Mechanisms of the contractile effects of levosimendan in the mammalian heart

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 1, 1997, Pages 277-283

  Bokník, Peter ^a   Neumann, Joachim ^a   Kaspareit, Grit ^a,b   Schmitz, Wilhelm ^a   Scholz, Hasso ^a,b   Vahlensieck, Ute ^a   Zimmermann, Norbert ^a,b,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOSIMENDAN;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG MECHANISM; GUINEA PIG; HEART FAILURE; HEART MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CARBACHOL; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HYDRAZONES; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PHOSPHORYLATION; PROTEINS; PYRIDAZINES;

EID: 0030974966     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. BETHKE, T., ESCHENHAGEN, T., KLIMKIEWICZ, A., KOHL, C., VON DER LEYEN, H., MEHL, H., MENDE, U., MEYER, W., NEUMANN, J., ROSSWAG, S., SCHMITZ, W., SCHOLZ, H., STARBATTY, J., STEIN, B., WENZLAFF, H., DÖRING, V., KALMÁR, P. AND HAVERICH, A.: Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts. Arzneim.-Forsch./Drug Res. 42: 437-445, 1992.
2. BETHKE, T., KLIMKIEWICZ, A., KOHL, C., VON DER LEYEN, H., MEHL, H., MENDE, U., MEYER, W., NEUMANN, J., SCHMITZ, W., SCHOLZ, H., STARBATTY, J., STEIN, B., WENZLAFF, H., DÖRING, V., KALMÁR, P. AND HAVERICH, A.: Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts. J. Cardiovasc. Pharmacol. 18: 386-397, 1991.
3. BÖHM, M., BRÜCKNER, R., HACKBARTH, I., HAUBITZ, B., LINHART, R., MEYER, W., SCHMIDT, B., SCHMITZ, W. AND SCHULZ, H.: Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular preparations. J. Pharmacol. Exp. Ther. 230: 483-492, 1984.
4. BRADFORD, M. M.: A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem, 72: 248-254, 1976.
5. BRISTOW, M. R., GINSBURG, R., MINOBE, W., CUBICCIOTTI, R. S., SAGEMAN, W. S., LURIE, K., BILLINGHAM, M. E., HARRISON, D. C. AND STINSON, E. B.: Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts. N. Engl. J. Med. 307: 205-211, 1982.
6. BRUNKHORST, D., v. DER LEYEN, H., MEYER, W., NIGBUR, R., SCHMIDT-SCHUMACHER, C. AND SCHOLZ, H.: Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 339: 575-583, 1989.
7. BRÜCKNER, R., SCHMITZ, W., SCHOLZ, H., SCHUMACHER, A., ERDMANN, E., KRAWIETZ, W. AND WERDAN, K.: Negative inotropic effect of vanadate in ventricular myocardium in the presence of 3-isobutyl-1-methylxanthine or isoprenaline. Naunyn-Schmiedeberg's Arch. Pharmacol. 315: 147-153, 1980.
8. EARL, C. Q., LINDEN, J. AND WEGLICKI, W. B.: Biochemical mechanisms for the inotropic effect of the cardiotonic drug milrinone. J. Cardiovasc. Pharmacol. 8: 864-872, 1986.
9. 2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circ. Res. 77: 107-113, 1995.
10. ENDOH, M. AND MOTOMURA, S.: Differentiation by cholinergic stimulation of positive inotropic actions mediated via alpha- and beta-adrenoceptors in the rabbit heart. Life Sci. 25: 759-768, 1979.
11. FELDMAN, M. D., COPELAS, L., GWATHMEY, J. K., PHILLIPS, P., WARREN, S. E., SCHOEN, F. J., GROSSMAN, W. AND MORGAN, J. P.: Deficient production of cyclic AMP: Pharmacologic evidence of an important cause of contractile dysfunction in patients with endstage heart failure. Circulation 75: 331-339, 1987.
12. 2+ activation and the inotropic effect of pimobendan: Comparison with milrinone. Circ. Res. 63: 911-922, 1988.
13. 1,-adenosine-receptor mediated inhibition of isoproterenol-stimulated protein phosphorylation in ventricular myocytes. Evidence against a cyclic AMP-dependent effect. Circ. Res. 72: 65-74, 1993.
14. HAIKALA, H., LEVIJOKI, J. AND LINDÉN, I. B.: Troponin C-mediated calcium sensitization by levosimendan accelerates the proportional development of isometric tension. J. Mol. Cell. Cardiol. 27: 2155-2165, 1995.
15. HARTZELL, H. C., MERY, F. R., FISCHMEISTER, R. AND SZABO, G.: Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation. Nature (Lond.) 351: 573-576, 1991.
16. HELLER, T., KÖCHER, M., NEUMANN, J., SCHMITZ, W., SCHOLZ, H., STEMMILDT, V. AND STÖRTZEL, K.: Effects of adenosine analogues on force and cAMP in the heart. Influence of adenosine deaminase. Eur. J. Pharmacol. 164: 179-187, 1989.
17. HEROLD, P., HERZIG, J. W., WENK, P., LEUTERT, T., ZBINDEN, P., FUHRER, P., STUTZ, S., SCHENKER, K., MEIER, M. AND RIHS, G.: 5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4-dione (BA 41899): Representative of a novel class of purely calcium-sensitizing agents. J. Med. Chem. 38: 2946-2954, 1995.
18. 2+ channels. Pflügers Arch. 420: 531-538, 1995.
19. 2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers. J. Gen. Physiol. 97: 1141-1163, 1991.
20. 4. Nature (Lond.) 227: 680-685, 1970.
21. LEE, J. A. AND ALLEN, D. G.: Calcium sensitizers and heart failure. Exp. Opin. Invest. Drugs 4: 1057-1065, 1995.
22. LUES, I., BEIER, N., JONAS, R., KLOCKOW, M. AND HAEUSLER, G.: The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J. Cardiovasc. Pharmacol. 21: 883-892, 1993.
23. LUO, W., GRUPP, I. L., HARRER, J., PONNIAH, S., GRUPP, G., DUFFY, J. J., DOETSCHMAN, T. AND KRANIAS, E. G.: Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation. Circ. Res. 75: 401-409, 1994.
24. NEUMANN, J., BOKNÍK, P., HERZIG, S., SCHMITZ, W., SCHOLZ, H., GUPTA, R. C. AND WATANABE, A. M.: Evidence for physiological functions of protein phosphatases in the heart: Evaluation with okadaic acid. Am. J. Physiol. 265: H257-H266, 1993.
25. NEUMANN, J., BOKNÍK, P., BODOR, G. S., JONES, L. R., SCHMITZ, W. AND SCHOLZ, H.: Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin. J. Pharmacol. Exp. Ther. 269: 1310-1318, 1994.
26. NEUMANN, J., BOKNÍK, P., KASPAREIT, G., BARTEL, S., KRAUSE, E. G., PASK, H. T., SCHMITZ, W. AND SCHOLZ, H.: Effects of the phosphatase inhibitor calyculin A on the phosphorylation of C-protein in mammalian ventricular cardiomyocytes. Biochem. Pharmacol, 49: 1583-1588, 1995a.
27. NEUMANN, J., BOKNÍK, P., SCHMITZ, W., SCHOLZ, H. AND ZIMMERMANN, N.: Comparison of stereoselective effects of a thiadiazinone derivative on contractile parameters and protein phosphorylation in the mammalian ventricle. J. Cardiovasc. Pharmacol. 25: 789-793, 1995c.
28. NEUMANN, J., GRUPP, I. L., GRUPP, G., HAVERICH, A., HERZIG, J. W., HIRT, S., SCHMITZ, W., SCHOLZ, H., WENZLAFF, H. AND ZIMMERMANN, N.: Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium. J. Pharmacol. Exp. Ther. 277: 1579-1585, 1996.
29. NEUMANN, J., HERZIG, S., BOKNÍK, P., APEL, M., KASPAREIT, G., SCHMITZ, W., SCHOLZ, H., TEPEL, M. AND ZIMMERMANN, N.: On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor. J. Pharmacol. Exp. Ther. 274: 530-539, 1995b.
30. 2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study. J. Biol. Chem. 269: 28584-28590, 1994.
31. RAASMAJA, A., TALO, A., NISSINEN, E., LINDEN, I. B. AND POHTO, P.: Biochemical mechanisms of the novel cardiotonic agent OR-1259, J. Moll. Cell. Cardiol. 23: suppl. V, S.129, 1991.
32. RAPUNDALO, S. T., SOLARO, R. J. AND KRANIAS, E. G.: Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: Comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins. Circ. Res. 64: 104-111, 1989.
33. RÜEGG, J. C. AND SOLARO, R. J.: Calcium-sensitizing positive inotropic drugs. In Heart Failure: Basic Science and Clinical Aspects, ed. by J. K. Gwathmey, G. M. Briggs and P. D. Allen, pp. 457-473, Marcell Dekker Inc., New York, 1993.
34. RUMP, A. F. E., ACAR, D. AND KLAUS, W.: A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase inhibitors amrinone, milrinone and levosimendan in rabbit isolated hearts. Br. J. Pharmacol. 112: 757-762, 1994.
35. SCHMITZ, W., ESCHENHAGEN, T., MENDS, U., MÜLLER, F. U., NEUMANN, J. AND SCHOLZ, H.: Phosphodiesterase inhibition and positive inotropy in failing human myocardium. In Cellular and Molecular Alterations in the Failing Human Heart, ed. by G. Hasenfuss, Ch. Holubarsch, H. Just and N. R. Alpert, pp. 65-71, Steinkopff Verlag, Darmstadt, FRG, 1992.
36. 2+ uptake in mammalian ventricular myocytes. Am. J. Physiol. 261: H1344-H1349, 1991.
37. 2-adrenoceptor mediated positive inotropic effects in human end-stage heart failure. Br. J. Pharmacol. 105: 463-469, 1992.
38. VÉGH, A., UDVARY, E. AND PAPP, J. G.: Effects of simendan in a model of acute heart failure produced by severe regional myocardial ischaemia in dogs. J. Mol. Cell. Cardiol. 24: suppl V, S.45, 1992.
39. WOLSKA, B. M., KITADA, Y., PALMITER, K. A., WESTFALL, M. V., JOHNSON, M. D. AND SOLARO, R. J.: CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction. Am. J. Physiol. 270: H24-H32, 1996.
40. ZIMMERMANN, N., BODOR, G. S., BOKNÍK, P., GAMS, E., JONES, L. R., NEUMANN, J. AND SCHOLZ, H.: Mechanisms of the contractile effects of flosequinoxan. Naunyn Schmiedeberg's Arch. Pharmacol. 351: 385-390, 1995.
41. ZIMMERMANN, N., BOKNÍK, P., GAMS, E., HERZIG, J. W., NEUMANN, J., SCHMITZ, W., SCHOLZ, H. AND WENZLAFF, H.: Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium. J. Pharmacol. Exp. Ther. 277: 1572-1578, 1996a.
42. ZIMMERMANN, N., BOKNÍK, P., GAMS, E., GSELL, S., JONES, L. R., MAAS, R., NEUMANN, J. AND SCHOLZ, H.: Mechanisms of the contractile effects of 2,3-butanedione-monoxime in the mammalian heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 354: 431-436, 1996b.