Role of MAPK signal transduction in synoviocytes of rheumatoid arthritis

Chinese Pharmacological Bulletin

Volumn 22, Issue 12, 2006, Pages 1424-1428

  Chen, Xiao Yu ^a   Chen, Ming ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

MAPK; Rheumatoid arthritis; Synoviocytes

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; ONCOGENE C FOS; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

EID: 33847032953     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Liu Q H, Shen L X, Teng Y, et al. Effects of methotrexate on cell proliferation and cell cycle of synovial fibroblasts in patients with rheumatoid arthritis[J]. J Huazhong Univ Sci Tech (Health Sci), 2004,33(5):599-601.
2. Yamamoto A, Fukuda A, Seto H, et al. Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative ras gene transfer to synoviocytes and osteoclasts[J]. Arthritis Rheum, 2003,48(6):2682- 92.
3. Liu W, Li S X. Study progress on fiber like synovial fibroblasts of rheumatoid arthritis[J]. Chin J Rheumatol, 2005,9(10):620-2.
4. Perlman H, Bradley K, Liu H, et al. IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts[J]. J Immunol, 2003,170(2):838-45.
5. Rutaule K, Hazzalin C A. Combination of ERK and p38 MAPK inhibitos ablate tumor necrosis factor-αmRNA induction: evidence for selective destabilization of TNF-α transcripts[J]. J Biol Chem, 2001,276(3):666-9.
6. Hashiramoto C V, McGuffie E M, Pacheco D, et al. Inhibition of gene expression and cell proliferation by triple helix-formming oligonucleotides directed to the c-myc gene[J]. Biochemistry, 2000,39:5126-38.
7. Hommes D W, Mppeppelenbosch. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targers[J]. Gut, 2003,52:144-51.
8. Gustin J A, Pincheira R, Mayo L D, et al. Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells [J]. Am J Physiol Cell Physiol, 2004,286(3):547-55.
9. Kato H, Nishida K, Yoshida A, et al. Effect of NOS gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration [J]. J Rheumatol, 2003,30:247-55.
10. Chabaud R M, Firestein G S. Expression and activation of mitogen-activated protein kinase kinases-3 and-6 in rheumatoid arthritis [J]. Am J Pathol, 2004,164(1):177-84.
11. Nishikawa M, Myoui A, Tomita T, et al. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653 [J]. Arthritis Rheum, 2003,48(9):2670-81.
12. Asahara H, Fujisawa K, Kobata T, et al. Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synvium[J]. Arthritis Rheum, 1997,40(5):912-8.
13. Papadukis K A, Targan S R. Role of cytokines in the pathogenesis of inflammator bowel disease [J]. Annu Rev Med, 2002,51(1): 289-99.
14. Sugden P, Clerk A. Stress-responsive mitogen-activated protein kinase in the myocardium[J]. Circ Res, 1998,83(6):345-52.
15. Migita K, Miyashita T, Ishibashi H, et al. Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1beta stimulated rheumatoid synovial fibroblasts [J]. Clin Exp Immunol, 2004,137(3):612-6.
16. Kumar S, Votta B J, Rieman D J, et al. IL-1 and TNF-α induced bone resorplion in mediated by p38 mitogen activated protein kinase [J]. J Cell Physiol, 2001,187(2):294-303.
17. Badger A M, Bradbeer J N, Votta B, et al. Pharmacological profile of SB203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of althritis bone resorption, endotoxin shock and immune function [J]. J Pharmacol Exp Ther, 1996,279(5):1453-61.
18. Han Z, Boyle D L, Manning A M, Firestein G S. AP-1 and NF-kappa B regulation in rheumatoid arthritis and murine collagen-induced arthritis[J]. Autoimmumiy, 1998,28(4):197-208.