-
1
-
-
0034269240
-
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
-
Aghazadeh B, Lowry WE, Huang XY, Rosen MK. (2000). Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell 102: 624-633.
-
(2000)
Cell
, vol.102
, pp. 624-633
-
-
Aghazadeh, B.1
Lowry, W.E.2
Huang, X.Y.3
Rosen, M.K.4
-
2
-
-
0025681492
-
Binding of SH2 domains of phospholipase Cγ1, GAP, and Src to activated growth factor receptors
-
Anderson D, Koch CA, Grey L, Ellis C,MoranMF, Pawson T. (1990). Binding of SH2 domains of phospholipase Cγ1, GAP, and Src to activated growth factor receptors. Science 250: 979-982.
-
(1990)
Science
, vol.250
, pp. 979-982
-
-
Anderson, D.1
Koch, C.A.2
Grey, L.3
Ellis, C.4
Moran, M.F.5
Pawson, T.6
-
3
-
-
33746363486
-
Domains, motifs, and scaffolds: The role of modular interactions in the evolution and wiring of cell signaling circuits
-
Bhattacharyya RP, Remenyi A, Yeh BJ, Lim WA. (2006). Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem 75: 655-680.
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 655-680
-
-
Bhattacharyya, R.P.1
Remenyi, A.2
Yeh, B.J.3
Lim, W.A.4
-
4
-
-
4043170088
-
Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors
-
Bilder D. (2004). Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 18: 1909-1925.
-
(2004)
Genes Dev
, vol.18
, pp. 1909-1925
-
-
Bilder, D.1
-
5
-
-
0029896163
-
Regulation, substrates and functions of Src
-
Brown MT, Cooper JA. (1996). Regulation, substrates and functions of Src. Biochem Biophys Acta 1287: 121-149.
-
(1996)
Biochem Biophys Acta
, vol.1287
, pp. 121-149
-
-
Brown, M.T.1
Cooper, J.A.2
-
6
-
-
0033582929
-
Akt promotes cell survival by phosphoylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999). Akt promotes cell survival by phosphoylating and inhibiting a forkhead transcription factor. Cell 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
-
7
-
-
0033974061
-
Regulatory and signaling properties of the Vav family
-
Bustelo XR. (2000). Regulatory and signaling properties of the Vav family. Mol Cell Biol 20: 1461-1477.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1461-1477
-
-
Bustelo, X.R.1
-
8
-
-
0141757323
-
Reprogramming control of an allosteric signaling switch through modular recombination
-
Dueber JE, Yeh BJ, Chak K, Lim WA. (2003). Reprogramming control of an allosteric signaling switch through modular recombination. Science 301: 1904-1908.
-
(2003)
Science
, vol.301
, pp. 1904-1908
-
-
Dueber, J.E.1
Yeh, B.J.2
Chak, K.3
Lim, W.A.4
-
9
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. (2006). The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
10
-
-
0033613455
-
Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling
-
Frischknecht F, Moreau V, Rottger S, Gonfloni S, Reckmann I, Superti-Furga G et al. (1999). Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling. Nature 401: 926-929.
-
(1999)
Nature
, vol.401
, pp. 926-929
-
-
Frischknecht, F.1
Moreau, V.2
Rottger, S.3
Gonfloni, S.4
Reckmann, I.5
Superti-Furga, G.6
-
11
-
-
0034842129
-
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells
-
Gruenheid S, DeVinney R, Bladt F, Goosney D, Gelkop S, Gish GD et al. (2001). Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol 3: 856-859.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 856-859
-
-
Gruenheid, S.1
DeVinney, R.2
Bladt, F.3
Goosney, D.4
Gelkop, S.5
Gish, G.D.6
-
12
-
-
27144529182
-
Ubiquitylation and cell signaling
-
Haglund K, Dikic I. (2005). Ubiquitylation and cell signaling. EMBO J 24: 3353-3359.
-
(2005)
EMBO J
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
13
-
-
0037089427
-
The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl
-
He Y, Wertheim JA, XuL, Miller JP, Karnell FG, Choi JK et al. (2002). The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. Blood 99: 2957-2968.
-
(2002)
Blood
, vol.99
, pp. 2957-2968
-
-
He, Y.1
Wertheim, J.A.2
Xu, L.3
Miller, J.P.4
Karnell, F.G.5
Choi, J.K.6
-
14
-
-
0028838012
-
Dimerization of cell surface receptors in signal transduction
-
Heldin CH. (1995). Dimerization of cell surface receptors in signal transduction. Cell 80: 213-223.
-
(1995)
Cell
, vol.80
, pp. 213-223
-
-
Heldin, C.H.1
-
15
-
-
0141483011
-
-
Howard PL, Chia MC, Del Rizzo S, LiuF-F, Pawson T. (2003). Re-directing tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci USA 100: 11267-11272.
-
Howard PL, Chia MC, Del Rizzo S, LiuF-F, Pawson T. (2003). Re-directing tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci USA 100: 11267-11272.
-
-
-
-
16
-
-
0346156078
-
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor
-
Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. (2003). Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell 12: 1379-1389.
-
(2003)
Mol Cell
, vol.12
, pp. 1379-1389
-
-
Hu, J.1
Liu, J.2
Ghirlando, R.3
Saltiel, A.R.4
Hubbard, S.R.5
-
17
-
-
0030766163
-
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
-
Hubbard SR. (1997). Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J 16: 5572-5581.
-
(1997)
EMBO J
, vol.16
, pp. 5572-5581
-
-
Hubbard, S.R.1
-
18
-
-
0033786922
-
Protein tyrosine kinase structure and function
-
Hubbard SR, Till JH. (2000). Protein tyrosine kinase structure and function. Annu Rev Biochem 69: 373-398.
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 373-398
-
-
Hubbard, S.R.1
Till, J.H.2
-
19
-
-
0034614490
-
Signaling - 2000 and beyond
-
Hunter T. (2000). Signaling - 2000 and beyond. Cell 100: 113-127.
-
(2000)
Cell
, vol.100
, pp. 113-127
-
-
Hunter, T.1
-
20
-
-
30544449081
-
A quantitative protein interaction network for the ErbB receptors using protein microarrays
-
Jones RB, Gordus A, Krall JA, Macbeath G. (2006). A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439: 168-174.
-
(2006)
Nature
, vol.439
, pp. 168-174
-
-
Jones, R.B.1
Gordus, A.2
Krall, J.A.3
Macbeath, G.4
-
21
-
-
0034624753
-
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
-
Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. (2000). Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404: 151-158.
-
(2000)
Nature
, vol.404
, pp. 151-158
-
-
Kim, A.S.1
Kakalis, L.T.2
Abdul-Manan, N.3
Liu, G.A.4
Rosen, M.K.5
-
22
-
-
20844448882
-
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species
-
Kim JH, Chu SC, Gramlich JL, Pride YB, Babendreier E, Chauhan D et al. (2005). Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood 105: 1717-1723.
-
(2005)
Blood
, vol.105
, pp. 1717-1723
-
-
Kim, J.H.1
Chu, S.C.2
Gramlich, J.L.3
Pride, Y.B.4
Babendreier, E.5
Chauhan, D.6
-
23
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran M, Seshagiri S, Zha J, ZhuW, Bhawe K, Mendoza N et al. (2006). Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 66: 283-289.
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
Zhu, W.4
Bhawe, K.5
Mendoza, N.6
-
24
-
-
33745185987
-
The human and mouse complement of SH2 domain proteins - establishing the boundaries of phosphotyrosine signaling
-
Liu BA, Jabonowski K, Raina M, Arce M, Pawson T, Nash PD. (2006). The human and mouse complement of SH2 domain proteins - establishing the boundaries of phosphotyrosine signaling. Mol Cell 22: 851-868.
-
(2006)
Mol Cell
, vol.22
, pp. 851-868
-
-
Liu, B.A.1
Jabonowski, K.2
Raina, M.3
Arce, M.4
Pawson, T.5
Nash, P.D.6
-
25
-
-
17844400362
-
Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3
-
Llorca O, Arias-Palomo E, Zugaza L, Bustelo XR. (2005). Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3. EMBO J 24: 1330-1340.
-
(2005)
EMBO J
, vol.24
, pp. 1330-1340
-
-
Llorca, O.1
Arias-Palomo, E.2
Zugaza, L.3
Bustelo, X.R.4
-
26
-
-
1542374119
-
Parsing the polarity code
-
Macara IG. (2004). Parsing the polarity code. Nat Rev Mol Cell Biol 5: 220-231.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 220-231
-
-
Macara, I.G.1
-
27
-
-
0027422977
-
A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins
-
McWhirter JR, Galasso DL, Wang JY. (1993). A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol Cell Biol 13: 7587-7595.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7587-7595
-
-
McWhirter, J.R.1
Galasso, D.L.2
Wang, J.Y.3
-
28
-
-
0034661522
-
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase
-
Million RP, Van Etten RA. (2000). The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase. Blood 96: 664-670.
-
(2000)
Blood
, vol.96
, pp. 664-670
-
-
Million, R.P.1
Van Etten, R.A.2
-
29
-
-
0035962644
-
Histone deacetylases: A common molecular target for differentiation treatment of acute myeloid leukemias
-
Minucci S, Nervi C, Lo Coco F, Pelicci PG. (2001). Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias. Oncogene 20: 3110-3115.
-
(2001)
Oncogene
, vol.20
, pp. 3110-3115
-
-
Minucci, S.1
Nervi, C.2
Lo Coco, F.3
Pelicci, P.G.4
-
30
-
-
0344626926
-
Structural basis for the autoinhibition of c-Abl tyrosine kinase
-
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W et al. (2003). Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 112: 859-872.
-
(2003)
Cell
, vol.112
, pp. 859-872
-
-
Nagar, B.1
Hantschel, O.2
Young, M.A.3
Scheffzek, K.4
Veach, D.5
Bornmann, W.6
-
31
-
-
0034193568
-
Protein-protein interactions define specificity in signal transduction
-
Pawson T, Nash P. (2000). Protein-protein interactions define specificity in signal transduction. Genes Dev 14: 1027-1047.
-
(2000)
Genes Dev
, vol.14
, pp. 1027-1047
-
-
Pawson, T.1
Nash, P.2
-
32
-
-
0037453510
-
Assembly of cell regulatory systems through protein interaction domains
-
Pawson T, Nash P. (2003). Assembly of cell regulatory systems through protein interaction domains. Science 300: 445-452.
-
(2003)
Science
, vol.300
, pp. 445-452
-
-
Pawson, T.1
Nash, P.2
-
33
-
-
0027368352
-
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
-
Pendergast AM, Quilliam LA, Cripe LD, Bassing CH, Dai Z, Li N et al. (1993). BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 75: 175-185.
-
(1993)
Cell
, vol.75
, pp. 175-185
-
-
Pendergast, A.M.1
Quilliam, L.A.2
Cripe, L.D.3
Bassing, C.H.4
Dai, Z.5
Li, N.6
-
34
-
-
0028147448
-
BCR-ABL oncoproteins bind directly to activators of the ras signalling pathway
-
Puil L, Liu X, Gish G, Mbamalu G, Bowtell D, Pelicci PG et al. (1994). BCR-ABL oncoproteins bind directly to activators of the ras signalling pathway. EMBO J 13: 764-773.
-
(1994)
EMBO J
, vol.13
, pp. 764-773
-
-
Puil, L.1
Liu, X.2
Gish, G.3
Mbamalu, G.4
Bowtell, D.5
Pelicci, P.G.6
-
35
-
-
0025350375
-
The Philadelphia chromosome translocation. A paradigm for understanding leukemia
-
Rowley JD. (1990). The Philadelphia chromosome translocation. A paradigm for understanding leukemia. Cancer 65: 2178-2184.
-
(1990)
Cancer
, vol.65
, pp. 2178-2184
-
-
Rowley, J.D.1
-
36
-
-
19044372472
-
Critical role for Gab2 in transformation by BCR/ABL
-
Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K et al. (2002). Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell 1: 479-492.
-
(2002)
Cancer Cell
, vol.1
, pp. 479-492
-
-
Sattler, M.1
Mohi, M.G.2
Pride, Y.B.3
Quinnan, L.R.4
Malouf, N.A.5
Podar, K.6
-
37
-
-
0031034930
-
Crystal structure of the Src family tyrosine kinase Hck
-
Sicheri F, Moarefi I, Kuriyan J. (1997). Crystal structure of the Src family tyrosine kinase Hck. Nature 385: 602-609.
-
(1997)
Nature
, vol.385
, pp. 602-609
-
-
Sicheri, F.1
Moarefi, I.2
Kuriyan, J.3
-
38
-
-
30544452459
-
The hScrib/Dig apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins
-
Thomas M, Massimi P, Navarro C, Borg JP, Banks L. (2005). The hScrib/Dig apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Oncogene 24: 6222-6230.
-
(2005)
Oncogene
, vol.24
, pp. 6222-6230
-
-
Thomas, M.1
Massimi, P.2
Navarro, C.3
Borg, J.P.4
Banks, L.5
-
39
-
-
0021176463
-
Mutagenesis of Fujinami sarcoma virus: Evidence that tyrosine phosphorylation of P130gap-fps modulates its biological activity
-
Weinmaster G, Zoller MJ, Smith M, Hinze E, Pawson T. (1984). Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gap-fps modulates its biological activity. Cell 37: 559-568.
-
(1984)
Cell
, vol.37
, pp. 559-568
-
-
Weinmaster, G.1
Zoller, M.J.2
Smith, M.3
Hinze, E.4
Pawson, T.5
-
40
-
-
0031025991
-
Three-dimensional structure of the tyrosine kinase c-Src
-
Xu W, Harrison SC, Eck MJ. (1997). Three-dimensional structure of the tyrosine kinase c-Src. Nature 385: 595-602.
-
(1997)
Nature
, vol.385
, pp. 595-602
-
-
Xu, W.1
Harrison, S.C.2
Eck, M.J.3
-
41
-
-
0013033597
-
The structure and function of proline recognition domains
-
Zarrinpar A, Bhattacharyya RP, Lim WA. (2003). The structure and function of proline recognition domains. Sci STKE, 2003. RE8.
-
(2003)
Sci STKE
, vol.2003
-
-
Zarrinpar, A.1
Bhattacharyya, R.P.2
Lim, W.A.3
-
43
-
-
33745161824
-
Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization
-
Zhou J, Peres L, Honore N, Nasr R, Zhu J, de The H. (2006). Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization. Proc Natl Acad Sci USA 103: 9238-9243.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9238-9243
-
-
Zhou, J.1
Peres, L.2
Honore, N.3
Nasr, R.4
Zhu, J.5
de The, H.6
-
44
-
-
13844269220
-
A sumoylation site in PML. RARA is essential for leukemic transformation
-
Zhu J, Zhou J, Peres L, Riaucoux F, Honore N, Kogan S et al. (2005). A sumoylation site in PML. RARA is essential for leukemic transformation. Cancer Cell 7: 143-153.
-
(2005)
Cancer Cell
, vol.7
, pp. 143-153
-
-
Zhu, J.1
Zhou, J.2
Peres, L.3
Riaucoux, F.4
Honore, N.5
Kogan, S.6
|