Prevention of hyperoxia-induced alterations in synaptosomal membrane- associated proteins by N-tert-butyl-α-phenylnitrone and 4-hydroxy-2,2,6,6- tetramethylpiperidin-1-oxyl (Tempol)

Journal of Neurochemistry

Volumn 67, Issue 5, 1996, Pages 2045-2050

  Howard, Beverly J ^a   Yatin, Servet ^a   Hensley, Kenneth ^a   Allen, Kerry L ^a   Kelly, Jennie P ^a   Carney, John ^a   Butterfield, D Allan ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

4 Hydroxy 2,2,6,6 tetramethylpiperidin 1 oxyl; Aging; Electron paramagnetic resonance; Free radicals; Hyperoxia; N tert Butyl phenylnitrone; Protein oxidation

Indexed keywords

MEMBRANE PROTEIN; N TERT BUTYL ALPHA PHENYLNITRONE; OXYGEN RADICAL; TEMPOL;

AGING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HYPEROXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYNAPTIC MEMBRANE;

ANIMALIA; GERBILLINAE; LETHRINIDAE;

EID: 0029826118     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67052045.x     Document Type: Article

References (36)

1. Bellary S., Anderson K. W., Arden W. A., and Butterfield D. A. (1994) Effect of lipopolysacchride on the physical conformation of the erythrocyte cytoskeletal proteins. Life Sci. 56, 91-98.
2. Bradmante S., Monti E., Paracchini L., Lazzarini E., and Piccinini F. (1992) Protective activity of the spin trap tert-butyl-α-phenyl nitrone (PBN) in reperfused rat heart. J. Mol. Cell. Cardiol. 24, 375-386.
3. Butterfield D. A. (1982) Spin labeling in disease. Biol. Magn. Reson. 4, 1-78.
4. Butterfield D. A., Carney J., Umhauer S., Isbell D., Hall N., Hensley K., and Rangachari A. (1993) Changes in membrane cytoskeletal protein-protein interactions upon interaction of potential Alzheimer's disease therapeutic agents, in Alzheimer's Disease: Advances in Clinical and Basic Research (Corain B., Iqbal K., Nicoline M., Winblad B., Wisniewshi H. M., and Zatta P. F., eds), pp. 333-340. Wiley, New York.
5. Butterfield D. A., Hensley K., Harris M., Mattson M., and Carney J. M. (1994) β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease. Biochem. Biophys. Res. Commun. 200, 710-715.
6. Butterfield D. A., Hensley K., Hall N., Subramaniam R., Howard B. J., Cole P., Yatin S., Lafontaine M., Harris M. E., Aksenova M., Aksenov M., and Carney J. (1996a) β-Amyloid-derived free radical oxidation: a fundamental process in Alzheimer's disease, in Molecular Models of Dementia (Tanzi R. and Wasco W., eds). Humana Press, Totowa, New Jersey (in press).
7. 2+, nitroxide spin probes, and synaptosomal membrane proteins. Life Sci. 58, 217-228.
8. Carney J., Starke-Reed P., Oliver C., Landum R. W., Cheng M. S., Wu J. F., and Floyd R. A. (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound tert-butyl-α-phenyl nitrone. Proc. Natl. Acad. Sci. USA 88, 3633-3636.
9. Clough-Helftman C. and Phillis J. (1991) The free radical trapping agent spin trap tert-butyl-α-phenyl nitrone (PBN) attenuates cerebral ischaemic injury in gerbils. Free Radic. Res. Commun. 15, 177-186.
10. Dedhia H. V. and Banks D. E. (1994) Pulmonary response to hyperoxia: effects of magnesium. Environ. Health Perspect. 102, 101-105.
11. Edamatsu R., Mori A., and Packer L. (1995) The spin-trap tert-butyl-α-phenyl nitrone prolongs the life span of the senescence accelerated mouse. Biochem. Biophys. Res. Commun. 211, 847-849.
12. Gutteridge J. M. C. (1993) Free radicals in disease processes: a complication of cause and consequence. Free Radic. Res. Commun. 19, 141-148.
13. Hahn S., Tochner Z., Krishna C., Glass J., Wilson L., Samuni A., Sprangue M., Venzon D., Glatstein E., Mitchell J., and Russo A. (1992) Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res. 52, 1750-1753.
14. Hall N., Carney J. M., Cheng M. S., and Butterfield D. A. (1995a) Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes. Neuroscience 64, 81-89.
15. Hall N., Carney J., Cheng M., and Butterfield D. A. (1995b) Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-α-phenylnitrone and difluoromethylornithine. Neuroscience 69, 591-600.
16. Hall N., Dempsey R. J., Carney J. M., Donaldson D. L., and Butterfield D. A. (1995c) Structural alterations in synaptosomal membrane-associated proteins and lipids by transient middle cerebral artery occlusion in the cat. Neurochem. Res. 20, 1161-1169.
17. Harman D. (1994) Free-radical theory of aging. Increasing the functional life span. Ann. NY Acad. Sci. 717, 1-15.
18. Hensley K., Carney J. M., Hall N. C., Shaw W., and Butterfield D. A. (1994) Electron paramagnetic resonance investigations of free radical induced alterations in neocortical synaptosomes membrane protein infrastructure. Free Radic. Biol. Med. 17, 321-331.
19. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S. P., Wu J. F., Carney J. M., Lovell M., Markesbury W. R., and Butterfield D. A. (1995a) Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65, 2146-2156.
20. Hensley K., Howard B., Carney J., and Butterfield D. A. (1995b) Membrane protein alterations in rodent erythrocytes and synaptosomes due to aging and hyperoxia. Biochim. Biophys. Acta 1270, 203-206.
21. Jenkinson S. (1993) Oxygen toxicity. New Horiz. 1, 504-511.
22. Kelly F. J. (1993) Free radical disorders of preterm infants. Br. Med. Bull. 49, 668-678.
23. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
24. Miller R. E., Hadenberg R., and Gersham H. (1978) Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP. Proc. Natl. Acad. Sci. USA 75, 1418-1422.
25. Mitchell J., Samuni A., Krishna M., DeGraff W., Ahn M., Samuni U., and Russo A. (1990) Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29, 2802-2807.
26. Mitchell J., DeGraff W., Kaufman D., Krishna M., Samuni A., Finkelstein E., Ahn M., Hahn S., Gamson J., and Russo A. (1991) Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, Tempol. Arch. Biochem. Biophys. 289, 62-70.
27. Niknahad H., Khan S., and O'Brien P. J. (1995) Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation. Chem. Biol. Interact. 98, 27-44.
28. Oliver C. N., Ahn B. W., Moerman E. J., Goldstein S., and Stadtman E. R. (1987) Age-related changes in oxidized proteins. J. Biol. Chem. 262, 5488-5491.
29. Phillis J. and Clough-Helfman C. (1990) Protection from cerebral ischemic injury in gerbils with the spin trap agent spin trap tert-butyl-α-phenyl nitrone (PBN). Neurosci. Lett. 116, 315-319.
30. Reddan J., Sevilla M., Giblin F., Padgaonkar V., Dziedzic D., Leverenz V., Misra I., and Peters J. (1993) The superoxide dismutase mimic Tempol protects cultured rabbit lens epithelial cells from hydrogen peroxide insult. Exp. Eye Res. 56, 543-554.
31. Rowe W. B., Remzio R. A., Wellner V. P., and Meister A. (1970) Glutamine synthetase (sheep brain). Methods Enzymol. 17, 900-910.
32. Sen S. and Phillis J. (1993) Alpha-phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischemia-reperfusion injury of rat brain: an EPR study. Free Radic. Res. Commun. 19, 255-265.
33. Stadtman E. (1992) Protein oxidation and aging. Science 257, 1120-1124.
34. Starke-Reed P. E. and Oliver C. N. (1989) Protein oxidation and proteolysis during aging and oxidative stress. Arch. Biochem. Biophys. 275, 559-567.
35. Trad C. and Butterfield D. A. (1994) Menadione induced cytotoxicity effects on human erythrocyte membranes studied by electron paramagnetic resonance. Toxicol. Lett. 73, 145-155.
36. Umhauer S. A., Isbell D. T., and Butterfield D. A. (1992) Spin labeling of membrane proteins in mammalian brain synaptic plasma membranes: partial characterization. Anal. Lett. 25, 1201-1215.