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Volumn 27, Issue 8, 2007, Pages 1964-1972

Long-term upregulation of protein kinase A and adenylate cyclase levels in human smokers

Author keywords

Addiction; cAMP; Neuroadaptations; Nicotine; Nucleus accumbens; PKA

Indexed keywords

ADENYLATE CYCLASE; BRAIN PROTEIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMATE RECEPTOR; TYROSINE 3 MONOOXYGENASE;

EID: 33847179783     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3661-06.2007     Document Type: Article
Times cited : (33)

References (86)
  • 2
    • 0142074865 scopus 로고    scopus 로고
    • Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: Enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal
    • Abreu-Villaca Y, Seidler FJ, Slotkin TA (2003) Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. Brain Res 988:164-172.
    • (2003) Brain Res , vol.988 , pp. 164-172
    • Abreu-Villaca, Y.1    Seidler, F.J.2    Slotkin, T.A.3
  • 3
    • 3242776354 scopus 로고    scopus 로고
    • The role of signaling molecules in rewardrelated incentive learning
    • Beninger RJ, Gerdjikov T (2004) The role of signaling molecules in rewardrelated incentive learning. Neurotox Res 6:91-104.
    • (2004) Neurotox Res , vol.6 , pp. 91-104
    • Beninger, R.J.1    Gerdjikov, T.2
  • 5
    • 0033695676 scopus 로고    scopus 로고
    • Addiction, dopamine, and the molecular mechanisms of memory
    • Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515-532.
    • (2000) Neuron , vol.25 , pp. 515-532
    • Berke, J.D.1    Hyman, S.E.2
  • 7
    • 0019871197 scopus 로고
    • Intracranial self-administration of morphine into the ventral tegmental area in rats
    • Bozarth MA, Wise RA (1981) Intracranial self-administration of morphine into the ventral tegmental area in rats. Life Sci 28:551-555.
    • (1981) Life Sci , vol.28 , pp. 551-555
    • Bozarth, M.A.1    Wise, R.A.2
  • 11
    • 0036499938 scopus 로고    scopus 로고
    • Nicotine addiction: The possible role of functional upregulation
    • Buisson B, Bertrand D (2002) Nicotine addiction: the possible role of functional upregulation. Trends Pharmacol Sci 23:130-136.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 130-136
    • Buisson, B.1    Bertrand, D.2
  • 12
    • 0016677479 scopus 로고
    • Dopamine-sensitive adenylyl cyclase in human caudate nucleus. A study in control subjects and schizophrenic patients
    • Carenzi A, Gillin JC, Guidotti A, Schwartz MA, Trabucchi M, Wyatt RJ (1975) Dopamine-sensitive adenylyl cyclase in human caudate nucleus. A study in control subjects and schizophrenic patients. Arch Gen Psychiatry 32:1056-1059.
    • (1975) Arch Gen Psychiatry , vol.32 , pp. 1056-1059
    • Carenzi, A.1    Gillin, J.C.2    Guidotti, A.3    Schwartz, M.A.4    Trabucchi, M.5    Wyatt, R.J.6
  • 13
    • 0036890466 scopus 로고    scopus 로고
    • Elevated levels of GluR1 in the midbrain: A trigger for sensitization to drugs of abuse?
    • Carlezon Jr WA, Nestler EJ (2002) Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci 25:610-615.
    • (2002) Trends Neurosci , vol.25 , pp. 610-615
    • Carlezon Jr, W.A.1    Nestler, E.J.2
  • 16
    • 0033013402 scopus 로고    scopus 로고
    • Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitization
    • Churchill L, Swanson CJ, Urbina M, Kalivas PW (1999) Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitization. J Neurochem 72:2397-2403.
    • (1999) J Neurochem , vol.72 , pp. 2397-2403
    • Churchill, L.1    Swanson, C.J.2    Urbina, M.3    Kalivas, P.W.4
  • 17
    • 0026521447 scopus 로고
    • The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
    • Corrigall WA, Franklin KB, Coen KM, Clarke PB (1992) The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology (Berl) 107:285-289.
    • (1992) Psychopharmacology (Berl) , vol.107 , pp. 285-289
    • Corrigall, W.A.1    Franklin, K.B.2    Coen, K.M.3    Clarke, P.B.4
  • 19
    • 0028088929 scopus 로고
    • Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims
    • Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, O'Neill C (1994) Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res 633:297-304.
    • (1994) Brain Res , vol.633 , pp. 297-304
    • Cowburn, R.F.1    Marcusson, J.O.2    Eriksson, A.3    Wiehager, B.4    O'Neill, C.5
  • 20
    • 0034860626 scopus 로고    scopus 로고
    • Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers
    • Dagher A, Bleicher C, Aston JA, Gunn RN, Clarke PB, Cumming P (2001) Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers. Synapse 42:48-53.
    • (2001) Synapse , vol.42 , pp. 48-53
    • Dagher, A.1    Bleicher, C.2    Aston, J.A.3    Gunn, R.N.4    Clarke, P.B.5    Cumming, P.6
  • 21
    • 0017646799 scopus 로고
    • Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine
    • De Wit H, Wise RA (1977) Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine. Can J Psychol 31:195-203.
    • (1977) Can J Psychol , vol.31 , pp. 195-203
    • De Wit, H.1    Wise, R.A.2
  • 22
    • 0032840527 scopus 로고    scopus 로고
    • G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: Effects of diagnosis, suicide, and treatment at the time of death
    • Dowlatshahi D, MacQueen GM, Wang JF, Reiach JS, Young LT (1999) G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. J Neurochem 73:1121-1126.
    • (1999) J Neurochem , vol.73 , pp. 1121-1126
    • Dowlatshahi, D.1    MacQueen, G.M.2    Wang, J.F.3    Reiach, J.S.4    Young, L.T.5
  • 25
    • 0030044516 scopus 로고    scopus 로고
    • Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: Common adaptations among cross-sensitizing agents
    • Fitzgerald LW, Ortiz J, Hamedani AG, Nestler EJ (1996) Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents. J Neurosci 16:274-282.
    • (1996) J Neurosci , vol.16 , pp. 274-282
    • Fitzgerald, L.W.1    Ortiz, J.2    Hamedani, A.G.3    Nestler, E.J.4
  • 27
    • 0032995803 scopus 로고    scopus 로고
    • Neurobiology of tobacco smoking and other addictive disorders
    • Gamberino WC, Gold MS (1999) Neurobiology of tobacco smoking and other addictive disorders. Psychiatr Clin North Am 22:301-312.
    • (1999) Psychiatr Clin North Am , vol.22 , pp. 301-312
    • Gamberino, W.C.1    Gold, M.S.2
  • 28
    • 0036136550 scopus 로고    scopus 로고
    • Early environmental stress and biological vulnerability to drug abuse
    • Gordon HW (2002) Early environmental stress and biological vulnerability to drug abuse. Psychoneuroendocrinology 27:115-126.
    • (2002) Psychoneuroendocrinology , vol.27 , pp. 115-126
    • Gordon, H.W.1
  • 30
    • 13244287883 scopus 로고    scopus 로고
    • Neuroadaptations of total levels of adenylate cyclase, protein kinase A, tyrosine hydroxylase, cdk5 and neurofilaments in the nucleus accumbens and ventral tegmental area do not correlate with expression of sensitized or tolerant locomotor responses to cocaine
    • Hope BT, Crombag HS, Jedynak JP, Wise RA (2005) Neuroadaptations of total levels of adenylate cyclase, protein kinase A, tyrosine hydroxylase, cdk5 and neurofilaments in the nucleus accumbens and ventral tegmental area do not correlate with expression of sensitized or tolerant locomotor responses to cocaine. J Neurochem 92:536-545.
    • (2005) J Neurochem , vol.92 , pp. 536-545
    • Hope, B.T.1    Crombag, H.S.2    Jedynak, J.P.3    Wise, R.A.4
  • 31
    • 0141642251 scopus 로고    scopus 로고
    • Attenuated 5-HT1A receptor signaling in brains of suicide victims: Involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase
    • Hsiung SC, Adlersberg M, Arango V, Mann JJ, Tamir H, Liu KP (2003) Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. J Neurochem 87:182-194.
    • (2003) J Neurochem , vol.87 , pp. 182-194
    • Hsiung, S.C.1    Adlersberg, M.2    Arango, V.3    Mann, J.J.4    Tamir, H.5    Liu, K.P.6
  • 32
    • 0030027553 scopus 로고    scopus 로고
    • Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of ad-enylyl cyclase activity in nucleus accumbens
    • Izenwasser S, Heller B, Cox BM (1996) Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of ad-enylyl cyclase activity in nucleus accumbens. Eur J Pharmacol 297:187-191.
    • (1996) Eur J Pharmacol , vol.297 , pp. 187-191
    • Izenwasser, S.1    Heller, B.2    Cox, B.M.3
  • 33
    • 0742323783 scopus 로고    scopus 로고
    • Glutamate systems in cocaine addiction
    • Kalivas PW (2004) Glutamate systems in cocaine addiction. Curr Opin Pharmacol 4:23-29.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 23-29
    • Kalivas, P.W.1
  • 34
    • 0023763088 scopus 로고
    • Cellular and molecular mechanisms of drug dependence
    • Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242:715-723.
    • (1988) Science , vol.242 , pp. 715-723
    • Koob, G.F.1    Bloom, F.E.2
  • 36
    • 0032104659 scopus 로고    scopus 로고
    • Drug dependence: Stress and dysregulation of brain reward pathways
    • Kreek MJ, Koob GF (1998) Drug dependence: stress and dysregulation of brain reward pathways. Drug Alcohol Depend 51:23-47.
    • (1998) Drug Alcohol Depend , vol.51 , pp. 23-47
    • Kreek, M.J.1    Koob, G.F.2
  • 37
    • 0036467269 scopus 로고    scopus 로고
    • Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes
    • Laviolette SR, Nader K, van der Kooy D (2002) Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes. Behav Brain Res 129:17-29.
    • (2002) Behav Brain Res , vol.129 , pp. 17-29
    • Laviolette, S.R.1    Nader, K.2    van der Kooy, D.3
  • 38
    • 0024393543 scopus 로고
    • Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine
    • Lett BT (1989) Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine. Psychopharmacology (Berl) 98:357-362.
    • (1989) Psychopharmacology (Berl) , vol.98 , pp. 357-362
    • Lett, B.T.1
  • 39
    • 0027243202 scopus 로고
    • Four isoforms of tyrosine hydroxylase are expressed in human brain
    • Lewis DA, Melchitzky DS, Haycock JW (1993) Four isoforms of tyrosine hydroxylase are expressed in human brain. Neuroscience 54:477-492.
    • (1993) Neuroscience , vol.54 , pp. 477-492
    • Lewis, D.A.1    Melchitzky, D.S.2    Haycock, J.W.3
  • 40
    • 0030325538 scopus 로고    scopus 로고
    • GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls
    • Lowther S, Crompton MR, Katona CL, Horton RW (1996) GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls. Mol Psychiatry 1:470-477.
    • (1996) Mol Psychiatry , vol.1 , pp. 470-477
    • Lowther, S.1    Crompton, M.R.2    Katona, C.L.3    Horton, R.W.4
  • 41
    • 0038472304 scopus 로고    scopus 로고
    • Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    • Lu L, Grimm JW, Shaham Y, Hope BT (2003) Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats. J Neurochem 85:1604-1613.
    • (2003) J Neurochem , vol.85 , pp. 1604-1613
    • Lu, L.1    Grimm, J.W.2    Shaham, Y.3    Hope, B.T.4
  • 42
    • 25844498570 scopus 로고    scopus 로고
    • Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens
    • Lynch WJ, Taylor JR (2005) Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. Eur J Neurosci 22:1214-1220.
    • (2005) Eur J Neurosci , vol.22 , pp. 1214-1220
    • Lynch, W.J.1    Taylor, J.R.2
  • 43
    • 28844442947 scopus 로고    scopus 로고
    • Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A
    • Mattson BJ, Bossert JM, Simmons DE, Nozaki N, Nagarkar D, Kreuter JD, Hope BT (2005) Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A. J Neurochem 95:1481-1494.
    • (2005) J Neurochem , vol.95 , pp. 1481-1494
    • Mattson, B.J.1    Bossert, J.M.2    Simmons, D.E.3    Nozaki, N.4    Nagarkar, D.5    Kreuter, J.D.6    Hope, B.T.7
  • 45
    • 0020643318 scopus 로고
    • Coupling of dopamine D1 recognition sites with adenylate cyclase in nuclei accumbens and caudatus of schizophrenics
    • Memo M, Kleinman JE, Hanbauer I (1983) Coupling of dopamine D1 recognition sites with adenylate cyclase in nuclei accumbens and caudatus of schizophrenics. Science 221:1304-1307.
    • (1983) Science , vol.221 , pp. 1304-1307
    • Memo, M.1    Kleinman, J.E.2    Hanbauer, I.3
  • 46
    • 0242486453 scopus 로고    scopus 로고
    • Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease
    • Mousavi M, Hellstrom-Lindahl E, Guan ZZ, Shan KR, Ravid R, Nordberg A (2003) Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease. Neuroscience 122:515-520.
    • (2003) Neuroscience , vol.122 , pp. 515-520
    • Mousavi, M.1    Hellstrom-Lindahl, E.2    Guan, Z.Z.3    Shan, K.R.4    Ravid, R.5    Nordberg, A.6
  • 47
    • 0026645205 scopus 로고
    • Molecular mechanisms of drug addiction
    • Nestler EJ (1992) Molecular mechanisms of drug addiction. J Neurosci 12:2439-2450.
    • (1992) J Neurosci , vol.12 , pp. 2439-2450
    • Nestler, E.J.1
  • 48
    • 0035260641 scopus 로고    scopus 로고
    • Molecular basis of long-term plasticity underlying addiction
    • Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119-128.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 119-128
    • Nestler, E.J.1
  • 49
    • 0025038304 scopus 로고
    • Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain
    • Nestler EJ, Terwilliger RZ, Walker JR, Sevarino KA, Duman RS (1990) Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain. J Neurochem 55:1079-1082.
    • (1990) J Neurochem , vol.55 , pp. 1079-1082
    • Nestler, E.J.1    Terwilliger, R.Z.2    Walker, J.R.3    Sevarino, K.A.4    Duman, R.S.5
  • 50
    • 0035917794 scopus 로고    scopus 로고
    • Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims
    • Odagaki Y, Garcia-Sevilla JA, Huguelet P, La Harpe R, Koyama T, Guimon J (2001) Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims. Brain Res 898:224-231.
    • (2001) Brain Res , vol.898 , pp. 224-231
    • Odagaki, Y.1    Garcia-Sevilla, J.A.2    Huguelet, P.3    La Harpe, R.4    Koyama, T.5    Guimon, J.6
  • 52
    • 23844458271 scopus 로고    scopus 로고
    • Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims
    • Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Mondal AC, Shukla PK, Conley RR (2005) Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims. Neuropsychopharmacology 30:1548-1556.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1548-1556
    • Pandey, G.N.1    Dwivedi, Y.2    Ren, X.3    Rizavi, H.S.4    Mondal, A.C.5    Shukla, P.K.6    Conley, R.R.7
  • 53
    • 0020045656 scopus 로고
    • The dopamine receptor adenylate cyclase complex: Evidence for post recognition site involvement for the development of supersensitivity
    • Parenti M, Gentleman S, Olianas MC, Neff NH (1982) The dopamine receptor adenylate cyclase complex: evidence for post recognition site involvement for the development of supersensitivity. Neurochem Res 7:115-124.
    • (1982) Neurochem Res , vol.7 , pp. 115-124
    • Parenti, M.1    Gentleman, S.2    Olianas, M.C.3    Neff, N.H.4
  • 56
    • 0344258434 scopus 로고    scopus 로고
    • Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies
    • Perry DC, Davila-Garcia MI, Stockmeier CA, Kellar KJ (1999) Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J Pharmacol Exp Ther 289:1545-1552.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1545-1552
    • Perry, D.C.1    Davila-Garcia, M.I.2    Stockmeier, C.A.3    Kellar, K.J.4
  • 57
    • 0025239977 scopus 로고
    • Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration
    • Piazza PV, Deminiere JM, le Moal M, Simon H (1990) Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res 514:22-26.
    • (1990) Brain Res , vol.514 , pp. 22-26
    • Piazza, P.V.1    Deminiere, J.M.2    le Moal, M.3    Simon, H.4
  • 58
    • 0033842346 scopus 로고    scopus 로고
    • Biological aspects of the link between smoking and depression
    • Quattrocki E, Baird A, Yurgelun-Todd D (2000) Biological aspects of the link between smoking and depression. Harv Rev Psychiatry 8:99-110.
    • (2000) Harv Rev Psychiatry , vol.8 , pp. 99-110
    • Quattrocki, E.1    Baird, A.2    Yurgelun-Todd, D.3
  • 59
    • 0033399399 scopus 로고    scopus 로고
    • Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims
    • Reiach JS, Li PP, Warsh JJ, Kish SJ, Young LT (1999) Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims. J Affect Disord 56:141-151.
    • (1999) J Affect Disord , vol.56 , pp. 141-151
    • Reiach, J.S.1    Li, P.P.2    Warsh, J.J.3    Kish, S.J.4    Young, L.T.5
  • 60
    • 0027305458 scopus 로고
    • The neural basis of drug craving: An incentive-sensitization theory of addiction
    • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-291.
    • (1993) Brain Res Brain Res Rev , vol.18 , pp. 247-291
    • Robinson, T.E.1    Berridge, K.C.2
  • 62
    • 1842451615 scopus 로고    scopus 로고
    • Repeated acetyl-L-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum
    • Scheggi S, Rauggi R, Nanni G, Tagliamonte A, Gambarana C (2004) Repeated acetyl-L-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum. Eur J Neurosci 19:1609-1620.
    • (2004) Eur J Neurosci , vol.19 , pp. 1609-1620
    • Scheggi, S.1    Rauggi, R.2    Nanni, G.3    Tagliamonte, A.4    Gambarana, C.5
  • 63
    • 0029958718 scopus 로고    scopus 로고
    • Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: Possible role in behavioral sensitization
    • Schoffelmeer AN, Voorn P, Jonker AJ, Wardeh G, Nestby P, Vanderschuren LJ, De Vries TJ, Mulder AH, Tjon GH (1996) Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: possible role in behavioral sensitization. Neurochem Res 21:1417-1423.
    • (1996) Neurochem Res , vol.21 , pp. 1417-1423
    • Schoffelmeer, A.N.1    Voorn, P.2    Jonker, A.J.3    Wardeh, G.4    Nestby, P.5    Vanderschuren, L.J.6    De Vries, T.J.7    Mulder, A.H.8    Tjon, G.H.9
  • 64
    • 0029620705 scopus 로고
    • Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration
    • Self DW, McClenahan AW, Beitner-Johnson D, Terwilliger RZ, Nestler EJ (1995) Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration. Synapse 21:312-318.
    • (1995) Synapse , vol.21 , pp. 312-318
    • Self, D.W.1    McClenahan, A.W.2    Beitner-Johnson, D.3    Terwilliger, R.Z.4    Nestler, E.J.5
  • 65
    • 0032031594 scopus 로고    scopus 로고
    • Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
    • Self DW, Genova LM, Hope BT, Barnhart WJ, Spencer JJ, Nestler EJ (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18:1848-1859.
    • (1998) J Neurosci , vol.18 , pp. 1848-1859
    • Self, D.W.1    Genova, L.M.2    Hope, B.T.3    Barnhart, W.J.4    Spencer, J.J.5    Nestler, E.J.6
  • 66
    • 0032067012 scopus 로고    scopus 로고
    • Shichinohe S, Ozawa H, Saito T, Hashimoto E, Lang C, Riederer P, Takahata N (1998) Differential alteration of adenylyl cyclase subtypes I, II, and V/VI in postmortem human brains of heroin addicts. Alcohol Clin Exp Res 22:84S-87S.
    • Shichinohe S, Ozawa H, Saito T, Hashimoto E, Lang C, Riederer P, Takahata N (1998) Differential alteration of adenylyl cyclase subtypes I, II, and V/VI in postmortem human brains of heroin addicts. Alcohol Clin Exp Res 22:84S-87S.
  • 67
    • 0034895756 scopus 로고    scopus 로고
    • Changes in the cAMP-related signal transduction mechanism in postmortem human brains of heroin addicts
    • Shichinohe S, Ozawa H, Hashimoto E, Tatschner T, Riederer P, Saito T (2001) Changes in the cAMP-related signal transduction mechanism in postmortem human brains of heroin addicts. J Neural Transm 108:335-347.
    • (2001) J Neural Transm , vol.108 , pp. 335-347
    • Shichinohe, S.1    Ozawa, H.2    Hashimoto, E.3    Tatschner, T.4    Riederer, P.5    Saito, T.6
  • 68
    • 0035853509 scopus 로고    scopus 로고
    • Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats
    • Slotkin TA, Pinkerton KE, Garofolo MC, Auman JT, McCook EC, Seidler FJ (2001) Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats. Brain Res 898:73-81.
    • (2001) Brain Res , vol.898 , pp. 73-81
    • Slotkin, T.A.1    Pinkerton, K.E.2    Garofolo, M.C.3    Auman, J.T.4    McCook, E.C.5    Seidler, F.J.6
  • 72
    • 0035878170 scopus 로고    scopus 로고
    • Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium
    • Stewart RJ, Chen B, Dowlatshahi D, MacQueen GM, Young LT (2001) Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium. Brain Res Bull 55:625-629.
    • (2001) Brain Res Bull , vol.55 , pp. 625-629
    • Stewart, R.J.1    Chen, B.2    Dowlatshahi, D.3    MacQueen, G.M.4    Young, L.T.5
  • 73
    • 9644302452 scopus 로고    scopus 로고
    • Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA
    • Suto N, Tanabe LM, Austin JD, Creekmore E, Pham CT, Vezina P (2004) Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA. Neuropsychopharmacology 29:2149-2159.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 2149-2159
    • Suto, N.1    Tanabe, L.M.2    Austin, J.D.3    Creekmore, E.4    Pham, C.T.5    Vezina, P.6
  • 75
    • 0025760593 scopus 로고
    • A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function
    • Terwilliger RZ, Beitner-Johnson D, Sevarino KA, Crain SM, Nestler EJ (1991) A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 548:100-110.
    • (1991) Brain Res , vol.548 , pp. 100-110
    • Terwilliger, R.Z.1    Beitner-Johnson, D.2    Sevarino, K.A.3    Crain, S.M.4    Nestler, E.J.5
  • 76
    • 0029739587 scopus 로고    scopus 로고
    • Evidence for dissociable mechanisms of amphetamine- and stress-induced behavioral sensitization: Effects of MK-801 and haloperidol pretreatment
    • Tolliver BK, Ho LB, Reid MS, Berger SP (1996) Evidence for dissociable mechanisms of amphetamine- and stress-induced behavioral sensitization: effects of MK-801 and haloperidol pretreatment. Psychopharmacology (Berl) 126:191-198.
    • (1996) Psychopharmacology (Berl) , vol.126 , pp. 191-198
    • Tolliver, B.K.1    Ho, L.B.2    Reid, M.S.3    Berger, S.P.4
  • 77
    • 0032892426 scopus 로고    scopus 로고
    • Necessary role for ventral tegmental area adenylate cyclase and protein kinase A in induction of behavioral sensitization to intraventral tegmental area amphetamine
    • Tolliver BK, Ho LB, Fox LM, Berger SP (1999) Necessary role for ventral tegmental area adenylate cyclase and protein kinase A in induction of behavioral sensitization to intraventral tegmental area amphetamine. J Pharmacol Exp Ther 289:38-47.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 38-47
    • Tolliver, B.K.1    Ho, L.B.2    Fox, L.M.3    Berger, S.P.4
  • 79
    • 0036457090 scopus 로고    scopus 로고
    • Nicotine withdrawal syndrome: Behavioural distress and selective up-regulation of the cyclic AMP pathway in the amygdala
    • Tzavara ET, Monory K, Hanoune J, Nomikos GG (2002) Nicotine withdrawal syndrome: behavioural distress and selective up-regulation of the cyclic AMP pathway in the amygdala. Eur J Neurosci 16:149-153.
    • (2002) Eur J Neurosci , vol.16 , pp. 149-153
    • Tzavara, E.T.1    Monory, K.2    Hanoune, J.3    Nomikos, G.G.4
  • 80
    • 0346850967 scopus 로고    scopus 로고
    • Adenylate cyclase activity in postmortem brain of suicide subjects: Reduced response to betaadrenergic stimulation
    • Valdizan EM, Gutierrez O, Pazos A (2003) Adenylate cyclase activity in postmortem brain of suicide subjects: reduced response to betaadrenergic stimulation. Biol Psychiatry 54:1457-1464.
    • (2003) Biol Psychiatry , vol.54 , pp. 1457-1464
    • Valdizan, E.M.1    Gutierrez, O.2    Pazos, A.3
  • 81
    • 0036615635 scopus 로고    scopus 로고
    • Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine
    • Vezina P, Lorrain DS, Arnold GM, Austin JD, Suto N (2002) Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine. J Neurosci 22:4654-4662.
    • (2002) J Neurosci , vol.22 , pp. 4654-4662
    • Vezina, P.1    Lorrain, D.S.2    Arnold, G.M.3    Austin, J.D.4    Suto, N.5
  • 82
    • 0033709968 scopus 로고    scopus 로고
    • Addiction becomes a brain disease
    • Wise RA (2000) Addiction becomes a brain disease. Neuron 26:27-33.
    • (2000) Neuron , vol.26 , pp. 27-33
    • Wise, R.A.1
  • 83
    • 2642519680 scopus 로고    scopus 로고
    • Dopamine, learning and motivation
    • Wise RA (2004) Dopamine, learning and motivation. Nat Rev Neurosci 5:483-494.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 483-494
    • Wise, R.A.1
  • 84
    • 0031908310 scopus 로고    scopus 로고
    • The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
    • Wolf ME (1998) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.
    • (1998) Prog Neurobiol , vol.54 , pp. 679-720
    • Wolf, M.E.1
  • 85
    • 0035937536 scopus 로고    scopus 로고
    • Increased levels of calcium-sensitive adenylyl cyclase subtypes in the limbic system of alcoholics: Evidence for a specific role of cAMP signaling in the human addictive brain
    • Yamamoto M, Pohli S, Durany N, Ozawa H, Saito T, Boissl KW, Zochling R, Riederer P, Boning J, Gotz ME (2001a) Increased levels of calcium-sensitive adenylyl cyclase subtypes in the limbic system of alcoholics: evidence for a specific role of cAMP signaling in the human addictive brain. Brain Res 895:233-237.
    • (2001) Brain Res , vol.895 , pp. 233-237
    • Yamamoto, M.1    Pohli, S.2    Durany, N.3    Ozawa, H.4    Saito, T.5    Boissl, K.W.6    Zochling, R.7    Riederer, P.8    Boning, J.9    Gotz, M.E.10


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