-
1
-
-
0037372003
-
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
-
Jaenisch R., and Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 (2003) 245-254
-
(2003)
Nat Genet
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
2
-
-
0346888538
-
The epigenome as a target for cancer chemoprevention
-
Kopelovich L., Crowell J.A., and Fay J.R. The epigenome as a target for cancer chemoprevention. J Natl Cancer Inst 95 23 (2003) 1747-1757
-
(2003)
J Natl Cancer Inst
, vol.95
, Issue.23
, pp. 1747-1757
-
-
Kopelovich, L.1
Crowell, J.A.2
Fay, J.R.3
-
3
-
-
0035755974
-
Histone deacetylases and cancer: causes and therapies
-
Marks P.A., Rifkind R.A., Richon V.M., Breslow R., Miller T., and Kelly W.K. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1 3 (2001) 194-202
-
(2001)
Nat Rev Cancer
, vol.1
, Issue.3
, pp. 194-202
-
-
Marks, P.A.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
4
-
-
0037169358
-
Apoptosis: a link between cancer genetics and chemotherapy
-
Johnstone R.W., Ruefli A.A., and Lowe S.W. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108 (2002) 153-164
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
5
-
-
0642286534
-
Protein deacetylases: enzymes with functional diversity as novel therapeutic targets
-
Yoshida M., Shimazu T., and Matsuyama A. Protein deacetylases: enzymes with functional diversity as novel therapeutic targets. Prog Cell Cycle Res 5 (2003) 269-278
-
(2003)
Prog Cell Cycle Res
, vol.5
, pp. 269-278
-
-
Yoshida, M.1
Shimazu, T.2
Matsuyama, A.3
-
6
-
-
0141988610
-
Histone deacetylase inhibitors: the Abbott experience
-
Curtin M., and Glaser K. Histone deacetylase inhibitors: the Abbott experience. Curr Med Chem 10 22 (2003) 2373-2392
-
(2003)
Curr Med Chem
, vol.10
, Issue.22
, pp. 2373-2392
-
-
Curtin, M.1
Glaser, K.2
-
7
-
-
0141885036
-
Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: synthesis and antiproliferative evaluation
-
Delorme B.A. Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: synthesis and antiproliferative evaluation. Curr Med Chem 10 22 (2003) 2359-2372
-
(2003)
Curr Med Chem
, vol.10
, Issue.22
, pp. 2359-2372
-
-
Delorme, B.A.1
-
9
-
-
0141953928
-
The discovery of NVP-LAQ824: from concept to clinic
-
Remiszewski S. The discovery of NVP-LAQ824: from concept to clinic. Curr Med Chem 10 22 (2003) 2393-2402
-
(2003)
Curr Med Chem
, vol.10
, Issue.22
, pp. 2393-2402
-
-
Remiszewski, S.1
-
10
-
-
2942659322
-
Oncogenic potential of the RUNX gene family: 'overview'
-
Ito Y. Oncogenic potential of the RUNX gene family: 'overview'. Oncogene 23 24 (2004) 4198-4208
-
(2004)
Oncogene
, vol.23
, Issue.24
, pp. 4198-4208
-
-
Ito, Y.1
-
11
-
-
0030666372
-
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
-
Otto F., Thornell A.P., Crompton T., Denzel A., Gilmour K.C., Rosewell I.R., et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89 (1997) 765-771
-
(1997)
Cell
, vol.89
, pp. 765-771
-
-
Otto, F.1
Thornell, A.P.2
Crompton, T.3
Denzel, A.4
Gilmour, K.C.5
Rosewell, I.R.6
-
12
-
-
18344389720
-
Causal relationship between the loss of RUNX3 expression and gastric cancer
-
Li Q.L., Ito K., Sakakura C., Fukamachi H., Inoue K., Chi X.Z., et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109 1 (2002) 113-124
-
(2002)
Cell
, vol.109
, Issue.1
, pp. 113-124
-
-
Li, Q.L.1
Ito, K.2
Sakakura, C.3
Fukamachi, H.4
Inoue, K.5
Chi, X.Z.6
-
13
-
-
24744470103
-
RUNX3, a novel tumor suppressor, is highly inactivated in gastric cancer by protein mislocalization
-
Ito K., Liu Q., Salto-Tellez M., Yano T., Tada K., Ida H., et al. RUNX3, a novel tumor suppressor, is highly inactivated in gastric cancer by protein mislocalization. Cancer Res 65 (2005) 7743-7750
-
(2005)
Cancer Res
, vol.65
, pp. 7743-7750
-
-
Ito, K.1
Liu, Q.2
Salto-Tellez, M.3
Yano, T.4
Tada, K.5
Ida, H.6
-
14
-
-
24344500170
-
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD
-
Chi X.Z., Yang J.O., Lee K.Y., Ito K., Sakakura C., Li Q.L., et al. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol 25 18 (2005) 8097-8107
-
(2005)
Mol Cell Biol
, vol.25
, Issue.18
, pp. 8097-8107
-
-
Chi, X.Z.1
Yang, J.O.2
Lee, K.Y.3
Ito, K.4
Sakakura, C.5
Li, Q.L.6
-
15
-
-
33746121227
-
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
-
Lau Q.C., Raja E., Salto-Tellez M., Liu Q., Ito K., Inoue M., et al. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res 66 13 (2006) 6512-6520
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6512-6520
-
-
Lau, Q.C.1
Raja, E.2
Salto-Tellez, M.3
Liu, Q.4
Ito, K.5
Inoue, M.6
-
16
-
-
22944435843
-
RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer
-
Imamura Y., Hibi K., Koike M., Fujiwara M., Kodera Y., Ito K., et al. RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer. Anticancer Res 25 4 (2005) 2627-2630
-
(2005)
Anticancer Res
, vol.25
, Issue.4
, pp. 2627-2630
-
-
Imamura, Y.1
Hibi, K.2
Koike, M.3
Fujiwara, M.4
Kodera, Y.5
Ito, K.6
-
17
-
-
33644876855
-
Epigenetic inactivation of the RUNX3 gene in lung cancer
-
Sato K., Tomizawa Y., Iijima H., Saito R., Ishizuka T., Nakajima T., et al. Epigenetic inactivation of the RUNX3 gene in lung cancer. Oncol Rep 15 1 (2006) 129-135
-
(2006)
Oncol Rep
, vol.15
, Issue.1
, pp. 129-135
-
-
Sato, K.1
Tomizawa, Y.2
Iijima, H.3
Saito, R.4
Ishizuka, T.5
Nakajima, T.6
-
18
-
-
24944523611
-
Hypermethylation of the RUNX3 gene in hepatocellular carcinoma
-
Park W.S., Cho Y.G., Kim C.J., Song J.H., Lee Y.S., Kim S.Y., et al. Hypermethylation of the RUNX3 gene in hepatocellular carcinoma. Exp Mol Med 37 4 (2005) 276-281
-
(2005)
Exp Mol Med
, vol.37
, Issue.4
, pp. 276-281
-
-
Park, W.S.1
Cho, Y.G.2
Kim, C.J.3
Song, J.H.4
Lee, Y.S.5
Kim, S.Y.6
-
19
-
-
1142275110
-
Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia
-
Kang G.H., Lee S., Lee H.J., and Hwang K.S. Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia. J Pathol 202 2 (2004) 233-240
-
(2004)
J Pathol
, vol.202
, Issue.2
, pp. 233-240
-
-
Kang, G.H.1
Lee, S.2
Lee, H.J.3
Hwang, K.S.4
-
20
-
-
0034176015
-
HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance
-
Ruefli A.A., Smyth S.M., and Johnstone R.W. HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 95 7 (2000) 2378-2385
-
(2000)
Blood
, vol.95
, Issue.7
, pp. 2378-2385
-
-
Ruefli, A.A.1
Smyth, S.M.2
Johnstone, R.W.3
-
21
-
-
0029693220
-
The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
-
Van Lint C., Emiliani S., and Verdin E. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gen Express 5 (1996) 245-253
-
(1996)
Gen Express
, vol.5
, pp. 245-253
-
-
Van Lint, C.1
Emiliani, S.2
Verdin, E.3
-
22
-
-
0035046529
-
Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers
-
Richon V.M., Zhou X., Rifkind R.A., and Marks P.A. Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers. Blood Cells Mol Dis 27 (2001) 260-264
-
(2001)
Blood Cells Mol Dis
, vol.27
, pp. 260-264
-
-
Richon, V.M.1
Zhou, X.2
Rifkind, R.A.3
Marks, P.A.4
-
23
-
-
2942755609
-
Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia
-
Romanski A., Bacic B., Bug G., Preifer H., Gul H., Remiszewski S., et al. Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. Haematologica 89 (2004) 419-426
-
(2004)
Haematologica
, vol.89
, pp. 419-426
-
-
Romanski, A.1
Bacic, B.2
Bug, G.3
Preifer, H.4
Gul, H.5
Remiszewski, S.6
-
24
-
-
12644307234
-
Functional dissection of the α and β subunits of transcription factor PEBP2 and the Redox susceptibility of Its DNA binding activity
-
Kagoshima H., Akamatsu Y., Ito Y., and Shigesada K. Functional dissection of the α and β subunits of transcription factor PEBP2 and the Redox susceptibility of Its DNA binding activity. J Biol Chem 20;271 51 (1996) 33074-33082
-
(1996)
J Biol Chem
, vol.20 271
, Issue.51
, pp. 33074-33082
-
-
Kagoshima, H.1
Akamatsu, Y.2
Ito, Y.3
Shigesada, K.4
-
25
-
-
0035962632
-
DNA methylation, chromatin inheritance, and cancer
-
Rountree M.R., Bachman K.E., Herman J.G., and Baylin S.B. DNA methylation, chromatin inheritance, and cancer. Oncogene 20 24 (2001) 3156-3165
-
(2001)
Oncogene
, vol.20
, Issue.24
, pp. 3156-3165
-
-
Rountree, M.R.1
Bachman, K.E.2
Herman, J.G.3
Baylin, S.B.4
-
26
-
-
0035943709
-
Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
-
Bachman K.E., Rountree M.R., and Baylin S.B. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem 276 34 (2001) 32282-32287
-
(2001)
J Biol Chem
, vol.276
, Issue.34
, pp. 32282-32287
-
-
Bachman, K.E.1
Rountree, M.R.2
Baylin, S.B.3
-
27
-
-
0033919595
-
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
-
Robertson K.D., Ait-Si-Ali S., Yokochi T., Wade P.A., Jones P.L., and Wolffe A.P. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25 (2000) 338-342
-
(2000)
Nat Genet
, vol.25
, pp. 338-342
-
-
Robertson, K.D.1
Ait-Si-Ali, S.2
Yokochi, T.3
Wade, P.A.4
Jones, P.L.5
Wolffe, A.P.6
-
28
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron E.E., Bachman K.E., Myohanen S., Herman J.G., and Baylin S.B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21 1 (1999) 103-107
-
(1999)
Nat Genet
, vol.21
, Issue.1
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
29
-
-
0037427805
-
Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2′-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells
-
Primeau M., Gagnon J., and Momparler R.L. Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2′-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells. Int J Cancer 103 2 (2003) 177-184
-
(2003)
Int J Cancer
, vol.103
, Issue.2
, pp. 177-184
-
-
Primeau, M.1
Gagnon, J.2
Momparler, R.L.3
-
30
-
-
0037310863
-
RUNX transcription factors as key targets of TGF-β superfamily signaling
-
Ito Y., and Miyazono K. RUNX transcription factors as key targets of TGF-β superfamily signaling. Curr Opin Genet Dev 13 (2003) 43-47
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 43-47
-
-
Ito, Y.1
Miyazono, K.2
-
31
-
-
0028168242
-
INK4B is a potential effector of TGF-beta-induced cell cycle arrest
-
INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371 (1994) 257-261
-
(1994)
Nature
, vol.371
, pp. 257-261
-
-
Hannon, G.J.1
Beach, D.2
-
32
-
-
0029153609
-
Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
-
Reynisdottir I., Polyak K., Iavarone A., and Massague J. Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9 (1995) 1831-1845
-
(1995)
Genes Dev
, vol.9
, pp. 1831-1845
-
-
Reynisdottir, I.1
Polyak, K.2
Iavarone, A.3
Massague, J.4
-
33
-
-
0037562075
-
Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation
-
Koeller K.M., Haggarty S.J., Perkins B.D., Leykin L., Wong J.C., Kao M.C., et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem Biol 10 5 (2003) 397-410
-
(2003)
Chem Biol
, vol.10
, Issue.5
, pp. 397-410
-
-
Koeller, K.M.1
Haggarty, S.J.2
Perkins, B.D.3
Leykin, L.4
Wong, J.C.5
Kao, M.C.6
-
34
-
-
0034816579
-
Transcriptional activation of p21WAF1/CIP1 by Apicidin, a novel histone deacetylase inhibitor
-
Kim J.S., Lee S., Lee T., Trepel J.B., and Lee Y.-W. Transcriptional activation of p21WAF1/CIP1 by Apicidin, a novel histone deacetylase inhibitor. Biochem Biophys Res Commun 281 (2001) 866-871
-
(2001)
Biochem Biophys Res Commun
, vol.281
, pp. 866-871
-
-
Kim, J.S.1
Lee, S.2
Lee, T.3
Trepel, J.B.4
Lee, Y.-W.5
-
35
-
-
14844353574
-
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors
-
Peart M.J., Smyth G.K., van Laar R.K., Bowtell D.D., Richon V.M., Marks P.A., et al. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Proc Natl Acad Sci USA 102 10 (2005) 3697-3702
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.10
, pp. 3697-3702
-
-
Peart, M.J.1
Smyth, G.K.2
van Laar, R.K.3
Bowtell, D.D.4
Richon, V.M.5
Marks, P.A.6
-
36
-
-
0035845541
-
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
-
Ruefli A.A., Ausserlechner M.J., Bernhard D., Sutton V.R., Tainton K.M., Kofler R., et al. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci USA 98 19 (2001) 10833-10838
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.19
, pp. 10833-10838
-
-
Ruefli, A.A.1
Ausserlechner, M.J.2
Bernhard, D.3
Sutton, V.R.4
Tainton, K.M.5
Kofler, R.6
-
37
-
-
0038485588
-
Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA)
-
Henderson C., Mizzau M., Paroni G., Maestro R., Schneider C., and Brancolini C. Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J Biol Chem 278 14 (2003) 12579-12589
-
(2003)
J Biol Chem
, vol.278
, Issue.14
, pp. 12579-12589
-
-
Henderson, C.1
Mizzau, M.2
Paroni, G.3
Maestro, R.4
Schneider, C.5
Brancolini, C.6
-
38
-
-
33745018595
-
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis
-
Yano T., Ito K., Fukamachi H., Chi X.Z., Wee H.J., Inoue K., et al. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol 26 12 (2006) 4474-4488
-
(2006)
Mol Cell Biol
, vol.26
, Issue.12
, pp. 4474-4488
-
-
Yano, T.1
Ito, K.2
Fukamachi, H.3
Chi, X.Z.4
Wee, H.J.5
Inoue, K.6
-
39
-
-
33646189483
-
RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells
-
Yamamura Y., Lee W.L., Inoue K., Ida H., and Ito Y. RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem 281 8 (2006) 5267-5276
-
(2006)
J Biol Chem
, vol.281
, Issue.8
, pp. 5267-5276
-
-
Yamamura, Y.1
Lee, W.L.2
Inoue, K.3
Ida, H.4
Ito, Y.5
-
40
-
-
0033367018
-
Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA)
-
Cohen L.A., Amin S., Marks P.A., Rifkind R.A., Desai D., and Richon V.M. Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA). Anticancer Res 19 6B (1999) 4999-5005
-
(1999)
Anticancer Res
, vol.19
, Issue.6 B
, pp. 4999-5005
-
-
Cohen, L.A.1
Amin, S.2
Marks, P.A.3
Rifkind, R.A.4
Desai, D.5
Richon, V.M.6
|