Characterization of the mouse and rat relaxin receptors

Annals of the New York Academy of Sciences

Volumn 1041, Issue , 2005, Pages 8-12

  Scott, D J ^a   Layfield, S ^a   Riesewijk, A ^b   Morita, H ^c   Tregear, G W ^a   Bathgate, R A D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NV ORGANON   (Netherlands)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

LGR7; Receptors; Relaxin

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 7; RELAXIN; UNCLASSIFIED DRUG;

BINDING AFFINITY; CONFERENCE PAPER; DATA BASE; FEMALE; GENE AMPLIFICATION; GENE SEQUENCE; LGR7 GENE; LIGAND BINDING; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; RECEPTOR GENE; SEQUENCE HOMOLOGY;

RODENTIA;

EID: 23644435314     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1282.002     Document Type: Conference Paper

References (6)

1. HSU, S.Y. et al. 2000. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol. Endocrinol. 14: 1257-1271.
2. SCOTT, D.J. et al. 2004. Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing g-protein-coupled receptor 7. Clin. Exp. Pharmacol. Physiol. 31: 828-832.
3. SCOTT, D.J., G.W. TREGEAR & R.A.D. BATHGATE. 2004. LGR7-Truncate is a splice variant of the relaxin receptor, LGR7, and is a relaxin antagonist in vitro. Ann. N.Y. Acad. Sci. This volume.
4. SUDO, S. et al. 2003. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J. Biol. Chem. 278: 7855-7862.
5. TAN, Y.Y. et al. 1999. Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment. Br. J. Pharmacol. 127: 91-98.
6. TAN, Y.Y. et al. 1998. Comparison of relaxin receptors in rat isolated atria and uterus by use of synthetic and native relaxin analogues. Br. J. Pharmacol. 123: 762-770.