Atomic detail peptide-membrane interactions: Molecular dynamics simulation of gramicidin S in a DMPC bilayer

Biophysical Journal

Volumn 79, Issue 4, 2000, Pages 1718-1730

  Mihailescu, Dan ^a,b   Smith, Jeremy C ^b  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; DIMETHYL SULFOXIDE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; GRAMICIDIN S; PROTEIN;

ARTICLE; DIPOLE; EXPERIMENTATION; LIPID BILAYER; MEMBRANE BINDING; MEMBRANE FLUIDITY; MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; PROTEIN INTERACTION; SIMULATION; WATER PERMEABILITY;

EID: 0033799251     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76424-1     Document Type: Article

References (9)

1. Balasubramanian, D. 1967. The conformation of gramicidin S in solution. J. Am. Chem. Soc. 89:5445-5449.
2. Bechinger, B. 1999. The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochim. Biophys. Acta. 1462:157-183.
3. Berneche, S., M. Nina, and B. Roux. 1998. Molecular dynamics simulation of melittin in a dimyristoylphosphatidylcholine bilayer membrane. Biophys. J. 75:1603-1618.
4. Bloom, M., E. Evans, and O. G. Mouritsen. 1991. Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective. Q. Rev. Biophys. 24:293-397.
5. Hull, E., R. Karlsson, P. Main, M. M. Woolfson, and E. J. Dodson. 1978. The crystal structure of a hydrated gramicidin S-urea complex. Nature. 75:206-207.
6. Huster, D., K. Arnold, and K. Gawrisch. 1999. Investigation of lipid organization in biological membranes by two-dimensional nuclear Over-hauser enhancement spectroscopy. J. Phys. Chem. B. 103:243-251.
7. Huster, D., and K. Gawrisch. 1999. NOESY NMR crosspeaks between lipid headgroups and hydrocarbon chains: spin diffusion or molecular disorder? J. Am. Chem. Soc. 121:1992-1993.
8. Jähnig, F. 1996. What is the surface tension of a lipid bilayer membrane? Biophys. J. 71:1348-1349.
9. Zidovetzki, R., U. Banerjee, D. W. Harrigton, and S. I. Chan. 1988. NMR study of the interaction of polymyxin B, gramicidin S, valinomycin with dimyristoyllecithin bilayers. Biochemistry. 27:5686-5692.