Borgmeyer U. PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. Biochem Biophys Res Commun 2002; 299: 872-879.
49. Hentschke M, Borgmeyer U. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. Biochem Biophys Res Commun 2003; 312: 975-982.
50. Ivell R, Brackett KH, Fields MJ, Richter D. Ovulation triggers oxytocin gene expression in the bovine ovary. FEBS Lett 1985; 190: 263-267.
51. Burbach JPH, Lopes da Silva S, van Schaick HAS, Cox JJ, Adan RAH. transcription factors of the supraoptic nucleus: activation and repression of the oxytocin gene. In: Gross P, Richter D, Robertson GL, eds. Vasopressin. Paris: John Libbey Eurotext, 1993: 95-109.