메뉴 건너뛰기




Volumn 73, Issue 7, 2007, Pages 1033-1040

Relaxin receptors in hepatic stellate cells and cirrhotic liver

Author keywords

Fibrosis; InsL3; LGR7; LGR8; Relaxin 3

Indexed keywords

COLLAGEN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; INSULIN LIKE PEPTIDE 3; LEUCINE RICH G PROTEIN COUPLED RECEPTOR 7; LEUCINE RICH G PROTEIN COUPLED RECEPTOR 8; PEPTIDE HORMONE; RELAXIN; RELAXIN 3; UNCLASSIFIED DRUG;

EID: 33847156731     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.12.007     Document Type: Article
Times cited : (31)

References (37)
  • 1
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • Sherwood O.D. Relaxin's physiological roles and other diverse actions. Endocr Rev 25 (2004) 205-234
    • (2004) Endocr Rev , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 2
    • 0028091261 scopus 로고
    • Human relaxins: chemistry and biology
    • Bryant-Greenwood G.D., and Schwabe C. Human relaxins: chemistry and biology. Endocr Rev 15 (1994) 5-26
    • (1994) Endocr Rev , vol.15 , pp. 5-26
    • Bryant-Greenwood, G.D.1    Schwabe, C.2
  • 4
    • 0026657306 scopus 로고
    • Relaxin alone and in conjunction with interferon-gamma decreases collagen synthesis by cultured human scleroderma fibroblasts
    • Unemori E.N., Bauer E.A., and Amento E.P. Relaxin alone and in conjunction with interferon-gamma decreases collagen synthesis by cultured human scleroderma fibroblasts. J Invest Dermatol 99 (1992) 337-342
    • (1992) J Invest Dermatol , vol.99 , pp. 337-342
    • Unemori, E.N.1    Bauer, E.A.2    Amento, E.P.3
  • 5
    • 0030453783 scopus 로고    scopus 로고
    • Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
    • Unemori E.N., Pickford L.B., Salles A.L., Piercy C.E., Grove B.H., Erikson M.E., et al. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest 98 (1996) 2739-2745
    • (1996) J Clin Invest , vol.98 , pp. 2739-2745
    • Unemori, E.N.1    Pickford, L.B.2    Salles, A.L.3    Piercy, C.E.4    Grove, B.H.5    Erikson, M.E.6
  • 6
    • 4344606223 scopus 로고    scopus 로고
    • Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
    • Samuel C.S., Unemori E.N., Mookerjee I., Bathgate R.A., Layfield S.L., Mak J., et al. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 145 (2004) 4125-4133
    • (2004) Endocrinology , vol.145 , pp. 4125-4133
    • Samuel, C.S.1    Unemori, E.N.2    Mookerjee, I.3    Bathgate, R.A.4    Layfield, S.L.5    Mak, J.6
  • 7
    • 0037271801 scopus 로고    scopus 로고
    • Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis
    • Samuel C.S., Zhao C., Bathgate R.A., Bond C.P., Burton M.D., Parry L.J., et al. Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis. FASEB J 17 (2003) 121-123
    • (2003) FASEB J , vol.17 , pp. 121-123
    • Samuel, C.S.1    Zhao, C.2    Bathgate, R.A.3    Bond, C.P.4    Burton, M.D.5    Parry, L.J.6
  • 8
  • 10
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis-from bench to bedside
    • Friedman S.L. Liver fibrosis-from bench to bedside. J Hepatol 38 Suppl. 1 (2003) S38-S53
    • (2003) J Hepatol , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 12
    • 7044231639 scopus 로고    scopus 로고
    • Stellate cells: a moving target in hepatic fibrogenesis
    • Friedman S.L. Stellate cells: a moving target in hepatic fibrogenesis. Hepatology 40 (2004) 1041-1043
    • (2004) Hepatology , vol.40 , pp. 1041-1043
    • Friedman, S.L.1
  • 13
    • 0036849481 scopus 로고    scopus 로고
    • Developing strategies for liver fibrosis treatment
    • Murphy F., Arthur M., and Iredale J. Developing strategies for liver fibrosis treatment. Expert Opin Invest Drugs 11 (2002) 1575-1585
    • (2002) Expert Opin Invest Drugs , vol.11 , pp. 1575-1585
    • Murphy, F.1    Arthur, M.2    Iredale, J.3
  • 14
    • 0035667474 scopus 로고    scopus 로고
    • The vasorelaxant hormone relaxin induces changes in liver sinusoid microcirculation: a morphologic study in the rat
    • Bani D., Nistri S., Quattrone S., Bigazzi M., and Bani Sacchi T. The vasorelaxant hormone relaxin induces changes in liver sinusoid microcirculation: a morphologic study in the rat. J Endocrinol 171 (2001) 541-549
    • (2001) J Endocrinol , vol.171 , pp. 541-549
    • Bani, D.1    Nistri, S.2    Quattrone, S.3    Bigazzi, M.4    Bani Sacchi, T.5
  • 15
    • 12244257489 scopus 로고    scopus 로고
    • Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype
    • Du X.-J., Samuel C.S., Gao X.-M., Zhao L., Parry L.J., and Tregear G.W. Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res 57 (2003) 395-404
    • (2003) Cardiovasc Res , vol.57 , pp. 395-404
    • Du, X.-J.1    Samuel, C.S.2    Gao, X.-M.3    Zhao, L.4    Parry, L.J.5    Tregear, G.W.6
  • 16
    • 0041428208 scopus 로고    scopus 로고
    • Inhibition of markers of hepatic stellate cell activation by the hormone relaxin
    • Bennett R.G., Kharbanda K.K., and Tuma D.J. Inhibition of markers of hepatic stellate cell activation by the hormone relaxin. Biochem Pharmacol 66 (2003) 867-874
    • (2003) Biochem Pharmacol , vol.66 , pp. 867-874
    • Bennett, R.G.1    Kharbanda, K.K.2    Tuma, D.J.3
  • 17
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams E.J., Benyon R.C., Trim N., Grove B.H., Arthur M.J., Unemori E.N., et al. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49 (2001) 577-583
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Grove, B.H.4    Arthur, M.J.5    Unemori, E.N.6
  • 19
    • 0022413232 scopus 로고
    • Perisinusoidal fat-storing cells are the main Vitamin A storage sites in rat liver
    • Hendriks H.F., Verhoofstad W.A., Brouwer A., de Leeuw A.M., and Knook D.L. Perisinusoidal fat-storing cells are the main Vitamin A storage sites in rat liver. Exp Cell Res 160 (1985) 138-149
    • (1985) Exp Cell Res , vol.160 , pp. 138-149
    • Hendriks, H.F.1    Verhoofstad, W.A.2    Brouwer, A.3    de Leeuw, A.M.4    Knook, D.L.5
  • 20
    • 0035027790 scopus 로고    scopus 로고
    • Use of rat models to mimic alterations in iron homeostasis during human alcohol abuse and cirrhosis
    • Gentry-Nielsen M.J., Preheim L.C., Lyman K.N., McDonough K.H., and Potter B.J. Use of rat models to mimic alterations in iron homeostasis during human alcohol abuse and cirrhosis. Alcohol 23 (2001) 71-81
    • (2001) Alcohol , vol.23 , pp. 71-81
    • Gentry-Nielsen, M.J.1    Preheim, L.C.2    Lyman, K.N.3    McDonough, K.H.4    Potter, B.J.5
  • 21
    • 0020470177 scopus 로고
    • High yield micronodular cirrhosis in the rat
    • Proctor E., and Chatamra K. High yield micronodular cirrhosis in the rat. Gastroenterology 83 (1982) 1183-1190
    • (1982) Gastroenterology , vol.83 , pp. 1183-1190
    • Proctor, E.1    Chatamra, K.2
  • 22
    • 0037200034 scopus 로고    scopus 로고
    • InsL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
    • Kumagai J., Hsu S.Y., Matsumi H., Roh J.S., Fu P., Wade J.D., et al. InsL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem 277 (2002) 31283-31286
    • (2002) J Biol Chem , vol.277 , pp. 31283-31286
    • Kumagai, J.1    Hsu, S.Y.2    Matsumi, H.3    Roh, J.S.4    Fu, P.5    Wade, J.D.6
  • 23
    • 0037424265 scopus 로고    scopus 로고
    • H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2
    • Sudo S., Kumagai J., Nishi S., Layfield S., Ferraro T., Bathgate R.A., et al. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem 278 (2003) 7855-7862
    • (2003) J Biol Chem , vol.278 , pp. 7855-7862
    • Sudo, S.1    Kumagai, J.2    Nishi, S.3    Layfield, S.4    Ferraro, T.5    Bathgate, R.A.6
  • 24
    • 0032742051 scopus 로고    scopus 로고
    • Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential
    • Knittel T., Kobold D., Saile B., Grundmann A., Neubauer K., Piscaglia F., et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 117 (1999) 1205-1221
    • (1999) Gastroenterology , vol.117 , pp. 1205-1221
    • Knittel, T.1    Kobold, D.2    Saile, B.3    Grundmann, A.4    Neubauer, K.5    Piscaglia, F.6
  • 27
    • 0346118862 scopus 로고    scopus 로고
    • Identification of Relaxin-3/INSL7 as a ligand for GPCR142
    • Liu C., Chen J., Sutton S., Roland B., Kuei C., Farmer N., et al. Identification of Relaxin-3/INSL7 as a ligand for GPCR142. J Biol Chem 278 (2003) 50765-50770
    • (2003) J Biol Chem , vol.278 , pp. 50765-50770
    • Liu, C.1    Chen, J.2    Sutton, S.3    Roland, B.4    Kuei, C.5    Farmer, N.6
  • 28
    • 10744224962 scopus 로고    scopus 로고
    • Identification of Relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135
    • Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., et al. Identification of Relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 278 (2003) 50754-50764
    • (2003) J Biol Chem , vol.278 , pp. 50754-50764
    • Liu, C.1    Eriste, E.2    Sutton, S.3    Chen, J.4    Roland, B.5    Kuei, C.6
  • 29
    • 0030934866 scopus 로고    scopus 로고
    • Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133
    • Houglum K., Lee K.S., and Chojkier M. Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest 99 (1997) 1322-1328
    • (1997) J Clin Invest , vol.99 , pp. 1322-1328
    • Houglum, K.1    Lee, K.S.2    Chojkier, M.3
  • 30
    • 0029892219 scopus 로고    scopus 로고
    • Inhibition of myofibroblastic transformation of cultured rat hepatic stellate cells by methylxanthines and dibutyryl cAMP
    • Kawada N., Kuroki T., Kobayashi K., Inoue M., and Kaneda K. Inhibition of myofibroblastic transformation of cultured rat hepatic stellate cells by methylxanthines and dibutyryl cAMP. Dig Dis Sci 41 (1996) 1022-1029
    • (1996) Dig Dis Sci , vol.41 , pp. 1022-1029
    • Kawada, N.1    Kuroki, T.2    Kobayashi, K.3    Inoue, M.4    Kaneda, K.5
  • 31
    • 0036789263 scopus 로고    scopus 로고
    • Regulation of endothelin-A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cells
    • Reinehr R., Fischer R., and Haussinger D. Regulation of endothelin-A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cells. Hepatology 36 (2002) 861-873
    • (2002) Hepatology , vol.36 , pp. 861-873
    • Reinehr, R.1    Fischer, R.2    Haussinger, D.3
  • 32
    • 0033617216 scopus 로고    scopus 로고
    • OPC-13013, a cyclic nucleotide phosphodiesterase type III, inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells
    • Shimizu E., Kobayashi Y., Oki Y., Kawasaki T., Yoshimi T., and Nakamura H. OPC-13013, a cyclic nucleotide phosphodiesterase type III, inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells. Life Sci 64 (1999) 2081-2088
    • (1999) Life Sci , vol.64 , pp. 2081-2088
    • Shimizu, E.1    Kobayashi, Y.2    Oki, Y.3    Kawasaki, T.4    Yoshimi, T.5    Nakamura, H.6
  • 33
    • 0042492020 scopus 로고    scopus 로고
    • G proteins are involved in the suppression of collagen alpha 1 (I) gene expression in cultured rat hepatic stellate cells
    • Solis-Herruzo J.A., Hernandez I., De la Torre P., Garcia I., Sanchez J.A., Fernandez I., et al. G proteins are involved in the suppression of collagen alpha 1 (I) gene expression in cultured rat hepatic stellate cells. Cell Signal 10 (1998) 173-183
    • (1998) Cell Signal , vol.10 , pp. 173-183
    • Solis-Herruzo, J.A.1    Hernandez, I.2    De la Torre, P.3    Garcia, I.4    Sanchez, J.A.5    Fernandez, I.6
  • 34
    • 0036798057 scopus 로고    scopus 로고
    • The role of insulin 3, testosterone Mullerian inhibiting substance and relaxin in rat gubernacular growth
    • Kubota Y., Temelcos C., Bathgate R.A., Smith K.J., Scott D., Zhao C., et al. The role of insulin 3, testosterone Mullerian inhibiting substance and relaxin in rat gubernacular growth. Mol Hum Reprod 8 (2002) 900-905
    • (2002) Mol Hum Reprod , vol.8 , pp. 900-905
    • Kubota, Y.1    Temelcos, C.2    Bathgate, R.A.3    Smith, K.J.4    Scott, D.5    Zhao, C.6
  • 37
    • 23644454431 scopus 로고    scopus 로고
    • Relaxin as an additional protective substance in preserving and reperfusion solution for liver transplantation, shown in a model of isolated perfused rat liver
    • Boehnert M.U., Hilbig H., and Armbruster F.P. Relaxin as an additional protective substance in preserving and reperfusion solution for liver transplantation, shown in a model of isolated perfused rat liver. Ann NY Acad Sci 1041 (2005) 434-440
    • (2005) Ann NY Acad Sci , vol.1041 , pp. 434-440
    • Boehnert, M.U.1    Hilbig, H.2    Armbruster, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.