Effects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in children

Asia Pacific Journal of Clinical Nutrition

Volumn 16, Issue 1, 2007, Pages 40-48

  Matsuyama, Takeshi ^a   Shoji, Kentaro ^b,d   Takase, Hideto ^b   Kamimaki, Isamu ^c   Tanaka, Yuriko ^a   Otsuka, Atsuko ^b   Watanabe, Hiroyuki ^b   Hase, Tadashi ^b   Tokimitsu, Ichiro ^b  

^a Fussa Hospital   (Japan)

^b KAO CORPORATION   (Japan)

^c SAITAMA NATIONAL HOSPITAL   (Japan)

^d NONE   (Japan)

Author keywords

Children; Cholesterol; Diacylglycerol; Lipoprotein(a); Phytosterols

Indexed keywords

CHOLESTEROL; DIACYLGLYCEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL;

ADOLESCENT; ARTICLE; BLOOD; CHILD; DIET THERAPY; FEMALE; HUMAN; HYPERLIPIDEMIA; MALE; TREATMENT OUTCOME;

ADOLESCENT; ANTICHOLESTEREMIC AGENTS; CHILD; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIGLYCERIDES; FEMALE; HUMANS; HYPERLIPIDEMIAS; MALE; PHYTOSTEROLS; TREATMENT OUTCOME;

EID: 33847103688     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. American Academy of Pediatrics. National Cholesterol Education Program: Report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 1992; 89: 525-584.
2. Bao W, Srinivasan SR, Valdez R, Greenlund KJ, Wattigney WA, Berenson GS. Longitudinal changes in cardiovascular risk from childhood to young adulthood in offspring of parents with coronary artery disease: The Bogalusa Heart Study. JAMA 1997; 278: 1749-1754.
3. th edn. New York: McGraw-Hill Book Co, 1995; 1981-2030.
4. Ducobu J, Brasseur D, Chaudron JM, Deslypere JP, Harvengt C, Muls E, Thomson M. Simvastatin use in children. Lancet 1992; 339: 1488.
5. Sinzinger H, Schmid P, Pirich C, Virgolini I, Pesau B, Granegger S, O'Grady J. Treatment of hypercholesterolaemia in children. Lancet 1992; 340: 548-549.
6. Lambert M, Lupien PJ, Gagne C, Levy E, Blaichman S, Langlois S, Hayden M, Rose V, Clarke JT, Wolfe BM, Clarson C, Parsons H, Stephure DK, Potvin D, Lambert J. Treatment of familial hypercholesterolemia in children and adolescents: effect of lovastatin: Canadian Lovastatin in Children Study Group. Pediatrics 1996; 97: 619-628.
7. Couture P, Brun LD, Szots F, Lelievre M, Gaudet D, Despres JP, Simard J, Lupien PJ, Gagne C. Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 1998; 18: 1007-1012.
8. Stefanutti C, Lucani G, Vivenzio A, Di Giacomo S. Diet only and diet plus simvastatin in the treatment of heterozygous familial hypercholesterolemia in childhood. Drugs Exp Clin Res 1999; 25: 23-28.
9. Stein EA, Illingworth DR, Kwiterovich PO Jr, Liacouras CA, Siimes MA, Jacobson MS, Brewster TG, Hopkins P, Davidson M, Graham K, Arensman F, Knopp RH, Du-Jovne C, Williams CL, Isaacsohn JL, Jacobsen CA, Laskarzewski PM, Ames S, Gormley GJ. Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia: a randomized controlled trial. JAMA 1999; 281: 137-144.
10. Mattson FH, Volpenhein RA, Erickson BA. Effect of plant sterol esters on the absorption of dietary cholesterol. J Nutr 1977; 107: 1139-1146.
11. Mattson FH, Grundy SM, Crouse JR. Optimizing the effect of plant sterols on cholesterol absorption in man. Am J Clin Nutr. 1982; 35: 697-700.
12. Grundy SM, Ahrens EH Jr. The interaction of cholesterol absorption and cholesterol synthesis in man. J Lipid Res 1969; 10: 304-315.
13. Gylling H, Siimes MA, Miettinen TA. Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. J Lipid Res 1995; 36: 1807-1812.
14. Pelletier X, Belbraouet S, Mirabel D, Mordret F, Perrin JL, Pages X, Debry G. A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann Nutr Metab. 1995; 39: 291-295.
15. Hendriks HF, Weststrate JA, van Vliet T, Meijer GW Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 1999; 53: 319-327.
16. Meguro S, Higashi K, Hase T, Honda Y, Otsuka A, Tokimitsu I, Itakura H. Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. Eur J Clin Nutr 2001; 55: 513-517.
17. Murase T, Aoki M, Wakisaka T, Hase T, Tokimitsu I. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism. J Lipid Res 2002; 43: 1312-1319.
18. Kondo H, Hase T, Murase T, Ichiro Tokimitsu. Digestion and assimilation features of dietary DG in the rat small intestine. Lipids 2003; 38: 25-30.
19. Taguchi H, Watanabe H, Onizawa K, Nagao T, Gotoh N, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J Am Coll Nutr 2000; 19: 789-796.
20. Tada N, Watanabe H, Matsuo N, Tokimitsu I, Okazaki M. Dynamics of postprandial remnant-like lipoprotein particles in serum after loading of diacylglycerols. Clin Chim Acta 2001; 311: 109-117.
21. Nagao T, Watanabe H, Goto N, Onizawa K, Taguchi H, Matsuo N, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr 2000; 130: 792-797.
22. Maki KC, Davidson MH, Tsushima R, Matsuo N, Tokimitsu I, Umporowicz DM, Dicklin MR, Foster GS, Ingram KA, Anderson BD, Frost SD, Bell M. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil. Am J Clin Nutr. 2002; 76: 1230-1236.
23. Vanhanen HT, Blomqvist S, Ehnholm C, Hyvonen M, Jauhiainen M, Torstila I, Miettinen TA. Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. J Lipid Res. 1993; 34: 1535-1544.
24. Ostlund RE Jr, Spilburg CA, Stenson WF. Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. Am J Clin Nutr 1999; 70: 826-831.
25. Ministry of Health and Welfare. Annual Report on Health and Welfare. 1986 [in Japanese]
26. Mabuchi H, Miyamoto S, Ueda K, Oota M, Takegoshi T, Wakasugi T, Takeda R. Causes of death in patients with familial hypercholesterolemia. Atherosclerosis 1986; 61: 1-6.
27. Goldstein JL, Sobhani MK, Faust JR, Brown MS. Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus. Cell 1976; 9: 195-203.
28. Birgitte HJ, Donna RG, Robert GJ. Studies on free and immobilized lipases from Mucor miehei. J Am Oil Chem Sci. 1992; 65: 905-910.
29. Hales CN, Randle PJ. Immunoassay of insulin with insulin antibody precipitate. Biochem J 1963; 88: 137-146.
30. Declerck PJ, Alessi MC, Verstreken M, Kruithof EK, Juhan-Vague I, Collen D. Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay. Blood 1988; 71: 220-225.
31. Ma ZA, Gingerich RL, Santiago JV, Klein S, Smith HC, Landt M. Radioimmunoassay of leptin in human plasma. Clin Chem 1996; 42: 942-946.
32. Nakajima K, Saito T, Tamura A. A new assay method for the quantification of cholesterol in remnant like lipoproteins in human serum using monoclonal anti apo B100 and apo A-I immunoaffinity mixed gels. Clin Chim Acta 1993; 223: 53-71.
33. Gylling H, Puska P, Vartiainen E, Miettinen TA. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. J Lipid Res 1999; 40: 593-600.
34. Teramoto T, Yamada N, Shimano H, Oka Y, Itakura H, Saito Y, Morisaki N, Shirai K, Ishikawa T, Tada N, Ito H, Yamanouchi T, Matsushima T, Kawakami M, Murase T, Okubo M, Totsuka Y, Kikuchi M. Dose-dependent effect of niceritrol on plasma lipoprotein-a. Scand J Clin Lab Invest 1996; 56: 359-365.
35. Teramoto T, Watanabe H, Ito K, Omata Y, Furukawa T, Shimoda K, Hoshino M, Nagao T, Naito S Significant effects of diacylglycerol on body fat and lipid metabolism in patients on hemodialysis. Clin Nutr 2004; 23: 1122-1126.
36. Maher VMG, Brown BG Lipoprotein (a) and coronary heart disease. Curr. Opin Lipidol 1995; 6: 229-235.
37. th edn. CR Scriver, AL Beaudet, WA Sly, D Valle, Eds. McGraw Hill Inc., New York. 1989; 1215-1250.
38. Becker M, Staab D, K. Von Berbmann. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J Pediatr 1993; 122: 292-296.
39. Naoumova RP, Marais AD, Mountney J, Firth JC, Rendell NB, Taylor GW, Thompson GR. Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolemia. Atherosclerosis 1996; 119: 201-213.
40. Tilvis RS, Miettinen TA. Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutr 1986; 43: 92-99.
41. Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, Pearson T, Roheim P, Ramakrishnan R, Reed R, Stewart K, Stewart P, Phillips K, Anderson N. Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in Healthy Subjects. Arterioscler Thromb Vasc Biol.1998; 18: 441-449.