-
1
-
-
31344461826
-
Sepsis in European intensive care units: Results of the SOAP study
-
Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34:344-353.
-
(2006)
Crit Care Med
, vol.34
, pp. 344-353
-
-
Vincent, J.L.1
Sakr, Y.2
Sprung, C.L.3
-
2
-
-
0038001565
-
Ringer's ethyl pyruvate solution: A novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis
-
Fink MP. Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis. J Trauma. 2003;54:S141-S143.
-
(2003)
J Trauma
, vol.54
-
-
Fink, M.P.1
-
3
-
-
0037616308
-
Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock
-
Venkataraman R, Kellum JA, Song M, Fink MP. Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock. Shock. 2002;18:507-512.
-
(2002)
Shock
, vol.18
, pp. 507-512
-
-
Venkataraman, R.1
Kellum, J.A.2
Song, M.3
Fink, M.P.4
-
4
-
-
0142249406
-
Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice
-
Miyaji T, Hu X, Yuen PS, et al. Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int. 2003;64:1620-1631.
-
(2003)
Kidney Int
, vol.64
, pp. 1620-1631
-
-
Miyaji, T.1
Hu, X.2
Yuen, P.S.3
-
5
-
-
0037125985
-
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
-
Ulloa L, Ochani M, Yang H, et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A. 2002;99:12 351-12 356.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
-
-
Ulloa, L.1
Ochani, M.2
Yang, H.3
-
6
-
-
0042829191
-
Low-dose vasopressin in the treatment of septic shock in sheep
-
Sun Q, Dimopoulos G, Nguyen DN, et al. Low-dose vasopressin in the treatment of septic shock in sheep. Am J Respir Crit Care Med. 2003;168:481-486.
-
(2003)
Am J Respir Crit Care Med
, vol.168
, pp. 481-486
-
-
Sun, Q.1
Dimopoulos, G.2
Nguyen, D.N.3
-
7
-
-
9644297875
-
Use of low tidal volume in septic shock may decrease severity of subsequent acute lung injury
-
Su F, Nguyen ND, Creteur J, et al. Use of low tidal volume in septic shock may decrease severity of subsequent acute lung injury. Shock. 2004;22:145-150.
-
(2004)
Shock
, vol.22
, pp. 145-150
-
-
Su, F.1
Nguyen, N.D.2
Creteur, J.3
-
8
-
-
0344309146
-
Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion
-
Uchiyama T, Delude RL, Fink MP. Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med. 2003;29:2050-2058.
-
(2003)
Intensive Care Med
, vol.29
, pp. 2050-2058
-
-
Uchiyama, T.1
Delude, R.L.2
Fink, M.P.3
-
9
-
-
0036088799
-
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock
-
Yang R, Gallo DJ, Baust JJ, et al. Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2002;283:G212-G221.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.283
-
-
Yang, R.1
Gallo, D.J.2
Baust, J.J.3
-
10
-
-
0036599639
-
Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats
-
Tawadrous ZS, Delude RL, Fink MP. Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock. 2002;17:473-477.
-
(2002)
Shock
, vol.17
, pp. 473-477
-
-
Tawadrous, Z.S.1
Delude, R.L.2
Fink, M.P.3
-
11
-
-
0037213248
-
Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers
-
Sappington PL, Han X, Yang R, Delude RL, Fink MP. Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers. J Pharmacol Exp Ther. 2003;304:464-476.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 464-476
-
-
Sappington, P.L.1
Han, X.2
Yang, R.3
Delude, R.L.4
Fink, M.P.5
-
12
-
-
7944233880
-
Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis
-
Yang R, Uchiyama T, Watkins SK, Han X, Fink MP. Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis. Shock. 2004;22:369-375.
-
(2004)
Shock
, vol.22
, pp. 369-375
-
-
Yang, R.1
Uchiyama, T.2
Watkins, S.K.3
Han, X.4
Fink, M.P.5
-
13
-
-
24944460440
-
Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia
-
Hauser B, Kick J, Asfar P, et al. Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. Crit Care Med. 2005;33:2034-2042.
-
(2005)
Crit Care Med
, vol.33
, pp. 2034-2042
-
-
Hauser, B.1
Kick, J.2
Asfar, P.3
-
14
-
-
0002015656
-
The estimation of the surface area of the body
-
Dubois EF, ed, Philadelphia, Pa: Lea & Febiger;
-
Dubois EF. The estimation of the surface area of the body. In: Dubois EF, ed. Basal Metabolism in Health and Disease. Philadelphia, Pa: Lea & Febiger; 1936:125-144.
-
(1936)
Basal Metabolism in Health and Disease
, pp. 125-144
-
-
Dubois, E.F.1
-
15
-
-
0030294357
-
Hyperoxia activates NF-kappaB and increases TNF-alpha and IFN-gamma gene expression in mouse pulmonary lymphocytes
-
Shea LM, Beehler C, Schwartz M, Shenkar R, Tuder R, Abraham E. Hyperoxia activates NF-kappaB and increases TNF-alpha and IFN-gamma gene expression in mouse pulmonary lymphocytes. J Immunol. 1996;157:3902-3908.
-
(1996)
J Immunol
, vol.157
, pp. 3902-3908
-
-
Shea, L.M.1
Beehler, C.2
Schwartz, M.3
Shenkar, R.4
Tuder, R.5
Abraham, E.6
-
16
-
-
0035217837
-
The antioxidant potential of pyruvate in the amitochondriate diplomonads Giardia intestinalis and Hexamita inflata
-
Biagini GA, Park JH, Lloyd D, Edwards MR. The antioxidant potential of pyruvate in the amitochondriate diplomonads Giardia intestinalis and Hexamita inflata. Microbiology. 2001;147:3359-3365.
-
(2001)
Microbiology
, vol.147
, pp. 3359-3365
-
-
Biagini, G.A.1
Park, J.H.2
Lloyd, D.3
Edwards, M.R.4
-
17
-
-
51149212381
-
Oxidation of α-diketons and α-keto-acids by hydrogen peroxide
-
Bunton CA. Oxidation of α-diketons and α-keto-acids by hydrogen peroxide. Nature. 1949;163:444-446.
-
(1949)
Nature
, vol.163
, pp. 444-446
-
-
Bunton, C.A.1
-
19
-
-
0032738998
-
Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia
-
Dobsak P, Courderot-Masuyer C, Zeller M, et al. Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J Cardiovasc Pharmacol. 1999;34:651-659.
-
(1999)
J Cardiovasc Pharmacol
, vol.34
, pp. 651-659
-
-
Dobsak, P.1
Courderot-Masuyer, C.2
Zeller, M.3
-
20
-
-
84961006890
-
-
Montgomery CM, Webb JL. Metabolic studies on heart mitochondria, II: the inhibitory action of parapyruvate on the tricarboxylic acid cycle. J Biol Chem. 1956;221:359-368.
-
Montgomery CM, Webb JL. Metabolic studies on heart mitochondria, II: the inhibitory action of parapyruvate on the tricarboxylic acid cycle. J Biol Chem. 1956;221:359-368.
-
-
-
-
21
-
-
0024600885
-
Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart: Near-complete prevention of reperfusion contractile failure
-
Bunger R, Mallet RT, Hartman DA. Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart: near-complete prevention of reperfusion contractile failure. Eur J Biochem. 1989;180:221-233.
-
(1989)
Eur J Biochem
, vol.180
, pp. 221-233
-
-
Bunger, R.1
Mallet, R.T.2
Hartman, D.A.3
-
22
-
-
0030030820
-
Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine
-
Cicalese L, Lee K, Schraut W, Watkins S, Borle A, Stanko R. Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am J Surg. 1996;171:97-100.
-
(1996)
Am J Surg
, vol.171
, pp. 97-100
-
-
Cicalese, L.1
Lee, K.2
Schraut, W.3
Watkins, S.4
Borle, A.5
Stanko, R.6
-
23
-
-
0035888871
-
Protection by pyruvate against transient forebrain ischemia in rats
-
Lee JY, Kim YH, Koh JY. Protection by pyruvate against transient forebrain ischemia in rats. J Neurosci. 2001;21:1-6.
-
(2001)
J Neurosci
, vol.21
, pp. 1-6
-
-
Lee, J.Y.1
Kim, Y.H.2
Koh, J.Y.3
-
24
-
-
0034910965
-
Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock
-
Slovin PN, Huang CJ, Cade JR, et al. Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock. Resuscitation. 2001;50:109-115.
-
(2001)
Resuscitation
, vol.50
, pp. 109-115
-
-
Slovin, P.N.1
Huang, C.J.2
Cade, J.R.3
-
25
-
-
0034891709
-
Pyruvate improves cerebral metabolism during hemorrhagic shock
-
Mongan PD, Capacchione J, Fontana JL, West S, Bunger R. Pyruvate improves cerebral metabolism during hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2001;281:H854-H864.
-
(2001)
Am J Physiol Heart Circ Physiol
, vol.281
-
-
Mongan, P.D.1
Capacchione, J.2
Fontana, J.L.3
West, S.4
Bunger, R.5
-
26
-
-
3142759947
-
Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis
-
Yang R, Uchiyama T, Alber SM, et al. Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med. 2004;32:1453-1459.
-
(2004)
Crit Care Med
, vol.32
, pp. 1453-1459
-
-
Yang, R.1
Uchiyama, T.2
Alber, S.M.3
-
27
-
-
0347758406
-
Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells
-
Song M, Kellum JA, Kaldas H, Fink MP. Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells. J Pharmacol Exp Ther. 2004;308:307-316.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 307-316
-
-
Song, M.1
Kellum, J.A.2
Kaldas, H.3
Fink, M.P.4
-
28
-
-
14344255881
-
Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65
-
Han Y, Englert JA, Yang R, Delude RL, Fink MP. Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther. 2005;312:1097-1105.
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 1097-1105
-
-
Han, Y.1
Englert, J.A.2
Yang, R.3
Delude, R.L.4
Fink, M.P.5
-
30
-
-
2342432453
-
Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia
-
Woo YJ, Taylor MD, Cohen JE, et al. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J Thorac Cardiovasc Surg. 2004;127:1262-1269.
-
(2004)
J Thorac Cardiovasc Surg
, vol.127
, pp. 1262-1269
-
-
Woo, Y.J.1
Taylor, M.D.2
Cohen, J.E.3
-
31
-
-
4544347659
-
Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts
-
Leon H, Atkinson LL, Sawicka J, Strynadka K, Lopaschuk GD, Schulz R. Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts. Can J Physiol Pharmacol. 2004;82:409-416.
-
(2004)
Can J Physiol Pharmacol
, vol.82
, pp. 409-416
-
-
Leon, H.1
Atkinson, L.L.2
Sawicka, J.3
Strynadka, K.4
Lopaschuk, G.D.5
Schulz, R.6
-
32
-
-
0942276499
-
The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium
-
Kristo G, Yoshimura Y, Niu J, et al. The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium. Am J Physiol Heart Circ Physiol. 2004;286:H517-H524.
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.286
-
-
Kristo, G.1
Yoshimura, Y.2
Niu, J.3
-
33
-
-
1342345252
-
Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure
-
Hermann HP, Arp J, Pieske B, et al. Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure. Eur J Heart Fail. 2004;6:213-218.
-
(2004)
Eur J Heart Fail
, vol.6
, pp. 213-218
-
-
Hermann, H.P.1
Arp, J.2
Pieske, B.3
-
35
-
-
0034042444
-
Pyruvate: Metabolic protector of cardiac performance
-
Mallet RT. Pyruvate: metabolic protector of cardiac performance. Proc Soc Exp Biol Med. 2000;223:136-148.
-
(2000)
Proc Soc Exp Biol Med
, vol.223
, pp. 136-148
-
-
Mallet, R.T.1
-
36
-
-
0026354819
-
Colloid oncotic pressure and body water dynamics in septic and injured patients
-
Lucas CE, Ledgerwood AM, Rachwal WJ, Grabow D, Saxe JM. Colloid oncotic pressure and body water dynamics in septic and injured patients. J Trauma. 1991;31:927-931.
-
(1991)
J Trauma
, vol.31
, pp. 927-931
-
-
Lucas, C.E.1
Ledgerwood, A.M.2
Rachwal, W.J.3
Grabow, D.4
Saxe, J.M.5
-
37
-
-
0034883436
-
Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats
-
Sims CA, Wattanasirichaigoon S, Menconi MJ, Ajami AM, Fink MP. Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Crit Care Med. 2001;29:1513-1518.
-
(2001)
Crit Care Med
, vol.29
, pp. 1513-1518
-
-
Sims, C.A.1
Wattanasirichaigoon, S.2
Menconi, M.J.3
Ajami, A.M.4
Fink, M.P.5
-
38
-
-
17144422899
-
Future strategies in the treatment of acute renal failure: Growth factors, stem cells, and other novel therapies
-
Bates CM, Lin F. Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies. Curr Opin Pediatr. 2005;17:215-220.
-
(2005)
Curr Opin Pediatr
, vol.17
, pp. 215-220
-
-
Bates, C.M.1
Lin, F.2
|