Continuous cocaine administration enhances μ- But not ο-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens

European Journal of Pharmacology

Volumn 297, Issue 1-2, 1996, Pages 187-191

  Izenwasser, Sari ^a   Heller, Brett ^a   Cox, Brian M ^b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Caudate; Cocaine; Nucleus accumbens; Opioid

Indexed keywords

ADENYLATE CYCLASE; COCAINE; DELTA OPIATE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MORPHINE; MU OPIATE RECEPTOR; NALTREXONE; RADIOLIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; MALE; NONHUMAN; NUCLEUS ACCUMBENS; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PUTAMEN; RAT; RECEPTOR DENSITY; SUBCUTANEOUS DRUG ADMINISTRATION;

ADENYLATE CYCLASE; ANALGESICS; ANIMALS; COCAINE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; KINETICS; MALE; MEMBRANES; NARCOTICS; NEOSTRIATUM; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0030027553     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00828-4     Document Type: Article

References (15)

1. Azaryan, A.V., L.J. Coughlin, B. Buzas, B.J. Clock and B.M. Cox, 1996, Effect of chronic cocaine treatment on μ- and δ-opioid receptor mRNA levels in dopaminergically innervated brain regions. J. Neurochem. 66 (in press).
2. Baumann, M.H. and R.B. Rothman, 1993, Effects of acute and chronic cocaine on the activity of tuberoinfundibular dopamine neurons in the rat, Brain Res. 608, 175.
3. Cote, T.E., S. Izenwasser and H.B. Weems, 1993, Naltrexone-induced upregulation of mu opioid receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting adenylyl cyclase, J. Pharmacol. Exp. Ther. 267, 238.
4. Goldstein, A. and P. Sheehan, 1969, Tolerance to opioid narcotics. I. Tolerance to the 'running fit' caused by levorphanol in the mouse, J. Pharmacol. Exp. Ther. 169, 175.
5. Hammer, Jr., R.P., 1989, Cocaine alters opiate receptor binding in critical brain reward regions, Synapse 3, 55.
6. 3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum, Brain Res. 531, 338.
7. Izenwasser, S. and B.M. Cox, 1992, Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments, Brain Res. 573, 119.
8. Izenwasser, S., B. Buzas and B.M. Cox, 1993, Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens, J. Pharmacol. Exp. Ther. 267, 145.
9. Pettit, H.O., H.-T. Pan, L.H. Parsons and J.B. Justice, Jr., 1990, Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration, J. Neurochem. 55, 798.
10. Pilotte, N.S., W.M. Mitchell, L.G. Sharpe, E.B. De Souza and E.M. Dax, 1991, Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain, Synapse 9, 111.
11. Reith, M.E.A., M. Benuck and A. Lajtha, 1987, Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice, J. Pharmacol. Exp. Ther. 243, 281.
12. Terry, P., J.M. Witkin and J.L. Katz, 1994, Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine, J. Pharmacol. Exp. Ther. 270, 1041.
13. Unterwald, E.M., J. Home-King and M.J. Kreek, 1992, Chronic cocaine alters brain mu opioid receptors, Brain Res. 584, 314.
14. Unterwald, E.M., B.M. Cox, M.J. Kreek, T.E. Cote and S. Izenwasser, 1993, Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity, Synapse 15, 33.
15. Unterwald, E.M., J.M. Rubenfeld and M.J. Kreek, 1994, Time course of cocaine-induced alterations in opioid and dopamine receptors and transporter sites, NIDA Res. Monogr. Problems of Drug Dependence 153, 507.