Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells

American Journal of Physiology - Cell Physiology

Volumn 292, Issue 2, 2007, Pages

  Kim, Yong Bae ^a   Lee, Sung Yul ^a   Ye, Sang Kyu ^a   Lee, Jung Weon ^a  

^a Seoul National University   (South Korea)

Author keywords

Cell adhesion; Gastric cancer; Histone acetylation; Integrin linked kinase

Indexed keywords

ACTIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FIBRONECTIN; HISTONE DEACETYLASE 3; HISTONE H3; INTEGRIN LINKED KINASE; LYSINE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PROTEIN P300; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ACETYLATION; ARTICLE; CELL ADHESION; CELL GROWTH; CELL SUSPENSION; CHROMATIN IMMUNOPRECIPITATION; CYTOPLASM; EPIGENETICS; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; STOMACH CARCINOMA;

ACETYLATION; CELL ADHESION; CELL LINE, TUMOR; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; FIBRONECTINS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HISTONES; HUMANS; METHYL-CPG-BINDING PROTEIN 2; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SMAD4 PROTEIN; STOMACH NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33847077605     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00169.2006     Document Type: Article

References (66)

1. Attwell S, Mills J, Troussard A, Wu C, Dedhar S. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell 14: 4813-4825, 2003.
2. Attwell S, Roskelley C, Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 19: 3811-3815, 2000.
3. Avizienyte E, Frame MC. Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol 17: 542-547, 2005.
4. Balda MS, Matter K. Epithelial cell adhesion and the regulation of gene expression. Trends Cell Biol 13: 310-318, 2003.
5. Ballestar E, Wolffe AP. Methyl-CpG-binding proteins. Targeting specific gene repression. Eur J Biochem 268: 1-6, 2001.
6. Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, Altruda F, Tarone G, Giancotti FG. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 275: 36532-36540, 2000.
7. Boudreau N, Myers C, Bissell MJ. From laminin to lamin: regulation of tissue-specific gene expression by the ECM. Trends Cell Biol 5: 1-4, 1995.
8. Brakebusch C, Fassler R. The integrin-actin connection, an eternal love affair. EMBO J 22: 2324-2333, 2003.
9. Burgers WA, Fuks F, Kouzarides T. DNA methyltransferases get connected to chromatin. Trends Genet 18: 275-277, 2002.
10. Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC. A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol 13: 1442-1450, 2003.
11. Czuwara-Ladykowska J, Sementchenko VI, Watson DK, Trojanowska M. Ets1 is an effector of the transforming growth factor β (TGF-β) signaling pathway and an antagonist of the profibrotic effects of TGF-β. J Biol Chem 277: 20399-20408, 2002.
12. Dedhar S. Cell-substrate interactions and signaling through ILK. Curr Opin Cell Biol 12: 250-256, 2000.
13. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 95: 11211-11216, 1998.
14. DeMali KA, Wennerberg K, Burridge K. Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol 15: 572-582, 2003.
15. Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem J 367: 517-524, 2002.
16. 2+-independent smooth muscle contraction. A novel function for integrin-linked kinase. J Biol Chem 276: 16365-16373, 2001.
17. Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463, 2004.
18. Ehrenhofer-Murray AE. Chromatin dynamics at DNA replication, transcription and repair. Eur J Biochem 271: 2335-2349, 2004.
19. Felsenfeld G, Groudine M. Controlling the double helix. Nature 421: 448-453, 2003.
20. Fischle W, Wang Y, Allis CD. Histone and chromatin cross-talk. Curr Opin Cell Biol 15: 172-183, 2003.
21. Geiman TM, Robertson KD. Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together? J Cell Biochem 87: 117-125, 2002.
22. Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5: 816-826, 2004.
23. Haller D, Holt L, Kim SC, Schwabe RF, Sartor RB, Jobin C. Transforming growth factor-β1 inhibits non-pathogenic Gram negative bacteria-induced NF-κB recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. J Biol Chem 278: 23851-23860, 2003.
24. Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5: 51-63, 2005.
25. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. Nature 379: 91-96, 1996.
26. Hendrich B, Tweedie S. The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet 19: 269-277, 2003.
27. Hirohashi S, Kanai Y. Cell adhesion system and human cancer morphogenesis. Cancer Sci 94: 575-581, 2003.
28. Iizuka M, Smith MM. Functional consequences of histone modifications. Curr Opin Genet Dev 13: 154-160, 2003.
29. Ito R, Oue N, Zhu X, Yoshida K, Nakayama H, Yokozaki H, Yasui W. Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch 442: 118 -123, 2003.
30. Juliano RL, Aplin AE, Howe AK, Short S, Lee JW, Alahari S. Integrin regulation of receptor tyrosine kinase and G protein-coupled receptor signaling to mitogen-activated protein kinases. Methods Enzymol 333: 151-163, 2001.
31. Juliano RL, Reddig P, Alahari S, Edin M, Howe A, Aplin A. Integrin regulation of cell signalling and motility. Biochem Soc Trans 32: 443-446, 2004.
32. Kim HP, Lee MS, Yu J, Park JA, Jong HS, Kim TY, Lee JW, Bang YJ. TGF-β1 (transforming growth factor-β1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity. Biochem J 379: 141-150, 2004.
33. Kim YB, Yu J, Lee SY, Lee MS, Ko SG, Ye SK, Jong HS, Kim TY, Bang YJ, Lee JW. Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities. J Biol Chem 280: 28357-28364, 2005.
34. Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Oncogene 23: 3454-3461, 2004.
35. Lee JW, Juliano R. Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways. Mol Cell 17: 188-202, 2004.
36. Lee JW, Juliano RL. α5β1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway. Mol Biol Cell 11: 1973-1987, 2000.
37. Lee JW, Juliano RL. The α5β1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/ Akt pathway in intestinal epithelial cells. Biochim Biophys Acta 1542: 23-31, 2002.
38. Lee MS, Kim TY, Kim YB, Lee SY, Ko SG, Jong HS, Kim TY, Bang YJ, Lee JW. The signaling network of transforming growth factor β1, protein kinase Cδ, and integrin underlies the spreading and invasiveness of gastric carcinoma cells. Mol Cell Biol 25: 6921-6936, 2005.
39. Lee MS, Ko SG, Kim HP, Kim YB, Lee SY, Kim SG, Jong HS, Kim TY, Lee JW, Bang YJ. Smad2 mediates Erk1/2 activation by TGF-β1 in suspended, but not in adherent, gastric carcinoma cells. Int J Oncol 24: 1229-1234, 2004.
40. Legube G, Trouche D. Regulating histone acetyltransferases and deacetylases. EMBO Rep 4: 944-947, 2003.
41. Liotta LA, Rao CN, Wewer UM. Biochemical interactions of tumor cells with the basement membrane. Annu Rev Biochem 55: 1037-1057, 1986.
42. Massague J. How cells read TGF-β signals. Nat Rev Mol Cell Biol 1: 169-178, 2000.
43. McPherson CE, Shim EY, Friedman DS, Zaret KS. An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array. Cell 75: 387-398, 1993.
44. Muller JM, Metzger E, Greschik H, Bosserhoff AK, Mercep L, Buettner R, Schule R. The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J 21: 736-748, 2002.
45. Nakashio T, Narita T, Sato M, Akiyama S, Kasai Y, Fujiwara M, Ito K, Takagi H, Kannagi R. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer. Anticancer Res 17: 293-299, 1997.
46. Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R, Gansmuller A, Chambon P, Losson R. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J 18: 6385-6395, 1999.
47. Ogryzko VV. Mammalian histone acetyltransferases and their complexes. Cell Mol Life Sci 58: 683-692, 2001.
48. Olson MF. Contraction reaction: mechanical regulation of Rho GTPase. Trends Cell Biol 14: 111-114, 2004.
49. Park JH, Jung Y, Kim TY, Kim SG, Jong HS, Lee JW, Kim DK, Lee JS, Kim NK, Kim TY, Bang YJ. Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res 10: 5271-5281, 2004.
50. Persad S, Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev 22: 375-384, 2003.
51. Radeva G, Petrocelli T, Behrend E, Leung-Hagesteijn C, Filmus J, Slingerland J, Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem 272: 13937-13944, 1997.
52. Reddig PJ, Juliano RL. Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev 24: 425-439, 2005.
53. Ren XD, Kiosses WB, Schwartz MA. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18: 578-585, 1999.
54. Ren XD, Wang R, Li Q, Kahek LAF, Kaibuchi K, Clark RAF. Disruption of Rho signal transduction upon cell detachment. J Cell Sci 117: 3511-3518, 2004.
55. Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol 200: 448-464, 2003.
56. Stanchi F, Bordoy R, Kudlacek O, Braun A, Pfeifer A, Moser M, Fassler R. Consequences of loss of PINCH2 expression in mice. J Cell Sci 118: 5899-5910, 2005.
57. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
58. Totsukawa G, Wu Y, Sasaki Y, Hartshorne DJ, Yamakita Y, Yamashiro S, Matsumura F. Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J Cell Biol 164: 427-439, 2004.
59. Ura H, Denno R, Hirata K, Yamaguchi K, Yasoshima T. Separate functions of α2β1 and α3β1 integrins in the metastatic process of human gastric carcinoma. Surg Today 28: 1001-1006, 1998.
60. Vermaak D, Ahmad K, Henikoff S. Maintenance of chromatin states: an open-and-shut case. Curr Opin Cell Biol 15: 266-274, 2003.
61. Wang SC, Makino K, Xia W, Kim JS, Im SA, Peng H, Mok SC, Singletary SE, Hung MC. DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway. Oncogene 20: 6960-6964, 2001.
62. 2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem J 392: 641-648, 2005.
63. Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim Biophys Acta 1692: 55-62, 2004.
64. Yamaguchi K, Ura H, Yasoshima T, Shishido T, Denno R, Hirata K. Establishment and characterization of a human gastric carcinoma cell line that is highly metastatic to lymph nodes. J Exp Clin Cancer Res 19: 113-120, 2000.
65. Yasoshima T, Denno R, Kawaguchi S, Sato N, Okada Y, Ura H, Kikuchi K, Hirata K. Establishment and characterization of human gastric carcinoma lines with high metastatic potential in the liver: changes in integrin expression associated with the ability to metastasize in the liver of nude mice. Jpn J Cancer Res 87: 153-160, 1996.
66. Ye SK, Agata Y, Lee HC, Kurooka H, Kitamura T, Shimizu A, Honjo T, Ikuta K. The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation. Immunity 15: 813- 823, 2001.