Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype

Diabetes

Volumn 56, Issue 2, 2007, Pages 424-430

  Chen, Yi Guang ^a   Silveira, Pablo A ^a,b   Osborne, Melissa A ^a   Chapman, Harold D ^a   Serreze, David V ^a  

^a JACKSON LABORATORY   (United States)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

H2 ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CD8+ T LYMPHOCYTE; CHIMERA; CONTROLLED STUDY; DENDRITIC CELL; ENGRAFTMENT; FEMALE; GENE DELETION; HAPLOTYPE; INSULIN DEPENDENT DIABETES MELLITUS; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD8; B-LYMPHOCYTES; BONE MARROW; CHIMERA; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; FEMALE; HAPLOTYPES; IMMUNITY, NATURAL; INSULIN-SECRETING CELLS; MACROPHAGES; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED NOD;

EID: 33847028326     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1303     Document Type: Article

References (28)

1. Serreze DV, Leiter EH: Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice. Curr Dir Autoimmun 4:31-67, 2001
2. Walker LS, Abbas AK: The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2:11-19, 2002
3. Kyewski B, Klein L: A central role for central tolerance. Annu Rev Immunol 24:571-606, 2006
4. Singer SM, Tisch R, Yang XD, McDevitt HO: An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc Natl Acad Sci U S A 90:9566-9570, 1993
5. Hanson MS, Cetkovic-Cvrlje M, Ramiya VK, Atkinson MA, Maclaren NK, Singh B, Elliott JF, Serreze DV, Leiter EH: Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol 157:1279-1287, 1996
6. Uehira M, Uno M, Kurner T, Kikutani H, Mori K, Inomoto T, Uede T, Miyazaki J, Nishimoto H, Kishimoto T, et al.: Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice. Int Immunol 1:209-213, 1989
7. Lund T, O'Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R, Chandler P, Dyson J, Picard JK, Edwards A, et al.: Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain. Nature 345:727-729, 1990
8. Wicker LS, Miller BJ, Fischer PA, Pressey A, Peterson LB: Genetic control of diabetes and insulitis in the nonobese diabetic mouse: pedigree analysis of a diabetic H-2nod/b heterozygote. J Immunol 142:781-784, 1989
9. Prochazka M, Serreze DV, Worthen SM, Leiter EH: Genetic control of diabetogenesis in NOD/Lt mice: development and analysis of congenic stocks. Diabetes 38:1446-1455, 1989
10. Serreze DV, Leiter EH: Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium. J Immunol 147:1222-1229, 1991
11. Wicker LS, Appel MC, Dotta F, Pressey A, Miller BJ, DeLarato NH, Fischer PA, Boltz RC Jr, Peterson LB: Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice: the NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med 176:67-77, 1992
12. Schmidt D, Amrani A, Verdaguer J, Bou S, Santamaria P: Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules. J Immunol 162:4627-4636, 1999
13. Schmidt D, Verdaguer J, Averill N, Santamaria P: A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med 186:1059-1075, 1997
14. Serreze DV, Holl TM, Marron MP, Graser RT, Johnson EA, Choisy-Rossi C, Slattery RM, Lieberman SM, DiLorenzo TP: MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice. J Immunol 172:871-879, 2004
15. Nepom GT, Kwok WW: Molecular basis for HLA-DQ associations with IDDM. Diabetes 47:1177-1184, 1998
16. Ikehara S, Ohtsuki H, Good RA, Asamoto H, Nakamura T, Sekita K, Muso E, Tochino Y, Ida T, Kuzuya H, et al.: Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation. Proc Natl Acad Sci U S A 82:7743-7747, 1985
17. LaFace DM, Peck AB: Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 38:894-901, 1989
18. Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST: Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 156:380-388, 1996
19. Mathieu C, Casteels K, Bouillon R, Waer M: Protection against autoimmune diabetes in mixed bone marrow chimeras: mechanisms involved. J Immunol 158:1453-1457, 1997
20. Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL: Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 95:2175-2182, 2000
21. Nikolic B, Takeuchi Y, Leykin I, Fudaba Y, Smith RN, Sykes M: Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes 53:376-383, 2004
22. Ildstad ST, Chilton PM, Xu H, Domenick MA, Ray MB: Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR+ and CD4+ cells negates the effect. Blood 105:2577-2584, 2005
23. Silveira PA, Johnson E, Chapman HD, Bui T, Tisch RM, Serreze DV: The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors. Eur J Immunol 32:3657-3666, 2002
24. Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV: Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164:3913-3918, 2000
25. Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tisch RM: B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 161:3912-3918, 1998
26. Johnson EA, Silveira P, Chapman HD, Leiter EH, Serreze DV: Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: additive, but unequal, involvement of multiple APC subtypes. J Immunol 167:2404-2410, 2001
27. Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL: Partial versus full allogeneic hematopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. J Immunol 177:6675-6684, 2006
28. Anderson MS, Bluestone JA: The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23:447-485, 2005