Proposed criteria for specific and non-specific chromosomal genotoxicity based on hydrophobic interactions

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 628, Issue 2, 2007, Pages 67-75

  Dorn, Susanne B ^a   Degen, Gisela H ^a   Müller, Tina ^a,b   Bonacker, Daniela ^a   Joosten, Harrie F P ^c   van der Louw, Jaap ^c   van Acker, Frederique A A ^c   Bolt, Hermann M ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c NV ORGANON   (Netherlands)

Author keywords

Genistein; Genotoxicity; Hormonal steroids; Hydrophobic interactions; Micronucleus test

Indexed keywords

17 PROPYLMESTEROLONE; BENZONITRILE; CLASTOGEN; DAIDZEIN; DIAMIDE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); GENISTEIN; NITROBENZENE; PHYTOESTROGEN; STEROID;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHROMOSOME ABERRATION; CHROMOSOME DISORDER; CONTROLLED STUDY; CYTOKINESIS; DATA BASE; DNA STRAND BREAKAGE; EXPERIMENTAL STUDY; GENOTOXICITY; HYDROPHOBICITY; IN VITRO STUDY; LIPOPHILICITY; MICRONUCLEUS TEST; MITOSIS SPINDLE; MOLECULAR INTERACTION; MULTINUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; SENSITIVITY ANALYSIS; STATISTICAL ANALYSIS;

ALGORITHMS; ANIMALS; CELLS, CULTURED; CRICETINAE; CRICETULUS; DATABASES; DNA DAMAGE; HYDROPHOBICITY; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; SENSITIVITY AND SPECIFICITY;

CRICETULUS GRISEUS;

EID: 33847264839     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.11.012     Document Type: Article

References (28)

1. Schultz N., and Önfelt A. Sensitivity of cytokinesis to hydrophobic interactions. Chemical induction of bi- and multinucleated cells. Chem. Biol. Interact. 126 (2000) 97-123
2. Joosten H.F., van Acker F.A., van den Dobbelsteen D.J., Horbach G.J., and Krajnc E.I. Genotoxicity of hormonal steroids. Toxicol. Lett. 151 (2004) 113-134
3. Bolt H.M. Genotoxicity-threshold or not? Introduction of cases of industrial chemicals. Toxicol. Lett. 140/141 (2003) 43-51
4. Foth H., Degen G.H., and Bolt H.M. New aspects in the classification of carcinogens. Arh. Hig. Rada. Toksikol. 56 (2005) 165-173
5. Bonacker D., Stoiber T., Böhm K.J., Unger E., Degen G.H., Thier R., and Bolt H.M. Chromosomal genotoxicity of nitrobenzene and benzonitrile. Arch. Toxicol. 78 (2004) 49-57
6. Di Virgilio A.L., Iwami K., Wätjen W., Kahl R., and Degen G.H. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicol. Lett. 151/152 (2004) 151-162
7. Kulling S.E., Rosenberg B., Jacobs E., and Metzler M. The phytoestrogens coumestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes. Arch. Toxicol. 73 (1999) 605-613
8. von der Hude W., Kalweit S., Engelhardt G., McKiernan S., Kasper P., Slacik-Erben R., Miltenburger H.G., Honarvar N., Fahrig R., Gorlitz B., Albertini S., Kirchner S., Utesch D., Potter-Locher F., Stopper H., and Madle S. In vitro micronucleus assay with Chinese hamster V 79 cells-results of a collaborative study with in situ exposure to 26 chemical substances. Mutat. Res. 468 (2000) 137-163
9. Lehmann L., Wagner J., and Metzler M. Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. Food Chem. Toxicol. 44 (2006) 398-408
10. In: Hansch C., Leo A., and Hoekma D. (Eds). Exploring QSAR-Hydrophobic, Electronic, and Steric Constants (1995), American Chemical Society, Washington, DC
11. Borenfreund E., Babich H., and Martin-Alguacil N. Comparisons of two in vitro cytotoxicity assays-the neutral red (NR) and tetrazolium MTT test. Toxicol. In Vitro 2 (1988) 1-6
12. Nociari M.M., Shalev A., Benias P., and Russo C. A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J. Immunol. Methods 213 (1998) 157-167
13. O'Brien J., Wilson I., Orton T., and Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 267 (2000) 5421-5426
14. Goegan P., Johnson G., and Vincent R. Effects of serum protein and colloid on the alamarBlue assay in cell cultures. Toxicol. In Vitro 9 (1995) 257-266
15. Matsuoka A., Yamazaki N., Suzuki T., Hayashi M., and Sofuni T. Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat. Res. 272 (1992) 223-236
16. Countryman P.I., and Heddle J.A. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res. 41 (1976) 321-332
17. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res. 285 (1993) 35-44
18. Renzi L., Pacchierotti F., and Russo A. The centromere as a target for the induction of chromosome damage in resting and proliferating mammalian cells: assessment of mitomycin C-induced genetic damage at kinetochores and centromeres by a micronucleus test in mouse splenocytes. Mutagenesis 11 (1996) 133-138
19. Russo A., Stocco A., and Majone F. Identification of kinetochore-containing (CREST+) micronuclei in mouse bone marrow erythrocytes. Mutagenesis 7 (1992) 195-197
20. Miller B.M., and Adler I.D. Application of antikinetochore antibody staining (CREST staining) to micronuclei in erythrocytes induced in vivo. Mutagenesis 5 (1990) 411-415
21. Schuler M., Rupa D.S., and Eastmond D.A. A critical evaluation of centromeric labeling to distinguish micronuclei induced by chromosomal loss and breakage in vitro. Mutat. Res. 392 (1997) 81-95
22. Rousseeuw P.J., and Leroy A.M. Robust Regression and Outlier Detection (1987), Wiley, New York
23. Salti G.I., Grewal S., Mehta R.R., Das Gupta T.K., Boddie A.W., and Constantinou A.I. Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells. Eur. J. Cancer 36 (2000) 796-802
24. Lynch A., Harvey J., Aylott M., Nicholas E., Burman M., Siddiqui A., Walker S., and Rees R. Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity. Mutagenesis 18 (2003) 345-353
25. Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
26. Kalweit S., Utesch D., von der Hude W., and Madle S. Chemically induced micronucleus formation in V79 cells-comparison of three different test approaches. Mutat. Res. 439 (1999) 183-190
27. Matsushima M., Hayashi M., Matsuoka A., Ishidate M., Miura K.F., Shimizu H., Suzuki Y., Morimoto K., Ogura H., Mure K., Koshi K., and Sofuni T. Validation study of the micro-nucleus test in a Chinese hamster lung cell line (CHL/IU). Mutagenesis 14 (1999) 569-580
28. Kirsch-Volders M., Sofuni T., Aardema M., Albertini S., Eastmond D., Fenech M., Ishidate Jr. M., Lorge E., Norppa H., Surralles J., von der Hude W., and Wakata A. Report from the In Vitro Micronucleus Assay Working Group. Environ. Mol. Mutagen. 35 (2000) 167-172