메뉴 건너뛰기




Volumn 39, Issue 1, 2007, Pages 2-17

The utility of levosimendan in the treatment of heart failure

Author keywords

Calcium sensitizer; Efficacy; Heart failure; Levosimendan; Pharmacology; Safety; Therapy

Indexed keywords

4,5 DIHYDRO 6 [4 (4 PYRIDYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; 5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; CALCIUM SENSITIZER; CONTRACTILE PROTEIN; DIURETIC AGENT; DOBUTAMINE; DRUG METABOLITE; INOTROPIC AGENT; LEVOSIMENDAN; N [4 (1,4,5,6 TETRAHYDRO 4 METHYL 6 OXO 3 PYRIDAZINYL)PHENYL]ACETAMIDE; OR 1855; PIMOBENDAN; PLACEBO; POTASSIUM CHANNEL; TROPONIN C; UNCLASSIFIED DRUG; VASODILATOR AGENT;

EID: 33847028846     PISSN: 07853890     EISSN: 16512219     Source Type: Journal    
DOI: 10.1080/07853890601073346     Document Type: Review
Times cited : (32)

References (85)
  • 1
    • 0034878357 scopus 로고    scopus 로고
    • Inotropic therapy for heart failure: An evidence-based approach
    • Felker GM, O'Connor CM. Inotropic therapy for heart failure: an evidence-based approach. Am Heart J. 2001;142:393-401.
    • (2001) Am Heart J , vol.142 , pp. 393-401
    • Felker, G.M.1    O'Connor, C.M.2
  • 2
    • 33645498542 scopus 로고    scopus 로고
    • Levosimendan, a new inotropic and vasodilator agent
    • Toller WG, Stranz C. Levosimendan, a new inotropic and vasodilator agent. Anesthesiology. 2006;104:556-69.
    • (2006) Anesthesiology , vol.104 , pp. 556-569
    • Toller, W.G.1    Stranz, C.2
  • 3
    • 0032416913 scopus 로고    scopus 로고
    • Parenteral inotropic support for advanced congestive heart failure
    • Leier CV, Binkley PH. Parenteral inotropic support for advanced congestive heart failure. Prog Cardiovasc Dis. 1998;41:207-24.
    • (1998) Prog Cardiovasc Dis , vol.41 , pp. 207-224
    • Leier, C.V.1    Binkley, P.H.2
  • 4
    • 0037181515 scopus 로고    scopus 로고
    • Short-term intravenous milrinone for acute exacerbation of chronic heart failure: A randomized controlled trial
    • Cuffe MS, Califf RM, Adams KF Jr, Benza R, Bourge R, Colucci WS, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA. 2002;287:1541-7.
    • (2002) JAMA , vol.287 , pp. 1541-1547
    • Cuffe, M.S.1    Califf, R.M.2    Adams Jr, K.F.3    Benza, R.4    Bourge, R.5    Colucci, W.S.6
  • 5
    • 33644997173 scopus 로고    scopus 로고
    • Mechanisms and use of calcium-sensitizing agents in the failing heart
    • Kass DA, Solaro RJ. Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation. 2006;113:305-15.
    • (2006) Circulation , vol.113 , pp. 305-315
    • Kass, D.A.1    Solaro, R.J.2
  • 6
    • 1442359935 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous inotropic agents
    • Lehtonen LA, Antila S, Pentikainen PJ. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43:187-203.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 187-203
    • Lehtonen, L.A.1    Antila, S.2    Pentikainen, P.J.3
  • 7
    • 0029810701 scopus 로고    scopus 로고
    • Calcium-sensitizing drugs: Positive inotropy by enhanced sensitivity of the contractile apparatus to calcium
    • Ver Donck L. Calcium-sensitizing drugs: positive inotropy by enhanced sensitivity of the contractile apparatus to calcium. Cardiovasc Drug Rev. 1996;14:185-212.
    • (1996) Cardiovasc Drug Rev , vol.14 , pp. 185-212
    • Ver Donck, L.1
  • 8
    • 0034185033 scopus 로고    scopus 로고
    • Levosimendan: A promising agent for the treatment of hospitalized patients with decompensated heart failure
    • Lehtonen L. Levosimendan: A promising agent for the treatment of hospitalized patients with decompensated heart failure. Curr Cardiol Rep. 2000;2:233-43.
    • (2000) Curr Cardiol Rep , vol.2 , pp. 233-243
    • Lehtonen, L.1
  • 12
    • 0027942068 scopus 로고
    • Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs
    • Pagel PS, Harkin CP, Hettrick DA, Warltier DC. Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs. Anesthesiology. 1994;81:974-87.
    • (1994) Anesthesiology , vol.81 , pp. 974-987
    • Pagel, P.S.1    Harkin, C.P.2    Hettrick, D.A.3    Warltier, D.C.4
  • 13
    • 0030955524 scopus 로고    scopus 로고
    • The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan
    • Haikala H, Kaheinen P, Levijoki J, Linden IB. The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan. Cardiovasc Res. 1997;34:536-46.
    • (1997) Cardiovasc Res , vol.34 , pp. 536-546
    • Haikala, H.1    Kaheinen, P.2    Levijoki, J.3    Linden, I.B.4
  • 14
    • 0032541979 scopus 로고    scopus 로고
    • Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium
    • Hasenfuss G, Pieske B, Castell M, Kretschmann B, Maier LS, Just H. Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium. Circulation. 1998;98:2141-7.
    • (1998) Circulation , vol.98 , pp. 2141-2147
    • Hasenfuss, G.1    Pieske, B.2    Castell, M.3    Kretschmann, B.4    Maier, L.S.5    Just, H.6
  • 15
  • 16
    • 0028908851 scopus 로고
    • Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction
    • Udvary E, Papp JG, Vegh A. Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction. Br J Pharmacol. 1995;114:656-61.
    • (1995) Br J Pharmacol , vol.114 , pp. 656-661
    • Udvary, E.1    Papp, J.G.2    Vegh, A.3
  • 17
    • 0030918670 scopus 로고    scopus 로고
    • Levosimendan enhances left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy
    • Pagel PS, McGough MF, Hettrick DA, Lowe D, Tessmer JP, Jamali IN, et al. Levosimendan enhances left ventricular systolic and diastolic function in conscious dogs with pacing-induced cardiomyopathy. J Cardiovasc Pharmacol. 1997;29:563-73.
    • (1997) J Cardiovasc Pharmacol , vol.29 , pp. 563-573
    • Pagel, P.S.1    McGough, M.F.2    Hettrick, D.A.3    Lowe, D.4    Tessmer, J.P.5    Jamali, I.N.6
  • 18
    • 0030608872 scopus 로고    scopus 로고
    • Levosimendan, a novel Ca2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes
    • Yokoshiki H, Katsube Y, Sunagawa M, Sperelakis N. Levosimendan, a novel Ca2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes. Eur J Pharmacol. 1997;333:249-59.
    • (1997) Eur J Pharmacol , vol.333 , pp. 249-259
    • Yokoshiki, H.1    Katsube, Y.2    Sunagawa, M.3    Sperelakis, N.4
  • 19
    • 0343049171 scopus 로고    scopus 로고
    • Comparison of the vasorelaxing effect of cromakalin and the new inodilator, levosimendan, in human isolated portal vein
    • Pataricza J, Hohn J, Petri A, Balogh A, Papp JG. Comparison of the vasorelaxing effect of cromakalin and the new inodilator, levosimendan, in human isolated portal vein. J Pharm Pharmacol. 2000;52:213-7.
    • (2000) J Pharm Pharmacol , vol.52 , pp. 213-217
    • Pataricza, J.1    Hohn, J.2    Petri, A.3    Balogh, A.4    Papp, J.G.5
  • 20
    • 0033959417 scopus 로고    scopus 로고
    • Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels
    • Kersten JR, Montgomery MW, Pagel PS, Warltier DC. Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels. Anesth Analg. 2000;90:5-11.
    • (2000) Anesth Analg , vol.90 , pp. 5-11
    • Kersten, J.R.1    Montgomery, M.W.2    Pagel, P.S.3    Warltier, D.C.4
  • 21
    • 0030771922 scopus 로고    scopus 로고
    • The novel calcium sensitizer levosimendan activates the ATPsensitive K+ channel in rat ventricular cells
    • Yokoshiki H, Katsube Y, Sunagawa M, Sperelakis N. The novel calcium sensitizer levosimendan activates the ATPsensitive K+ channel in rat ventricular cells. J Pharmacol Exp Ther. 1997;283:375-83.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 375-383
    • Yokoshiki, H.1    Katsube, Y.2    Sunagawa, M.3    Sperelakis, N.4
  • 23
    • 0028339593 scopus 로고
    • Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts
    • Rump AF, Acar D, Rosen R, Klaus W. Functional and antiischaemic effects of the phosphodiesterase inhibitor levosimendan in isolated rabbit hearts. Pharmacol Toxicol. 1994;74:24424-8.
    • (1994) Pharmacol Toxicol , vol.74 , pp. 24424-24428
    • Rump, A.F.1    Acar, D.2    Rosen, R.3    Klaus, W.4
  • 25
    • 0032104314 scopus 로고    scopus 로고
    • Effects of levosimendan on myocardial contractility and Ca2+ transients in aequorin-loaded right-ventricular papillary muscles and indo-1-loaded single ventricular cardiomyocytes of the rabbit
    • Sato S, Talukder MA, Sugawara H, Sawada H, Endoh M. Effects of levosimendan on myocardial contractility and Ca2+ transients in aequorin-loaded right-ventricular papillary muscles and indo-1-loaded single ventricular cardiomyocytes of the rabbit. J Mol Cell Cardiol. 1998;30:1115-28.
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 1115-1128
    • Sato, S.1    Talukder, M.A.2    Sugawara, H.3    Sawada, H.4    Endoh, M.5
  • 27
  • 28
    • 0034469050 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic interactions between the novel calcium sensitiser levosimendan and warfarin
    • Antila S, Jarvinen A, Honkanen T, Lehtonen L. Pharmacokinetic and pharmacodynamic interactions between the novel calcium sensitiser levosimendan and warfarin. Eur J Clin Pharmacol. 2000;56:705-10.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 705-710
    • Antila, S.1    Jarvinen, A.2    Honkanen, T.3    Lehtonen, L.4
  • 30
    • 0031775152 scopus 로고    scopus 로고
    • Integrated pharmacokinetics and pharmacodynamics of the novel calcium sensitizer levosimendan as assessed by systolic time intervals
    • Sundberg S, Antila S, Scheinin H, Häyha M, Virtanen M, Lehtonen L. Integrated pharmacokinetics and pharmacodynamics of the novel calcium sensitizer levosimendan as assessed by systolic time intervals. Int J Clin Pharmacol Ther. 1998;36:629-35.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , pp. 629-635
    • Sundberg, S.1    Antila, S.2    Scheinin, H.3    Häyha, M.4    Virtanen, M.5    Lehtonen, L.6
  • 33
    • 0034648108 scopus 로고    scopus 로고
    • Inotropic effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium
    • Takahashi R, Talukder MA, Endoh M. Inotropic effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium. Eur J Pharmacol. 2000;400:103-12.
    • (2000) Eur J Pharmacol , vol.400 , pp. 103-112
    • Takahashi, R.1    Talukder, M.A.2    Endoh, M.3
  • 34
    • 1642441317 scopus 로고    scopus 로고
    • The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig
    • Szilagyi S, Pollesello P, Levijoki J, Kaheinen P, Haikala H, Edes I, et al. The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig. Eur J Pharmacol. 2004;486:67-74.
    • (2004) Eur J Pharmacol , vol.486 , pp. 67-74
    • Szilagyi, S.1    Pollesello, P.2    Levijoki, J.3    Kaheinen, P.4    Haikala, H.5    Edes, I.6
  • 35
    • 0036795429 scopus 로고    scopus 로고
    • Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure
    • Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure. Int J Clin Pharmacol Ther. 2002;40:465-71.
    • (2002) Int J Clin Pharmacol Ther , vol.40 , pp. 465-471
    • Kivikko, M.1    Antila, S.2    Eha, J.3    Lehtonen, L.4    Pentikainen, P.J.5
  • 36
    • 0036137181 scopus 로고    scopus 로고
    • Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure
    • Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. J Clin Pharmacol. 2002;42:43-51.
    • (2002) J Clin Pharmacol , vol.42 , pp. 43-51
    • Kivikko, M.1    Antila, S.2    Eha, J.3    Lehtonen, L.4    Pentikainen, P.J.5
  • 37
    • 5644302941 scopus 로고    scopus 로고
    • Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators
    • Antila S, Pesonen U, Lehtonen L, Tapanainen P, Nikkanen H, Vaahtera K, et al. Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators. Eur J Pharm Sci. 2004;23:213-22.
    • (2004) Eur J Pharm Sci , vol.23 , pp. 213-222
    • Antila, S.1    Pesonen, U.2    Lehtonen, L.3    Tapanainen, P.4    Nikkanen, H.5    Vaahtera, K.6
  • 38
    • 1942455382 scopus 로고    scopus 로고
    • Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan
    • Antila S, Kivikko M, Lehtonen L, Eha J, Heikkila A, Pohjanjousi P, et al. Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan. Br J Clin Pharmacol. 2004;57:412-5.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 412-415
    • Antila, S.1    Kivikko, M.2    Lehtonen, L.3    Eha, J.4    Heikkila, A.5    Pohjanjousi, P.6
  • 43
    • 0034669441 scopus 로고    scopus 로고
    • Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure
    • Nieminen MS, Akkila J, Hasenfuss G, Kleber FX, Lehtonen LA, Mitrovic V, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Coll Cardiol. 2000;36:1903-12.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1903-1912
    • Nieminen, M.S.1    Akkila, J.2    Hasenfuss, G.3    Kleber, F.X.4    Lehtonen, L.A.5    Mitrovic, V.6
  • 45
    • 0032542385 scopus 로고    scopus 로고
    • A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators
    • Cohn JN, Goldstein SO, Greenberg BH, Lorell BH, Bourge RC, Jaski BE, et al. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators. N Engl J Med. 1998;339:1810-16.
    • (1998) N Engl J Med , vol.339 , pp. 1810-1816
    • Cohn, J.N.1    Goldstein, S.O.2    Greenberg, B.H.3    Lorell, B.H.4    Bourge, R.C.5    Jaski, B.E.6
  • 46
    • 0034033977 scopus 로고    scopus 로고
    • Neurohormonal activation in severe heart failure: Relations to patient death and the effect of treatment with flosequinan
    • Moe GW, Rouleau JL, Charbonneau L, Proulx G, Arnold JM, Hall C, et al. Neurohormonal activation in severe heart failure: relations to patient death and the effect of treatment with flosequinan. Am Heart J. 2000;139:587-95.
    • (2000) Am Heart J , vol.139 , pp. 587-595
    • Moe, G.W.1    Rouleau, J.L.2    Charbonneau, L.3    Proulx, G.4    Arnold, J.M.5    Hall, C.6
  • 47
    • 0029038397 scopus 로고
    • Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men
    • Sundberg S, Lilleberg J, Nieminen MS, Lehtonen L. Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men. Am J Cardiol. 1995;75:1061-6.
    • (1995) Am J Cardiol , vol.75 , pp. 1061-1066
    • Sundberg, S.1    Lilleberg, J.2    Nieminen, M.S.3    Lehtonen, L.4
  • 48
    • 0034032582 scopus 로고    scopus 로고
    • Haemodynamic interactions between the novel calcium sensitiser levosimendan and isosorbide-5-mononitrate in healthy subjects
    • Sundberg S, Lehtonen L. Haemodynamic interactions between the novel calcium sensitiser levosimendan and isosorbide-5-mononitrate in healthy subjects. Eur J Clin Pharmacol. 2000;55:793-9.
    • (2000) Eur J Clin Pharmacol , vol.55 , pp. 793-799
    • Sundberg, S.1    Lehtonen, L.2
  • 49
    • 0030909430 scopus 로고    scopus 로고
    • Myocardial efficiency during calcium sensitization with levosimendan: A noninvasive study with positron emission tomography and echocardiography in healthy volunteers
    • Ukkonen H, Saraste M, Akkila J, Knuuti MJ, Lehikoinen P, Någren K, et al. Myocardial efficiency during calcium sensitization with levosimendan: a noninvasive study with positron emission tomography and echocardiography in healthy volunteers. Clin Pharmacol Ther. 1997;61:596-607.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 596-607
    • Ukkonen, H.1    Saraste, M.2    Akkila, J.3    Knuuti, M.J.4    Lehikoinen, P.5    Någren, K.6
  • 50
    • 2942574937 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia
    • Sonntag S, Sundberg S, Lehtonen LA, Kleber FX. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol. 2004;43:2177-82.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2177-2182
    • Sonntag, S.1    Sundberg, S.2    Lehtonen, L.A.3    Kleber, F.X.4
  • 52
    • 0037422531 scopus 로고    scopus 로고
    • Sustained hemodynamic effects of intravenous levosimendan
    • Kivikko M, Lehtonen L, Colucci WS. Sustained hemodynamic effects of intravenous levosimendan. Circulation. 2003;107:81-6.
    • (2003) Circulation , vol.107 , pp. 81-86
    • Kivikko, M.1    Lehtonen, L.2    Colucci, W.S.3
  • 53
    • 0037142946 scopus 로고    scopus 로고
    • Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomised double-blind trial
    • Follath F, Cleland JG, Just H, Papp JG, Scholz H, Peuhkurinen K, et al. Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet. 2002;360:196-202.
    • (2002) Lancet , vol.360 , pp. 196-202
    • Follath, F.1    Cleland, J.G.2    Just, H.3    Papp, J.G.4    Scholz, H.5    Peuhkurinen, K.6
  • 54
    • 0036032273 scopus 로고    scopus 로고
    • The contractility enhancing effect of the calcium sensitiser levosimendan is not attenuated by carvedilol in healthy subjects
    • Lehtonen L, Sundberg S. The contractility enhancing effect of the calcium sensitiser levosimendan is not attenuated by carvedilol in healthy subjects. Eur J Clin Pharmacol. 2002;58:449-52.
    • (2002) Eur J Clin Pharmacol , vol.58 , pp. 449-452
    • Lehtonen, L.1    Sundberg, S.2
  • 55
    • 0031976338 scopus 로고    scopus 로고
    • Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting
    • Lilleberg J, Nieminen MS, Akkila J, Heikkila L, Kuitunen A, Lehtonen L, et al. Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting. Eur Heart J. 1998;19:660-8.
    • (1998) Eur Heart J , vol.19 , pp. 660-668
    • Lilleberg, J.1    Nieminen, M.S.2    Akkila, J.3    Heikkila, L.4    Kuitunen, A.5    Lehtonen, L.6
  • 56
    • 24944553441 scopus 로고    scopus 로고
    • Levosimendan improves hemodynamics and coronary flow reserve after percutaneous coronary intervention in patients with acute myocardial infarction and left ventricular dysfunction
    • De Luca L, Proietti P, Celotto A, Bucciarelli-Ducci C, Benedetti G, Di Roma A, et al. Levosimendan improves hemodynamics and coronary flow reserve after percutaneous coronary intervention in patients with acute myocardial infarction and left ventricular dysfunction. Am Heart J. 2005;150:563-8.
    • (2005) Am Heart J , vol.150 , pp. 563-568
    • De Luca, L.1    Proietti, P.2    Celotto, A.3    Bucciarelli-Ducci, C.4    Benedetti, G.5    Di Roma, A.6
  • 57
    • 33847021181 scopus 로고    scopus 로고
    • Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure: Results with levosimendan in the REVIVE-1 study. Abstract
    • August-3 September, Vienna, Austria
    • Packer M, Colucci WS, Fisher L, Massie BM, Teerlink JR, Young JB, et al. Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure: results with levosimendan in the REVIVE-1 study. Abstract. ESC Congress 2003, 30 August-3 September 2003, Vienna, Austria. http://cic.escardio.org/AbstractDetails.aspx?id56596&eevtid51.
    • (2003) ESC Congress 2003, 30
    • Packer, M.1    Colucci, W.S.2    Fisher, L.3    Massie, B.M.4    Teerlink, J.R.5    Young, J.B.6
  • 59
    • 0036764821 scopus 로고    scopus 로고
    • Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN)
    • Moiseyev VS, Põder P, Andrejevs N, Ruda MY, Golikov AP, Lazebnik LB, et al. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN). Eur Heart J. 2002;18:1422-32.
    • (2002) Eur Heart J , vol.18 , pp. 1422-1432
    • Moiseyev, V.S.1    Põder, P.2    Andrejevs, N.3    Ruda, M.Y.4    Golikov, A.P.5    Lazebnik, L.B.6
  • 60
    • 33847074147 scopus 로고    scopus 로고
    • The Effect of a Calcium Sensitizer or an Inotrope or None in Chronic Low Output Decompensated Heart Failure: Results From the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO). Abstract
    • 7-10 March, New Orleans, USA
    • Zairis MN, Apostolatos C, Anastasiadis P, Mytas D, Katsaris C, Kouris N, et al. The Effect of a Calcium Sensitizer or an Inotrope or None in Chronic Low Output Decompensated Heart Failure: Results From the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO). Abstract. Annual Scientific Sessions of the American College of Cardiology, 7-10 March 2004, New Orleans, USA.
    • (2004) Annual Scientific Sessions of the American College of Cardiology
    • Zairis, M.N.1    Apostolatos, C.2    Anastasiadis, P.3    Mytas, D.4    Katsaris, C.5    Kouris, N.6
  • 61
    • 17644414685 scopus 로고    scopus 로고
    • Study design of a mortality trial with intravenous levosimendan-the SURVIVE study-in patients with acutely decompensated heart failure
    • Mebazaa A, Cohen-Solal A, Kleber F, Nieminen M, Packer M, Pocock S, et al. Study design of a mortality trial with intravenous levosimendan-the SURVIVE study-in patients with acutely decompensated heart failure. Crit Care Med. 2004;8 Suppl 1:P87.
    • (2004) Crit Care Med , vol.8 , Issue.SUPPL. 1
    • Mebazaa, A.1    Cohen-Solal, A.2    Kleber, F.3    Nieminen, M.4    Packer, M.5    Pocock, S.6
  • 63
    • 0034126327 scopus 로고    scopus 로고
    • Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function
    • Toivonen L, Viitasalo M, Sundberg S, Akkila J, Lehtonen L. Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function. J Cardiovasc Pharmacol. 2000;35:664-9.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 664-669
    • Toivonen, L.1    Viitasalo, M.2    Sundberg, S.3    Akkila, J.4    Lehtonen, L.5
  • 64
    • 0004959878 scopus 로고    scopus 로고
    • Effects of levosimendan on cardiac arrhythmia: Electrophysiologic and ambulatory electrocardiographic findings in phase II and phase IIII clinical studies in cardiac failure
    • Singh BN, Lilleberg J, Sandell EP, Ylönen V, Lehtonen L, Toivonen L. Effects of levosimendan on cardiac arrhythmia: electrophysiologic and ambulatory electrocardiographic findings in phase II and phase IIII clinical studies in cardiac failure. Am J Cardiol. 1999;83 Suppl 12B:9-11.
    • (1999) Am J Cardiol , vol.83 , Issue.SUPPL. 12B , pp. 9-11
    • Singh, B.N.1    Lilleberg, J.2    Sandell, E.P.3    Ylönen, V.4    Lehtonen, L.5    Toivonen, L.6
  • 65
    • 2442662755 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan and cardiac arrhythmias: An analysis of the safety database of heart failure treatment studies
    • Lilleberg J, Ylonen V, Lehtonen L, Toivonen L. The calcium sensitizer levosimendan and cardiac arrhythmias: an analysis of the safety database of heart failure treatment studies. Scand Cardiovasc J. 2004;38:80-4.
    • (2004) Scand Cardiovasc J , vol.38 , pp. 80-84
    • Lilleberg, J.1    Ylonen, V.2    Lehtonen, L.3    Toivonen, L.4
  • 66
    • 0031596437 scopus 로고    scopus 로고
    • The CYP3A4 inhibitor intraconazole does not affect the pharmacokinetics of a new calcium-sensitizing drug levosimendan
    • Antila S, Honkanen T, Lehtonen L, Neuvonen PJ. The CYP3A4 inhibitor intraconazole does not affect the pharmacokinetics of a new calcium-sensitizing drug levosimendan. Int J Clin Pharmacol Ther. 1998;36:446-9.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , pp. 446-449
    • Antila, S.1    Honkanen, T.2    Lehtonen, L.3    Neuvonen, P.J.4
  • 67
    • 17744401974 scopus 로고    scopus 로고
    • Pharmacodynamic interactions of levosimendan and felodipine in patients with coronary heart disease
    • Põder P, Eha J, Antila S, Heinpalu M, Planken Ü , Loogna I, et al. Pharmacodynamic interactions of levosimendan and felodipine in patients with coronary heart disease. Cardiovasc Drugs Ther. 2003;17:451-8.
    • (2003) Cardiovasc Drugs Ther , vol.17 , pp. 451-458
    • Põder, P.1    Eha, J.2    Antila, S.3    Heinpalu, M.4    Planken, U.5    Loogna, I.6
  • 69
    • 0033600154 scopus 로고    scopus 로고
    • Oral levosimendan improves cardiac function and hemodynamics in patients with severe congestive heart failure
    • Harjola VP, Peuhkurinen K, Nieminen MS, Niemelä M, Sundberg S. Oral levosimendan improves cardiac function and hemodynamics in patients with severe congestive heart failure. Am J Cardiol. 1999;83 Suppl 12B:4-8.
    • (1999) Am J Cardiol , vol.83 , Issue.SUPPL. 12B , pp. 4-8
    • Harjola, V.P.1    Peuhkurinen, K.2    Nieminen, M.S.3    Niemelä, M.4    Sundberg, S.5
  • 70
    • 4444363048 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of oral levosimendan and its metabolites in patients with severe congestive heart failure: A dosing interval study
    • Põder P, Eha J, Sundberg S, Antila S, Heinpalu M, Loogna I, et al. Pharmacodynamics and pharmacokinetics of oral levosimendan and its metabolites in patients with severe congestive heart failure: a dosing interval study. J Clin Pharmacol. 2004;44:1143-50.
    • (2004) J Clin Pharmacol , vol.44 , pp. 1143-1150
    • Põder, P.1    Eha, J.2    Sundberg, S.3    Antila, S.4    Heinpalu, M.5    Loogna, I.6
  • 71
    • 0033600181 scopus 로고    scopus 로고
    • Levosimendan, a novel myofilament calcium sensitizer, allows weaning of parenteral inotropic therapy in patients with severe congestive heart failure
    • and the oral levosimendan study group
    • Hosenpud JD, and the oral levosimendan study group, Levosimendan, a novel myofilament calcium sensitizer, allows weaning of parenteral inotropic therapy in patients with severe congestive heart failure. Am J Cardiol. 1999;83 Suppl 12B:9-11.
    • (1999) Am J Cardiol , vol.83 , Issue.SUPPL. 12B , pp. 9-11
    • Hosenpud, J.D.1
  • 72
    • 20044379730 scopus 로고    scopus 로고
    • ESC Committee for Practice Guideline (CPG). Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: The Task Force on Acute Heart Failure of the European Society of Cardiology
    • Nieminen MS, Bohm M, Cowie MR, Drexler H, Filippatos GS, Jondeau G, et al. ESC Committee for Practice Guideline (CPG). Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J. 2005;26:384-416.
    • (2005) Eur Heart J , vol.26 , pp. 384-416
    • Nieminen, M.S.1    Bohm, M.2    Cowie, M.R.3    Drexler, H.4    Filippatos, G.S.5    Jondeau, G.6
  • 73
    • 0033600141 scopus 로고    scopus 로고
    • Dose-ranging and safety with intravenous levosimendan in low-output heart failure: Experience in three pilot studies and outline of the levosimendan infusion versus dobutamine (LIDO) trial
    • Follath F, Hinkka S, Jäger D, Just H, Mitrovic V, Papp JG, et al. Dose-ranging and safety with intravenous levosimendan in low-output heart failure: Experience in three pilot studies and outline of the levosimendan infusion versus dobutamine (LIDO) trial. Am J Cardiol. 1999;83 Suppl 12B:21-5.
    • (1999) Am J Cardiol , vol.83 , Issue.SUPPL. 12B , pp. 21-25
    • Follath, F.1    Hinkka, S.2    Jäger, D.3    Just, H.4    Mitrovic, V.5    Papp, J.G.6
  • 74
    • 0032771929 scopus 로고    scopus 로고
    • Levosimendan enhances cardiac performance after cardiopulmonary bypass: A prospective, randomized placebo-controlled trial
    • Nijhawan N, Nicolosi AC, Montgomery MW, Aggarwal A, Pagel PS, Warltier DC. Levosimendan enhances cardiac performance after cardiopulmonary bypass: a prospective, randomized placebo-controlled trial. J Cardiovasc Pharmacol. 1999;34:219-28.
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 219-228
    • Nijhawan, N.1    Nicolosi, A.C.2    Montgomery, M.W.3    Aggarwal, A.4    Pagel, P.S.5    Warltier, D.C.6
  • 75
    • 29444454634 scopus 로고    scopus 로고
    • Clinical trials update from the American Heart Association: REPAIRAMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE
    • Cleland JG, Freemantle N, Coletta AP, Clark AL. Clinical trials update from the American Heart Association: REPAIRAMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE. Eur J Heart Fail. 2006;8:105-10.
    • (2006) Eur J Heart Fail , vol.8 , pp. 105-110
    • Cleland, J.G.1    Freemantle, N.2    Coletta, A.P.3    Clark, A.L.4
  • 76
    • 33646873253 scopus 로고    scopus 로고
    • Preconditioning effects of levosimendan in coronary artery bypass grafting - a pilot study
    • Tritapepe L, De Santis V, Vitale D, Santulli M, Morelli A, Nofroni I, et al. Preconditioning effects of levosimendan in coronary artery bypass grafting - a pilot study. Br J Anaesth. 2006;96:694-700.
    • (2006) Br J Anaesth , vol.96 , pp. 694-700
    • Tritapepe, L.1    De Santis, V.2    Vitale, D.3    Santulli, M.4    Morelli, A.5    Nofroni, I.6
  • 78
    • 16344362711 scopus 로고    scopus 로고
    • Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake
    • Michaels AD, McKeown B, Kostal M, Vakharia KT, Jordan MV, Gerber IL, et al. Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake. Circulation. 2005;111:1504-9.
    • (2005) Circulation , vol.111 , pp. 1504-1509
    • Michaels, A.D.1    McKeown, B.2    Kostal, M.3    Vakharia, K.T.4    Jordan, M.V.5    Gerber, I.L.6
  • 79
    • 33847068691 scopus 로고    scopus 로고
    • Duration of the haemodynamic action of a 24-hour infusion of levosimendan in patients with congestive heart failure
    • Jul 6; [Epub ahead of print
    • Lilleberg J, Laine M, Palkama T, Kivikko M, Pohjanjousi P, Kupari M. Duration of the haemodynamic action of a 24-hour infusion of levosimendan in patients with congestive heart failure. Eur J Heart Fail 2006 Jul 6; [Epub ahead of print].
    • (2006) Eur J Heart Fail
    • Lilleberg, J.1    Laine, M.2    Palkama, T.3    Kivikko, M.4    Pohjanjousi, P.5    Kupari, M.6
  • 82
    • 33748925936 scopus 로고    scopus 로고
    • Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure
    • Braun JP, Jasulaitis D, Moshirzadeh M, Doepfmer UR, Kastrup M, von Heymann C, et al. Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure. Crit Care. 2006;10:R17.
    • (2006) Crit Care , vol.10
    • Braun, J.P.1    Jasulaitis, D.2    Moshirzadeh, M.3    Doepfmer, U.R.4    Kastrup, M.5    von Heymann, C.6
  • 83
    • 33847064231 scopus 로고    scopus 로고
    • Orion Corporation, Company communication June 6, Available from
    • Orion Corporation, Results of PERSIST study with oral levosimendan. Company communication June 6, 2006. Available from: http://www. orionennenjakautumista.fi/english/investors/stockreleases.shtml/a05?24526.
    • (2006) Results of PERSIST study with oral levosimendan
  • 84
    • 13444277652 scopus 로고    scopus 로고
    • Levosimendan: A new inodilatory drug for the treatment of decompensated heart failure
    • Kivikko M, Lehtonen L. Levosimendan: a new inodilatory drug for the treatment of decompensated heart failure. Curr Pharm Des. 2005;1:435-55.
    • (2005) Curr Pharm Des , vol.1 , pp. 435-455
    • Kivikko, M.1    Lehtonen, L.2
  • 85
    • 0037028773 scopus 로고    scopus 로고
    • Medical management of advanced heart failure
    • Nohria A, Lewis E, Stevenson LW. Medical management of advanced heart failure. JAMA. 2002;287:628-40.
    • (2002) JAMA , vol.287 , pp. 628-640
    • Nohria, A.1    Lewis, E.2    Stevenson, L.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.